| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P A Low, T L Opfer-Gehrking, M Kihar. In vivo studies on receptor pharmacology of the human eccrine sweat gland. Clinical autonomic research : official journal of the Clinical Autonomic Research Society. vol 2. issue 1. 1992-09-01. PMID:1638102. |
the axon-reflex response to nicotine and acetylcholine was partially blocked by pilocarpine, especially when application of pilocarpine preceded the procedure. |
1992-09-01 |
2023-08-11 |
human |
| J Connolly, J Boulter, S F Heineman. Alpha 4-2 beta 2 and other nicotinic acetylcholine receptor subtypes as targets of psychoactive and addictive drugs. British journal of pharmacology. vol 105. issue 3. 1992-08-20. PMID:1378342. |
for each subtype, the relative potency of nicotine compared with acetylcholine was obtained by estimating the relative concentration of nicotine which would elicit the same current response as 0.1 microm ach. |
1992-08-20 |
2023-08-11 |
mouse |
| K R Rogers, J C Fernando, R G Thompson, J J Valdes, M E Eldefraw. Detection of nicotinic receptor ligands with a light addressable potentiometric sensor. Analytical biochemistry. vol 202. issue 1. 1992-08-06. PMID:1621972. |
this biosensor detected both agonists (acetylcholine, carbamylcholine, succinylcholine, suberyldicholine, and nicotine) and competitive antagonists (d-tubocurarine, alpha-bungarotoxin, and alpha-naja toxin) of the receptor with affinities comparable to those obtained using radioactive ligand binding assays. |
1992-08-06 |
2023-08-11 |
Not clear |
| K Lee, S Miwa, K Koshimura, A It. Characterization of nicotinic acetylcholine receptors on cultured bovine adrenal chromaffin cells using modified L-[3H]nicotine binding assay. Naunyn-Schmiedeberg's archives of pharmacology. vol 345. issue 4. 1992-07-31. PMID:1620238. |
characterization of nicotinic acetylcholine receptors on cultured bovine adrenal chromaffin cells using modified l-[3h]nicotine binding assay. |
1992-07-31 |
2023-08-11 |
cattle |
| K Lee, S Miwa, K Koshimura, A It. Characterization of nicotinic acetylcholine receptors on cultured bovine adrenal chromaffin cells using modified L-[3H]nicotine binding assay. Naunyn-Schmiedeberg's archives of pharmacology. vol 345. issue 4. 1992-07-31. PMID:1620238. |
to characterize the properties of nicotinic acetylcholine receptors (nachrs) in autonomic ganglia, we examined l-[3h]nicotine binding to membrane fraction prepared from cultured bovine adrenal chromaffin cells, using a modified filtration method. |
1992-07-31 |
2023-08-11 |
cattle |
| M Li, P Morley, J L Schwartz, J F Whitfield, B K Tsan. Muscarinic cholinergic stimulation elevates intracellular pH in chicken granulosa cells by a Ca(2+)-dependent, Na(+)-independent mechanism. Endocrinology. vol 131. issue 1. 1992-07-27. PMID:1612000. |
the effect of carbachol was mimicked by acetylcholine (1 mm) and muscarine (1 mm), but not by nicotine (0.1 mm). |
1992-07-27 |
2023-08-11 |
chicken |
| H Miyata, K Ando, T Yanagit. [Studies on the involvement of the nucleus accumbens in the discriminative effects of nicotine in rats]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 98. issue 5. 1992-06-16. PMID:1813370. |
2) among the drugs, acetylcholine at 0.5-10 micrograms administered into the lateral ventricle and methamphetamine at 5-40 micrograms and dopamine at 1-10 micrograms administered into the nucleus accumbens, none substituted for subcutaneously administered nicotine. |
1992-06-16 |
2023-08-11 |
rat |
| K Barnes, A J Turner, A J Kenn. Membrane localization of endopeptidase-24.11 and peptidyl dipeptidase A (angiotensin converting enzyme) in the pig brain: a study using subcellular fractionation and electron microscopic immunocytochemistry. Journal of neurochemistry. vol 58. issue 6. 1992-06-04. PMID:1315375. |
ligand-binding assays using (-)-[3h]nicotine and [3h]quinuclidinyl benzilate served to delineate fractions containing nicotinic and muscarinic acetylcholine receptors. |
1992-06-04 |
2023-08-11 |
Not clear |
| M G López, R Shukla, A G García, A R Wakad. A dihydropyridine-resistant component in the rat adrenal secretory response to splanchnic nerve stimulation. Journal of neurochemistry. vol 58. issue 6. 1992-06-04. PMID:1374118. |
electrically mediated secretory responses were compared to chemically mediated responses (exogenous acetylcholine, nicotine, or high k+). |
1992-06-04 |
2023-08-11 |
rat |
| M G López, R Shukla, A G García, A R Wakad. A dihydropyridine-resistant component in the rat adrenal secretory response to splanchnic nerve stimulation. Journal of neurochemistry. vol 58. issue 6. 1992-06-04. PMID:1374118. |
bay k 8644 (an l-type ca2+ channel activator) potentiated mildly the secretory responses to electrical stimulation at 10 hz and to acetylcholine, but increased threefold the responses to k+ and nicotine. |
1992-06-04 |
2023-08-11 |
rat |
