| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M R Kilbourn, K A Frey, T Vander Borght, P S Sherma. Effects of dopaminergic drug treatments on in vivo radioligand binding to brain vesicular monoamine transporters. Nuclear medicine and biology. vol 23. issue 4. 1997-01-16. PMID:8832701. |
in contrast, radiotracer distributions remained unchanged after treatments with other dopaminergic drugs, whether given by single injection (haloperidol, 1 mg/kg i.p., pargyline 80 mg/kg), repeatedly (pargyline, 80 mg/kg s.c., 14 days), or by continuous infusion (deprenyl, 10 mg/kg/day, 5 days; l-dopa methyl ester 100 mg/kg/day, 5 days). |
1997-01-16 |
2023-08-12 |
rat |
| A Dalia, N J Uretsky, L J Wallac. Induction of locomotor activity by the glutamate antagonist DNQX injected into the ventral tegmental area. Brain research. vol 728. issue 2. 1997-01-15. PMID:8864484. |
however, the locomotor stimulation produced by dnqx was markedly attenuated following blockade of dopaminergic receptors by haloperidol (0.5 mg/kg, s.c.) or following dopamine depletion induced by reserpine plus alpha-methyl-para-tyrosine pretreatment. |
1997-01-15 |
2023-08-12 |
Not clear |
| E D Levin, D Torr. Acute and chronic nicotine effects on working memory in aged rats. Psychopharmacology. vol 123. issue 1. 1996-12-03. PMID:8741959. |
after a 2 week withdrawal period the remaining rats underwent a series of acute drug challenges with nicotinic and muscarinic agonists and antagonists as well as the dopaminergic antagonist haloperidol. |
1996-12-03 |
2023-08-12 |
rat |
| M F Egan, S J Chrapusta, F Karoum, R J Wyat. The effects of acute and chronic haloperidol treatment on dopamine release mediated by the medial forebrain bundle in the striatum and nucleus accumbens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 14. issue 3. 1996-12-03. PMID:8866705. |
these data suggest that dopaminergic neuronal impulse flow modulates similar amounts of total transmitter release after both acute and chronic haloperidol treatment. |
1996-12-03 |
2023-08-12 |
rat |
| P Khosla, S Kothari, M C Gupta, R K Srivastav. Evaluation of haloperidol, a dopamine antagonist, on intraocular pressure in experimental glaucoma. Indian journal of experimental biology. vol 34. issue 6. 1996-11-27. PMID:8792645. |
haloperidol, a dopaminergic antagonist, was found to be very effective in lowering intraocular pressure in normal and glaucomatous eyes. |
1996-11-27 |
2023-08-12 |
Not clear |
| D R Lynch, M J Gallaghe. Inhibition of N-methyl-D-aspartate receptors by haloperidol: developmental and pharmacological characterization in native and recombinant receptors. The Journal of pharmacology and experimental therapeutics. vol 279. issue 1. 1996-11-18. PMID:8858988. |
the dopaminergic antagonist haloperidol also acts at the psychotomimetic sigma receptor and has been proposed to act at n-methyl-d-aspartate (nmda) receptors. |
1996-11-18 |
2023-08-12 |
Not clear |
| J P Doucet, Y Nakabeppu, P J Bedard, B T Hope, E J Nestler, B J Jasmin, J S Chen, M J Iadarola, M St-Jean, N Wigle, P Blanchet, R Grondin, G S Robertso. Chronic alterations in dopaminergic neurotransmission produce a persistent elevation of deltaFosB-like protein(s) in both the rodent and primate striatum. The European journal of neuroscience. vol 8. issue 2. 1996-10-22. PMID:8714707. |
chronic haloperidol administration also selectively elevated expression of these fos-related antigens, suggesting that their induction after dopaminergic denervation is mediated by reduced activation of d2-like dopamine receptors. |
1996-10-22 |
2023-08-12 |
rat |
| J P Doucet, Y Nakabeppu, P J Bedard, B T Hope, E J Nestler, B J Jasmin, J S Chen, M J Iadarola, M St-Jean, N Wigle, P Blanchet, R Grondin, G S Robertso. Chronic alterations in dopaminergic neurotransmission produce a persistent elevation of deltaFosB-like protein(s) in both the rodent and primate striatum. The European journal of neuroscience. vol 8. issue 2. 1996-10-22. PMID:8714707. |
western blot immunostaining using an antibody which recognizes the n-terminus of fosb indicated that the 43 and 45 kda fos-related antigens induced by dopaminergic denervation and chronic haloperidol administration may be related to a truncated form of fosb known as deltafosb. |
1996-10-22 |
2023-08-12 |
rat |
| K Ossowska, S Wolfart. Lack of a strong influence of neuroleptic decanoates on dopaminergic and GABAergic functions. Polish journal of pharmacology. vol 47. issue 2. 1996-08-29. PMID:8688897. |
present results indicate that the dopaminergic supersensitivity after administration of depot neuroleptics is weak and appears very late, and that haloperidol decanoate does not induce nigral supersensitivity to gaba. |
1996-08-29 |
2023-08-12 |
Not clear |
| I M Lacau-Mengido, D Becú-Villalobos, S M Thyssen, E B Rey, V A Lux-Lantos, C Libertu. Antidopaminergic-induced hypothalamic LHRH release and pituitary gonadotrophin secretion in 12 day-old female and male rats. Journal of neuroendocrinology. vol 5. issue 6. 1996-08-21. PMID:8680445. |
