| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Rosaria Melis, Salvatora Succu, Maria Stefania Mascia, Antonio Argiola. PD-168077, a selective dopamine D4 receptor agonist, induces penile erection when injected into the paraventricular nucleus of male rats. Neuroscience letters. vol 379. issue 1. 2005-06-13. PMID:15814200. |
the proerectile effect of pd-168077 was reduced almost completely by l-745,870 (3-(4-[chlorophenyl]piperazin-1-yl)-methyl-1h-pyrrolo[2,3-b]pyridine trihydrochloride), a selective d4 dopamine receptor antagonist, (1 microg) given into the paraventricular nucleus before the d4 dopamine agonist, and by other nonselective dopamine receptor antagonists, such as haloperidol (1 microg) and clozapine (1 microg), which block all dopamine receptor subtypes. |
2005-06-13 |
2023-08-12 |
rat |
| b' N V Zvezdochkina, L N Muranova, V V Andrianov, S S Arkhipova, Kh L Ga\\xc4\\xadnutdinov, A I Golubev, I N Pleshchinski\\xc4\\xa. [Locomotor reactions and excitability of neurons during the blockade of dopamine by haloperidol in vertebrate and invertebrate animals]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 90. issue 11. 2005-05-16. PMID:15646206.' |
[locomotor reactions and excitability of neurons during the blockade of dopamine by haloperidol in vertebrate and invertebrate animals]. |
2005-05-16 |
2023-08-12 |
rat |
| b' N V Zvezdochkina, L N Muranova, V V Andrianov, S S Arkhipova, Kh L Ga\\xc4\\xadnutdinov, A I Golubev, I N Pleshchinski\\xc4\\xa. [Locomotor reactions and excitability of neurons during the blockade of dopamine by haloperidol in vertebrate and invertebrate animals]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 90. issue 11. 2005-05-16. PMID:15646206.' |
the blockade of dopamine receptors by haloperidol led to depression of locomotor activity in both groups of rats; in grape snails, haloperidol caused a decrease of the velocity of locomotor responses. |
2005-05-16 |
2023-08-12 |
rat |
| Jee-Yeon Kim, In-Kwa Jung, Changsu Han, Sook-Haeng Cho, Leen Kim, Seung-Hyun Kim, Bun-Hee Lee, Heon-Jeong Lee, Yong-Ku Ki. Antipsychotics and dopamine transporter gene polymorphisms in delirium patients. Psychiatry and clinical neurosciences. vol 59. issue 2. 2005-05-16. PMID:15823165. |
relatively low doses of risperidone and haloperidol exhibited similar efficacies, and dopamine transporter polymorphisms do not appear to play a major role in the action of antipsychotics on delirium. |
2005-05-16 |
2023-08-12 |
human |
| Tomohisa Mori, Shinobu Ito, Minoru Narita, Tsutomu Suzuki, Toshiko Sawaguch. Combined effects of psychostimulants and morphine on locomotor activity in mice. Journal of pharmacological sciences. vol 96. issue 4. 2005-04-28. PMID:15599100. |
it is well known that psychostimulants- and opioids-induced hyperlocomotion is mediated by the activation of the dopaminergic system, however, haloperidol (a dopamine receptor antagonist) and u50,488h (which attenuates dopamine release from nerve terminals) significantly increased the effects of methamphetamine and morphine on the locomotor activity. |
2005-04-28 |
2023-08-12 |
mouse |
| Michael Soyka, Catja Winter, Sabine Kagerer, Manfred Brunnauer, Gerd Laux, Hans-Jürgen Mölle. Effects of haloperidol and risperidone on psychomotor performance relevant to driving ability in schizophrenic patients compared to healthy controls. Journal of psychiatric research. vol 39. issue 1. 2005-04-12. PMID:15504428. |
the present study was designed to evaluate the effects of an atypical neuroleptic (risperidone) in comparison to a conventional dopamine antagonist neuroleptic (haloperidol) on several dimensions of psychomotor performance (visual perception, attention, reaction time, and sensorimotor performance) considered to be of relevance in evaluating driving fitness. |
