| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Björn Schilström, Nina Rawal, Monica Mameli-Engvall, George G Nomikos, Torgny H Svensso. Dual effects of nicotine on dopamine neurons mediated by different nicotinic receptor subtypes. The international journal of neuropsychopharmacology. vol 6. issue 1. 2009-04-06. PMID:12899731. |
dual effects of nicotine on dopamine neurons mediated by different nicotinic receptor subtypes. |
2009-04-06 |
2023-08-12 |
Not clear |
| Björn Schilström, Nina Rawal, Monica Mameli-Engvall, George G Nomikos, Torgny H Svensso. Dual effects of nicotine on dopamine neurons mediated by different nicotinic receptor subtypes. The international journal of neuropsychopharmacology. vol 6. issue 1. 2009-04-06. PMID:12899731. |
nicotine also increased fos-like immunoreactivity in dopamine target areas, an effect that was antagonized with mla but not with dh beta e. our data suggest that nicotine's augmenting effect on burst firing is, indeed, due to stimulation of alpha 7 nicotinic receptors whereas other nicotinic receptors seem to induce an increase in firing frequency. |
2009-04-06 |
2023-08-12 |
Not clear |
| Mario E Alburges, Paul S Frankel, Amanda J Hoonakker, Glen R Hanso. Responses of limbic and extrapyramidal substance P systems to nicotine treatment. Psychopharmacology. vol 201. issue 4. 2009-04-01. PMID:18773198. |
the effects of nicotine on these dopamine systems have also been extensively studied; however, its effects on the associated sp pathways have received little attention. |
2009-04-01 |
2023-08-12 |
Not clear |
| Raffaella Isola, Hailin Zhang, Gopi A Tejwani, Norton H Neff, Maria Hadjiconstantino. Acute nicotine changes dynorphin and prodynorphin mRNA in the striatum. Psychopharmacology. vol 201. issue 4. 2009-04-01. PMID:18807250. |
nicotine displays rewarding and aversive effects, and while dopamine has been linked with nicotine's reward, the neurotransmitter(s) involved with aversion remains speculative. |
2009-04-01 |
2023-08-12 |
Not clear |
| Edward D Levin, Susan Slade, Michael Johnson, Ann Petro, Kofi Horton, Paul Williams, Amir H Rezvani, Jed E Ros. Ketanserin, a 5-HT2 receptor antagonist, decreases nicotine self-administration in rats. European journal of pharmacology. vol 600. issue 1-3. 2009-03-27. PMID:18950618. |
nicotine induces serotonin (5-ht) release, which has not classically been thought to be involved in tobacco addiction as dopamine has. |
2009-03-27 |
2023-08-12 |
rat |
| Hiroki Takeuchi, Takashi Yanagida, Masatoshi Inden, Kazuyuki Takata, Yoshihisa Kitamura, Kentaro Yamakawa, Hideyuki Sawada, Yasuhiko Izumi, Noriyuki Yamamoto, Takeshi Kihara, Kengo Uemura, Haruhisa Inoue, Takashi Taniguchi, Akinori Akaike, Ryosuke Takahashi, Shun Shimoham. Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models. Journal of neuroscience research. vol 87. issue 2. 2009-03-25. PMID:18803299. |
nicotine, a releaser of dopamine from da neurons, is one of the candidates of antiparkinson agents in tobacco. |
2009-03-25 |
2023-08-12 |
mouse |
| Jun Zhu, Subbu Apparsundaram, Linda P Dwoski. Nicotinic receptor activation increases [3H]dopamine uptake and cell surface expression of dopamine transporters in rat prefrontal cortex. The Journal of pharmacology and experimental therapeutics. vol 328. issue 3. 2009-03-24. PMID:19088301. |
previous research shows that nicotine increases dopamine (da) clearance in rat prefrontal cortex (pfc) and striatum via a nicotinic receptor (nachr)-mediated mechanism. |
2009-03-24 |
2023-08-12 |
rat |
| Neil E Paterso. Behavioural and pharmacological mechanisms of bupropion's anti-smoking effects: recent preclinical and clinical insights. European journal of pharmacology. vol 603. issue 1-3. 2009-03-18. PMID:19101536. |
third, it is suggested that the unique mixed pharmacological profile of bupropion provides (1) attenuation of the multiple negative consequences of withdrawal via blockade of dopamine and noradrenaline reuptake; (2) replacement of the reward-facilitating and subjective effects of nicotine via blockade of dopaminergic reuptake; (3) attenuation of the rewarding effects of acute nicotine by nicotinic acetylcholine receptor blockade. |
2009-03-18 |
2023-08-12 |
Not clear |
| J Zhu, M E A Reit. Role of the dopamine transporter in the action of psychostimulants, nicotine, and other drugs of abuse. CNS & neurological disorders drug targets. vol 7. issue 5. 2009-03-05. PMID:19128199. |
role of the dopamine transporter in the action of psychostimulants, nicotine, and other drugs of abuse. |
2009-03-05 |
2023-08-12 |
Not clear |
| Allison B Gold, Ashleigh B Keller, David C Perr. Prenatal exposure of rats to nicotine causes persistent alterations of nicotinic cholinergic receptors. Brain research. vol 1250. 2009-02-27. PMID:19028470. |
