| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P H Tonner, S C Wood, K W Mille. Can nicotine self-inhibition account for its low efficacy at the nicotinic acetylcholine receptor from Torpedo? Molecular pharmacology. vol 42. issue 5. 1992-12-09. PMID:1279379. |
the presence of ethanol increased the efficacy of nicotine, producing an increase in the initial rate of cation efflux from acetylcholine receptor-rich membrane vesicles, as measured by a rapid quench-flow tracer ion assay. |
1992-12-09 |
2023-08-11 |
Not clear |
| P H Tonner, S C Wood, K W Mille. Can nicotine self-inhibition account for its low efficacy at the nicotinic acetylcholine receptor from Torpedo? Molecular pharmacology. vol 42. issue 5. 1992-12-09. PMID:1279379. |
the apparent affinity of nicotine for its inhibitory site, derived from the aforementioned data, agreed with that determined independently by measuring the inhibition by nicotine of initial rates of ion efflux in response to acetylcholine. |
1992-12-09 |
2023-08-11 |
Not clear |
| K Anderson, P J Robinson, P D Marle. Cholinoceptor regulation of cyclic AMP levels in bovine adrenal medullary cells. British journal of pharmacology. vol 106. issue 2. 1992-11-13. PMID:1382780. |
acetylcholine (100 microm), nicotine (10 microm) and dimethylphenylpiperazinium (20 microm) each increased cellular cyclic amp levels 2 to 4 fold over 5 min in the absence of phosphodiesterase inhibitors. |
1992-11-13 |
2023-08-11 |
cattle |
| K Anderson, P J Robinson, P D Marle. Cholinoceptor regulation of cyclic AMP levels in bovine adrenal medullary cells. British journal of pharmacology. vol 106. issue 2. 1992-11-13. PMID:1382780. |
the responses to acetylcholine and nicotine were unaffected by atropine (1 microm) but were abolished by mecamylamine (5 microm). |
1992-11-13 |
2023-08-11 |
cattle |
| H L Hahn, M Lang, S Bleicher, S Zwerenz, C Rausc. Nicotine-induced airway smooth muscle contraction: neural mechanisms involving the airway epithelium. Functional and histologic studies in vitro. The Clinical investigator. vol 70. issue 3-4. 1992-10-15. PMID:1355677. |
dose-response curves to acetylcholine (ach) and nicotine were established for pairs of tissues with and without epithelium, each pair receiving only one dose of nicotine. |
1992-10-15 |
2023-08-11 |
Not clear |
| K Racké, H Schwöre. Nicotinic and muscarinic modulation of 5-hydroxytryptamine (5-HT) release from porcine and canine small intestine. The Clinical investigator. vol 70. issue 3-4. 1992-10-15. PMID:1381648. |
in the dog, the effect of nicotine is mediated via the release of acetylcholine which then stimulates 5-ht release via muscarine receptors on the enterochromaffin cells. |
1992-10-15 |
2023-08-11 |
dog |
| I Wessler, C Apel, M Garmsen, A Klei. Effects of nicotine receptor agonists on acetylcholine release from the isolated motor nerve, small intestine and trachea of rats and guinea-pigs. The Clinical investigator. vol 70. issue 3-4. 1992-10-15. PMID:1521033. |
effects of nicotine receptor agonists on acetylcholine release from the isolated motor nerve, small intestine and trachea of rats and guinea-pigs. |
1992-10-15 |
2023-08-11 |
rat |
| I Wessler, C Apel, M Garmsen, A Klei. Effects of nicotine receptor agonists on acetylcholine release from the isolated motor nerve, small intestine and trachea of rats and guinea-pigs. The Clinical investigator. vol 70. issue 3-4. 1992-10-15. PMID:1521033. |
the effects of nicotine receptor agonists on the release of [3h]acetylcholine from the phrenic nerve, the small intestine and the trachea were investigated to characterize neuronal nicotine receptors within the peripheral nervous system. |
1992-10-15 |
2023-08-11 |
rat |
| I Wessler, C Apel, M Garmsen, A Klei. Effects of nicotine receptor agonists on acetylcholine release from the isolated motor nerve, small intestine and trachea of rats and guinea-pigs. The Clinical investigator. vol 70. issue 3-4. 1992-10-15. PMID:1521033. |
nicotine, cytisine, 1,1-dimethyl-4-phenylpiperazinium and 2-(4-aminophenyl)-ethyl-trimethyl-ammoniumiodide caused a concentration-dependent (0.1-30 microm) increase in evoked [3h]acetylcholine release from the phrenic nerve, whereby bell-shaped concentration-response curves were obtained. |
1992-10-15 |
2023-08-11 |
rat |
| I Wessler, C Apel, M Garmsen, A Klei. Effects of nicotine receptor agonists on acetylcholine release from the isolated motor nerve, small intestine and trachea of rats and guinea-pigs. The Clinical investigator. vol 70. issue 3-4. 1992-10-15. PMID:1521033. |
