| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Arbilla, L A Kamal, S Z Lange. Inhibition by apomorphine of the potassium-evoked release of [3H]-gamma-aminobutyric acid from the rat substantia nigra in vitro. British journal of pharmacology. vol 74. issue 2. 1982-03-13. PMID:7317688. |
in vivo administration of haloperidol 0.2 mg/kg antagonized the in vitro inhibition by apomorphine of the k(+)-evoked release of [(3)h]-gaba.5 the results obtained with apomorphine and haloperidol suggest the presence of presynaptic dopamine-like inhibitory receptors in gabaergic nerve terminals.6 dopamine in concentrations ranging up to 300 mum did not modify either the spontaneous or the k(+)-evoked release of [(3)h]-gaba from the substantia nigra. |
1982-03-13 |
2023-08-12 |
rat |
| L D'Angelo, J M Mont. Effects of oxolinic acid on the sleep-wakefulness cycle of the rat. British journal of pharmacology. vol 74. issue 2. 1982-03-13. PMID:7317689. |
1 a study was carried out in rats (prepared for chronic sleep recording) of the effects of oxolinic acid on the sleep-wakefulness cycle.2 in addition, the actions of oxolinic acid on the sleep-wake cycle were assessed after pretreatment with drugs interfering with central catecholamine mechanisms or facilitating central gamma-aminobutyric acid (gaba) activity.3 oxolinic acid (8-32 mg/kg) induced a significant and dose-related increase of waking eeg, while slow wave and rem sleep were decreased.4 the effects of oxolinic acid on waking, slow wave and rem sleep were antagonized by alpha-methyl-p-tyrosine (50-100 mg/kg) which interferes with the synthesis of catecholamines.5 fla-63 (25 mg/kg) which is a specific inhibitor of noradrenaline synthesis, was effective in blocking oxolinic acid-related increase of waking and decrease of slow wave sleep.6 haloperidol (0.4-0.6 mg/kg) which blocks central dopamine and noradrenaline receptors, reversed oxolinic acid-induced actions on waking and slow wave sleep. |
1982-03-13 |
2023-08-12 |
rat |
| G Almazan, T L Sourke. Effect of haloperidol on adrenal ornithine decarboxylase activity of the rat. European journal of pharmacology. vol 75. issue 2-3. 1982-03-13. PMID:7318901. |
the administration of the dopamine antagonist haloperidol (hlp) to rats produced a temporary increase in adrenomedullary and cortical ornithine decarboxylase (odc) activity. |
1982-03-13 |
2023-08-12 |
rat |
| Y Watanabe, T Matsumiya, T Ok. Effects of fusaric (5-butylpicolinic) acid on the monosynaptic reflex neural activity of cat spinal cord. The Tokai journal of experimental and clinical medicine. vol 6. issue 4. 1982-03-13. PMID:7324082. |
the fa-induced neural activity was gradually depressed by treatment with haloperidol, a dopamine and/or a alpha receptor blocker and methysergide, a serotonin receptor blocker, respectively. |
1982-03-13 |
2023-08-12 |
cat |
| I Takayanagi, H Murakami, Y Iwayama, Y Yoshida, S Mik. Dopamine receptor in anterior byssus retractor muscle of Mytilus edulis. Japanese journal of pharmacology. vol 31. issue 2. 1982-02-25. PMID:7311143. |
the concentration-curves of dopamine, its derivatives and norepinephrine shifted in parallel with application of haloperidol but were not influenced by the alpha- and beta-adrenoceptor antagonists. |
1982-02-25 |
2023-08-12 |
Not clear |
| R G O'Rega. Responses of carotid body chemosensory activity and blood flow to stimulation of sympathetic nerves in the cat. The Journal of physiology. vol 315. 1982-02-22. PMID:7310725. |
type i responses displayed elevations in impulse frequencies which were usually maximal in the initial 10-20 sec of stimulation, resisted alpha-adrenoceptor antagonism induced by phentolamine or phenoxybenzamine and were enhanced after administration of the dopamine antagonist, haloperidol. |
1982-02-22 |
2023-08-12 |
cat |
| J A Severson, H H Osterburg, C E Finc. Aging and haloperidol-induced dopamine turnover in the nigro-striatal pathway of C57BL/6J mice. Neurobiology of aging. vol 2. issue 3. 1982-02-12. PMID:7312097. |
the responsiveness of male c57bl/6j mice to acute haloperidol (2.5 mg/kg, ip) was studied throughout the average adult lifespan (4, 8, 12, 21, 28 months) by effects on dopamine (da) turnover, as estimated by da loss after alpha-methyl-p-tyrosine (ampt). |
1982-02-12 |
2023-08-12 |
mouse |
| J L Marin. Serotonergic and dopaminergic effects of yawning in the cat. Pharmacology, biochemistry, and behavior. vol 15. issue 5. 1982-02-12. PMID:7312907. |
the dopamine antagonist haloperidol had no effect on limb flicking at doses from 0.008 to 0.512 mg/kg, but produced a significantly increased frequency of yawning at 0.256 mg/kg, an effect antagonized by lisuride administration. |
1982-02-12 |
2023-08-12 |
cat |
| A S Levine, J E Morle. Peptidergic control of insulin-induced feeding. Peptides. vol 2. issue 3. 1982-01-28. PMID:7029493. |
the dopamine antagonist haloperidol, the cholinergic antagonist atropine, and the putative satiety factors cck-8, bombesin, histidyl-proline diketopiperazine and calcitonin suppressed insulin-induced feeding. |
1982-01-28 |
2023-08-12 |
rat |
