| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Khosla, S Kothari, M C Gupta, R K Srivastav. Evaluation of haloperidol, a dopamine antagonist, on intraocular pressure in experimental glaucoma. Indian journal of experimental biology. vol 34. issue 6. 1996-11-27. PMID:8792645. |
haloperidol, a dopaminergic antagonist, was found to be very effective in lowering intraocular pressure in normal and glaucomatous eyes. |
1996-11-27 |
2023-08-12 |
Not clear |
| D R Lynch, M J Gallaghe. Inhibition of N-methyl-D-aspartate receptors by haloperidol: developmental and pharmacological characterization in native and recombinant receptors. The Journal of pharmacology and experimental therapeutics. vol 279. issue 1. 1996-11-18. PMID:8858988. |
the dopaminergic antagonist haloperidol also acts at the psychotomimetic sigma receptor and has been proposed to act at n-methyl-d-aspartate (nmda) receptors. |
1996-11-18 |
2023-08-12 |
Not clear |
| J P Doucet, Y Nakabeppu, P J Bedard, B T Hope, E J Nestler, B J Jasmin, J S Chen, M J Iadarola, M St-Jean, N Wigle, P Blanchet, R Grondin, G S Robertso. Chronic alterations in dopaminergic neurotransmission produce a persistent elevation of deltaFosB-like protein(s) in both the rodent and primate striatum. The European journal of neuroscience. vol 8. issue 2. 1996-10-22. PMID:8714707. |
chronic haloperidol administration also selectively elevated expression of these fos-related antigens, suggesting that their induction after dopaminergic denervation is mediated by reduced activation of d2-like dopamine receptors. |
1996-10-22 |
2023-08-12 |
rat |
| J P Doucet, Y Nakabeppu, P J Bedard, B T Hope, E J Nestler, B J Jasmin, J S Chen, M J Iadarola, M St-Jean, N Wigle, P Blanchet, R Grondin, G S Robertso. Chronic alterations in dopaminergic neurotransmission produce a persistent elevation of deltaFosB-like protein(s) in both the rodent and primate striatum. The European journal of neuroscience. vol 8. issue 2. 1996-10-22. PMID:8714707. |
western blot immunostaining using an antibody which recognizes the n-terminus of fosb indicated that the 43 and 45 kda fos-related antigens induced by dopaminergic denervation and chronic haloperidol administration may be related to a truncated form of fosb known as deltafosb. |
1996-10-22 |
2023-08-12 |
rat |
| K Ossowska, S Wolfart. Lack of a strong influence of neuroleptic decanoates on dopaminergic and GABAergic functions. Polish journal of pharmacology. vol 47. issue 2. 1996-08-29. PMID:8688897. |
present results indicate that the dopaminergic supersensitivity after administration of depot neuroleptics is weak and appears very late, and that haloperidol decanoate does not induce nigral supersensitivity to gaba. |
1996-08-29 |
2023-08-12 |
Not clear |
| I M Lacau-Mengido, D Becú-Villalobos, S M Thyssen, E B Rey, V A Lux-Lantos, C Libertu. Antidopaminergic-induced hypothalamic LHRH release and pituitary gonadotrophin secretion in 12 day-old female and male rats. Journal of neuroendocrinology. vol 5. issue 6. 1996-08-21. PMID:8680445. |
the effect was blocked by bromocriptine and not by phentolamine indicating that haloperidol acted on the dopaminergic receptor, and that unspecific stimulation of the noradrenergic system was not involved. |
1996-08-21 |
2023-08-12 |
rat |
| A M Oyarce, T A Hand, R E Mains, B A Eippe. Dopaminergic regulation of secretory granule-associated proteins in rat intermediate pituitary. Journal of neurochemistry. vol 67. issue 1. 1996-08-06. PMID:8666996. |
