| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S W Tobin, S Hashemi, K Dadson, S Turdi, K Ebrahimian, J Zhao, G Sweeney, J Grigull, J C McDermot. Heart Failure and MEF2 Transcriptome Dynamics in Response to β-Blockers. Scientific reports. vol 7. issue 1. 2019-01-10. PMID:28667250. |
rarres2 was identified as a novel mef2 target gene that is upregulated with tac in vivo and isoproterenol treatment in vitro which may have implications in cardiomyocyte apoptosis and hypertrophy. |
2019-01-10 |
2023-08-13 |
mouse |
| Subbiah Ramasamy, Ganesan Velmurugan, Balakrishnan Rekha, Sivakumar Anusha, K Shanmugha Rajan, Suresh Shanmugarajan, Tharmarajan Ramprasath, Pandi Gopal, Dhanendra Tomar, Karuppusamy V Karthik, Suresh Kumar Verma, Venkata Naga Srikanth Garikipati, Rajan Sudarsa. Egr-1 mediated cardiac miR-99 family expression diverges physiological hypertrophy from pathological hypertrophy. Experimental cell research. vol 365. issue 1. 2019-01-02. PMID:29481791. |
physiological and pathological cardiac hypertrophy was induced in h9c2 cardiomyoblast cell lines using α-2m and isoproterenol respectively. |
2019-01-02 |
2023-08-13 |
Not clear |
| Jing Gao, Yuhong Li, Tongmei Wang, Zhuo Shi, Yiqi Zhang, Shuang Liu, Pushuai Wen, Chunyan M. Analyzing gene expression profiles with preliminary validations in cardiac hypertrophy induced by pressure overload. Canadian journal of physiology and pharmacology. vol 96. issue 8. 2018-11-02. PMID:29510080. |
furthermore, the top degs were further validated using quantitative pcr in the hypertrophic heart tissue induced by isoprenaline. |
2018-11-02 |
2023-08-13 |
Not clear |
| Zhao Li, Yamin Liu, Xiaofan Guo, Guozhe Sun, Qun Ma, Ying Dai, Guangshuo Zhu, Yingxian Su. Long noncoding RNA myocardial infarction‑associated transcript is associated with the microRNA‑150‑5p/P300 pathway in cardiac hypertrophy. International journal of molecular medicine. vol 42. issue 3. 2018-10-26. PMID:29786749. |
neonatal rat ventricular myocytes (nrvms) were induced by isoproterenol (iso) to create a cell hypertrophy model, and mice were intraperitoneally injected with iso to establish an animal model. |
2018-10-26 |
2023-08-13 |
mouse |
| Jie-Kun Cheng, Xiao-Hui Sun, Li-Ping Gao, Le L. [Effects of fasudil on isoproterenol induced cardiac hypertrophy in rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 32. issue 5. 2018-10-18. PMID:29931844. |
[effects of fasudil on isoproterenol induced cardiac hypertrophy in rats]. |
2018-10-18 |
2023-08-13 |
rat |
| Jie-Kun Cheng, Xiao-Hui Sun, Li-Ping Gao, Le L. [Effects of fasudil on isoproterenol induced cardiac hypertrophy in rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 32. issue 5. 2018-10-18. PMID:29931844. |
to investigate the effects and mechanisms of fasudil (fas) on cardiac hypertrophy (ch) induced by isoprenaline(iso) in rats. |
2018-10-18 |
2023-08-13 |
rat |
| Nikhat Saleem, Anamika Prasad, Shyamal K Goswam. Apocynin prevents isoproterenol-induced cardiac hypertrophy in rat. Molecular and cellular biochemistry. vol 445. issue 1-2. 2018-09-17. PMID:29256115. |
as evident from the hw/bw ratio, hw/tl ratio, echocardiography, and histopathology, hypertrophic responses induced by isoproterenol (iso; 5 mg/kg body weight, subcutaneous) were blocked by apo (10 mg/kg body weight, intraperitoneal). |
2018-09-17 |
2023-08-13 |
rat |
| Hua-Li Chen, Yan Liu, Wei Jiang, Xiao-Xiao Wang, Guo-Lin Yuan, Yi-Lin Zhao, Chao Y. Secretoneurin suppresses cardiac hypertrophy through suppression of oxidant stress. European journal of pharmacology. vol 822. 2018-08-20. PMID:29337195. |
