| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C K Meshul, R K Stallbaumer, B Taylor, A Janowsk. Haloperidol-induced morphological changes in striatum are associated with glutamate synapses. Brain research. vol 648. issue 2. 1994-11-21. PMID:7922533. |
sub-chronic treatment with the typical neuroleptic, haloperidol (0.5 mg/kg/d, s.c.), but not the atypical neuroleptic, clozapine (35 mg/kg/day, s.c.), causes an increase in synapses containing a perforated postsynaptic density (referred to as 'perforated' synapses) and in dopamine (da) d2 receptors within the caudate nucleus [46]. |
1994-11-21 |
2023-08-12 |
Not clear |
| M G Richard, J P Bennet. Regulation by D2 dopamine receptors of in vivo dopamine synthesis in striata of rats and mice with experimental parkinsonism. Experimental neurology. vol 129. issue 1. 1994-11-16. PMID:7925842. |
the effects of d2 dopamine (da) receptor antagonism or stimulation by systemic haloperidol or quinpirole, respectively, on in vivo da synthesis in 6-hydroxydopamine (6-ohda)-lesioned rats and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated black mice were assessed by measuring the rate of dihydroxyphenylalanine (dopa) accumulation following acute inhibition of l-aromatic amino acid decarboxylase with nsd-1015. |
1994-11-16 |
2023-08-12 |
mouse |
| B Zadow, W J Schmid. Lesions of the entopeduncular nucleus and the subthalamic nucleus reduce dopamine receptor antagonist-induced catalepsy in the rat. Behavioural brain research. vol 62. issue 1. 1994-11-04. PMID:7917035. |
five days after bilateral lesions of ep and stn respectively with the excitotoxin quinolinic acid (15, 30 nmol/0.5 microliter/side and 24 nmol/0.5 microliter/side, respectively) rats were injected intraperitoneally with the dopamine d1 receptor antagonist sch 23390 (0.5 mg/kg) or the dopamine d2 receptor antagonist haloperidol (0.5 mg/kg). |
1994-11-04 |
2023-08-12 |
rat |
| F Petty, G Kramer, M Moelle. Does learned helplessness induction by haloperidol involve serotonin mediation? Pharmacology, biochemistry, and behavior. vol 48. issue 3. 1994-11-04. PMID:7938121. |
helpless behavior was induced in naive rats by the dopamine d2 receptor blocker haloperidol (hdl) in a dose-dependent manner, with the greatest effects seen at 20 mg/kg (ip). |
1994-11-04 |
2023-08-12 |
rat |
| I M White, D P Miller, W White, G L Dike, G V Rebec, J E Steinmet. Neuronal activity in rabbit neostriatum during classical eyelid conditioning. Experimental brain research. vol 99. issue 2. 1994-11-02. PMID:7925801. |
the activity of some multiple and single units was monitored after injection of haloperidol, a neuroleptic and dopamine antagonist known to disrupt neostriatal function. |
1994-11-02 |
2023-08-12 |
rabbit |
| L Naudon, I Leroux-Nicollet, J Costenti. Short-term treatments with haloperidol or bromocriptine do not alter the density of the monoamine vesicular transporter in the substantia nigra. Neuroscience letters. vol 173. issue 1-2. 1994-10-25. PMID:7523993. |
it was not modified after s.c. administration of either the direct dopamine (da) receptor agonist bromocriptine (four injections of 4 or 6 mg/kg) or the da receptor antagonist haloperidol (four injections of 0.5-1-1.5-2 mg/kg). |
1994-10-25 |
2023-08-12 |
rat |
| M Broccardo, G Improt. Sauvagine-induced hypothermia: evidence for an interaction with the dopaminergic system. European journal of pharmacology. vol 258. issue 3. 1994-10-19. PMID:7916301. |
to clarify the regulatory mechanisms and to ascertain which neurotransmitter systems mediate sauvagine-induced hypothermia, we administered sauvagine intracerebroventricularly and subcutaneously in rats pretreated with antagonists of muscarinic receptors (atropine), opiate receptors (naloxone), alpha-adrenoceptors (phentolamine, yohimbine and prazosin), beta-adrenoceptors (propranolol) and dopamine receptors (haloperidol and spiperone). |
1994-10-19 |
2023-08-12 |
rat |
| M Broccardo, G Improt. Sauvagine-induced hypothermia: evidence for an interaction with the dopaminergic system. European journal of pharmacology. vol 258. issue 3. 1994-10-19. PMID:7916301. |
pretreatment with haloperidol (2 mg/kg, s.c.), a non-selective dopamine receptor antagonist, and spiperone (80 micrograms/kg, s.c.), a selective dopamine d2 receptor antagonist, significantly reduced the temperature fall induced by centrally (4 micrograms/rat) and peripherally (20 micrograms/kg) administered sauvagine. |
1994-10-19 |
2023-08-12 |
rat |
| B M Chronwall, D S Dickerson, B S Huerter, D R Sibley, W R Millingto. Regulation of heterogeneity in D2 dopamine receptor gene expression among individual melanotropes in the rat pituitary intermediate lobe. Molecular and cellular neurosciences. vol 5. issue 1. 1994-10-19. PMID:8087413. |
