| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Castrén, M da Penha Berzaghi, D Lindholm, H Thoene. Differential effects of MK-801 on brain-derived neurotrophic factor mRNA levels in different regions of the rat brain. Experimental neurology. vol 122. issue 2. 1993-10-26. PMID:8405262. |
pentobarbital (an enhancer of gabaergic functions) and scopolamine (a muscarinic receptor antagonist) blocked the effects of mk-801 on bdnf mrna levels in the retrosplenial cortex, but the nicotinic and dopaminergic receptor antagonists mecamylamine and haloperidol, respectively, were ineffective. |
1993-10-26 |
2023-08-12 |
rat |
| C L Nilsson, E Eriksso. Haloperidol increases prolactin release and cyclic AMP formation in vitro: inverse agonism at dopamine D2 receptors? Journal of neural transmission. General section. vol 92. issue 2-3. 1993-10-12. PMID:7690232. |
it is suggested that haloperidol may act as an inverse agonist rather than as a neutral antagonist at dopaminergic d2 receptors. |
1993-10-12 |
2023-08-12 |
Not clear |
| J Caboche, P Vernier, M Rogard, M J Besso. Haloperidol increases PPE mRNA levels in the caudal part of the nucleus accumbens in the rat. Neuroreport. vol 4. issue 5. 1993-07-22. PMID:8513136. |
in this study, the effects of an interruption of dopamine transmission by haloperidol (a dopaminergic receptor antagonist) were examined in the rat nucleus accumbens. |
1993-07-22 |
2023-08-12 |
rat |
| B V Kumar, P S Sastr. Dopamine receptors in human foetal brains: characterization, regulation and ontogeny of [3H]spiperone binding sites in striatum. Neurochemistry international. vol 20. issue 4. 1993-07-15. PMID:1304871. |
spiperone binding sites were characterized in a 40-week-old foetal brain to be dopamine receptors by the following criteria: (1) it was localized in a crude mitochondrial pellet that included synaptosomes; (2) binding was saturable at 0.8 nm concentration; (3) dopaminergic antagonists spiperone, haloperidol, pimozide, trifluperazine and chlorpromazine competed for the binding with ic50 values in the range of 0.3-14 nm while agonists--apomorphine and dopamine gave ic50 values of 2.5 and 10 microm, respectively suggesting a d2 type receptor. |
1993-07-15 |
2023-08-11 |
human |
| B Levant, E B DeSouz. Differential pharmacological profile of striatal and cerebellar dopamine receptors labeled by [3H]quinpirole: identification of a discrete population of putative D3 receptors. Synapse (New York, N.Y.). vol 14. issue 1. 1993-07-15. PMID:8099762. |
dopaminergic compounds inhibited the specific binding of [3h]quinpirole in the caudate/putamen with the following rank order of potencies: spiperone > haloperidol > or = (+)butaclamol > or = quinpirole > or = 7-oh-dpat > or = bromocriptine > clozapine > (-)sulpiride. |
1993-07-15 |
2023-08-12 |
Not clear |
| G Pelletie. Regulation of proopiomelanocortin gene expression in rat brain and pituitary as studied by in situ hybridization. Annals of the New York Academy of Sciences. vol 680. 1993-07-15. PMID:8512219. |
the role of dopamine was investigated following the administration of the dopaminergic antagonist haloperidol and the d2 dopaminergic receptor agonist bromocriptine. |
1993-07-15 |
2023-08-12 |
rat |
| T I Lidsky, S P Banerje. Acute administration of haloperidol enhances dopaminergic transmission. The Journal of pharmacology and experimental therapeutics. vol 265. issue 3. 1993-07-14. PMID:8389855. |
acute administration of haloperidol enhances dopaminergic transmission. |
1993-07-14 |
2023-08-12 |
rat |
| T I Lidsky, S P Banerje. Acute administration of haloperidol enhances dopaminergic transmission. The Journal of pharmacology and experimental therapeutics. vol 265. issue 3. 1993-07-14. PMID:8389855. |
however, it is generally assumed that augmentation of dopaminergic transmission is precluded by haloperidol's postsynaptic actions. |
1993-07-14 |
2023-08-12 |
rat |
| T I Lidsky, S P Banerje. Acute administration of haloperidol enhances dopaminergic transmission. The Journal of pharmacology and experimental therapeutics. vol 265. issue 3. 1993-07-14. PMID:8389855. |
the present data suggest that acute administration of haloperidol actually augments dopaminergic activity due to relatively strong presynaptic actions and relatively weak postsynaptic blocking effects. |
1993-07-14 |
2023-08-12 |
rat |
| T I Lidsky, S P Banerje. Acute administration of haloperidol enhances dopaminergic transmission. The Journal of pharmacology and experimental therapeutics. vol 265. issue 3. 1993-07-14. PMID:8389855. |
it is plausible that this initial increase in dopaminergic transmission may participate in producing the neural changes evoked by chronic haloperidol administration that allow this drug to have antipsychotic potency. |
1993-07-14 |
2023-08-12 |
rat |
