| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M-B Assié, N Consul-Denjean, W Koek, A Newman-Tancred. Differential in vivo inhibition of [3H]nemonapride binding by atypical antipsychotics in rat striatum, olfactory lobes, and frontal cortex. Pharmacology. vol 75. issue 2. 2005-11-29. PMID:16020947. |
in the striatum, [3h]nemonapride binding was inhibited in a dose-dependent manner with the following order of potency (ed50, mg/kg): nemonapride (0.04), raclopride (0.13), spiperone and risperidone (0.14), haloperidol (0.21), clozapine (7.2) and thioridazine (9.4); in the olfactory lobes: nemonapride (0.03), raclopride and spiperone (0.09), haloperidol (0.10), risperidone (0.15), thioridazine and clozapine (11); in the frontal cortex, only the high affinity dopamine d2 antagonist compounds nemonapride (0.05), haloperidol (0.09), and raclopride (0.12) significantly decreased the binding of [3h]nemonapride. |
2005-11-29 |
2023-08-12 |
rat |
| Marie-Bernadette Assié, Véronique Ravailhe, Valérie Faucillon, Adrian Newman-Tancred. Contrasting contribution of 5-hydroxytryptamine 1A receptor activation to neurochemical profile of novel antipsychotics: frontocortical dopamine and hippocampal serotonin release in rat brain. The Journal of pharmacology and experimental therapeutics. vol 315. issue 1. 2005-11-28. PMID:15987834. |
haloperidol, nemonapride, and the d2 partial agonists, aripiprazole and bifeprunox, did not significantly alter dopamine release. |
2005-11-28 |
2023-08-12 |
rat |
| Shi-Bing Yang, Felix Major, Lutz F Tietze, Marjan Rupni. Block of delayed-rectifier potassium channels by reduced haloperidol and related compounds in mouse cortical neurons. The Journal of pharmacology and experimental therapeutics. vol 315. issue 1. 2005-11-28. PMID:16014573. |
haloperidol is known as an antagonist of dopamine d2 receptors. |
2005-11-28 |
2023-08-12 |
mouse |
| Junji Ichikawa, Young-Chul Chung, Jin Dai, Herbert Y Meltze. Valproic acid potentiates both typical and atypical antipsychotic-induced prefrontal cortical dopamine release. Brain research. vol 1052. issue 1. 2005-10-27. PMID:16061211. |
clozapine and risperidone, as well as the anticonvulsant mood-stabilizers, valproic acid (vpa), zonisamide, and carbamazepine, but not the typical apd haloperidol, increase dopamine (da) release in rat medial prefrontal cortex (mpfc). |
2005-10-27 |
2023-08-12 |
rat |
| Takeshi Inoue, Takeshi Izumi, Xiao Bai Li, Yuji Kitaichi, Shin Nakagawa, Tsukasa Koyam. Effect of a dopamine D1/5 receptor antagonist on haloperidol-induced inhibition of the acquisition of conditioned fear. European journal of pharmacology. vol 519. issue 3. 2005-10-25. PMID:16135362. |
this study examined the effects of combined treatment with the typical antipsychotic drug haloperidol and dopamine d1/5 receptor antagonist sch 23390 on the acquisition of contextual conditioned fear (re-exposure to an environment paired previously with inescapable electric footshocks), compared with those of various antipsychotic adjuvants, which may increase the effects of antipsychotic drugs. |
2005-10-25 |
2023-08-12 |
rat |
| Robert B Zipursky, Bruce K Christensen, Zafiris Daskalakis, Irvin Epstein, Paul Roy, Ivana Furimsky, Todd Sanger, Shitij Kapu. Treatment response to olanzapine and haloperidol and its association with dopamine D receptor occupancy in first-episode psychosis. Canadian journal of psychiatry. Revue canadienne de psychiatrie. vol 50. issue 8. 2005-10-04. PMID:16127964. |
treatment response to olanzapine and haloperidol and its association with dopamine d receptor occupancy in first-episode psychosis. |
2005-10-04 |
2023-08-12 |
Not clear |
| E A Del Bel, F S Guimarães, M Bermúdez-Echeverry, M Z Gomes, A Schiaveto-de-souza, F E Padovan-Neto, V Tumas, A P Barion-Cavalcanti, M Lazzarini, L P Nucci-da-Silva, D de Paula-Souz. Role of nitric oxide on motor behavior. Cellular and molecular neurobiology. vol 25. issue 2. 2005-09-01. PMID:16047547. |
