| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A N Gifford, K M Johnso. Effect of chronic cocaine treatment on D2 receptors regulating the release of dopamine and acetylcholine in the nucleus accumbens and striatum. Pharmacology, biochemistry, and behavior. vol 41. issue 4. 1992-06-30. PMID:1534415. |
effect of chronic cocaine treatment on d2 receptors regulating the release of dopamine and acetylcholine in the nucleus accumbens and striatum. |
1992-06-30 |
2023-08-11 |
rat |
| L Pulvirenti, N R Swerdlow, G F Koo. Nucleus accumbens NMDA antagonist decreases locomotor activity produced by cocaine, heroin or accumbens dopamine, but not caffeine. Pharmacology, biochemistry, and behavior. vol 40. issue 4. 1992-06-30. PMID:1687766. |
nucleus accumbens nmda antagonist decreases locomotor activity produced by cocaine, heroin or accumbens dopamine, but not caffeine. |
1992-06-30 |
2023-08-11 |
rat |
| L Pulvirenti, N R Swerdlow, G F Koo. Nucleus accumbens NMDA antagonist decreases locomotor activity produced by cocaine, heroin or accumbens dopamine, but not caffeine. Pharmacology, biochemistry, and behavior. vol 40. issue 4. 1992-06-30. PMID:1687766. |
for this purpose, rats treated with cocaine (10 mg/kg ip), dopamine (20 micrograms directly into the nac), heroin (0.5 mg/kg sc), or caffeine (10 mg/kg sc) were challenged with intra-nac microinfusion of 2-amino-5-phosphonovaleric acid (apv), a selective nmda receptor antagonist. |
1992-06-30 |
2023-08-11 |
rat |
| L Pulvirenti, N R Swerdlow, G F Koo. Nucleus accumbens NMDA antagonist decreases locomotor activity produced by cocaine, heroin or accumbens dopamine, but not caffeine. Pharmacology, biochemistry, and behavior. vol 40. issue 4. 1992-06-30. PMID:1687766. |
apv reduced locomotor activation induced by cocaine, heroin and intra-nac dopamine, but not caffeine. |
1992-06-30 |
2023-08-11 |
rat |
| P A Broderic. Cocaine: on-line analysis of an accumbens amine neural basis for psychomotor behavior. Pharmacology, biochemistry, and behavior. vol 40. issue 4. 1992-06-30. PMID:1816582. |
time course studies showed that the neurochemical effects of cocaine (10, 20, and 40 mg/kg sc) significantly (p less than 0.0001) increased accumbens synaptic concentrations of dopamine (da) and concurrently and significantly (p less than 0.0001) decreased accumbens synaptic concentrations of serotonin (5-ht) in a dose response manner. |
1992-06-30 |
2023-08-11 |
rat |
| P A Broderic. In vivo voltammetric studies on release mechanisms for cocaine with gamma-butyrolactone. Pharmacology, biochemistry, and behavior. vol 40. issue 4. 1992-06-30. PMID:1816583. |
the effect of cocaine (20 mg/kg sc) on presynaptic mechanisms of release for dopamine (da) and for serotonin (5-ht) was studied in nucleus accumbens of unrestrained rats (rattus norvegicus). |
1992-06-30 |
2023-08-11 |
rat |
| P M Callahan, M F Piercey, K A Cunningha. Effects of the putative dopamine autoreceptor antagonists (+)-AJ 76 and (+)-UH 232 on the discriminative stimulus properties of cocaine. Psychopharmacology. vol 107. issue 1. 1992-06-24. PMID:1589564. |
effects of the putative dopamine autoreceptor antagonists (+)-aj 76 and (+)-uh 232 on the discriminative stimulus properties of cocaine. |
1992-06-24 |
2023-08-11 |
rat |
| F I Carroll, Y Gao, P Abraham, A H Lewin, R Lew, A Patel, J W Boja, M J Kuha. Probes for the cocaine receptor. Potentially irreversible ligands for the dopamine transporter. Journal of medicinal chemistry. vol 35. issue 10. 1992-06-23. PMID:1588560. |
several potentially irreversible ligands (i.e., wash-resistant binding inhibitors) for the cocaine receptor site on the dopamine transporter, derived from (-)-cocaine or 3 beta-phenyltropan-2 beta-carboxylic acid methyl ester (win 35,065-2), were prepared and shown to produce wash-resistant inhibition of [3h]-3 beta-(p-fluorophenyl)tropan-2 beta-carboxylic acid methyl ester ([3h]win 35,428) binding. |
1992-06-23 |
2023-08-11 |
Not clear |
| J Peris, N Decambre, M L Coleman-Hardee, J W Simpkin. Estradiol enhances behavioral sensitization to cocaine and amphetamine-stimulated striatal [3H]dopamine release. Brain research. vol 566. issue 1-2. 1992-06-23. PMID:1814541. |
estradiol enhances behavioral sensitization to cocaine and amphetamine-stimulated striatal [3h]dopamine release. |
1992-06-23 |
2023-08-11 |
rat |
| D A Gorelic. Alcohol and cocaine. Clinical and pharmacological interactions. Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism. vol 10. 1992-06-22. PMID:1317047. |
while their reinforcing properties have neuropharmacological and behavioral differences, a unified theory of reinforcement by alcohol and cocaine has been proposed, involving dopamine activity in the ventral tegmental area-nucleus accumbens circuit. |
