| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephen J Winters, Dushan T Ghooray, Rong Q Yang, Joshua B Holmes, Andrew Rw O'Brien, Jay Morgan, Joseph P Moor. Dopamine-2 receptor activation suppresses PACAP expression in gonadotrophs. Endocrinology. vol 155. issue 7. 2014-08-25. PMID:24823390. |
furthermore, blockade of dopamine receptors by injecting haloperidol into newborn rat pups partially reversed the developmental decline in pituitary pacap mrna that occurs between pn1 and pn4. |
2014-08-25 |
2023-08-13 |
rat |
| Patrick Oeckl, Bastian Hengerer, Boris Ferge. G-protein coupled receptor 6 deficiency alters striatal dopamine and cAMP concentrations and reduces dyskinesia in a mouse model of Parkinson's disease. Experimental neurology. vol 257. 2014-08-13. PMID:24747358. |
gpr6(-/-) mice showed higher locomotor activity in the open field, which persisted after treatment with the dopamine d2 receptor antagonist haloperidol. |
2014-08-13 |
2023-08-13 |
mouse |
| Cristiano Termine, Claudia Selvini, Giorgio Rossi, Umberto Balotti. Emerging treatment strategies in Tourette syndrome: what's in the pipeline? International review of neurobiology. vol 112. 2014-07-14. PMID:24295630. |
the most commonly prescribed drugs are dopamine antagonists, such as typical (e.g., haloperidol, pimozide) and atypical neuroleptics (e.g., risperidone, aripiprazole), and α-2-adrenoreceptor agonists (e.g., clonidine). |
2014-07-14 |
2023-08-12 |
Not clear |
| Gregory B Crawford, Meera Agar M, Stephen J Quinn, Jane Phillips, Caroline Litster, Natasha Michael, Matthew Doogue, Debra Rowett, David C Curro. Pharmacovigilance in hospice/palliative care: net effect of haloperidol for delirium. Journal of palliative medicine. vol 16. issue 11. 2014-07-09. PMID:24138282. |
haloperidol, a butyrophenone derivative and dopamine antagonist, is commonly prescribed for nausea, vomiting, and delirium in hospice/palliative care. |
2014-07-09 |
2023-08-12 |
human |
| Ana Caroline Colombo, Amanda Ribeiro de Oliveira, Adriano Edgar Reimer, Marcus Lira Brandã. Dopaminergic mechanisms underlying catalepsy, fear and anxiety: do they interact? Behavioural brain research. vol 257. 2014-06-25. PMID:24120401. |
haloperidol is a dopamine d2 receptor antagonist that induces catalepsy when systemically administered to rodents. |
2014-06-25 |
2023-08-12 |
rat |
| Gil M Lewitus, Horia Pribiag, Rachna Duseja, Michel St-Hilaire, David Stellwage. An adaptive role of TNFα in the regulation of striatal synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 18. 2014-06-23. PMID:24790185. |
striatal tnfα signaling appears to be adaptive in nature, as tnfα is upregulated in response to the prolonged blockade of d2 dopamine receptors and is necessary to reduce the expression of extrapyramidal symptoms induced by chronic haloperidol treatment. |
2014-06-23 |
2023-08-13 |
mouse |
| V G Kolpakov, M A Gilinsky, T A Alekhina, N N Barykina, E M Nikulina, N N Voitenko, A V Kulikov, N I Shtilma. Experimental studies on genetically determined predisposition to catatonia in rats as a model of schizophrenia. Behavioural processes. vol 14. issue 3. 2014-06-14. PMID:24925295. |
the effects of haloperidol and apomorphine on motor activity of cataleptic and normal animals point to a higher sensitivity of postsynaptic dopamine receptors in the former. |
2014-06-14 |
2023-08-13 |
rat |
| D Bury, W J Schmid. Effects of systemically and intrastriatally injected haloperidol and apomorphine on grooming, feeding and locomotion in the rat. Behavioural processes. vol 15. issue 2-3. 2014-06-14. PMID:24925658. |
thus, the sedative effects of peripherally administered haloperidol on locomotion and feeding are not mediated by dopamine in the antero-dorsal striatum. |
2014-06-14 |
2023-08-13 |
rat |
| D Bury, W J Schmid. Effects of systemically and intrastriatally injected haloperidol and apomorphine on grooming, feeding and locomotion in the rat. Behavioural processes. vol 15. issue 2-3. 2014-06-14. PMID:24925658. |
the inhibition of grooming is opposite to the effect of haloperidol and may indicate that dopamine in the antero-dorsal striatum is at least partly involved in a direct control of grooming. |
2014-06-14 |
2023-08-13 |
rat |
| Ulrike Stadlbauer, Wolfgang Langhans, Urs Meye. Administration of the Y2 receptor agonist PYY3-36 in mice induces multiple behavioral changes relevant to schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 38. issue 12. 2014-06-03. PMID:23748226. |
this effect was fully antagonized by acute treatment with the preferential dopamine d2 receptor antagonist haloperidol, but not with clozapine. |
2014-06-03 |
2023-08-12 |
mouse |
| Jan Booij, Guus van Loon, Kora de Bruin, Pieter Voor. Acute administration of haloperidol does not influence 123I-FP-CIT binding to the dopamine transporter. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 55. issue 4. 2014-06-02. PMID:24604911. |
acute administration of haloperidol does not influence 123i-fp-cit binding to the dopamine transporter. |
2014-06-02 |
2023-08-12 |
rat |
