| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Carlsson, W Kehr, M Lindqvis. Agonist--antagonist interaction on dopamine receptors in brain, as reflected in the rates of tyrosine and tryptophan hydroxylation. Journal of neural transmission. vol 40. issue 2. 1977-06-22. PMID:323424. |
the threshold dose was severalfold higher in the noradrenaline-predominated hemisphere portion than in the dopamine-rich striatal and limbic regions, suggesting a higher affinity of haloperidol for dopamine than for noradrenaline receptors. |
1977-06-22 |
2023-08-11 |
rat |
| C J Pycock, P G Jenner, C D Marsde. The interaction of clonidine with dopamine-dependent behaviour in rodents. Naunyn-Schmiedeberg's archives of pharmacology. vol 297. issue 2. 1977-06-22. PMID:558529. |
clonidine (0.5 mg/kg) potentiated the cataleptic effect of the dopamine antagonist haloperidol (0.1-2 mg/kg) in rats. |
1977-06-22 |
2023-08-11 |
mouse |
| S A Darwish, B L Furma. Effects of levodopa and dopamine of plasma glucose concentration in mice. European journal of pharmacology. vol 41. issue 4. 1977-05-20. PMID:139316. |
the hypoglycaemic response to levodopa was prevented by the dopamine antagonists, haloperidol and pimozide. |
1977-05-20 |
2023-08-11 |
mouse |
| M J Bastie, N Vaysse, B Brenac, J P Pascal, A Ribe. Effects of catecholamines and their inhibitors on the isolated canine pancreas. II. Dopamine. Gastroenterology. vol 72. issue 4 Pt 1. 1977-04-28. PMID:838228. |
dopaminergic agonists (dopamine, 2, 10, 50, and 250 mug; apomorphine, 1 mg; noradrenaline, 2, 20, and 200 mug), and inhibitors (haloperidol, 5 mg; pentamethonium, 500 mg; phenoxybenzamine, 15 mg, and atropine sulfate, 10 mg), were tested on isolated perfused canine pancreas; under basal conditions and under stimulation by a background of secretin (0.1, 0.5, and 10.0 clinical unit per hr), or of caerulein (1200 ng per hr). |
1977-04-28 |
2023-08-11 |
Not clear |
| M J Bastie, N Vaysse, B Brenac, J P Pascal, A Ribe. Effects of catecholamines and their inhibitors on the isolated canine pancreas. II. Dopamine. Gastroenterology. vol 72. issue 4 Pt 1. 1977-04-28. PMID:838228. |
low doses of dopamine induced a vasodilation inhibited by haloperidol large doses induced a vasoconstriction, presumably by stimulation of alpha adrenergic receptors. |
1977-04-28 |
2023-08-11 |
Not clear |
| M J Bastie, N Vaysse, B Brenac, J P Pascal, A Ribe. Effects of catecholamines and their inhibitors on the isolated canine pancreas. II. Dopamine. Gastroenterology. vol 72. issue 4 Pt 1. 1977-04-28. PMID:838228. |
secretory response to noradrenaline after phenoxy benzamine was inhibited by haloperidol, suggesting that this effect was mediated by the stimulation of dopamine receptors of the cells. |
1977-04-28 |
2023-08-11 |
Not clear |
| M Laubie, H Schmitt, M Drouilla. Central sites and mechanisms of the hypotensive and bradycardic effects of the narcotic analgesic agent fentanyl. Naunyn-Schmiedeberg's archives of pharmacology. vol 296. issue 3. 1977-04-25. PMID:14307. |
blockade of dopamine receptors by haloperidol or pimozide or of serotonin receptors by methysergide did not change the hypotensive, bradycardic and sympathoinhibitory effects of fentanyl. |
1977-04-25 |
2023-08-11 |
Not clear |
| J Bockaert, J P Tassin, A M Thierry, J Glowinski, J Premon. Characteristics of dopamine and beta-adrenergic sensitive adenylate cyclases in the frontal cerebral cortex of the rat. Comparative effects of neuroleptics on frontal cortex and striatal dopamine sensitive adenylate cyclases. Brain research. vol 122. issue 1. 1977-04-15. PMID:837225. |
thus, haloperidol was less effective than fluphenazine in blocking the striatal dopaminergic receptors, and equally potent than fluphenazine in inhibiting the frontal cerebral cortex dopamine sensitive adenylate cyclase. |
1977-04-15 |
2023-08-11 |
rat |
| K M Braunstein, K E Sarji, J Kleinfelder, H B Schraibman, J A Colwell, K Eureniu. The effects of dopamine on human platelet aggregation, in vitro. The Journal of pharmacology and experimental therapeutics. vol 200. issue 2. 1977-04-15. PMID:839449. |
phentolamine is able to block dopamine enhancement of adp aggregation, but propranolol and haloperidol fail to prevent dopamine inhibition of epinephrine aggregation. |
1977-04-15 |
2023-08-11 |
human |
| P Protais, J Costentin, J C Schwart. Climbing behavior induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum. Psychopharmacology. vol 50. issue 1. 1977-03-31. PMID:827755. |
