| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T F Meert, F Awouter. Central 5-HT2 antagonists: A preclinical evaluation of a therapeutic potential. Acta neuropsychiatrica. vol 2. issue 4. 2016-03-09. PMID:26952556. |
risperidone has, as opposed to classical neuroleptics such as haloperidol, less risks of inducing a dopamine d2 overblockade. |
2016-03-09 |
2023-08-13 |
Not clear |
| Binoj J Matthew, Joanna S Gedzio. Drug-induced parkinsonism following chronic methamphetamine use by a patient on haloperidol decanoate. International journal of psychiatry in medicine. vol 50. issue 4. 2016-02-23. PMID:26526398. |
the report also illustrates the neuronal workings due to chronic methamphetamine-use and the additive effects of dopamine blockade by antipsychotics such as haloperidol. |
2016-02-23 |
2023-08-13 |
Not clear |
| Andrea de Bartolomeis, Felice Iasevoli, Federica Marmo, Elisabetta F Buonaguro, Anna Eramo, Rodolfo Rossi, Livia Avvisati, Gianmarco Latte, Carmine Tomasett. Progressive recruitment of cortical and striatal regions by inducible postsynaptic density transcripts after increasing doses of antipsychotics with different receptor profiles: insights for psychosis treatment. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 4. 2016-01-11. PMID:25649681. |
we analyzed the differential topography of psd transcripts by incremental doses of two antipsychotics: haloperidol, the prototypical first generation antipsychotic with prevalent dopamine d2 receptors antagonism, and asenapine, a second generation antipsychotic characterized by multiple receptors occupancy. |
2016-01-11 |
2023-08-13 |
Not clear |
| Ming Zheng, Haili Zhang, David L Dill, J David Clark, Susan Tu, Arielle L Yablonovitch, Meng How Tan, Rui Zhang, Dan Rujescu, Manhong Wu, Lino Tessarollo, Wilfred Vieira, Michael M Gottesman, Suhua Deng, Livia S Eberlin, Richard N Zare, Jean-Martin Billard, Jean-Pierre Gillet, Jin Billy Li, Gary Pelt. The role of Abcb5 alleles in susceptibility to haloperidol-induced toxicity in mice and humans. PLoS medicine. vol 12. issue 2. 2015-12-28. PMID:25647612. |
for example, haloperidol is a potent dopamine antagonist that is used to treat psychotic disorders, but 50% of treated patients develop characteristic extrapyramidal symptoms caused by haloperidol-induced toxicity (hit), which limits its clinical utility. |
2015-12-28 |
2023-08-13 |
mouse |
| Yanyan Qiu, Yanan Zhang, Jun-Xu L. Discriminative stimulus effects of the imidazoline I2 receptor ligands BU224 and phenyzoline in rats. European journal of pharmacology. vol 749. 2015-11-16. PMID:25617792. |
naltrexone, dopamine d2 receptor antagonist haloperidol and serotonin (5-ht)2a receptor antagonist mdl100907 failed to alter the discriminative stimulus effects of bu224 or phenyzoline. |
2015-11-16 |
2023-08-13 |
rat |
| Susanna Waters, Henrik Ponten, Malin Edling, Boel Svanberg, Daniel Klamer, Nicholas Water. The dopaminergic stabilizers pridopidine and ordopidine enhance cortico-striatal Arc gene expression. Journal of neural transmission (Vienna, Austria : 1996). vol 121. issue 11. 2015-11-04. PMID:24817271. |
in the striatum, significant increases in arc expression were seen with both pridopidine and ordopidine as well as the dopamine d2 receptor antagonists, remoxipride and haloperidol. |
2015-11-04 |
2023-08-13 |
Not clear |
| Geancarlo Zanatta, Gustavo Nunes, Eveline M Bezerra, Roner F da Costa, Alice Martins, Ewerton W S Caetano, Valder N Freire, Carmem Gottfrie. Antipsychotic haloperidol binding to the human dopamine D3 receptor: beyond docking through QM/MM refinement toward the design of improved schizophrenia medicines. ACS chemical neuroscience. vol 5. issue 10. 2015-11-02. PMID:25181639. |
antipsychotic haloperidol binding to the human dopamine d3 receptor: beyond docking through qm/mm refinement toward the design of improved schizophrenia medicines. |