we observed that, in isoproterenol (iso) treatment induced cardiac or cardiomyocytes hypertrophy, a marked increase in the expression of endogenous sn in mouse plasma, myocardium and primary-cultured cardiomyocytes occurs. |
2018-08-20 |
2023-08-13 |
mouse |
| Mohammad Nazmul Alam, Md Murad Hossain, Md Mizanur Rahman, Nusrat Subhan, Md Abdullah Al Mamun, Anayt Ulla, Hasan Mahmud Reza, Md Ashraful Ala. Astaxanthin Prevented Oxidative Stress in Heart and Kidneys of Isoproterenol-Administered Aged Rats. Journal of dietary supplements. vol 15. issue 1. 2018-08-13. PMID:28489954. |
the objective of this study was to investigate the effect of astaxanthin on isoproterenol (iso)-induced myocardial infarction and cardiac hypertrophy in rats. |
2018-08-13 |
2023-08-13 |
rat |
| Yonggang Yuan, Wanzhong Peng, Yongxing Liu, Zesheng X. Palmatine attenuates isoproterenol-induced pathological hypertrophy via selectively inhibiting HDAC2 in rats. International journal of immunopathology and pharmacology. vol 30. issue 4. 2018-08-13. PMID:29164959. |
rat hypertrophy model was established by intraperitoneal isoproterenol (iso) injection. |
2018-08-13 |
2023-08-13 |
rat |
| Yuhee Ryu, Li Jin, Hae Jin Kee, Zhe Hao Piao, Jae Yeong Cho, Gwi Ran Kim, Sin Young Choi, Ming Quan Lin, Myung Ho Jeon. Gallic acid prevents isoproterenol-induced cardiac hypertrophy and fibrosis through regulation of JNK2 signaling and Smad3 binding activity. Scientific reports. vol 6. 2018-06-18. PMID:27703224. |
cardiac hypertrophy was induced by isoproterenol (isp) in mice and primary neonatal cardiomyocytes. |
2018-06-18 |
2023-08-13 |
mouse |
| Siyuan Wu, Lihui Lu, Mingyue Zhao, Wenchao Wu, Hua Fu, Xiajing Li. [Study on Potential Role of Calreticulin in Pressure Overload Induced Cardiac Hypertrophy]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 33. issue 3. 2018-05-24. PMID:29709152. |
this study aims to investigate the role of calreticulin in(crt)pressure overload induced cardiac hypertrophy.in our study,cardiac hypertrophy was induced by left ventricular pressure overload in male sd rats subjected to transverse aortic constriction(tac)operation.expression of gene and protein of calreticulin,markers of cardiac hypertrophy and endoplasmic reticulum stress(ers)were measured with real-time qpcr and western blot respectively.meanwhile,atorvastatin(a known ers inhibitor)and calreticulin-specific small interference ribonucleic acid(sirna)were used to inhibit the expression of ers and calreticulin respectively.the experimental data demonstrated that the gene and protein levels of calreticulin,hypertrophic and ers markers were increased significantly in the heart tissues of tac rat models after 4weeks.moreover,atorvastatin administration improved the cardiac function and reduced the expression of calreticulin and ers markers in tac rats.in addition,cultured primary neonatal rat cardiomyocytes(ncms)were treated with norepinephrine(ne),angiotensionⅡ(angⅡ)or isoprenaline(iso)to induce hypertrophic phenotype and ers.the expression of hypertrophic markers was reduced in ncms transfected with calreticulin-sirna.the results suggested that calreticulin might be a promising target for the treatment of cardiac hypertrophy. |
2018-05-24 |
2023-08-13 |
rat |
| Mengen Zhai, Zhenhua Liu, Bin Zhang, Lin Jing, Buying Li, Kaifeng Li, Xiuju Chen, Meng Zhang, Bo Yu, Kai Ren, Yang Yang, Wei Yi, Jian Yang, Jincheng Liu, Dinghua Yi, Hongliang Liang, Zhenxiao Jin, Russel J Reiter, Weixun Duan, Shiqiang Y. Melatonin protects against the pathological cardiac hypertrophy induced by transverse aortic constriction through activating PGC-1β: In vivo and in vitro studies. Journal of pineal research. vol 63. issue 3. 2018-05-18. PMID:28708271. |