the effect was blocked by bromocriptine and not by phentolamine indicating that haloperidol acted on the dopaminergic receptor, and that unspecific stimulation of the noradrenergic system was not involved. |
1996-08-21 |
2023-08-12 |
rat |
| A M Oyarce, T A Hand, R E Mains, B A Eippe. Dopaminergic regulation of secretory granule-associated proteins in rat intermediate pituitary. Journal of neurochemistry. vol 67. issue 1. 1996-08-06. PMID:8666996. |
rats were treated with a dopaminergic agonist (bromocriptine) or antagonist (haloperidol) for periods ranging from 1 h to 5 days, followed by analyses of mrna levels and protein biosynthetic rates. |
1996-08-06 |
2023-08-12 |
rat |
| V H Sethy, B R Ellerbrock, H W. Comparative dopaminergic and muscarinic antagonist activity of clozapine and haloperidol. Life sciences. vol 58. issue 7. 1996-07-01. PMID:8632711. |
comparative dopaminergic and muscarinic antagonist activity of clozapine and haloperidol. |
1996-07-01 |
2023-08-12 |
mouse |
| G Debonnel, C de Montign. Modulation of NMDA and dopaminergic neurotransmissions by sigma ligands: possible implications for the treatment of psychiatric disorders. Life sciences. vol 58. issue 9. 1996-06-28. PMID:8632719. |
this link was later reinforced with the demonstration that several neuroleptics, such as haloperidol, have a high affinity for sigma receptors, whereas, some new molecules with a high affinity for sigma receptors, but a low affinity for dopaminergic receptors demonstrated a "neuroleptic-like" pharmacological profile. |
1996-06-28 |
2023-08-12 |
Not clear |
| Y Is. [Repeated MK-801 administration but not methamphetamine produces up-regulation of muscarinic acetylcholine receptors in mice]. Masui. The Japanese journal of anesthesiology. vol 44. issue 12. 1996-03-19. PMID:8583660. |
coadministration of haloperidol (0, 0.125, 0.5 and 2 mg.kg-1), a dopamine receptor antagonist, prevented the up-regulation of muscarinic acetylcholine receptors (machr) induced by mk-801 (1 mg.kg-1) in a dose-dependent way, indicating involvement of the dopaminergic mechanism in the induction of up-regulation of machrs. |
1996-03-19 |
2023-08-12 |
mouse |
| J Fang, D Zuo, P H Y. Comparison of cytotoxicity of a quaternary pyridinium metabolite of haloperidol (HP+) with neurotoxin N-methyl-4-phenylpyridinium (MPP+) towards cultured dopaminergic neuroblastoma cells. Psychopharmacology. vol 121. issue 3. 1996-03-19. PMID:8584620. |
comparison of cytotoxicity of a quaternary pyridinium metabolite of haloperidol (hp+) with neurotoxin n-methyl-4-phenylpyridinium (mpp+) towards cultured dopaminergic neuroblastoma cells. |
1996-03-19 |
2023-08-12 |
human |
| J Fang, D Zuo, P H Y. Comparison of cytotoxicity of a quaternary pyridinium metabolite of haloperidol (HP+) with neurotoxin N-methyl-4-phenylpyridinium (MPP+) towards cultured dopaminergic neuroblastoma cells. Psychopharmacology. vol 121. issue 3. 1996-03-19. PMID:8584620. |
this conversion of haloperidol to hp+ appears to be similar to the activation of the dopaminergic neurotoxin n-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) to n-methyl-4-phenyl pyridinium ion (mpp+). |
1996-03-19 |
2023-08-12 |
human |
| J Fang, D Zuo, P H Y. Comparison of cytotoxicity of a quaternary pyridinium metabolite of haloperidol (HP+) with neurotoxin N-methyl-4-phenylpyridinium (MPP+) towards cultured dopaminergic neuroblastoma cells. Psychopharmacology. vol 121. issue 3. 1996-03-19. PMID:8584620. |
it seemed sensible to investigate whether or not hp+ might be toxic towards dopaminergic neurons and perhaps associated with some of the residual moto-function side effects of haloperidol. |
1996-03-19 |
2023-08-12 |
human |
| F W Bach, T L Yaks. Release into ventriculo-cisternal perfusate of beta-endorphin- and Met-enkephalin-immunoreactivity: effects of electrical stimulation in the arcuate nucleus and periaqueductal gray of the rat. Brain research. vol 690. issue 2. 1996-02-07. PMID:8535833. |
systemic administration of the dopaminergic antagonist haloperidol increased plasma, but not perfusate levels of beta-epir. |
1996-02-07 |
2023-08-12 |
rat |
| C Iñiguez, P Tamayo, A Gómez, M J Gayos. Effects of perinatal administration of haloperidol on GH pituitary contents and serum levels during the first postnatal month. Neuroendocrinology. vol 62. issue 3. 1996-02-07. PMID:8538869. |
perinatal dopaminergic blockade with haloperidol caused prl increases in rat pituitary gland and serum which persisted during the first postnatal month. |
1996-02-07 |
2023-08-12 |
human |
| C A Tieppo, A M Silva, J Palermo-Neto, A G Nasello, L F Felici. Intracerebroventricular administration of cholecystokinin reduces stereotypy in dopamine-supersensitive rats. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 28. issue 3. 1996-01-24. PMID:8520531. |
dopaminergic supersensitivity was induced by long-term haloperidol (hal) treatment (30 days: 1.0 mg/kg twice a day). |
1996-01-24 |
2023-08-12 |
rat |