this peculiar behavior appears to be elicited by stimulation of dopamine receptors in the striatum: it is suppressed after coagulation of this structure while it is facilitated when these receptors are made hypersensitive by previous treatments with 6-hydroxy-dopamine or haloperidol; on the other hand, it is not modified by coagulation of the nucleus accumbens. |
1977-03-31 |
2023-08-11 |
mouse |
| P Laduron, K de Bie, J Leyse. Specific effect of haloperidol on dopamine turnover in the frontal cortex. Naunyn-Schmiedeberg's archives of pharmacology. vol 296. issue 2. 1977-03-31. PMID:834317. |
specific effect of haloperidol on dopamine turnover in the frontal cortex. |
1977-03-31 |
2023-08-11 |
rabbit |
| E Laschka, A Herz, J Bläsi. Activity of the nigro-striatal dopaminergic system during precipitated morphine withdrawal investigated in rats with acute unilateral inactivation of the striatum. Naunyn-Schmiedeberg's archives of pharmacology. vol 296. issue 1. 1977-03-21. PMID:1034882. |
this contralateral circling was only slightly enhanced by haloperidol, but strongly enhanced by a low dosage of apomorphine as well as by some weak dopamine agonists such as cb 154 or by 101. |
1977-03-21 |
2023-08-11 |
rat |
| A K Mukhopadhyay, N Weisbrod. Effect of dopamine on esophageal motor function. The American journal of physiology. vol 232. issue 1. 1977-03-15. PMID:835699. |
both haloperidol and bulbocapnine potently antagonized the effect of dopamine. |
1977-03-15 |
2023-08-11 |
Not clear |
| G Gianutsos, J E Thornburg, K E Moor. Differential actions of dopamine agonists and antagonists on the gamma-butyrolactone-induced in mouse brain dopamine. Psychopharmacology. vol 50. issue 3. 1977-02-26. PMID:826966. |
after chronic treatment with haloperidol or pimozide, there was no alteration of the maximum gbl-induced increase in dopamine nor was there any significant change in the antagonism by apomorphine, although a trend toward increased sensitivity to apomorphine was noted in the group withdrawn from haloperidol. |
1977-02-26 |
2023-08-11 |
mouse |
| G Gianutsos, J E Thornburg, K E Moor. Differential actions of dopamine agonists and antagonists on the gamma-butyrolactone-induced in mouse brain dopamine. Psychopharmacology. vol 50. issue 3. 1977-02-26. PMID:826966. |
these results suggest that in the mouse, haloperidol is a more effective antagonist of presynaptic dopamine autoreceptors than pimozide, while apomorphine is a better presynaptic agonist than piribedil. |
1977-02-26 |
2023-08-11 |
mouse |
| M H Van Woert, R Jutkowitz, D Rosenbaum, M B Bower. Gilles de la Tourette's syndrome: biochemical approaches. Research publications - Association for Research in Nervous and Mental Disease. vol 55. 1977-02-24. PMID:1070064. |
this supports the hypothesis that tourette symptoms are related to an increased firing of dopaminergic neurons in the central nervous system; haloperidol relieves these symptoms by blocking dopamine receptors. |
1977-02-24 |
2023-08-11 |
Not clear |
| J Engel, S Liljequis. The effect of long-term ethanol treatment on the sensitivity of the dopamine receptors in the nucleus accumbens. Psychopharmacology. vol 49. issue 3. 1977-02-16. PMID:826942. |
this effect of dopamine was antagonized by intraperitoneally administered haloperidol indicating a specific effect on dopamine receptors. |
1977-02-16 |
2023-08-11 |
rat |
| H Huckauf, B Ramdohr, R Schröde. Dopamine induced hypoxemia in patients with left heart failure. International journal of clinical pharmacology and biopharmacy. vol 14. issue 3. 1977-02-16. PMID:1002356. |
how haloperidol abolishes this dopamine effect on arterial oxygen tension remains unknown. |
1977-02-16 |
2023-08-11 |
Not clear |
| G M Brown, P Seeman, T Le. Dopamine/neuroleptic receptors in basal hypothalamus and pituitary. Endocrinology. vol 99. issue 5. 1977-01-29. PMID:991828. |
high affinity receptors for haloperidol and dopamine were found in the rat pituitary while none were detected in rat basal hypothalamus. |
1977-01-29 |
2023-08-11 |
rat |
| G M Brown, P Seeman, T Le. Dopamine/neuroleptic receptors in basal hypothalamus and pituitary. Endocrinology. vol 99. issue 5. 1977-01-29. PMID:991828. |
the lack of receptors capable of binding (3h)haloperidol or (3h)dopamine in the basal hypothalamus strongly suggests that the ti neurons do not produce postsynaptic effects in this region. |
1977-01-29 |
2023-08-11 |
rat |