| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Kitayama, S Shimada, H Xu, L Markham, D M Donovan, G R Uh. Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 16. 1992-09-15. PMID:1502198. |
replacement of aspartate at position 79 with alanine, glycine, or glutamate dramatically reduced uptake of [3h]dopamine and the tritium-labeled parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium (mpp+) and reduced the mutants' affinity for the tritium-labeled cocaine analog (-)-2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane (cft) without affecting bmax. |
1992-09-15 |
2023-08-11 |
Not clear |
| S Kitayama, S Shimada, H Xu, L Markham, D M Donovan, G R Uh. Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 16. 1992-09-15. PMID:1502198. |
these results demonstrate that aspartate and serine residues lying within the first and seventh hydrophobic putative transmembrane regions are crucial for dat function and provide identification of residues differentially important for cocaine binding and for dopamine uptake. |
1992-09-15 |
2023-08-11 |
Not clear |
| I A Ivens, P H Janak, J L Martine. Microdialysis measurement of striatal dopamine levels in freely moving rats after cocaine or amphetamine treatment. Proceedings of the Western Pharmacology Society. vol 35. 1992-09-15. PMID:1502217. |
microdialysis measurement of striatal dopamine levels in freely moving rats after cocaine or amphetamine treatment. |
1992-09-15 |
2023-08-11 |
rat |
| Y Xia, D J Goebel, G Kapatos, M J Banno. Quantitation of rat dopamine transporter mRNA: effects of cocaine treatment and withdrawal. Journal of neurochemistry. vol 59. issue 3. 1992-09-09. PMID:1494906. |
quantitation of rat dopamine transporter mrna: effects of cocaine treatment and withdrawal. |
1992-09-09 |
2023-08-11 |
human |
| Y Xia, D J Goebel, G Kapatos, M J Banno. Quantitation of rat dopamine transporter mRNA: effects of cocaine treatment and withdrawal. Journal of neurochemistry. vol 59. issue 3. 1992-09-09. PMID:1494906. |
repeated cocaine administration (15 mg/kg, twice a day for 6.5 days) resulted in a greater than 40% decrease in nigral dopamine transporter mrna levels. |
1992-09-09 |
2023-08-11 |
human |
| Y Xia, D J Goebel, G Kapatos, M J Banno. Quantitation of rat dopamine transporter mRNA: effects of cocaine treatment and withdrawal. Journal of neurochemistry. vol 59. issue 3. 1992-09-09. PMID:1494906. |
in contrast, dopamine transporter mrna levels were unchanged after either acute treatment (4 h before death) or repeated cocaine treatment followed by a 72-h withdrawal period. |
1992-09-09 |
2023-08-11 |
human |
| Y Xia, D J Goebel, G Kapatos, M J Banno. Quantitation of rat dopamine transporter mRNA: effects of cocaine treatment and withdrawal. Journal of neurochemistry. vol 59. issue 3. 1992-09-09. PMID:1494906. |
thus, blockade of the dopamine transporter by repeated cocaine administration may result in the down-regulation of dopamine transporter gene expression in dopamine neurons. |
1992-09-09 |
2023-08-11 |
human |
| M J Bannon, M S Poosch, Y Xia, D J Goebel, B Cassin, G Kapato. Dopamine transporter mRNA content in human substantia nigra decreases precipitously with age. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 15. 1992-09-04. PMID:1353885. |
the dopamine transporter is the primary means of inactivating synaptic dopamine as well as a major site of action for psychostimulants (such as cocaine and amphetamine) and for neurotoxins that induce parkinsonism. |
1992-09-04 |
2023-08-11 |
human |
| W L Woolverto. Determinants of cocaine self-administration by laboratory animals. Ciba Foundation symposium. vol 166. 1992-09-03. PMID:1638910. |
a substantial amount of research indicates that increased dopamine neurotransmission in the brain, particularly in mesolimbic and mesocortical regions, plays a major role in cocaine self-administration. |
1992-09-03 |
2023-08-11 |
human |
| W L Woolverto. Determinants of cocaine self-administration by laboratory animals. Ciba Foundation symposium. vol 166. 1992-09-03. PMID:1638910. |
