| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I V Komissarov, G K Krivobok, A N Talalaenk. [Monoaminergic influences of the caudate nucleus on conditioned food-getting reactions in rats]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 25. issue 4. 1976-03-11. PMID:1210722. |
the effects of dopamine are achieved through neurone receptors of the caudate nucleus which are sensitive to haloperidol and chlorpromazine; effects of serotonin are mediated through the d-serotoninoreactive systems, and those of noradrenaline, through the alpha-adrenoreactive systems of the neostriatum neurones. |
1976-03-11 |
2023-08-11 |
rat |
| A N Talalaenko, G K Krivobo. [Neurochemical mechanisms of the inhibitory influence of the hippocampus on the conditioned food-getting reaction in rats]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 25. issue 5. 1976-03-11. PMID:1210741. |
the dopamine effects are achieved through archicortex neurones receptors, sensitive to haloperidol, the noradrenaline effects, through alpha-adrenoreactive, and of serotonin, through m-serotoninsensitive structures of the hippocampal neuronal systems. |
1976-03-11 |
2023-08-11 |
rat |
| P Seeman, M Chau-Wong, J Tedesco, K Won. Brain receptors for antipsychotic drugs and dopamine: direct binding assays. Proceedings of the National Academy of Sciences of the United States of America. vol 72. issue 11. 1976-02-19. PMID:1060115. |
in order to test the suggestion that antipsychotic drugs act by blocking dopamine receptors in the brain, the direct effects of such neuroleptic drugs were tested on the stereospecific binding of [3h]dopamine and of [3h]haloperidol to rat brain striata and their subfractions. |
1976-02-19 |
2023-08-11 |
rat |
| P Seeman, M Chau-Wong, J Tedesco, K Won. Brain receptors for antipsychotic drugs and dopamine: direct binding assays. Proceedings of the National Academy of Sciences of the United States of America. vol 72. issue 11. 1976-02-19. PMID:1060115. |
the stereospecific component of binding was defined as that amount of [3h]dopamine or [3h]haloperidol bound in the presence of (-)-butaclamol (an inactive drug) minus that bound in the presence of (+)-butaclamol (a potent neuroleptic drug); 100 nm butaclamol was used for the [3h]haloperidol assay, while 1 mum butaclamol was used for the [3h]dopamine assay. |
1976-02-19 |
2023-08-11 |
rat |
| P Seeman, M Chau-Wong, J Tedesco, K Won. Brain receptors for antipsychotic drugs and dopamine: direct binding assays. Proceedings of the National Academy of Sciences of the United States of America. vol 72. issue 11. 1976-02-19. PMID:1060115. |
various antipsychotic drugs inhibited this stereospecific component in both the dopamine and haloperidol assays. |
1976-02-19 |
2023-08-11 |
rat |
| S Wilk, E Watson, M E Stanle. Differential sensitivity of two dopaminergic structures in rat brain to haloperidol and to clozapine. The Journal of pharmacology and experimental therapeutics. vol 195. issue 2. 1976-01-30. PMID:1185596. |
the mechanisms underlying the dissociation of the extrapyramidal and antipsychotic properties of haloperidol as compared to clozapine were explored by studying the effects of these drugs on dopamine metabolism in the straitum and tuberculum olfactorium (to) of the rat. |
1976-01-30 |
2023-08-11 |
rat |
| S Wilk, E Watson, M E Stanle. Differential sensitivity of two dopaminergic structures in rat brain to haloperidol and to clozapine. The Journal of pharmacology and experimental therapeutics. vol 195. issue 2. 1976-01-30. PMID:1185596. |
the effect of haloperidol on dopamine metabolism in the striatum was more persistent than that in the to. |
1976-01-30 |
2023-08-11 |
rat |
| S Wilk, E Watson, M E Stanle. Differential sensitivity of two dopaminergic structures in rat brain to haloperidol and to clozapine. The Journal of pharmacology and experimental therapeutics. vol 195. issue 2. 1976-01-30. PMID:1185596. |
the extrapyramidal effects of haloperidol may be due to the persistent action of this drug on dopamine metabolism in the striatum, and the lack of extrapyramidal effects of clozapine may be due to its brief action on dopamine metabolism in the striatum. |
1976-01-30 |
2023-08-11 |
rat |
| S Consolo, H Ladinsky, S Bianch. Decrease in rat striatal acetylcholine levels by some direct- and indirect-acting dopaminergic antagonists. European journal of pharmacology. vol 33. issue 2. 1976-01-26. PMID:1183479. |
these data suggest that haloperidol and pimozide act on the striatal cholinergic neurons through strong blockade of dopamine receptors. |
1976-01-26 |
