| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T F Meert, P De Haes, N Aerts, G Clinck. Antagonism of the discriminative stimulus properties of cocaine with the combination of a dopamine D1 and D2 antagonist. Acta neurobiologiae experimentalis. vol 56. issue 4. 1997-03-18. PMID:9033125. |
antagonism of the discriminative stimulus properties of cocaine with the combination of a dopamine d1 and d2 antagonist. |
1997-03-18 |
2023-08-12 |
rat |
| T F Meert, P De Haes, N Aerts, G Clinck. Antagonism of the discriminative stimulus properties of cocaine with the combination of a dopamine D1 and D2 antagonist. Acta neurobiologiae experimentalis. vol 56. issue 4. 1997-03-18. PMID:9033125. |
antagonism of the discriminative stimulus properties of 10 mg/kg cocaine was studied in rats by use of the dopamine d1 antagonist sch 23390 and the d2 antagonist haloperidol. |
1997-03-18 |
2023-08-12 |
rat |
| T F Meert, P De Haes, N Aerts, G Clinck. Antagonism of the discriminative stimulus properties of cocaine with the combination of a dopamine D1 and D2 antagonist. Acta neurobiologiae experimentalis. vol 56. issue 4. 1997-03-18. PMID:9033125. |
whereas sch 23390 and haloperidol were by themselves unable to antagonize the cueing properties of cocaine, the combination of both dopamine antagonists resulted in a complete blockade of the cocaine cue. |
1997-03-18 |
2023-08-12 |
rat |
| T F Meert, P De Haes, N Aerts, G Clinck. Antagonism of the discriminative stimulus properties of cocaine with the combination of a dopamine D1 and D2 antagonist. Acta neurobiologiae experimentalis. vol 56. issue 4. 1997-03-18. PMID:9033125. |
these results indicate that the cueing properties of cocaine are both dopamine d1- and d2-mediated and that a combined antagonism of both receptor subtypes can lead to a complete antagonism of the cueing properties of cocaine which is associated with severe attenuation of response rate. |
1997-03-18 |
2023-08-12 |
rat |
| L Chai, W S Choi, O K Rönneklei. Maternal cocaine treatment alters dynorphin and enkephalin mRNA expression in brains of fetal rhesus macaques. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 3. 1997-03-17. PMID:8994065. |
cocaine exposure in utero is known to cause a variety of behavioral and motor deficits that may be attributable to alterations in the dopamine neurocircuitry. |
1997-03-17 |
2023-08-12 |
monkey |
| L Chai, W S Choi, O K Rönneklei. Maternal cocaine treatment alters dynorphin and enkephalin mRNA expression in brains of fetal rhesus macaques. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 3. 1997-03-17. PMID:8994065. |
changes in the expression of these opioid peptides in presumed dopamine target neurons, which mediate motivation and reward, as well as motor control, provide further evidence for profound consequences of in utero cocaine exposure on the developing dopamine neurocircuitry. |
1997-03-17 |
2023-08-12 |
monkey |
| M A Nader, K A Grant, H M Davies, R H Mach, S R Childer. The reinforcing and discriminative stimulus effects of the novel cocaine analog 2beta-propanoyl-3beta-(4-tolyl)-tropane in rhesus monkeys. The Journal of pharmacology and experimental therapeutics. vol 280. issue 2. 1997-03-17. PMID:9023262. |
2beta-propanoyl-3beta-(4-tolyl)-tropane (ptt), is a cocaine analog that inhibits dopamine uptake, binding with high affinity and selectivity to the dopamine transporter. |
1997-03-17 |
2023-08-12 |
monkey |
| M A Nader, K A Grant, H M Davies, R H Mach, S R Childer. The reinforcing and discriminative stimulus effects of the novel cocaine analog 2beta-propanoyl-3beta-(4-tolyl)-tropane in rhesus monkeys. The Journal of pharmacology and experimental therapeutics. vol 280. issue 2. 1997-03-17. PMID:9023262. |
these results demonstrated that the long-acting indirect dopamine agonist ptt was effective in decreasing cocaine self-administration and in abuse liability testing showed a unique behavioral profile, not functioning as a reinforcer when substituted for cocaine and producing discriminative stimulus effects similar to cocaine. |
1997-03-17 |
2023-08-12 |
monkey |
| J L Neisewander, L E O'Dell, L T Tran-Nguyen, E Castañeda, R A Fuch. Dopamine overflow in the nucleus accumbens during extinction and reinstatement of cocaine self-administration behavior. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 5. 1997-03-14. PMID:8914124. |
dopamine overflow in the nucleus accumbens during extinction and reinstatement of cocaine self-administration behavior. |
1997-03-14 |
2023-08-12 |
rat |
| M Roy, A Roy, J Williams, L Weinberger, D Smelso. Reduced blue cone electroretinogram in cocaine-withdrawn patients. Archives of general psychiatry. vol 54. issue 2. 1997-03-13. PMID:9040283. |