| B S Qiu, C H Cho, S C Hui, C W Ogl. Chronic nicotine intake increases the responses to muscarinic receptor stimulation. Pharmacology. vol 44. issue 1. 1992-04-30. PMID:1348128. |
acetylcholine, 0.1, 0.3, 1 or 3 micrograms/kg given intravenously, decreased the mean blood pressure; this acetylcholine-evoked blood pressure fall was intensified by nicotine pretreatment. |
1992-04-30 |
2023-08-11 |
rat |
| L Calzada, M A Wens, E L Salaza. Action of cholinergic drugs on accumulation of TPMP+ on human spermatozoa. Archives of andrology. vol 28. issue 1. 1992-04-21. PMID:1550423. |
the addition of nicotine or acetylcholine to the low-k+ and high-k+ medium induced a hyperpolarization of 17% and 20%, respectively. |
1992-04-21 |
2023-08-11 |
human |
| Y Fraenkel, B Ohana, J M Gershoni, G Navo. NMR studies of recombinant active site peptides of the nicotinic acetylcholine receptor. Journal of basic and clinical physiology and pharmacology. vol 2. issue 3. 1992-04-10. PMID:1797095. |
monitoring the selective t1 relaxation of the protons of acetylcholine, nicotine, d-tubocurarine, and gallamine reveals specific binding to peptide constructs containing the alpha 183-204 or shorter sequences of the nicotinic acetylcholine receptor of torpedo, human, chicken, xenopus, mouse, calf, and drosophila. |
1992-04-10 |
2023-08-11 |
mouse |
| K Zayasu, T Ohrui, K Sekizawa, M Yamaya, T Fukushima, H Sasaki, T Takishim. Capsaicin desensitization inhibits cigarette smoke-induced increase in cytoplasmic motility of alveolar macrophages in guinea pigs. The American review of respiratory disease. vol 145. issue 1. 1992-02-14. PMID:1370598. |
injection of nicotine or acetylcholine increased respiratory resistance to a degree similar to that observed with cigarette smoke, but it did not change lambda 0. |
1992-02-14 |
2023-08-11 |
Not clear |
| I Takayanagi, M Moriya, Y Kizawa, K Koike, M Shinkai, H Murakam. Effect of ageing on response to nicotine in rabbit bronchial preparation. General pharmacology. vol 22. issue 5. 1992-02-13. PMID:1761181. |
choline acetyltransferase activity, the amount of acetylcholine released by nicotine and acetylcholineesterase activity decreased in the preparations from the 125 week-old rabbits. |
1992-02-13 |
2023-08-11 |
rabbit |
| I Takayanagi, M Moriya, Y Kizawa, K Koike, M Shinkai, H Murakam. Effect of ageing on response to nicotine in rabbit bronchial preparation. General pharmacology. vol 22. issue 5. 1992-02-13. PMID:1761181. |
decrease in the pd2 value of nicotine in the preparation from the older rabbit is due to a decline in choline acetyltransferase activity followed by a reduction in the acetylcholine released, and not to a change in characteristics of nicotine receptors. |
1992-02-13 |
2023-08-11 |
rabbit |
| C J Hillard, J J Pound. [3H]tetraphenylphosphonium accumulation in cerebral cortical synaptosomes as a measure of nicotine-induced changes in membrane potential. The Journal of pharmacology and experimental therapeutics. vol 259. issue 3. 1992-02-07. PMID:1762066. |
this effect of nicotine was mimicked by other nicotinic agonists (1,1-dimethyl-4-phenylpiperazinium iodide, cytisine, suberyldicholine and acetylcholine) and was partially blocked by 10 microm mecamylamine and 30 microm hexamethonium. |
1992-02-07 |
2023-08-11 |
rat |
| C J Hillard, J J Pound. [3H]tetraphenylphosphonium accumulation in cerebral cortical synaptosomes as a measure of nicotine-induced changes in membrane potential. The Journal of pharmacology and experimental therapeutics. vol 259. issue 3. 1992-02-07. PMID:1762066. |
atropine (1 microm) and the removal of calcium from the incubation mixture both enhanced the effect of nicotine while the addition of physostigmine (10 microm) reduced the nicotine-induced decrease in [3h]tpp+ accumulation, evidence that acetylcholine released from the synaptosomes by nicotine may produce hyperpolarization of synaptosomes via stimulation of presynaptic muscarinic receptors. |
1992-02-07 |
2023-08-11 |
rat |
| J L Galzi, D Bertrand, A Devillers-Thiéry, F Revah, S Bertrand, J P Changeu. Functional significance of aromatic amino acids from three peptide loops of the alpha 7 neuronal nicotinic receptor site investigated by site-directed mutagenesis. FEBS letters. vol 294. issue 3. 1992-02-05. PMID:1756861. |
all mutations significantly decreased the apparent affinities for acetylcholine and nicotine, and to a lesser extent, those for the competitive antagonists dihydro-beta-erythroidine and alpha-bungarotoxin. |
1992-02-05 |
2023-08-11 |
xenopus_laevis |
| D L Tanelia. Cholinergic activation of a population of corneal afferent nerves. Experimental brain research. vol 86. issue 2. 1992-02-03. PMID:1756814. |
acetylcholine sensitive afferents were also stimulated by carbachol (10(-5) to 10(-3) m) and nicotine (10(-6) to 10(-4) m) but not by bethanecol (10(-5) to 10(-3) m). |
1992-02-03 |
2023-08-11 |
rabbit |