1992-06-22 |
2023-08-11 |
Not clear |
| G F Koob, F Weis. Neuropharmacology of cocaine and ethanol dependence. Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism. vol 10. 1992-06-22. PMID:1350359. |
the reinforcing actions of acute cocaine as measured by intravenous cocaine self-administration appear to be mediated by the presynaptic release of dopamine in the region of the nucleus accumbens and may preferentially involve the dopamine d-1 receptor subtype. |
1992-06-22 |
2023-08-11 |
rat |
| G F Koob, F Weis. Neuropharmacology of cocaine and ethanol dependence. Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism. vol 10. 1992-06-22. PMID:1350359. |
chronic cocaine produces increases in brain reward thresholds that may reflect the "dysphoria" and anhedonia associated with cocaine dependence and suggests a dysregulation of brain reward systems possibly involving dopamine. |
1992-06-22 |
2023-08-11 |
rat |
| M C Ritz, M J Kuhar, F R Georg. Molecular mechanisms associated with cocaine effects. Possible relationships with effects of ethanol. Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism. vol 10. 1992-06-22. PMID:1350361. |
the nature of cocaine interactions with monoamine transporters is also discussed, especially with the dopamine transporter, which has been shown to be the cocaine binding site that is primarily associated with the reinforcing effects of cocaine. |
1992-06-22 |
2023-08-11 |
Not clear |
| X M Yang, A L Gorman, A J Dunn, N E Goeder. Anxiogenic effects of acute and chronic cocaine administration: neurochemical and behavioral studies. Pharmacology, biochemistry, and behavior. vol 41. issue 3. 1992-06-18. PMID:1584846. |
both acute and chronic cocaine treatments significantly increased plasma concentrations of corticosterone and reduced the ratios of 3,4-dihydroxyphenylacetic acid to dopamine and 5-hydroxyindoleacetic acid to serotonin in several brain regions. |
1992-06-18 |
2023-08-11 |
mouse |
| A Biegon, K Dillon, N D Volkow, R J Hitzemann, J S Fowler, A P Wol. Quantitative autoradiography of cocaine binding sites in human brain postmortem. Synapse (New York, N.Y.). vol 10. issue 2. 1992-06-18. PMID:1585256. |
preliminary competition experiments with several drugs indicate that dopamine uptake inhibitors completely block cocaine binding to the basal ganglia, while serotonin uptake inhibitors were more effective in the hippocampus. |
1992-06-18 |
2023-08-11 |
human |
| A Biegon, K Dillon, N D Volkow, R J Hitzemann, J S Fowler, A P Wol. Quantitative autoradiography of cocaine binding sites in human brain postmortem. Synapse (New York, N.Y.). vol 10. issue 2. 1992-06-18. PMID:1585256. |
these findings suggest that cocaine binds to dopamine uptake sites in the human basal ganglia postmortem but that it also interacts with other classes of binding sites, depending on the concentration and brain region examined. |
1992-06-18 |
2023-08-11 |
human |
| B Costall, R J Naylo. Serotonin and psychiatric disorders. A key to new therapeutic approaches. Arzneimittel-Forschung. vol 42. issue 2A. 1992-06-16. PMID:1586395. |
the 5-ht3 receptor antagonists exert a breadth of action over a wide dose range in rodent and primate models to inhibit aversive behaviour in animal models of anxiety and certain symptoms of withdrawal from drugs of abuse, alcohol, nicotine, diazepam and cocaine, to antagonise increased locomotor activity caused by mesolimbic dopamine excess, and facilitate performance in cognitive tests. |
1992-06-16 |
2023-08-11 |
Not clear |
| S Benmansour, S M Tejani-Butt, M Hauptmann, D J Brunswic. Lack of effect of high-dose cocaine on monoamine uptake sites in rat brain measured by quantitative autoradiography. Psychopharmacology. vol 106. issue 4. 1992-06-10. PMID:1579620. |
there have been a number of claims that high-dose administration of cocaine to rats leads to neurotoxic effects on dopamine neurons. |
1992-06-10 |
2023-08-11 |
rat |
| S Benmansour, S M Tejani-Butt, M Hauptmann, D J Brunswic. Lack of effect of high-dose cocaine on monoamine uptake sites in rat brain measured by quantitative autoradiography. Psychopharmacology. vol 106. issue 4. 1992-06-10. PMID:1579620. |
in this study possible neurotoxic effects on monoamine neurons were examined by measuring the effects of cocaine (35 mg/kg daily for 10 days) on the binding of radioligands to uptake sites for dopamine, serotonin and norepinephrine using qualitative autoradiography. |
1992-06-10 |
2023-08-11 |
rat |
| S Izenwasser, B M Co. Inhibition of dopamine uptake by cocaine and nicotine: tolerance to chronic treatments. Brain research. vol 573. issue 1. 1992-06-08. PMID:1576529. |
inhibition of dopamine uptake by cocaine and nicotine: tolerance to chronic treatments. |
1992-06-08 |
2023-08-11 |
rat |