| Jan Booij, Guus van Loon, Kora de Bruin, Pieter Voor. Acute administration of haloperidol does not influence 123I-FP-CIT binding to the dopamine transporter. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 55. issue 4. 2014-06-02. PMID:24604911. |
a recent (123)i-fp-cit ((123)-i-n-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane) spect study on rats suggested that a single 1 mg/kg dose of the antipsychotic haloperidol induces enough dopamine release to compete with (123)i-fp-cit for binding to the dopamine transporter. |
2014-06-02 |
2023-08-12 |
rat |
| Kazuhiro Takamats. [Diabetic chorea]. Brain and nerve = Shinkei kenkyu no shinpo. vol 66. issue 2. 2014-05-20. PMID:24523310. |
if the chorea is uncomfortable, disabling, or persistent, symptomatic therapy (e.g., administration of haloperidol, a dopamine antagonist) should be initiated. |
2014-05-20 |
2023-08-12 |
Not clear |
| Natalia Gass, Adam James Schwarz, Alexander Sartorius, Dirk Cleppien, Lei Zheng, Esther Schenker, Celine Risterucci, Andreas Meyer-Lindenberg, Wolfgang Weber-Fah. Haloperidol modulates midbrain-prefrontal functional connectivity in the rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 10. 2014-04-24. PMID:23165219. |
haloperidol induced focal changes in functional connectivity were found to be the most strongly associated with ascending dopamine projections. |
2014-04-24 |
2023-08-12 |
rat |
| Maartje Luijten, Dick J Veltman, Robert Hester, Marion Smits, Ilse M T Nijs, Lolke Pepplinkhuizen, Ingmar H A Franke. The role of dopamine in inhibitory control in smokers and non-smokers: a pharmacological fMRI study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 10. 2014-04-24. PMID:23194834. |
haloperidol (2 mg), a dopamine d2/d3 receptor antagonist, and placebo were administered to 25 smokers and 25 non-smoking controls in a double-blind randomized cross-over design while performing a go/nogo task during fmri scanning. |
2014-04-24 |
2023-08-12 |
Not clear |
| Maartje Luijten, Dick J Veltman, Robert Hester, Marion Smits, Ilse M T Nijs, Lolke Pepplinkhuizen, Ingmar H A Franke. The role of dopamine in inhibitory control in smokers and non-smokers: a pharmacological fMRI study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 10. 2014-04-24. PMID:23194834. |
haloperidol reduced nogo accuracy and associated brain activation in the acc, right sfg and left ifg, showing that optimal dopamine levels are crucial to effectively implement inhibitory control. |
2014-04-24 |
2023-08-12 |
Not clear |
| Maartje Luijten, Dick J Veltman, Robert Hester, Marion Smits, Ilse M T Nijs, Lolke Pepplinkhuizen, Ingmar H A Franke. The role of dopamine in inhibitory control in smokers and non-smokers: a pharmacological fMRI study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 10. 2014-04-24. PMID:23194834. |
haloperidol had a stronger impact on prefrontal brain activation in non-smoking controls compared to smokers, which is in line with the inverted 'u' curve theory of dopamine and cognitive control. |
2014-04-24 |
2023-08-12 |
Not clear |
| Maja Zivković, Alma Mihaljević-Peles, Nada Bozina, Marina Sagud, Matea Nikolac-Perkovic, Bjanka Vuksan-Cusa, Dorotea Muck-Sele. The association study of polymorphisms in DAT, DRD2, and COMT genes and acute extrapyramidal adverse effects in male schizophrenic patients treated with haloperidol. Journal of clinical psychopharmacology. vol 33. issue 5. 2014-04-01. PMID:23963056. |
the aim of this study was to determine the association between dopaminergic type 2 receptor (drd2) dopamine transporter (slc6a3) and catechol-o-methyltransferase (comt) gene polymorphisms and acute epss in 240 male schizophrenic patients treated with haloperidol (15-mg/d) over a period of 2 weeks. |
2014-04-01 |
2023-08-12 |
Not clear |
| Lissandra Castellan Baldan, Kyle A Williams, Jean-Dominique Gallezot, Vladimir Pogorelov, Maximiliano Rapanelli, Michael Crowley, George M Anderson, Erin Loring, Roxanne Gorczyca, Eileen Billingslea, Suzanne Wasylink, Kaitlyn E Panza, A Gulhan Ercan-Sencicek, Kuakarun Krusong, Bennett L Leventhal, Hiroshi Ohtsu, Michael H Bloch, Zoë A Hughes, John H Krystal, Linda Mayes, Ivan de Araujo, Yu-Shin Ding, Matthew W State, Christopher Pittenge. Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice. Neuron. vol 81. issue 1. 2014-03-07. PMID:24411733. |
hdc knockout mice exhibited potentiated tic-like stereotypies, recapitulating core phenomenology of ts; these were mitigated by the dopamine (da) d2 antagonist haloperidol, a proven pharmacotherapy, and by ha infusion into the brain. |
2014-03-07 |
2023-08-12 |
mouse |
| Phillip Gran. Letter to the Editor: haloperidol but not dopamine rapidly induces neuronal death: comments on 'A systematic review of the effects of antipsychotic drugs on brain volume'. Psychological medicine. vol 43. issue 7. 2014-02-17. PMID:23651623. |
letter to the editor: haloperidol but not dopamine rapidly induces neuronal death: comments on 'a systematic review of the effects of antipsychotic drugs on brain volume'. |
2014-02-17 |
2023-08-12 |
Not clear |