d2 dopamine receptor-binding experiments showed that chronic haloperidol treatment (2 mg/kg for 14 days) significantly increased the bmax but not kd of [3h]spiperone binding, whereas bromocriptine treatment (2 mg/kg for 14 days) produced no change in either parameter. |
1994-10-19 |
2023-08-12 |
rat |
| J E Leysen, P M Janssen, A A Megens, A Schott. Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity. The Journal of clinical psychiatry. vol 55 Suppl. 1994-09-29. PMID:7520908. |
clozapine primarily bound to histamine h1 receptors and haloperidol to dopamine d2 receptors. |
1994-09-29 |
2023-08-12 |
human |
| M B Knable, T M Hyde, M F Egan, M Tosayali, R J Wyatt, J E Kleinma. Quantitative autoradiography of striatal dopamine D1, D2 and re-uptake sites in rats with vacuous chewing movements. Brain research. vol 646. issue 2. 1994-09-23. PMID:8069667. |
rats treated with haloperidol that developed vacuous chewing movements (vcm), a possible animal model of tardive dyskinesia, were studied with quantitative autoradiography for dopamine type-1 (d1) and type-2 (d2) receptors as well as dopamine re-uptake sites. |
1994-09-23 |
2023-08-12 |
rat |
| M B Knable, T M Hyde, M F Egan, M Tosayali, R J Wyatt, J E Kleinma. Quantitative autoradiography of striatal dopamine D1, D2 and re-uptake sites in rats with vacuous chewing movements. Brain research. vol 646. issue 2. 1994-09-23. PMID:8069667. |
haloperidol increased striatal d2 receptors, but did not affect d1 receptors or the dopamine re-uptake site. |
1994-09-23 |
2023-08-12 |
rat |
| J S Meyer, P Robinson, M S Todtenkop. Prenatal cocaine treatment reduces haloperidol-induced catalepsy on postnatal day 10. Neurotoxicology and teratology. vol 16. issue 2. 1994-09-06. PMID:8052194. |
this study examined the influence of prenatal cocaine on subsequent cataleptic responses to the dopamine (da) receptor antagonist haloperidol. |
1994-09-06 |
2023-08-12 |
human |
| U Köhler, H Schröder, W Augustin, B A Sabe. A new animal model of dopamine supersensitivity using s.c. implantation of haloperidol releasing polymers. Neuroscience letters. vol 170. issue 1. 1994-08-25. PMID:8041522. |
a new animal model of dopamine supersensitivity using s.c. implantation of haloperidol releasing polymers. |
1994-08-25 |
2023-08-12 |
rat |
| U Köhler, H Schröder, W Augustin, B A Sabe. A new animal model of dopamine supersensitivity using s.c. implantation of haloperidol releasing polymers. Neuroscience letters. vol 170. issue 1. 1994-08-25. PMID:8041522. |
dopamine supersensitivity was induced by either the continuous daily release of 1.0 mg/kg haloperidol from controlled release polymers implanted subcutaneously in rats or by daily bolus injection. |
1994-08-25 |
2023-08-12 |
rat |
| S P Gygi, J W Gibb, G R Hanso. Differential effects of antipsychotic and psychotomimetic drugs on neurotensin systems of discrete extrapyramidal and limbic regions. The Journal of pharmacology and experimental therapeutics. vol 270. issue 1. 1994-08-15. PMID:7913495. |
the effects of two antipsychotic (dopamine antagonist) drugs, haloperidol and clozapine, and of two psychotomimetic (dopamine-releasing) drugs, methamphetamine and cocaine, on neurotensin (nt) concentrations in discrete regions of the caudate nucleus, nucleus accumbens and globus pallidus were examined. |
1994-08-15 |
2023-08-12 |
Not clear |
| B K Yamamoto, M A Cooperma. Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 7. 1994-08-11. PMID:7913120. |
the purpose of this study was to examine basal and locally stimulated glutamate and dopamine efflux in the caudate, nucleus accumbens, and medial prefrontal cortex using in vivo microdialysis after chronic clozapine and haloperidol treatment. |
1994-08-11 |
2023-08-12 |
Not clear |
| B K Yamamoto, M A Cooperma. Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 14. issue 7. 1994-08-11. PMID:7913120. |
depolarization-induced dopamine release with 80 mm k+ in all three brain regions was attenuated by haloperidol treatment. |
1994-08-11 |
2023-08-12 |
Not clear |
| L Kostal, C J Savor. Influence of pharmacological manipulation of dopamine and opioid receptor subtypes on stereotyped behaviour of restricted-fed fowls. Pharmacology, biochemistry, and behavior. vol 48. issue 1. 1994-08-10. PMID:8029296. |
with dopamine antagonists, inhibition of both stereotypes was most marked with haloperidol (d2), intermediate with clozapine (d4), and lowest with sch 23390 (d1). |
1994-08-10 |
2023-08-12 |
Not clear |
| M Jaber, F Tison, M C Fournier, B Bloc. Differential influence of haloperidol and sulpiride on dopamine receptors and peptide mRNA levels in the rat striatum and pituitary. Brain research. Molecular brain research. vol 23. issue 1-2. 1994-08-08. PMID:7518029. |
differential influence of haloperidol and sulpiride on dopamine receptors and peptide mrna levels in the rat striatum and pituitary. |
1994-08-08 |
2023-08-12 |
rat |