| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R D Pinnoc. The actions of antipsychotic drugs on dopamine receptors in the rat substantia nigra. British journal of pharmacology. vol 81. issue 4. 1984-07-18. PMID:6144343. |
the inhibitory effects of dopamine were antagonized by (-)-sulpiride (pa2 7.5), haloperidol (pa2 8.4) and cis-flupenthixol (pa2 6.9). |
1984-07-18 |
2023-08-12 |
rat |
| L R Sterank. Effects of antipsychotic drugs on the long-term effects of amphetamine on nigro-striatal dopamine neurons in iprindole-treated rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 325. issue 3. 1984-07-18. PMID:6145099. |
the decrease in striatal dopamine (da) at 1 week after the administration of a single injection of (+)-amphetamine sulfate (9.2 mg/kg) to iprindole-treated (10 mg/kg of iprindole hydrochloride) rats was prevented by haloperidol (0.2 mg/kg), sulpiride (32 mg/kg), pimozide (2 mg/kg), chlorpromazine hydrochloride (3.5 mg/kg), fluphenazine 2-hydrochloride (0.25 mg/kg) and (+)-butaclamol hydrochloride (1 mg/kg) but not by (-)-butaclamol hydrochloride (1 mg/kg) or clozapine (40 mg/kg). |
1984-07-18 |
2023-08-12 |
rat |
| G Fontani, F Farabollin. Effect of DSP-4, pCPA, and haloperidol on hippocampal electrical activity and behavior in rabbits. Behavioral and neural biology. vol 40. issue 2. 1984-07-17. PMID:6233963. |
the block of dopamine receptors by chronic haloperidol administration (5 mg/kg ip/day) did not seem to exert any effect on rsa parameters. |
1984-07-17 |
2023-08-12 |
Not clear |
| B Costall, A M Domeney, R J Naylo. Long-term consequences of antagonism by neuroleptics of behavioural events occurring during mesolimbic dopamine infusion. Neuropharmacology. vol 23. issue 3. 1984-07-12. PMID:6145111. |
it is concluded that the long-term consequences (up to 1 year) of a brief period (13 days) of overactivity induced by mesolimbic infusion of dopamine cannot be prevented by daily treatment with haloperidol or sulpiride in doses adequate to prevent the behavioural expression of the effects of the dopamine stimulation during its infusion. |
1984-07-12 |
2023-08-12 |
rat |
| M Kemali, N Milici, D Kemal. Drugs and the frog retina. Effect of dopaminergic agents on the pigment screening of light- and dark-adapted frogs. Neuropharmacology. vol 23. issue 3. 1984-07-12. PMID:6610134. |
this is a study, using the light and electron microscope, of the action of a dopamine agonist (apomorphine) and of a dopamine antagonist (haloperidol) on the retinal pigment screening (ps) of light- and dark-adapted frogs. |
1984-07-12 |
2023-08-12 |
Not clear |
| H N Bhargav. Effects of prolyl-leucyl-glycinamide and cyclo(leucyl-glycine) on the supersensitivity of dopamine receptors in brain induced by chronic administration of haloperidol to rats. Neuropharmacology. vol 23. issue 4. 1984-07-10. PMID:6145116. |
effects of prolyl-leucyl-glycinamide and cyclo(leucyl-glycine) on the supersensitivity of dopamine receptors in brain induced by chronic administration of haloperidol to rats. |
1984-07-10 |
2023-08-12 |
rat |
| H N Bhargav. Effects of prolyl-leucyl-glycinamide and cyclo(leucyl-glycine) on the supersensitivity of dopamine receptors in brain induced by chronic administration of haloperidol to rats. Neuropharmacology. vol 23. issue 4. 1984-07-10. PMID:6145116. |
the effects of melanotropin release-inhibiting factor, a tripeptide (pro-leu-gly-nh2) derived from the hypothalamus, and its enzymatically stable analog, cyclo(leu-gly) on the supersensitivity of dopamine receptors in brain induced by chronic administration of haloperidol to male sprague-dawley rats was determined. |
1984-07-10 |
2023-08-12 |
rat |
| H N Bhargav. Effects of prolyl-leucyl-glycinamide and cyclo(leucyl-glycine) on the supersensitivity of dopamine receptors in brain induced by chronic administration of haloperidol to rats. Neuropharmacology. vol 23. issue 4. 1984-07-10. PMID:6145116. |
oral administration of haloperidol (1.5 mg/kg per day) for 21 days induced supersensitivity of dopamine receptors as shown by enhanced locomotor activity in response to apomorphine, and an increase in the number of binding sites for [3h]spiroperidol in the striatum. |
1984-07-10 |
2023-08-12 |
rat |
| M Memo, I Hanbaue. Phosphorylation of membrane proteins in response to persistent stimulation of adenylate cyclase-linked dopamine receptors in slices of striatum. Neuropharmacology. vol 23. issue 4. 1984-07-10. PMID:6728131. |
preincubation of slices with haloperidol (10(-6) m) greatly reduced, while (-)sulpiride (10(-6) m) failed to alter the increase of phosphorylation elicited by dopamine. |
1984-07-10 |
2023-08-12 |
Not clear |
| R D Pinnoc. Sensitivity of compacta neurones in the rat substantia nigra slice to dopamine agonists. European journal of pharmacology. vol 96. issue 3-4. 1984-07-09. PMID:6676108. |