rats were treated with a dopaminergic agonist (bromocriptine) or antagonist (haloperidol) for periods ranging from 1 h to 5 days, followed by analyses of mrna levels and protein biosynthetic rates. |
1996-08-06 |
2023-08-12 |
rat |
| V H Sethy, B R Ellerbrock, H W. Comparative dopaminergic and muscarinic antagonist activity of clozapine and haloperidol. Life sciences. vol 58. issue 7. 1996-07-01. PMID:8632711. |
comparative dopaminergic and muscarinic antagonist activity of clozapine and haloperidol. |
1996-07-01 |
2023-08-12 |
mouse |
| G Debonnel, C de Montign. Modulation of NMDA and dopaminergic neurotransmissions by sigma ligands: possible implications for the treatment of psychiatric disorders. Life sciences. vol 58. issue 9. 1996-06-28. PMID:8632719. |
this link was later reinforced with the demonstration that several neuroleptics, such as haloperidol, have a high affinity for sigma receptors, whereas, some new molecules with a high affinity for sigma receptors, but a low affinity for dopaminergic receptors demonstrated a "neuroleptic-like" pharmacological profile. |
1996-06-28 |
2023-08-12 |
Not clear |
| Y Is. [Repeated MK-801 administration but not methamphetamine produces up-regulation of muscarinic acetylcholine receptors in mice]. Masui. The Japanese journal of anesthesiology. vol 44. issue 12. 1996-03-19. PMID:8583660. |
coadministration of haloperidol (0, 0.125, 0.5 and 2 mg.kg-1), a dopamine receptor antagonist, prevented the up-regulation of muscarinic acetylcholine receptors (machr) induced by mk-801 (1 mg.kg-1) in a dose-dependent way, indicating involvement of the dopaminergic mechanism in the induction of up-regulation of machrs. |
1996-03-19 |
2023-08-12 |
mouse |
| J Fang, D Zuo, P H Y. Comparison of cytotoxicity of a quaternary pyridinium metabolite of haloperidol (HP+) with neurotoxin N-methyl-4-phenylpyridinium (MPP+) towards cultured dopaminergic neuroblastoma cells. Psychopharmacology. vol 121. issue 3. 1996-03-19. PMID:8584620. |
comparison of cytotoxicity of a quaternary pyridinium metabolite of haloperidol (hp+) with neurotoxin n-methyl-4-phenylpyridinium (mpp+) towards cultured dopaminergic neuroblastoma cells. |
1996-03-19 |
2023-08-12 |
human |
| J Fang, D Zuo, P H Y. Comparison of cytotoxicity of a quaternary pyridinium metabolite of haloperidol (HP+) with neurotoxin N-methyl-4-phenylpyridinium (MPP+) towards cultured dopaminergic neuroblastoma cells. Psychopharmacology. vol 121. issue 3. 1996-03-19. PMID:8584620. |
this conversion of haloperidol to hp+ appears to be similar to the activation of the dopaminergic neurotoxin n-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) to n-methyl-4-phenyl pyridinium ion (mpp+). |
1996-03-19 |
2023-08-12 |
human |
| J Fang, D Zuo, P H Y. Comparison of cytotoxicity of a quaternary pyridinium metabolite of haloperidol (HP+) with neurotoxin N-methyl-4-phenylpyridinium (MPP+) towards cultured dopaminergic neuroblastoma cells. Psychopharmacology. vol 121. issue 3. 1996-03-19. PMID:8584620. |
it seemed sensible to investigate whether or not hp+ might be toxic towards dopaminergic neurons and perhaps associated with some of the residual moto-function side effects of haloperidol. |
1996-03-19 |
2023-08-12 |
human |
| F W Bach, T L Yaks. Release into ventriculo-cisternal perfusate of beta-endorphin- and Met-enkephalin-immunoreactivity: effects of electrical stimulation in the arcuate nucleus and periaqueductal gray of the rat. Brain research. vol 690. issue 2. 1996-02-07. PMID:8535833. |