2015-11-02 |
2023-08-13 |
human |
| Geancarlo Zanatta, Gustavo Nunes, Eveline M Bezerra, Roner F da Costa, Alice Martins, Ewerton W S Caetano, Valder N Freire, Carmem Gottfrie. Antipsychotic haloperidol binding to the human dopamine D3 receptor: beyond docking through QM/MM refinement toward the design of improved schizophrenia medicines. ACS chemical neuroscience. vol 5. issue 10. 2015-11-02. PMID:25181639. |
besides, it highlights the relevance of the haloperidol hydroxyl group axial orientation, which interacts with the tyr365 and thr369 residues, enhancing its binding to dopamine receptors. |
2015-11-02 |
2023-08-13 |
human |
| Geancarlo Zanatta, Gustavo Nunes, Eveline M Bezerra, Roner F da Costa, Alice Martins, Ewerton W S Caetano, Valder N Freire, Carmem Gottfrie. Antipsychotic haloperidol binding to the human dopamine D3 receptor: beyond docking through QM/MM refinement toward the design of improved schizophrenia medicines. ACS chemical neuroscience. vol 5. issue 10. 2015-11-02. PMID:25181639. |
finally, our computations indicate that functional substitutions in the 4-clorophenyl and in the 4-hydroxypiperidin-1-yl fragments (such as c3h and c12h hydrogen replacement by oh or cooh) can lead to haloperidol derivatives with distinct dopamine antagonism profiles. |
2015-11-02 |
2023-08-13 |
human |
| John R Atack, Brian C Shook, Stefanie Rassnick, Paul F Jackson, Kenneth Rhodes, Wilhelmus H Drinkenburg, Abdallah Ahnaou, Paula Te Riele, Xavier Langlois, Brian Hrupka, Patrick De Haes, Herman Hendrickx, Nancy Aerts, Koen Hens, Annemie Wellens, Jef Vermeire, Anton A H P Megen. JNJ-40255293, a novel adenosine A2A/A1 antagonist with efficacy in preclinical models of Parkinson's disease. ACS chemical neuroscience. vol 5. issue 10. 2015-11-02. PMID:25203719. |
however, it was able to reverse effects (catalepsy, hypolocomotion, and conditioned avoidance impairment in rats; hypolocomotion in mice) produced by the dopamine d2 antagonist haloperidol. |
2015-11-02 |
2023-08-13 |
mouse |
| Ian D Blum, Lei Zhu, Luc Moquin, Maia V Kokoeva, Alain Gratton, Bruno Giros, Kai-Florian Storc. A highly tunable dopaminergic oscillator generates ultradian rhythms of behavioral arousal. eLife. vol 3. 2015-09-21. PMID:25546305. |
period lengthening also results from chemogenetic activation of midbrain dopamine neurons and psychostimulant treatment, while the antipsychotic haloperidol has the opposite effect. |
2015-09-21 |
2023-08-13 |
mouse |
| Sven Bestmann, Diane Ruge, John Rothwell, Joseph M Gale. The role of dopamine in motor flexibility. Journal of cognitive neuroscience. vol 27. issue 2. 2015-08-20. PMID:25170792. |
we found that dopamine receptor blockade by high-dose haloperidol (d1/d2 dopamine receptors) impaired participants' ability to react to unexpected events occurring in a predictable context, which elicit large prediction errors and necessitate motor flexibility. |
2015-08-20 |
2023-08-13 |
human |
| Yan Li, Zhuo R Zhu, Bao C Ou, Ya Q Wang, Zhou B Tan, Chang M Deng, Yi Y Gao, Ming Tang, Ji H So, Yang L Mu, Lan Q Zhan. Dopamine D2/D3 but not dopamine D1 receptors are involved in the rapid antidepressant-like effects of ketamine in the forced swim test. Behavioural brain research. vol 279. 2015-08-20. PMID:25449845. |
notably, pretreatment with haloperidol (0.15 mg/kg, a nonselective dopamine d2/d3 antagonist), but not sch23390 (0.04 and 0.1 mg/kg, a selective dopamine d1 receptor antagonist), significantly prevented the effects of ketamine or mk-801. |
2015-08-20 |
2023-08-13 |
Not clear |
| Marija Bošković, Iztok Grabnar, Tea Terzič, Blanka Kores Plesničar, Tomaž Vov. Oxidative stress in schizophrenia patients treated with long-acting haloperidol decanoate. Psychiatry research. vol 210. issue 3. 2015-08-03. PMID:24041751. |