2005-04-12 |
2023-08-12 |
human |
| L N Markova, T V Ostroumova, V V Bezuglov, G A Buzniko. [Effects of arachidonoyl dopamine, haloperidol, and their mixtures on regeneration of freshwater Hydra attenuata]. Ontogenez. vol 35. issue 5. 2005-04-08. PMID:15552576. |
[effects of arachidonoyl dopamine, haloperidol, and their mixtures on regeneration of freshwater hydra attenuata]. |
2005-04-08 |
2023-08-12 |
Not clear |
| L N Markova, T V Ostroumova, V V Bezuglov, G A Buzniko. [Effects of arachidonoyl dopamine, haloperidol, and their mixtures on regeneration of freshwater Hydra attenuata]. Ontogenez. vol 35. issue 5. 2005-04-08. PMID:15552576. |
arachidonoyl dopamine and haloperidol, both separately and in different combinations, inhibit regeneration of the gastral and basal regions of hydra. |
2005-04-08 |
2023-08-12 |
Not clear |
| B Ribeiro Do Couto, M A Aguilar, C Manzanedo, M Rodríguez-Arias, J Miñarr. NMDA glutamate but not dopamine antagonists blocks drug-induced reinstatement of morphine place preference. Brain research bulletin. vol 64. issue 6. 2005-04-01. PMID:15639545. |
following extinction of a place preference induced by morphine (40 mg/kg), a non-contingent injection of the dopaminergic antagonists sch 23390 (0.125, 0.5 mg/kg), raclopride (0.3, 1.2 mg/kg), haloperidol (0.1, 0.2 mg/kg) and the dopamine (da) release inhibitor cgs 10746b (1, 10 mg/kg) or glutamatergic nmda antagonists memantine (10, 20, 40 mg/kg) and mk-801 (0.1, 0.2, 0.3 mg/kg) alone or with 10 mg/kg morphine was given. |
2005-04-01 |
2023-08-12 |
mouse |
| Robert B Moreland, Marc A Terranova, Renjie Chang, Marie E Uchic, Mark A Matulenko, Bruce W Surber, Andrew O Stewart, Jorge D Brion. [3H] A-369508 ([2-[4-(2-cyanophenyl)-1-piperazinyl]-N-(3-methylphenyl) acetamide): an agonist radioligand selective for the dopamine D4 receptor. European journal of pharmacology. vol 497. issue 2. 2005-03-15. PMID:15306199. |
when compared to the d(2)-like antagonist [(3)h] spiperone, competition binding for agonists like dopamine and apomorphine were 2-10-fold more potent with [(3)h] a-369508, while the antagonists clozapine, haloperidol and l-745870 bind with similar affinity to both ligands. |
2005-03-15 |
2023-08-12 |
human |
| M Jászberényi, E Bujdosó, G Telegd. Behavioral, neuroendocrine and thermoregulatory actions of apelin-13. Neuroscience. vol 129. issue 3. 2005-03-07. PMID:15541902. |
to determine the mediation of the actions of apelin, a corticotropin-releasing hormone (crh) antagonist, the nonselective dopamine antagonist haloperidol, the selective dopamine d1 receptor antagonist sch-23390 and the nitric oxide synthase inhibitor nomega-nitro-l-arginine-methyl ester (l-name) were administered to the rats. |
2005-03-07 |
2023-08-12 |
rat |
| Zhu Li, Junji Ichikawa, Jin Dai, Herbert Y Meltze. Aripiprazole, a novel antipsychotic drug, preferentially increases dopamine release in the prefrontal cortex and hippocampus in rat brain. European journal of pharmacology. vol 493. issue 1-3. 2005-02-28. PMID:15189766. |
haloperidol, produce significant increases in dopamine and acetylcholine release in the medial prefrontal cortex in rats, effects believed to be related to the ability to improve cognitive function. |
2005-02-28 |
2023-08-12 |
rat |
| Zhu Li, Junji Ichikawa, Jin Dai, Herbert Y Meltze. Aripiprazole, a novel antipsychotic drug, preferentially increases dopamine release in the prefrontal cortex and hippocampus in rat brain. European journal of pharmacology. vol 493. issue 1-3. 2005-02-28. PMID:15189766. |
aripiprazole, 0.3 mg/kg, transiently potentiated haloperidol (0.1 mg/kg)-induced dopamine release in the medial prefrontal cortex but inhibited that in the nucleus accumbens. |
2005-02-28 |
2023-08-12 |
rat |