acute administration of l-noarg has an additive cataleptic effect with haloperidol, a dopamine d2 antagonist. |
2005-09-01 |
2023-08-12 |
mouse |
| Shinji Eguchi, Satoko Tezuka, Narumi Hobara, Shinji Akiyama, Yuji Kurosaki, Hiromu Kawasak. Vanilloid receptors mediate adrenergic nerve- and CGRP-containing nerve-dependent vasodilation induced by nicotine in rat mesenteric resistance arteries. British journal of pharmacology. vol 142. issue 7. 2005-08-04. PMID:15249421. |
nicotine-induced vasodilation was not inhibited by treatment with 3,4-dihydroxyphenylalanine (dopa) receptor antagonist (l-dopa cyclohexyl ester; 0.001-10 microm), dopamine d1 receptor-selective antagonist (sch23390; 1-10 microm), dopamine d2 receptor antagonist (haloperidol; 0.1-0.5 microm), atp p2x receptor-desensitizing agonist (alpha,beta-methylene atp; 1-10 microm), adenosine a2 receptor antagonist (8(p-sulfophenyl)theophylline; 10-50 microm) or neuropeptide y (npy)-y1 receptor antagonist (bibp3226; 0.1-0.5 microm). |
2005-08-04 |
2023-08-12 |
rat |
| Erik Hjerde, Svein G Dahl, Ingebrigt Sylt. Atypical and typical antipsychotic drug interactions with the dopamine D2 receptor. European journal of medicinal chemistry. vol 40. issue 2. 2005-07-26. PMID:15694653. |
a model of the dopamine d2 receptor was used to study the receptor interactions of dopamine, the typical antipsychotics haloperidol and loxapine, and the atypical antipsychotics clozapine and melperone. |
2005-07-26 |
2023-08-12 |
Not clear |
| C Cristina, G Díaz-Torga, A Baldi, A Góngora, M Rubinstein, M J Low, D Becú-Villalobo. Increased pituitary vascular endothelial growth factor-a in dopaminergic D2 receptor knockout female mice. Endocrinology. vol 146. issue 7. 2005-07-21. PMID:15817666. |
in wild-type mice, prolonged treatment with the d2r antagonist, haloperidol, enhanced pituitary vegf expression and prolactin release, suggesting that dopamine inhibits pituitary vegf expression. |
2005-07-21 |
2023-08-12 |
mouse |
| Claire Advoka. Differential effects of clozapine versus other antipsychotics on clinical outcome and dopamine release in the brain. Essential psychopharmacology. vol 6. issue 2. 2005-07-11. PMID:15765792. |
moreover, after long-term treatment, tolerance develops to haloperidol, but not to clozapine, with regard to the amount of dopamine released in the brain. |
2005-07-11 |
2023-08-12 |
Not clear |
| Jiawei Zheng, Yan Yang, Shaohua Tian, Jin Chen, Fraser A W Wilson, Yuanye M. The dynamics of hippocampal sensory gating during the development of morphine dependence and withdrawal in rats. Neuroscience letters. vol 382. issue 1-2. 2005-07-11. PMID:15911142. |
moreover, the da antagonist haloperidol was used to assess the contribution of dopamine to hippocampal gating induced by morphine. |
2005-07-11 |
2023-08-12 |
rat |
| Diego Centonze, Alessandro Usiello, Cinzia Costa, Barbara Picconi, Eric Erbs, Giorgio Bernardi, Emiliana Borrelli, Paolo Calabres. Chronic haloperidol promotes corticostriatal long-term potentiation by targeting dopamine D2L receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 38. 2005-07-07. PMID:15385604. |
chronic haloperidol promotes corticostriatal long-term potentiation by targeting dopamine d2l receptors. |
2005-07-07 |
2023-08-12 |
mouse |
| Diego Centonze, Alessandro Usiello, Cinzia Costa, Barbara Picconi, Eric Erbs, Giorgio Bernardi, Emiliana Borrelli, Paolo Calabres. Chronic haloperidol promotes corticostriatal long-term potentiation by targeting dopamine D2L receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 38. 2005-07-07. PMID:15385604. |
haloperidol effects were mimicked and occluded in mice lacking both d2l and d2s isoforms of dopamine d2 receptors (d2r-/-), in mice lacking d2l receptors and expressing normal levels of d2s receptors (d2r-/-;d2l-/-), and in mice lacking d2l receptors and overexpressing d2s receptors (d2l-/-). |