since dopamine is found in high concentrations in the retina, we investigated whether cocaine dependence may be associated with abnormalities of the electroretinogram. |
1997-03-13 |
2023-08-12 |
Not clear |
| G Bono, C Balducci, P Richelmi, G F Koob, L Pulvirent. Dopamine partial receptor agonists reduce ethanol intake in the rat. European journal of pharmacology. vol 296. issue 3. 1997-03-12. PMID:8904074. |
these results suggest that dopamine partial receptor agonists reduce the reinforcing properties of ethanol in the rat, an effect similar to that previously observed with cocaine. |
1997-03-12 |
2023-08-12 |
rat |
| W S Choi, O K Rønneklei. Effects of in utero cocaine exposure on the expression of mRNAS encoding the dopamine transporter and the D1, D2 and D5 dopamine receptor subtypes in fetal rhesus monkey. Brain research. Developmental brain research. vol 96. issue 1-2. 1997-03-11. PMID:8922687. |
effects of in utero cocaine exposure on the expression of mrnas encoding the dopamine transporter and the d1, d2 and d5 dopamine receptor subtypes in fetal rhesus monkey. |
1997-03-11 |
2023-08-12 |
human |
| W S Choi, O K Rønneklei. Effects of in utero cocaine exposure on the expression of mRNAS encoding the dopamine transporter and the D1, D2 and D5 dopamine receptor subtypes in fetal rhesus monkey. Brain research. Developmental brain research. vol 96. issue 1-2. 1997-03-11. PMID:8922687. |
the effects of in utero cocaine exposure on the development of the mrnas encoding the dopamine transporter (dat) and the d1, d2 and d5 dopamine receptor subtypes were determined in fetal monkey brains at day 45 and day 60 of gestation. |
1997-03-11 |
2023-08-12 |
human |
| W S Choi, O K Rønneklei. Effects of in utero cocaine exposure on the expression of mRNAS encoding the dopamine transporter and the D1, D2 and D5 dopamine receptor subtypes in fetal rhesus monkey. Brain research. Developmental brain research. vol 96. issue 1-2. 1997-03-11. PMID:8922687. |
in utero cocaine exposure caused a significant increase in dopamine d1, d2 and d5 receptor subtype mrnas in the frontal cortex/striatal area of day 60 fetal monkeys. |
1997-03-11 |
2023-08-12 |
human |
| N D Volkow, Y S Ding, J S Fowler, G J Wan. Cocaine addiction: hypothesis derived from imaging studies with PET. Journal of addictive diseases. vol 15. issue 4. 1997-03-11. PMID:8943582. |
analysis of the behavior of cocaine in the human brain with positron emission tomography reveals that it is not only its affinity for the dopamine transporter that gives it its unique properties but also its fast pharmacokinetics. |
1997-03-11 |
2023-08-12 |
human |
| M J Kree. Cocaine, dopamine and the endogenous opioid system. Journal of addictive diseases. vol 15. issue 4. 1997-03-11. PMID:8943583. |
cocaine, dopamine and the endogenous opioid system. |
1997-03-11 |
2023-08-12 |
Not clear |
| M J Kree. Cocaine, dopamine and the endogenous opioid system. Journal of addictive diseases. vol 15. issue 4. 1997-03-11. PMID:8943583. |
fundamental studies from many laboratories including our own have shown that cocaine has profound effects on dopaminergic function, primarily from its well-established primary action of blocking the reuptake of dopamine from the synaptic cleft, an action of cocaine directed at the specific dopamine transporter. |
1997-03-11 |
2023-08-12 |
Not clear |
| A Imperato, M C Obinu, M S Mascia, M A Casu, A Zocchi, S Cabib, S Puglisi-Allegr. Strain-dependent effects of dopamine agonists on acetylcholine release in the hippocampus: an in vivo study in mice. Neuroscience. vol 70. issue 3. 1997-03-06. PMID:9045078. |
the effects of selective d1 or d2 dopamine receptor agonists and the indirect dopamine agonist cocaine on hippocampal acetylcholine release in mice of the c57bl/6 and dba/2 inbred strains were investigated using intracerebral microdialysis. |
1997-03-06 |
2023-08-12 |
mouse |
| E Friedman, E Yadin, H Y Wan. Effect of prenatal cocaine on dopamine receptor-G protein coupling in mesocortical regions of the rabbit brain. Neuroscience. vol 70. issue 3. 1997-03-06. PMID:9045085. |
effect of prenatal cocaine on dopamine receptor-g protein coupling in mesocortical regions of the rabbit brain. |
1997-03-06 |
2023-08-12 |
rabbit |
| E Friedman, E Yadin, H Y Wan. Effect of prenatal cocaine on dopamine receptor-G protein coupling in mesocortical regions of the rabbit brain. Neuroscience. vol 70. issue 3. 1997-03-06. PMID:9045085. |
the effects of in utero exposure to cocaine on dopamine receptors in the frontal and cingulate areas of the developing rabbit cortex were assessed by examining receptor-mediated stimulations in gtp binding to alpha-subunits of g proteins. |
1997-03-06 |
2023-08-12 |
rabbit |