| G Roger, F Dollé, B De Bruin, X Liu, L Besret, Y Bramoullé, C Coulon, M Ottaviani, M Bottlaender, H Valette, M Kassio. Radiosynthesis and pharmacological evaluation of [11C]EMD-95885: a high affinity ligand for NR2B-containing NMDA receptors. Bioorganic & medicinal chemistry. vol 12. issue 12. 2005-01-31. PMID:15158791. |
use of haloperidol as a blocking drug also resulted in a homogeneous inhibition of [11c]-1 uptake by 66-60%, which does not reflect binding to dopamine or sigma receptors. |
2005-01-31 |
2023-08-12 |
rat |
| Raina M Rogoza, David F Fairfax, Paul Henry, Sevil N-Marandi, Rao F Khan, Suresh K Gupta, Ram K Mishr. Electron spin resonance spectroscopy reveals alpha-phenyl-N-tert-butylnitrone spin-traps free radicals in rat striatum and prevents haloperidol-induced vacuous chewing movements in the rat model of human tardive dyskinesia. Synapse (New York, N.Y.). vol 54. issue 3. 2005-01-31. PMID:15452862. |
haloperidol (hp) has been hypothesized to potentiate increases in oxidative stress or free radical-mediated levels of toxic metabolites in rat striatum while simultaneous upregulating dopamine (da)-d2 receptors leading to presumed da supersensitivity. |
2005-01-31 |
2023-08-12 |
human |
| V Coronas, K Bantubungi, J Fombonne, S Krantic, S N Schiffmann, M Roge. Dopamine D3 receptor stimulation promotes the proliferation of cells derived from the post-natal subventricular zone. Journal of neurochemistry. vol 91. issue 6. 2005-01-21. PMID:15584906. |
this effect was prevented by a co-treatment with haloperidol, sulpiride or u-99194a, a d3-preferring antagonist, and mimicked by the dopamine d3 receptor selective agonist 7-hydroxy-dipropylaminotetralin (7-oh-dpat). |
2005-01-21 |
2023-08-12 |
Not clear |
| Ingmar H A Franken, Vincent M Hendriks, Cornelis J Stam, Wim Van den Brin. A role for dopamine in the processing of drug cues in heroin dependent patients. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 14. issue 6. 2005-01-13. PMID:15589390. |
the present study tests the hypothesis that enhanced attention for heroin cues is mediated by the dopaminergic system using haloperidol as dopamine antagonist. |
2005-01-13 |
2023-08-12 |
Not clear |
| C K Chang, N L Wang, M T Li. Inhibition of the dopamine system in rat amygdala attenuates the picrotoxin-induced locomoter hyperactivity and hypertension. Clinical and experimental pharmacology & physiology. vol 31. issue 5-6. 2005-01-07. PMID:15191399. |
blockade of dopamine receptors with systemic or intra-amygdaloid injection of haloperidol (a dopamine receptor antagonist) significantly attenuated the picrotoxin-induced locomotor hyperactivity and hypertension. |
2005-01-07 |
2023-08-12 |
rat |
| Gabriele Mas. Pharmacotherapy of pervasive developmental disorders in children and adolescents. CNS drugs. vol 18. issue 14. 2004-12-29. PMID:15584771. |
pharmacological, efficacy and safety data on drugs acting on serotonin (serotonergic agents such as clomipramine, fluoxetine, paroxetine, sertraline, citalopram and fluvoxamine), on both serotonin and norepinephrine (venlafaxine and mirtazapine), dopamine (dopamine-blocking antipsychotics such as haloperidol and pimozide), and on both serotonin and dopamine (atypical antipsychotics such as clozapine, risperidone, olanzapine, quetiapine and ziprasidone) are presented. |
2004-12-29 |
2023-08-12 |
Not clear |
| Il-Woong Seol, Na Youn Kuo, Kyeong Man Ki. Effects of dopaminergic drugs on the mast cell degranulation and nitric oxide generation in RAW 264.7 cells. Archives of pharmacal research. vol 27. issue 1. 2004-11-02. PMID:14969346. |
on the other hand, dopamine, bromocriptine, 7-oh-dapt, and haloperidol markedly inhibited the nitric oxide production from raw 264.7 cells (ic50 values, 10-20 microm). |
2004-11-02 |
2023-08-12 |
Not clear |