2005-07-07 |
2023-08-12 |
mouse |
| Marion Wittmann, Michael J Marino, Darrell A Henze, Guy R Seabrook, P Jeffrey Con. Clozapine potentiation of N-methyl-D-aspartate receptor currents in the nucleus accumbens: role of NR2B and protein kinase A/Src kinases. The Journal of pharmacology and experimental therapeutics. vol 313. issue 2. 2005-07-05. PMID:15659539. |
we demonstrate that bath application of clozapine but not haloperidol or the selective 5-hydroxytryptamine 2a antagonist mdl100907 [(r)-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluoro-phenyl)ethyl]-4-piperidine methanol] induces a robust potentiation of nmda-evoked currents and of glutamatergic epscs and that this potentiation is dependent on dopamine release and postsynaptic activation of d1 receptors. |
2005-07-05 |
2023-08-12 |
rat |
| Maria Rosaria Melis, Salvatora Succu, Maria Stefania Mascia, Antonio Argiola. PD-168077, a selective dopamine D4 receptor agonist, induces penile erection when injected into the paraventricular nucleus of male rats. Neuroscience letters. vol 379. issue 1. 2005-06-13. PMID:15814200. |
the proerectile effect of pd-168077 was reduced almost completely by l-745,870 (3-(4-[chlorophenyl]piperazin-1-yl)-methyl-1h-pyrrolo[2,3-b]pyridine trihydrochloride), a selective d4 dopamine receptor antagonist, (1 microg) given into the paraventricular nucleus before the d4 dopamine agonist, and by other nonselective dopamine receptor antagonists, such as haloperidol (1 microg) and clozapine (1 microg), which block all dopamine receptor subtypes. |
2005-06-13 |
2023-08-12 |
rat |
| b' N V Zvezdochkina, L N Muranova, V V Andrianov, S S Arkhipova, Kh L Ga\\xc4\\xadnutdinov, A I Golubev, I N Pleshchinski\\xc4\\xa. [Locomotor reactions and excitability of neurons during the blockade of dopamine by haloperidol in vertebrate and invertebrate animals]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 90. issue 11. 2005-05-16. PMID:15646206.' |
[locomotor reactions and excitability of neurons during the blockade of dopamine by haloperidol in vertebrate and invertebrate animals]. |
2005-05-16 |
2023-08-12 |
rat |
| b' N V Zvezdochkina, L N Muranova, V V Andrianov, S S Arkhipova, Kh L Ga\\xc4\\xadnutdinov, A I Golubev, I N Pleshchinski\\xc4\\xa. [Locomotor reactions and excitability of neurons during the blockade of dopamine by haloperidol in vertebrate and invertebrate animals]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 90. issue 11. 2005-05-16. PMID:15646206.' |
the blockade of dopamine receptors by haloperidol led to depression of locomotor activity in both groups of rats; in grape snails, haloperidol caused a decrease of the velocity of locomotor responses. |
2005-05-16 |
2023-08-12 |
rat |
| Jee-Yeon Kim, In-Kwa Jung, Changsu Han, Sook-Haeng Cho, Leen Kim, Seung-Hyun Kim, Bun-Hee Lee, Heon-Jeong Lee, Yong-Ku Ki. Antipsychotics and dopamine transporter gene polymorphisms in delirium patients. Psychiatry and clinical neurosciences. vol 59. issue 2. 2005-05-16. PMID:15823165. |
relatively low doses of risperidone and haloperidol exhibited similar efficacies, and dopamine transporter polymorphisms do not appear to play a major role in the action of antipsychotics on delirium. |
2005-05-16 |
2023-08-12 |
human |
| Tomohisa Mori, Shinobu Ito, Minoru Narita, Tsutomu Suzuki, Toshiko Sawaguch. Combined effects of psychostimulants and morphine on locomotor activity in mice. Journal of pharmacological sciences. vol 96. issue 4. 2005-04-28. PMID:15599100. |
it is well known that psychostimulants- and opioids-induced hyperlocomotion is mediated by the activation of the dopaminergic system, however, haloperidol (a dopamine receptor antagonist) and u50,488h (which attenuates dopamine release from nerve terminals) significantly increased the effects of methamphetamine and morphine on the locomotor activity. |
2005-04-28 |
2023-08-12 |
mouse |