systemic administration of the dopaminergic antagonist haloperidol increased plasma, but not perfusate levels of beta-epir. |
1996-02-07 |
2023-08-12 |
rat |
| C Iñiguez, P Tamayo, A Gómez, M J Gayos. Effects of perinatal administration of haloperidol on GH pituitary contents and serum levels during the first postnatal month. Neuroendocrinology. vol 62. issue 3. 1996-02-07. PMID:8538869. |
perinatal dopaminergic blockade with haloperidol caused prl increases in rat pituitary gland and serum which persisted during the first postnatal month. |
1996-02-07 |
2023-08-12 |
human |
| C A Tieppo, A M Silva, J Palermo-Neto, A G Nasello, L F Felici. Intracerebroventricular administration of cholecystokinin reduces stereotypy in dopamine-supersensitive rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 28. issue 3. 1996-01-24. PMID:8520531. |
dopaminergic supersensitivity was induced by long-term haloperidol (hal) treatment (30 days: 1.0 mg/kg twice a day). |
1996-01-24 |
2023-08-12 |
rat |
| B Jardon, N Bonaventur. Different effects of dopamine and piribedil (a dopamine D2 agonist) on frog monocular optokinetic nystagmus asymmetry. Vision research. vol 35. issue 19. 1995-12-12. PMID:7483308. |
the monocular okn n-t component still appears after administration of piribedil even if this injection is preceded by administration of haloperidol which blocks the dopaminergic d2 receptors. |
1995-12-12 |
2023-08-12 |
Not clear |
| Y Fischer, J Thomas, J Kamp, E Jüngling, H Rose, Carpéné, H Kammermeie. 5-hydroxytryptamine stimulates glucose transport in cardiomyocytes via a monoamine oxidase-dependent reaction. The Biochemical journal. vol 311 ( Pt 2). 1995-11-28. PMID:7487898. |
the effect of 5-ht was not affected by (i) the 5-ht receptor antagonists methysergide (1 microm), ketanserin (1 microm), cyproheptadine (1 microm), mdl 72222 (1 microm) or ics 205-930 (3 microm), nor by (ii) the adrenergic receptor antagonists prazosin (1 microm), yohimbine (1 microm) or propranolol (5 microm), nor by (iii) the dopaminergic antagonists sch 23390 (1 microm) or haloperidol (1 microm). |
1995-11-28 |
2023-08-12 |
rat |
| M Volonté, A Ceci, F Borsin. Effect of the 5-hydroxytryptamine3 receptor antagonist itasetron (DAU 6215) on (+)-N-allylnormetazocine-induced dopamine release in the nucleus accumbens and in the corpus striatum of the rat: an in vivo microdialysis study. The Journal of pharmacology and experimental therapeutics. vol 275. issue 1. 1995-11-21. PMID:7562571. |
the in vivo brain microdialysis technique has been used to study the ability of itasetron, [dau 6215, (3-alpha-tropanyl)1h-benzimidazolone-3-carboxamide hydrochloride], a novel 5-hydroxytryptamine3 (5-ht3)-receptor antagonist, to antagonize the effect of the sigma-agonist (+)-n-allylnormetazocine (skf 10,047) in inducing the release of dopamine from mesolimbic and nigrostriatal dopaminergic neurons, in comparison with haloperidol and clozapine. |
1995-11-21 |
2023-08-12 |
rat |
| J M Cook-Mills, R L Cohen, R L Perlman, D A Chamber. Inhibition of lymphocyte activation by catecholamines: evidence for a non-classical mechanism of catecholamine action. Immunology. vol 85. issue 4. 1995-11-20. PMID:7558147. |
the inhibition of lymphocyte activation by catecholamines could not be reversed by antagonists to beta-adrenergic receptors (propranolol), alpha-adrenergic receptors (phentolamine), or dopaminergic receptors (haloperidol). |
1995-11-20 |
2023-08-12 |
mouse |