| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W H Pan, N H Chen, F Y Tsai, H Y Lia. Intrategmental infusion of cocaine decreases dopamine release and enhances norepinephrine release in the medial prefrontal cortex. European journal of pharmacology. vol 317. issue 2-3. 1997-04-03. PMID:8997602. |
after intrategmental cocaine infusion (either 20 or 200 microm), extracellular dopamine and norepinephrine in the ventral tegmental area both increased significantly to a steady state level (208 +/- 42 and 148 +/- 23% for low dose and 220 +/- 24 and 150 +/- 15% for high dose). |
1997-04-03 |
2023-08-12 |
rat |
| W H Pan, N H Chen, F Y Tsai, H Y Lia. Intrategmental infusion of cocaine decreases dopamine release and enhances norepinephrine release in the medial prefrontal cortex. European journal of pharmacology. vol 317. issue 2-3. 1997-04-03. PMID:8997602. |
simultaneously, the 200-microm cocaine infusion caused a significant decrease in extracellular dopamine (77 +/- 5%) but an increase in norepinephrine (140 +/- 6%) in the medial prefrontal cortex. |
1997-04-03 |
2023-08-12 |
rat |
| W H Pan, N H Chen, F Y Tsai, H Y Lia. Intrategmental infusion of cocaine decreases dopamine release and enhances norepinephrine release in the medial prefrontal cortex. European journal of pharmacology. vol 317. issue 2-3. 1997-04-03. PMID:8997602. |
this study not only supports recent findings of an increase in extracellular dopamine and norepinephrine in the ventral tegmental area on intrategmental cocaine infusion, but also demonstrates that cocaine infused locally in the ventral tegmental area can decrease dopamine and increase norepinephrine at a remote terminal area (medial prefrontal cortex). |
1997-04-03 |
2023-08-12 |
rat |
| R Spangler, Y Zhou, C E Maggos, A Zlobin, A Ho, M J Kree. Dopamine antagonist and "binge' cocaine effects on rat opioid and dopamine transporter mRNAs. Neuroreport. vol 7. issue 13. 1997-03-28. PMID:8930988. |
dopamine antagonist and "binge' cocaine effects on rat opioid and dopamine transporter mrnas. |
1997-03-28 |
2023-08-12 |
rat |
| R Spangler, Y Zhou, C E Maggos, A Zlobin, A Ho, M J Kree. Dopamine antagonist and "binge' cocaine effects on rat opioid and dopamine transporter mRNAs. Neuroreport. vol 7. issue 13. 1997-03-28. PMID:8930988. |
the modulation by selective dopamine receptor antagonists of the effects of "binge' cocaine (3 x 15 mg kg-1 day-1, i.p., for 3 days after 11 days of adaptation to saline injections) on preproenkephalin, preprodynorphin, kappa opioid receptor and dopamine transporter mrnas was determined. |
1997-03-28 |
2023-08-12 |
rat |
| R Spangler, Y Zhou, C E Maggos, A Zlobin, A Ho, M J Kree. Dopamine antagonist and "binge' cocaine effects on rat opioid and dopamine transporter mRNAs. Neuroreport. vol 7. issue 13. 1997-03-28. PMID:8930988. |
dopamine transporter mrna levels showed a cocaine treatment-antagonist interaction. |
1997-03-28 |
2023-08-12 |
rat |
| L D Middaugh, W O Boggan, S A Bingel, K S Patrick, W X. A murine model of prenatal cocaine exposure: effects on the mother and the fetus. Pharmacology, biochemistry, and behavior. vol 55. issue 4. 1997-03-28. PMID:8981587. |
when injected daily during gestation days 12-18, the period of prenatal development of dopamine systems, cocaine at doses producing plasma concentrations consistent with its stimulatory effects reduced food ingestion and weight gains during pregnancy and fetal body and brain weights at term. |
1997-03-28 |
2023-08-12 |
mouse |
| J S Meyer, L P Shearman, L M Collin. Monoamine transporters and the neurobehavioral teratology of cocaine. Pharmacology, biochemistry, and behavior. vol 55. issue 4. 1997-03-28. PMID:8981589. |
in support of the hypothesis that cocaine effects may be mediated partly by monoamine uptake inhibition, we and other investigators have recently demonstrated the presence of functional dopamine (da), serotonin (5-ht), and norepinephrine (ne) transporters in the fetal rat brain. |
1997-03-28 |
2023-08-12 |
human |
| D R Wallace, C F Mactutus, R M Booz. Repeated intravenous cocaine administration: locomotor activity and dopamine D2/D3 receptors. Synapse (New York, N.Y.). vol 23. issue 3. 1997-03-24. PMID:8807743. |
repeated intravenous cocaine administration: locomotor activity and dopamine d2/d3 receptors. |
1997-03-24 |
2023-08-12 |
rat |
| D R Wallace, C F Mactutus, R M Booz. Repeated intravenous cocaine administration: locomotor activity and dopamine D2/D3 receptors. Synapse (New York, N.Y.). vol 23. issue 3. 1997-03-24. PMID:8807743. |
the dopamine d3 receptor has been implicated as a possible mediator in the reinforcement or abuse of psychostimulants such as cocaine. |
1997-03-24 |
2023-08-12 |
rat |