| P K Randall, J A Severson, C E Finc. Aging and the regulation of striatal dopaminergic mechanisms in mice. The Journal of pharmacology and experimental therapeutics. vol 219. issue 3. 1982-01-28. PMID:7197719. |
chronic treatment with haloperidol (dopamine antagonist) (1.2 or 2 mg/kg/day for 21 days) induced supersensitivity in younger mice (5 and 12 months) as monitored by increased striatal spiroperidol binding sites and increased intensity of apomorphine-induced stereotyped behavior; in contrast, old mice were unaffected. |
1982-01-28 |
2023-08-12 |
mouse |
| B D Davies, L G Aboo. Covalent interaction of [3H]-dopamine with rat brain proteins in vivo and with the dopamine-reuptake site of nerve endings in vitro. Journal of neuroscience research. vol 6. issue 4. 1982-01-28. PMID:7299853. |
with intact nerve endings, under conditions where dopamine reuptake occurs, benztropine and cocaine (inhibitors of dopamine reuptake), but not atropine or haloperidol (a postsynaptic antagonist), prevent the reaction. |
1982-01-28 |
2023-08-12 |
rat |
| R T Rubin, R E Poland, J R Sowers, J M Hershma. Influence of methyl-TRH-induced prolactin increase on serum testosterone levels in normal adult men. The Journal of clinical endocrinology and metabolism. vol 46. issue 5. 1982-01-20. PMID:122292. |
to rule out a direct effect of haloperidol on the testis, serum samples from a methyl-trh study in normal men, in whom serum prl levels were increased by a stimulus other than dopamine blockade, were analyzed for t. fourteen subjects received both a low dose (6.25-12.5 micrograms) and a high dose (100-500 micrograms) of methyl-trh on separate days; blood sampling was done for 15 min before and for 4 h after drug infusion. |
1982-01-20 |
2023-08-11 |
human |
| K O Perry, B I Diamond, J Z Fields, J H Gordo. Hypophysectomy induced hypersensitivity to dopamine: antagonism by estrogen. Brain research. vol 226. issue 1-2. 1982-01-20. PMID:7197571. |
the hypox induced increase in dopamine sensitivity could be increased by chronic treatment and withdrawal of haloperidol. |
1982-01-20 |
2023-08-12 |
rat |
| N Oudart, R Sercombe, P Aubineau, R G Boulu, J Seyla. Relaxation by dopaminergic agonists in cerebral and peripheral arteries (in vitro). Archives internationales de pharmacodynamie et de therapie. vol 252. issue 2. 1982-01-20. PMID:7305558. |
the effects of the dopamine receptor antagonists, sulpiride, haloperidol and droperidol, and a beta-adrenergic antagonist, propranolol, were tested on the concentration-response curves obtained with dopamine. |
1982-01-20 |
2023-08-12 |
rabbit |
| N Oudart, R Sercombe, P Aubineau, R G Boulu, J Seyla. Relaxation by dopaminergic agonists in cerebral and peripheral arteries (in vitro). Archives internationales de pharmacodynamie et de therapie. vol 252. issue 2. 1982-01-20. PMID:7305558. |
in the c.e.a., haloperidol and droperidol exerted complex effects on the dopamine relaxation, and sulpiride had inconsistent effects. |
1982-01-20 |
2023-08-12 |
rabbit |
| J L Montastruc, P Montastru. Antihypertensive action of bromocriptine in neurogenic hypertensive dogs. Archives internationales de pharmacodynamie et de therapie. vol 252. issue 2. 1982-01-20. PMID:7305559. |
this anti-hypertensive action of bromocriptine was abolished by pretreatment with dopamine antagonists: haloperidol, sulpiride or metoclopramide. |
1982-01-20 |
2023-08-12 |
Not clear |
| L P Felpel, R L Polzin, R D Huffma. Supersensitivity to microiontophoretically applied dopamine and GABA in feline spinal trigeminal and hypoglossal neurons following chronic haloperidol. Substance and alcohol actions/misuse. vol 1. issue 5-6. 1982-01-09. PMID:6272435. |
supersensitivity to microiontophoretically applied dopamine and gaba in feline spinal trigeminal and hypoglossal neurons following chronic haloperidol. |
1982-01-09 |
2023-08-12 |
Not clear |
| K Uvnäs-Wallensten, M Goiny, M A Oriowo, S Ceka. Effects of apomorphine and haloperidol on plasma cortisol levels in conscious dogs. Acta physiologica Scandinavica. vol 112. issue 3. 1981-12-22. PMID:7293796. |
the fact that not only apomorphine but also haloperidol stimulated cortisol release suggests a complex role or dopamine transmission involving different dopaminergic pathways as well as different dopamine receptors. |
1981-12-22 |
2023-08-12 |
Not clear |
| N Anwar, D F Maso. Actions of dopamine and apomorphine on the vasoconstrictor responses of perfused mesenteric arteries of mouse, rat and rabbit. The Journal of pharmacy and pharmacology. vol 33. issue 3. 1981-12-21. PMID:6116755. |
the inhibitory effects of both dopamine and apomorphine were prevented by haloperidol (3 x 10(-7) m) but not by yohimbine (3 x 10(-8) m) in rat and rabbit mesenteric artery preparations. |
1981-12-21 |
2023-08-12 |
mouse |
| N Anwar, D F Maso. Actions of dopamine and apomorphine on the vasoconstrictor responses of perfused mesenteric arteries of mouse, rat and rabbit. The Journal of pharmacy and pharmacology. vol 33. issue 3. 1981-12-21. PMID:6116755. |
in contrast, yohimbine (3 x 10(-8) m), but not haloperidol, antagonized the inhibitory effect of dopamine and apomorphine in mouse mesenteric artery preparations. |
1981-12-21 |
2023-08-12 |
mouse |