the presynaptic effects of nicotine depended strongly on the exposure time: facilitation occurred after a short 20 s exposure and inhibition after a 3 min exposure, whereas nicotine no longer affected evoked [3h]acetylcholine release after a 15 min exposure. |
1992-10-15 |
2023-08-11 |
rat |
| I Wessler, C Apel, M Garmsen, A Klei. Effects of nicotine receptor agonists on acetylcholine release from the isolated motor nerve, small intestine and trachea of rats and guinea-pigs. The Clinical investigator. vol 70. issue 3-4. 1992-10-15. PMID:1521033. |
nicotine (10 microm) produced a substantial release of [3h]acetylcholine in the small intestine but not in the isolated trachea. |
1992-10-15 |
2023-08-11 |
rat |
| Y F Zhang, C C Zhan. [Effects of cholinergic agonists and antagonists on unit discharge of dorsal hippocampal CA1 area in rat]. Zhongguo yao li xue bao = Acta pharmacologica Sinica. vol 12. issue 6. 1992-10-07. PMID:1824002. |
the effects of icv cholinergic agonists (acetylcholine 6 micrograms, physostigmine 10 micrograms, and nicotine 20 micrograms) and cholinergic antagonists (scopolamine 40 micrograms and hexamethonium 250 micrograms) on 174 cells unit discharges of the dorsal hippocampal ca1 area in 42 rats were studied. |
1992-10-07 |
2023-08-11 |
rat |
| Y F Zhang, C C Zhan. [Effects of cholinergic agonists and antagonists on unit discharge of dorsal hippocampal CA1 area in rat]. Zhongguo yao li xue bao = Acta pharmacologica Sinica. vol 12. issue 6. 1992-10-07. PMID:1824002. |
after the electrolytic lesion of the septal region, the effects of acetylcholine and nicotine on unit discharges disappeared. |
1992-10-07 |
2023-08-11 |
rat |
| J L Medina, C Navarrete, C Lama, A Roa, M A Cruz, M I Rudolp. Nicotine stimulates adrenergic terminals and inhibits contractions of mouse uterine horns. General pharmacology. vol 23. issue 3. 1992-09-30. PMID:1511857. |
acetylcholine (10 microm), in the presence of atropine (10 microm) was able to reproduce the inhibitory effect of nicotine. |
1992-09-30 |
2023-08-11 |
mouse |
| J A Rosecran. Nicotine as a discriminative stimulus: a neurobehavioral approach to studying central cholinergic mechanisms. Journal of substance abuse. vol 1. issue 3. 1992-09-24. PMID:2535609. |
whether acetylcholine is the mediator of nicotine's effects at these receptor sites, as was once thought, has yet to be clearly determined. |
1992-09-24 |
2023-08-11 |
mouse |
| A Figl, B N Cohen, M W Quick, N Davidson, H A Leste. Regions of beta 4.beta 2 subunit chimeras that contribute to the agonist selectivity of neuronal nicotinic receptors. FEBS letters. vol 308. issue 3. 1992-09-23. PMID:1505662. |
responses to cytisine, nicotine, or tetramethylammonium were compared to acetylcholine responses for these subunits expressed in xenopus oocytes with alpha 3 subunits. |
1992-09-23 |
2023-08-11 |
xenopus_laevis |
| A Akaik. Ionic mechanisms involved in muscarinic regulation of neuronal and paraneuronal activity. Japanese journal of pharmacology. vol 58. issue 2. 1992-09-22. PMID:1380572. |
in cn neurons, either acetylcholine (ach), carbachol, or muscarine inhibited orthodromically activated firing, while nicotine had no effect on neuronal activity. |
1992-09-22 |
2023-08-11 |
rat |
| M Shinkai, I Takayanag. Effects of tachykinins and guanethidine on the acetylcholine output stimulated by nicotine from guinea-pig bladder. Japanese journal of pharmacology. vol 58 Suppl 2. 1992-09-18. PMID:1507565. |
effects of tachykinins and guanethidine on the acetylcholine output stimulated by nicotine from guinea-pig bladder. |
1992-09-18 |
2023-08-11 |
Not clear |
| b' E K\\xc3\\xa1rp\\xc3\\xa1ti, K B\\xc3\\xadr\\xc3\\xb. [Pharmacologic effects of pipecuronium bromide (Arduan)]. Acta pharmaceutica Hungarica. vol 62. issue 3. 1992-09-16. PMID:1323913.' |
its mechanism of action is twofold: 1. antagonism of acetylcholine effect at neuromuscular junction (postsynaptic nicotine receptors), 2. inhibition of acetylcholine release (presynaptic nicotine receptors). |
1992-09-16 |
2023-08-11 |
Not clear |
| P A Low, T L Opfer-Gehrking, M Kihar. In vivo studies on receptor pharmacology of the human eccrine sweat gland. Clinical autonomic research : official journal of the Clinical Autonomic Research Society. vol 2. issue 1. 1992-09-01. PMID:1638102. |
the axon-reflex response was mediated by nicotinic receptors which were activated by nicotine and acetylcholine, but not pilocarpine, and inhibited by hexamethonium. |
1992-09-01 |
2023-08-11 |
human |