although noradrenaline was equipotent to dopamine, alpha- and beta-adrenoreceptors were not involved since propranolol and phentolamine were not antagonists, while (-)-sulpiride, haloperidol and alpha-flupentixol were potent antagonists of the dopamine mediated responses. |
1984-07-09 |
2023-08-12 |
rat |
| C Ferretti, F Benfenati, M Cimino, G Vantini, M Lipartiti, G Muccioli, R di Carlo, S Alger. Effects of systemic and intracerebroventricular domperidone treatment on striatal and hypothalamic dopaminergic neurons. Medical biology. vol 61. issue 6. 1984-07-09. PMID:6676604. |
in this study we compared the effects of systemic administration of haloperidol (hal), a typical dopaminergic antagonist and of domperidone (dom), a dopamine (da) receptor blocker which does not cross the blood brain barrier but has a potency similar to hal at da receptors, on hypothalamic and striatal da system turnover (evaluated by means of hva and dopac levels) and prolactin (prl) secretion in male rats. |
1984-07-09 |
2023-08-12 |
rat |
| H Fink, R Morgenstern, W Oelssne. Clozapine--a serotonin antagonist? Pharmacology, biochemistry, and behavior. vol 20. issue 4. 1984-07-09. PMID:6728869. |
clozapine, injected into nucleus accumbens (0.2 micrograms), increased apomorphine-induced hypermotility, whereas the dopamine antagonist haloperidol suppressed it. |
1984-07-09 |
2023-08-12 |
rat |
| W L Collier, M De Rossi, F Ament. Dopamine-sensitive adenylate-cyclase in rabbit superior mesenteric artery. Archives internationales de pharmacodynamie et de therapie. vol 268. issue 1. 1984-07-02. PMID:6329113. |
the stimulation of camp levels elicited by dopamine was unaffected by alpha or beta-adrenergic receptor blocking agents but was remarkably reduced by the dopamine receptor blocking agents fluphenazine and haloperidol. |
1984-07-02 |
2023-08-12 |
rabbit |
| J Palermo-Neto, M M Bernardi, R Saba. Kinetic analysis of central nervous system supersensitivity induced in rats by long-term haloperidol administration. I. pA2 determination. Pharmacology. vol 28. issue 4. 1984-06-22. PMID:6539476. |
a kinetic analysis of central dopamine receptors in control and in experimental rats, withdrawn from long-term haloperidol treatment was made in vivo. |
1984-06-22 |
2023-08-12 |
rat |
| R A Felder, M Blecher, G M Eisner, P A Jos. Cortical tubular and glomerular dopamine receptors in the rat kidney. The American journal of physiology. vol 246. issue 5 Pt 2. 1984-06-20. PMID:6720961. |
the binding of [3h]haloperidol to glomeruli and tubules was rapid, saturable with time and ligand concentration, reversible, of high affinity, and demonstrated stereoselectivity and antagonist and agonist rank potency for binding to dopamine receptors. |
1984-06-20 |
2023-08-12 |
rat |
| C P Robinso. Relaxation of rabbit aorta by chlordimeform. Journal of applied toxicology : JAT. vol 4. issue 1. 1984-06-18. PMID:6585419. |
relaxations by cdf of aorta strips contracted by 5 x 10(-7) m prostaglandin f2 alpha were not altered by the antimuscarinic agent atropine (10(-5) m), the beta-adrenergic antagonist propranolol (10(-5) m), the histamine h2 antagonist cimetidine (2 x 10(-4) m), the dopamine antagonist haloperidol (10(-5) m) or the na+-k+-atpase inhibitor ouabain (5 x 10(-6) m). |
1984-06-18 |
2023-08-12 |
rabbit |
| A V Christensen, J Arnt, J Hyttel, J J Larsen, O Svendse. Pharmacological effects of a specific dopamine D-1 antagonist SCH 23390 in comparison with neuroleptics. Life sciences. vol 34. issue 16. 1984-06-14. PMID:6144029. |
neuroleptics such as thioxanthenes (cis(z)-flupentixol and cis(z)-clopenthixol) and phenothiazines (fluphenazine and perphenazine), which block both dopamine (da) d-1 and d-2 receptors and the butyrophenones (haloperidol and spiroperidol), which block d-2 receptors only, are equipotent both behaviorally and clinically. |
1984-06-14 |
2023-08-12 |
mouse |
| D H Versteeg, D Van Heuven-Nolsen, D De Wie. Pre-decapitation state of arousal of rats predetermines the effect of des-Tyr1-gamma-endorphin on dopamine release from nucleus accumbens slices in vitro. Life sciences. vol 34. issue 16. 1984-06-14. PMID:6717245. |
this latter effect resembled that of haloperidol, which dose-dependently enhanced basal dopamine efflux in vitro. |
1984-06-14 |
2023-08-12 |
rat |
| O Serri, A M Marchisio, M Somma, J Hardy, R Coll. Interaction of sulpiride with human pituitary dopaminergic receptors is sodium dependent. Hormone research. vol 19. issue 3. 1984-06-08. PMID:6714932. |
on the contrary, the interaction of neuroleptics (d-butaclamol and haloperidol) and dopamine agonists (apomorphine and bromocriptine) was unaffected by the nacl conditions. |
1984-06-08 |
2023-08-12 |
human |
| C D Blaha, R F Lan. Direct in vivo electrochemical monitoring of dopamine release in response to neuroleptic drugs. European journal of pharmacology. vol 98. issue 1. 1984-06-06. PMID:6143672. |
the ability of stearate-modified graphite paste electrodes to monitor changes in dopamine (da) release in response to haloperidol and chlorpromazine was examined in rat striatum. |
1984-06-06 |
2023-08-12 |
rat |