antioxidant activity of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and concentrations of malondialdehyde, protein carbonyls, nitrite, nitrate, glutathione, dopamine, noradrenaline, adrenaline, and serotonin were measured in 52 outpatients with dsm-iv diagnosis of schizophrenia treated with haloperidol decanoate. |
2015-08-03 |
2023-08-12 |
Not clear |
| Matthew J O'Callaghan, Cecilie Bay-Richter, Colm Mp O'Tuathaigh, David M Heery, John L Waddington, Paula M Mora. Potentiation of latent inhibition by haloperidol and clozapine is attenuated in Dopamine D2 receptor (Drd-2)-deficient mice: do antipsychotics influence learning to ignore irrelevant stimuli via both Drd-2 and non-Drd-2 mechanisms? Journal of psychopharmacology (Oxford, England). vol 28. issue 10. 2015-06-09. PMID:25122042. |
potentiation of latent inhibition by haloperidol and clozapine is attenuated in dopamine d2 receptor (drd-2)-deficient mice: do antipsychotics influence learning to ignore irrelevant stimuli via both drd-2 and non-drd-2 mechanisms? |
2015-06-09 |
2023-08-13 |
mouse |
| Nathalie Wrobel, Katja Wiech, Katarina Forkmann, Christoph Ritter, Ulrike Binge. Haloperidol blocks dorsal striatum activity but not analgesia in a placebo paradigm. Cortex; a journal devoted to the study of the nervous system and behavior. vol 57. 2015-06-04. PMID:24796219. |
to this end, we investigated the effect of the dopamine d2/d3 receptor antagonist haloperidol on behavioral and neural measures of placebo analgesia using functional magnetic resonance imaging (fmri) in healthy volunteers. |
2015-06-04 |
2023-08-13 |
human |
| Fabrizio Sanna, Maria Antonietta Piludu, Maria Giuseppa Corda, Antonio Argiolas, Osvaldo Giorgi, Maria Rosaria Meli. Dopamine is involved in the different patterns of copulatory behaviour of Roman high and low avoidance rats: studies with apomorphine and haloperidol. Pharmacology, biochemistry, and behavior. vol 124. 2015-05-19. PMID:24955864. |
dopamine is involved in the different patterns of copulatory behaviour of roman high and low avoidance rats: studies with apomorphine and haloperidol. |
2015-05-19 |
2023-08-13 |
rat |
| Felice Iasevoli, Elisabetta F Buonaguro, Chiara Sarappa, Federica Marmo, Gianmarco Latte, Rodolfo Rossi, Anna Eramo, Carmine Tomasetti, Andrea de Bartolomei. Regulation of postsynaptic plasticity genes' expression and topography by sustained dopamine perturbation and modulation by acute memantine: relevance to schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 54. 2015-05-12. PMID:25025505. |
subchronic treatment by: a) gbr-12909, a dopamine receptor indirect agonist; b) haloperidol, a d2r antagonist; c) sch-23390, a dopamine d1 receptor (d1r) antagonist; and d) sch-23390+haloperidol. |
2015-05-12 |
2023-08-13 |
rat |
| Souha Mahmoudi, Daniel Lévesque, Pierre J Blanche. Upregulation of dopamine D3, not D2, receptors correlates with tardive dyskinesia in a primate model. Movement disorders : official journal of the Movement Disorder Society. vol 29. issue 9. 2015-04-20. PMID:24838395. |
unlike clozapine, haloperidol strongly induced dopamine d3 receptor binding sites in the anterior caudate-putamen, particularly in td animals, and binding levels positively correlated with td intensity. |
2015-04-20 |
2023-08-13 |
human |
| M A Cheĭdo, G V Idov. [Effect of dopamine D1 and D2 receptor blockade on the immunostimulating effect of δ1 opioid receptor agonist DPDPE in mice with different psychoemotional states]. Eksperimental'naia i klinicheskaia farmakologiia. vol 78. issue 1. 2015-04-17. PMID:25826871. |
sch-23390 (1.0 mg/kg), selective antagonist of dopamine d1 receptors, and selective d2 receptor blocker haloperidol (1 mg/kg) prevented the immunostimulating effect of dpdpe in animals not subjected to social stress. |
2015-04-17 |
2023-08-13 |
mouse |