| T Scimonelli, M Marucco, M E Celi. Evidence for catecholaminergic control of alpha-melanotropin (alpha-MSH) content in hypothalamic areas. Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia. vol 42. issue 2. 1993-05-25. PMID:1363745. |
haloperidol (1.2mg/kg), a dopaminergic receptor antagonist, propranolol (6.0mg/kg) and yohimbine (10mg/kg) (non selective beta- and alpha 2-adrenergic antagonist drugs respectively) had no effect on the alpha-msh in any of the hypothalamic areas studied. |
1993-05-25 |
2023-08-11 |
rat |
| E Perez-Oso, E Arill. Effect of prenatal dopamine receptor blocking on somatostatin receptor binding in the developing rat brain. Brain research bulletin. vol 31. issue 1-2. 1993-04-22. PMID:8095841. |
pregnant sprague-dawley rats were injected intraperitoneally with either haloperidol (2.5 mg/kg/day), which blocks dopaminergic receptors, or saline. |
1993-04-22 |
2023-08-12 |
rat |
| G Rudolf, N Wiolan. Acute blockade of dopamine receptors with haloperidol: a retinal model to study impairments of dopaminergic transmission. European journal of pharmacology. vol 230. issue 3. 1993-04-01. PMID:8382615. |
acute blockade of dopamine receptors with haloperidol: a retinal model to study impairments of dopaminergic transmission. |
1993-04-01 |
2023-08-12 |
chicken |
| G Rudolf, N Wiolan. Acute blockade of dopamine receptors with haloperidol: a retinal model to study impairments of dopaminergic transmission. European journal of pharmacology. vol 230. issue 3. 1993-04-01. PMID:8382615. |
acute blockade of retinal dopaminergic transmission with haloperidol, a mixed antagonist, produced a dose-correlated tep voltage decrease which was rapidly reversed by intravitreal injection of dopamine. |
1993-04-01 |
2023-08-12 |
chicken |
| M C Arenas, A Parra, V M Simó. Gender differences in escape-avoidance behavior of mice after haloperidol administration. Pharmacology, biochemistry, and behavior. vol 44. issue 1. 1993-03-09. PMID:8430126. |
several possible mechanisms responsible for this greater susceptibility of males to the inhibitory effects of haloperidol on escape-avoidance learning are discussed, especially the modulating role of female hormones on dopaminergic activity. |
1993-03-09 |
2023-08-12 |
mouse |
| F Marchal, A Bairam, P Haouzi, J M Hascoet, J P Crance, P Vert, S Lahir. Dual responses of carotid chemosensory afferents to dopamine in the newborn kitten. Respiration physiology. vol 90. issue 2. 1993-03-08. PMID:1494718. |
it is concluded that the dopaminergic mechanisms are active in the carotid body of the kitten, and the observed responses to dopamine and haloperidol are qualitatively similar to those reported in the adult cat. |
1993-03-08 |
2023-08-11 |
cat |
| J W Kebabian, D R Britton, M P DeNinno, R Perner, L Smith, P Jenner, R Schoenleber, M William. A-77636: a potent and selective dopamine D1 receptor agonist with antiparkinsonian activity in marmosets. European journal of pharmacology. vol 229. issue 2-3. 1993-03-02. PMID:1362704. |
in rats with unilateral 6-ohda (6-hydroxydopamine) lesions of the nigro-striatal dopaminergic pathway, a-77636 elicits prolonged (> 20 h) contralateral turning that is blocked by sch 23390, a d1 receptor antagonist, but not by haloperidol at doses selective for the dopamine d2 receptor. |
1993-03-02 |
2023-08-11 |
mouse |
| S Li, G Pelletie. Dopamine regulation of gonadotropin-releasing hormone (GnRH) gene expression in the female rat brain. Neuroscience letters. vol 146. issue 2. 1993-03-02. PMID:1491791. |
the effects of the dopaminergic antagonist haloperidol (hal) as well as the d2 dopamine receptor agonist bromocriptine (bro) on gonadotropin-releasing hormone (gnrh) mrna levels in intact and hypophysectomized rats were investigated by quantitative in situ hybridization. |
1993-03-02 |
2023-08-11 |
rat |
| M A Hossain, J M Masserano, N Weine. Comparative effects of electroconvulsive shock and haloperidol on in vivo tyrosine hydroxylation and tetrahydrobiopterin in the brain of rats with 6-hydroxydopamine lesions. Brain research. vol 598. issue 1-2. 1993-02-25. PMID:1486474. |
these results suggest that the nigrostriatal system, although up-regulated following 6-ohda lesions, still maintains the potential for further up-regulation of dopaminergic function in response to haloperidol and ecs treatment. |
1993-02-25 |
2023-08-11 |
rat |
| G E Ploeger, B M Spruijt, A R Cool. Effects of haloperidol on the acquisition of a spatial learning task. Physiology & behavior. vol 52. issue 5. 1993-02-18. PMID:1484855. |
the effects of systemic injections of the dopaminergic antagonist haloperidol on the acquisition of the morris water maze with either a visible or an invisible platform (nonspatial vs. spatial learning) were investigated. |
1993-02-18 |
2023-08-11 |
Not clear |