in addition, evidence suggests that dopamine but not noradrenaline (norepinephrine) or serotonin antagonists can attenuate the reinforcing effect of cocaine. |
1992-09-03 |
2023-08-11 |
human |
| M J Kuha. Molecular pharmacology of cocaine: a dopamine hypothesis and its implications. Ciba Foundation symposium. vol 166. 1992-09-03. PMID:1638923. |
molecular pharmacology of cocaine: a dopamine hypothesis and its implications. |
1992-09-03 |
2023-08-11 |
human |
| M J Kuha. Molecular pharmacology of cocaine: a dopamine hypothesis and its implications. Ciba Foundation symposium. vol 166. 1992-09-03. PMID:1638923. |
the reinforcing properties of cocaine have been related to cocaine binding at the dopamine transporter in mesolimbocortical neurons. |
1992-09-03 |
2023-08-11 |
human |
| H C Fibiger, A G Phillips, E E Brow. The neurobiology of cocaine-induced reinforcement. Ciba Foundation symposium. vol 166. 1992-09-03. PMID:1638924. |
cocaine has potent pharmacological actions on a number of monoaminergic systems in the brain, including those that use noradrenaline, dopamine and serotonin as neurotransmitters. |
1992-09-03 |
2023-08-11 |
Not clear |
| H C Fibiger, A G Phillips, E E Brow. The neurobiology of cocaine-induced reinforcement. Ciba Foundation symposium. vol 166. 1992-09-03. PMID:1638924. |
similarly, selective lesions of dopaminergic terminals in the nucleus accumbens, a major target of the mesolimbic dopamine projection, disrupt cocaine self-administration in a manner that is consistent with loss of cocaine-induced reward. |
1992-09-03 |
2023-08-11 |
Not clear |
| H C Fibiger, A G Phillips, E E Brow. The neurobiology of cocaine-induced reinforcement. Ciba Foundation symposium. vol 166. 1992-09-03. PMID:1638924. |
the introduction of in vivo brain microdialysis as a tool with which to investigate the neurochemical correlates of motivated behaviour has provided new opportunities for investigating the role of dopamine in the nucleus accumbens in the acquisition and maintenance of cocaine self-administration. |
1992-09-03 |
2023-08-11 |
Not clear |
| J D Lane, C L Pickering, M L Hooper, K Fagan, M B Tyers, M W Emmett-Oglesb. Failure of ondansetron to block the discriminative or reinforcing stimulus effects of cocaine in the rat. Drug and alcohol dependence. vol 30. issue 2. 1992-08-27. PMID:1386019. |
in contrast sch23390, a dopamine d1 antagonist known to block cocaine discrimination, acted as previously reported. |
1992-08-27 |
2023-08-11 |
rat |
| N S Pilotte, W M Mitchell, L G Sharpe, E B De Souza, E M Da. Chronic cocaine administration and withdrawal of cocaine modify neurotensin binding in rat brain. Synapse (New York, N.Y.). vol 9. issue 2. 1992-08-19. PMID:1821482. |
neurotensin (nt) is a peptide colocalized with dopamine (da) within some mesocorticolimbic da neurons that are affected by cocaine. |
1992-08-19 |
2023-08-11 |
rat |
| M S Hooks, G H Jones, A D Smith, D B Neill, J B Justic. Response to novelty predicts the locomotor and nucleus accumbens dopamine response to cocaine. Synapse (New York, N.Y.). vol 9. issue 2. 1992-08-19. PMID:1821483. |
response to novelty predicts the locomotor and nucleus accumbens dopamine response to cocaine. |
1992-08-19 |
2023-08-11 |
human |
| M S Hooks, G H Jones, A D Smith, D B Neill, J B Justic. Response to novelty predicts the locomotor and nucleus accumbens dopamine response to cocaine. Synapse (New York, N.Y.). vol 9. issue 2. 1992-08-19. PMID:1821483. |
following cocaine administration (15.0 mg/kg) hr rats showed a larger nacc dopamine response and greater locomotor activity than lr rats. |
1992-08-19 |
2023-08-11 |
human |
| P Robledo, R Maldonado-Lopez, G F Koo. Role of dopamine receptors in the nucleus accumbens in the rewarding properties of cocaine. Annals of the New York Academy of Sciences. vol 654. 1992-08-17. PMID:1385935. |
role of dopamine receptors in the nucleus accumbens in the rewarding properties of cocaine. |
1992-08-17 |
2023-08-11 |
Not clear |