| D R Wallace, C F Mactutus, R M Booz. Repeated intravenous cocaine administration: locomotor activity and dopamine D2/D3 receptors. Synapse (New York, N.Y.). vol 23. issue 3. 1997-03-24. PMID:8807743. |
the present studies examined the effects of repeated (14 day) intravenous cocaine administration (saline vehicle, 0.5, 1.0 and 3.0 mg/kg) on locomotor activity and dopamine d2 and d3 receptor density in the rat striatum and nucleus accumbens. |
1997-03-24 |
2023-08-12 |
rat |
| T A Kosten, J L DeCaprio, E J Nestle. Long-term haloperidol administration enhances and short-term administration attenuates the behavioral effects of cocaine in a place conditioning procedure. Psychopharmacology. vol 128. issue 3. 1997-03-24. PMID:8972550. |
many behavioral effects of cocaine are attenuated by dopamine (da) receptor antagonists. |
1997-03-24 |
2023-08-12 |
rat |
| E M Apostolakis, J Garai, J H Clark, B W O'Malle. In vivo regulation of central nervous system progesterone receptors: cocaine induces steroid-dependent behavior through dopamine transporter modulation of D5 receptors in rats. Molecular endocrinology (Baltimore, Md.). vol 10. issue 12. 1997-03-20. PMID:8961269. |
in vivo regulation of central nervous system progesterone receptors: cocaine induces steroid-dependent behavior through dopamine transporter modulation of d5 receptors in rats. |
1997-03-20 |
2023-08-12 |
rat |
| E M Apostolakis, J Garai, J H Clark, B W O'Malle. In vivo regulation of central nervous system progesterone receptors: cocaine induces steroid-dependent behavior through dopamine transporter modulation of D5 receptors in rats. Molecular endocrinology (Baltimore, Md.). vol 10. issue 12. 1997-03-20. PMID:8961269. |
collectively, the data provide strong evidence for cocaine modulation of reproductive behavior through presynaptic cocaine-sensitive dopamine transporters and postsynaptic d5 dopamine receptor mediation of progesterone receptor-dependent behavior in rat central nervous system. |
1997-03-20 |
2023-08-12 |
rat |
| T F Meert, P De Haes, N Aerts, G Clinck. Antagonism of the discriminative stimulus properties of cocaine with the combination of a dopamine D1 and D2 antagonist. Acta neurobiologiae experimentalis. vol 56. issue 4. 1997-03-18. PMID:9033125. |
antagonism of the discriminative stimulus properties of cocaine with the combination of a dopamine d1 and d2 antagonist. |
1997-03-18 |
2023-08-12 |
rat |
| T F Meert, P De Haes, N Aerts, G Clinck. Antagonism of the discriminative stimulus properties of cocaine with the combination of a dopamine D1 and D2 antagonist. Acta neurobiologiae experimentalis. vol 56. issue 4. 1997-03-18. PMID:9033125. |
antagonism of the discriminative stimulus properties of 10 mg/kg cocaine was studied in rats by use of the dopamine d1 antagonist sch 23390 and the d2 antagonist haloperidol. |
1997-03-18 |
2023-08-12 |
rat |
| T F Meert, P De Haes, N Aerts, G Clinck. Antagonism of the discriminative stimulus properties of cocaine with the combination of a dopamine D1 and D2 antagonist. Acta neurobiologiae experimentalis. vol 56. issue 4. 1997-03-18. PMID:9033125. |
whereas sch 23390 and haloperidol were by themselves unable to antagonize the cueing properties of cocaine, the combination of both dopamine antagonists resulted in a complete blockade of the cocaine cue. |
1997-03-18 |
2023-08-12 |
rat |
| T F Meert, P De Haes, N Aerts, G Clinck. Antagonism of the discriminative stimulus properties of cocaine with the combination of a dopamine D1 and D2 antagonist. Acta neurobiologiae experimentalis. vol 56. issue 4. 1997-03-18. PMID:9033125. |
these results indicate that the cueing properties of cocaine are both dopamine d1- and d2-mediated and that a combined antagonism of both receptor subtypes can lead to a complete antagonism of the cueing properties of cocaine which is associated with severe attenuation of response rate. |
1997-03-18 |
2023-08-12 |
rat |
| L Chai, W S Choi, O K Rönneklei. Maternal cocaine treatment alters dynorphin and enkephalin mRNA expression in brains of fetal rhesus macaques. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 3. 1997-03-17. PMID:8994065. |
cocaine exposure in utero is known to cause a variety of behavioral and motor deficits that may be attributable to alterations in the dopamine neurocircuitry. |
1997-03-17 |
2023-08-12 |
monkey |
| L Chai, W S Choi, O K Rönneklei. Maternal cocaine treatment alters dynorphin and enkephalin mRNA expression in brains of fetal rhesus macaques. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 3. 1997-03-17. PMID:8994065. |
changes in the expression of these opioid peptides in presumed dopamine target neurons, which mediate motivation and reward, as well as motor control, provide further evidence for profound consequences of in utero cocaine exposure on the developing dopamine neurocircuitry. |
1997-03-17 |
2023-08-12 |
monkey |