melatonin, a circadian molecule secreted by the pineal gland, confers a protective role against cardiac hypertrophy induced by hyperthyroidism, chronic hypoxia, and isoproterenol. |
2018-05-18 |
2023-08-13 |
mouse |
| Hao Su, Marco Pistolozzi, Xingjuan Shi, Xiaoou Sun, Wen Ta. Alterations in NO/ROS ratio and expression of Trx1 and Prdx2 in isoproterenol-induced cardiac hypertrophy. Acta biochimica et biophysica Sinica. vol 49. issue 11. 2018-05-18. PMID:29036266. |
here we investigated the development of isoproterenol (iso)-induced cardiac hypertrophy in an in vitro experimental model. |
2018-05-18 |
2023-08-13 |
Not clear |
| Xin Li, Zhou-Long Zhang, Hui-Fen Wan. Fusaric acid (FA) protects heart failure induced by isoproterenol (ISP) in mice through fibrosis prevention via TGF-β1/SMADs and PI3K/AKT signaling pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 93. 2018-04-23. PMID:28624424. |
isoproterenol (isp) was used to induce cardiac fibrosis and hypertrophy in vitro and in vivo. |
2018-04-23 |
2023-08-13 |
mouse |
| Ilona Schirmer, Tippaporn Bualeong, Heidi Budde, Diana Cimiotti, Avinash Appukuttan, Nicole Klein, Philip Steinwascher, Peter Reusch, Andreas Mügge, Rainer Meyer, Yury Ladilov, Kornelia Jaque. Soluble adenylyl cyclase: A novel player in cardiac hypertrophy induced by isoprenaline or pressure overload. PloS one. vol 13. issue 2. 2018-04-09. PMID:29466442. |
soluble adenylyl cyclase: a novel player in cardiac hypertrophy induced by isoprenaline or pressure overload. |
2018-04-09 |
2023-08-13 |
Not clear |
| Ashenafi H Betrie, Scott Ayton, Ashley I Bush, James A Angus, Peng Lei, Christine E Wrigh. Evidence of a Cardiovascular Function for Microtubule-Associated Protein Tau. Journal of Alzheimer's disease : JAD. vol 56. issue 2. 2018-02-23. PMID:28059795. |
tau ko mice showed an increased systolic blood pressure and cardiac hypertrophy at 13 months, which was accompanied by a significantly lower right atrial rate and a subtle decrease in the maximum contractility to calcium, isoprenaline, and electrical sympathetic nerve stimulation. |
2018-02-23 |
2023-08-13 |
mouse |
| Ashenafi H Betrie, Scott Ayton, Ashley I Bush, James A Angus, Peng Lei, Christine E Wrigh. Evidence of a Cardiovascular Function for Microtubule-Associated Protein Tau. Journal of Alzheimer's disease : JAD. vol 56. issue 2. 2018-02-23. PMID:28059795. |
aging tau ko mice to 23 months resulted in cardiac hypertrophy with significantly attenuated left atrial contractility, increased blood pressure, and sensitivity of isolated mesenteric arteries to angiotensin ii contraction and isoprenaline relaxation compared to their younger counterparts. |
2018-02-23 |
2023-08-13 |
mouse |
| Zhen-Guo Ma, Yu-Pei Yuan, Xin Zhang, Si-Chi Xu, Sha-Sha Wang, Qi-Zhu Tan. Piperine Attenuates Pathological Cardiac Fibrosis Via PPAR-γ/AKT Pathways. EBioMedicine. vol 18. 2018-01-17. PMID:28330809. |
here, we show that piperine-treated mice had similar hypertrophic responses as mice treated with vehicle but exhibited significantly attenuated cardiac fibrosis after pressure overload or isoprenaline (iso) injection. |
2018-01-17 |
2023-08-13 |
mouse |
| Chunmei Li, Dan Huang, Jing Tang, Mengqing Chen, Qun Lu, He Li, Mengzhen Zhang, Bin Xu, Jianwen Ma. ClC-3 chloride channel is involved in isoprenaline-induced cardiac hypertrophy. Gene. vol 642. 2017-12-26. PMID:29158167. |
isoprenaline, an activator of β-adrenergic receptor, has been found to induce cardiac hypertrophy in vivo and in vitro, but the exact mechanism is still unclear. |
2017-12-26 |
2023-08-13 |
mouse |