nicotine exposure in adolescents caused decreased nicotine-stimulated dopamine release in striatum; this effect was lost in animals prenatally exposed to nicotine. |
2009-02-27 |
2023-08-12 |
rat |
| Allison B Gold, Ashleigh B Keller, David C Perr. Prenatal exposure of rats to nicotine causes persistent alterations of nicotinic cholinergic receptors. Brain research. vol 1250. 2009-02-27. PMID:19028470. |
nicotine-stimulated striatal dopamine release (both total and alpha-conotoxin mii-resistant release) increased with age in naïve animals, but not in those prenatally exposed to nicotine. |
2009-02-27 |
2023-08-12 |
rat |
| Arthur L Brody, Mark A Mandelkern, Richard E Olmstead, Zoe Allen-Martinez, David Scheibal, Anna L Abrams, Matthew R Costello, Judah Farahi, Sanjaya Saxena, John Monterosso, Edythe D Londo. Ventral striatal dopamine release in response to smoking a regular vs a denicotinized cigarette. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 2. 2009-02-23. PMID:18563061. |
prior studies have demonstrated that both nicotine administration and cigarette smoking lead to dopamine (da) release in the ventral striatum/nucleus accumbens. |
2009-02-23 |
2023-08-12 |
Not clear |
| Evelyn K Lambe, Tony P Georg. Perspective: Translational studies on glutamate and dopamine neurocircuitry in addictions: implications for addiction treatment. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 2. 2009-02-23. PMID:18987625. |
new research suggests that the modulation of dopamine neurocircuitry by glutamate plays a key role in the development of nicotine and other addictions. |
2009-02-23 |
2023-08-12 |
Not clear |
| Yan Qi Liang, Xiao Tian Huang, Xi Can Tan. Huperzine A reverses cholinergic and monoaminergic dysfunction induced by bilateral nucleus basalis magnocellularis injection of beta-amyloid peptide (1-40) in rats. Cellular and molecular neurobiology. vol 28. issue 1. 2009-01-28. PMID:17636406. |
likewise, this treatment ameliorated the beta-amyloid peptide-(1-40)-induced deficits in extracellular acetylcholine, dopamine, and norepinephrine (though not 5-hydroxytryptamine) in medial prefrontal cortex, and lessened the reduction in nicotine or methoctramine-stimulated release of acetylcholine and k(+)-evoked releases of acetylcholine and dopamine. |
2009-01-28 |
2023-08-12 |
rat |
| Adrie W Bruijnzeel, Athina Marko. Decreased sensitivity to the effects of dopamine D1-like, but not D2-like, receptor antagonism in the posterior hypothalamic region/anterior ventral tegmental area on brain reward function during chronic exposure to nicotine in rats. Brain research. vol 1058. issue 1-2. 2009-01-26. PMID:16126181. |
decreased sensitivity to the effects of dopamine d1-like, but not d2-like, receptor antagonism in the posterior hypothalamic region/anterior ventral tegmental area on brain reward function during chronic exposure to nicotine in rats. |
2009-01-26 |
2023-08-12 |
rat |
| Adrie W Bruijnzeel, Athina Marko. Decreased sensitivity to the effects of dopamine D1-like, but not D2-like, receptor antagonism in the posterior hypothalamic region/anterior ventral tegmental area on brain reward function during chronic exposure to nicotine in rats. Brain research. vol 1058. issue 1-2. 2009-01-26. PMID:16126181. |
the present studies were conducted to assess the effects of chronic nicotine administration on dopamine d1- and d2-like receptor activity in the posterior hypothalamus/anterior ventral tegmental area (vta). |
2009-01-26 |
2023-08-12 |
rat |
| Paul J Fletcher, Anh Dzung Lê, Guy A Higgin. Serotonin receptors as potential targets for modulation of nicotine use and dependence. Progress in brain research. vol 172. 2009-01-15. PMID:18772042. |
some behavioural effects of nicotine, including its reinforcing efficacy result in part from activation of mesolimbic dopamine neurons. |
2009-01-15 |
2023-08-12 |
Not clear |
| Paul J Fletcher, Anh Dzung Lê, Guy A Higgin. Serotonin receptors as potential targets for modulation of nicotine use and dependence. Progress in brain research. vol 172. 2009-01-15. PMID:18772042. |
modulation of dopamine function is one potential treatment strategy that could treat nicotine dependence. |
2009-01-15 |
2023-08-12 |
Not clear |
| Paul J Fletcher, Anh Dzung Lê, Guy A Higgin. Serotonin receptors as potential targets for modulation of nicotine use and dependence. Progress in brain research. vol 172. 2009-01-15. PMID:18772042. |
5-ht(2c) receptor agonists block the stimulatory action of nicotine on midbrain dopamine function. |
2009-01-15 |
2023-08-12 |
Not clear |
| Andon N Placzek, John A Dan. Synaptic plasticity within midbrain dopamine centers contributes to nicotine addiction. Nebraska Symposium on Motivation. Nebraska Symposium on Motivation. vol 55. 2009-01-14. PMID:19013936. |
synaptic plasticity within midbrain dopamine centers contributes to nicotine addiction. |
2009-01-14 |
2023-08-12 |
Not clear |