2023-08-11 |
rat |
| B Hine, M B Wallach, S Gersho. Involvement of biogenic amines in drug-induced aggressive pecking in chicks. Psychopharmacologia. vol 43. issue 3. 1976-01-23. PMID:127189. |
haloperidol completely antagonized amp but not imi pecking, while phentolamine and propranolol did not modify amp pecking, suggesting involvement of dopamine. |
1976-01-23 |
2023-08-11 |
chicken |
| J T Fitzsimons, P E Setle. The relative importance of central nervous catecholaminergic and cholinergic mechanisms in drinking in response to antiotensin and other thirst stimuli. The Journal of physiology. vol 250. issue 3. 1975-12-20. PMID:240934. |
preventing dopaminergic transmission with intracranial haloperidol decreased the water to food ratio of the rat's intake after overnight starvation, whereas increasing the dopamine levels with the combination of fla-63 and l-dopa increased the ratio. |
1975-12-20 |
2023-08-11 |
rat |
| J L Imbs, M Schmidt, J Schwart. Effect of dopamine on renin secretion in the anesthetized dog. European journal of pharmacology. vol 33. issue 1. 1975-12-20. PMID:1175682. |
the role of intrarenal dopaminergic receptors has been studied: (a) haloperidol (intrarenal perfusion of 50 mug/kg/min for 20 min) suppresses the renal vasodilation and renin hypersecretion induced by dopamine. |
1975-12-20 |
2023-08-11 |
dog |
| A Spring, W Winkelmülle. Ventral midbrain stimulation, blood pressure responses and their relation to the dopaminergic nigro-striatal pathways. Pflugers Archiv : European journal of physiology. vol 358. issue 4. 1975-12-11. PMID:1172615. |
drugs (haloperidol, alpha-methyltyrosin and 6-hydroxydopamine), affecting the dopamine metabolism in different ways, abolished the stimulation-induced blood pressure responses. |
1975-12-11 |
2023-08-11 |
Not clear |
| B Scatton, C Garret, L Julo. Acute and subacute effects of neuroleptics dopamine synthesis and release in the rat striatum. Naunyn-Schmiedeberg's archives of pharmacology. vol 289. issue 4. 1975-12-04. PMID:240136. |
the effects of acute and subacute treatments with moderate doses of thioproperazine and haloperidol on dopamine synthesis and release have been examined in rat striatal slices. |
1975-12-04 |
2023-08-11 |
rat |
| H Akil, J C Liebeskin. Monoaminergic mechanisms of stimulation-produced analgesia. Brain research. vol 94. issue 2. 1975-11-07. PMID:125141. |
(4) blockade of catecholamine receptors by haloperidol or of dopamine receptors by pimozide. |
1975-11-07 |
2023-08-11 |
rat |
| H Akil, J C Liebeskin. Monoaminergic mechanisms of stimulation-produced analgesia. Brain research. vol 94. issue 2. 1975-11-07. PMID:125141. |
when a general catecholamine receptor blocker (haloperidol) was employed, spa was diminished, suggesting that the influence of dopamine in spa is greater than that of noradrenaline. |
1975-11-07 |
2023-08-11 |
rat |
| T Nose, H Takemot. The effect of penfluridol and some psychotropic drugs on monoamine metabolism in central nervous system. European journal of pharmacology. vol 31. issue 2. 1975-11-07. PMID:238856. |
penfluridol accelerated the turnover rate of brain dopamine (da), wheras haloperidol accelerated both da and noradrenaline turnover rates. |
1975-11-07 |
2023-08-11 |
mouse |
| G G Yarbroug. Supersensitivity of caudate neurones after repeated administration of haloperidol. European journal of pharmacology. vol 31. issue 2. 1975-11-07. PMID:1149799. |
the microiontophoretic potencies of dopamine, apomorphine and alpha-aminobutyric acid were examined on caudate neurones, using the same electrodes, in control animals and animals that had received 2mg/kg/day of haloperidol for 9 days. |
1975-11-07 |
2023-08-11 |
Not clear |
| G G Yarbroug. Supersensitivity of caudate neurones after repeated administration of haloperidol. European journal of pharmacology. vol 31. issue 2. 1975-11-07. PMID:1149799. |
in the haloperidol group, a greater percentage of cells were inhibited by dopamine and apomorphine, indicating the development of a post-synaptic supersensitivity. |
1975-11-07 |
2023-08-11 |
Not clear |
| A R Cools, G Hendriks, J Korte. The acetylcholine-dopamine balance in the basal ganglia of rhesus monkeys and its role in dynamic, dystonic, dyskinetic, and epileptoid motor activities. Journal of neural transmission. vol 36. issue 2. 1975-11-07. PMID:1151371. |
behavioural analyses have been made of effects brought about by both single and combined injections of dopamine, haloperidol, carbachol and atropine into the caput nuclei caudati of rhesus monkeys. |
1975-11-07 |
2023-08-11 |
monkey |