| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Kitayama, K Morita, T Doh. Cocaine inhibits the release of MPP+ but not dopamine through the rat dopamine transporter. European journal of pharmacology. vol 309. issue 1. 1997-01-31. PMID:8864700. |
the release of preloaded [3h]mpp+ but not [3h]dopamine was dose-dependently inhibited by cocaine and other compounds known as dopamine uptake inhibitor, 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-piperazine (gbr12,935) and nomifensine, although the uptake of both [3h]dopamine and [3h]mpp+ was sensitive to these compounds. |
1997-01-31 |
2023-08-12 |
rat |
| S Kitayama, K Morita, T Doh. Cocaine inhibits the release of MPP+ but not dopamine through the rat dopamine transporter. European journal of pharmacology. vol 309. issue 1. 1997-01-31. PMID:8864700. |
the different sensitivity of the outward transport of dopamine and mpp+ to the uptake inhibitors might provide a clue to the identity of the specific site(s) for cocaine on the transporter. |
1997-01-31 |
2023-08-12 |
rat |
| S H Lee, J Rhee, J K Koh, Y S Le. Species differences in functions of dopamine transporter: paucity of MPP+ uptake and cocaine binding in bovine dopamine transporter. Neuroscience letters. vol 214. issue 2-3. 1997-01-31. PMID:8878118. |
species differences in functions of dopamine transporter: paucity of mpp+ uptake and cocaine binding in bovine dopamine transporter. |
1997-01-31 |
2023-08-12 |
human |
| S H Lee, J Rhee, J K Koh, Y S Le. Species differences in functions of dopamine transporter: paucity of MPP+ uptake and cocaine binding in bovine dopamine transporter. Neuroscience letters. vol 214. issue 2-3. 1997-01-31. PMID:8878118. |
human dat showed the highest activities for dopamine uptake, mpp+ uptake and cocaine binding, indicating that humans are more vulnerable to 1-methyl-4-phenylpyridinium (mpp+) toxicity and cocaine addiction. |
1997-01-31 |
2023-08-12 |
human |
| S H Lee, J Rhee, J K Koh, Y S Le. Species differences in functions of dopamine transporter: paucity of MPP+ uptake and cocaine binding in bovine dopamine transporter. Neuroscience letters. vol 214. issue 2-3. 1997-01-31. PMID:8878118. |
however, bovine dat showed poor mpp+ uptake and cocaine binding, even though its dopamine uptake ability was quite avid. |
1997-01-31 |
2023-08-12 |
human |
| A A Wilson, J N DaSilva, S Houl. In vivo evaluation of [11C]- and [18F]-labelled cocaine analogues as potential dopamine transporter ligands for positron emission tomography. Nuclear medicine and biology. vol 23. issue 2. 1997-01-30. PMID:8868286. |
in vivo evaluation of [11c]- and [18f]-labelled cocaine analogues as potential dopamine transporter ligands for positron emission tomography. |
1997-01-30 |
2023-08-12 |
rat |
| M A De Souza Silva, C Mattern, R Häcker, P J Nogueira, J P Huston, R K Schwartin. Intranasal administration of the dopaminergic agonists L-DOPA, amphetamine, and cocaine increases dopamine activity in the neostriatum: a microdialysis study in the rat. Journal of neurochemistry. vol 68. issue 1. 1997-01-27. PMID:8978730. |
intranasal administration of the dopaminergic agonists l-dopa, amphetamine, and cocaine increases dopamine activity in the neostriatum: a microdialysis study in the rat. |
1997-01-27 |
2023-08-12 |
rat |
| E A Kiyatkin, E A Stei. Conditioned changes in nucleus accumbens dopamine signal established by intravenous cocaine in rats. Neuroscience letters. vol 211. issue 2. 1997-01-23. PMID:8830847. |
conditioned changes in nucleus accumbens dopamine signal established by intravenous cocaine in rats. |
1997-01-23 |
2023-08-12 |
rat |
| E A Kiyatkin, E A Stei. Conditioned changes in nucleus accumbens dopamine signal established by intravenous cocaine in rats. Neuroscience letters. vol 211. issue 2. 1997-01-23. PMID:8830847. |
to explore the role of cocaine-induced conditioning in the regulation of mesolimbic dopamine (da) activity, high-speed chronoamperometry with nafion-coated carbon fiber electrodes was used to measure changes in nucleus accumbens (nac) da-dependent signal induced by a light stimulus previously paired and not paired with intravenous cocaine (0.85 mg/kg per injection), and cocaine injections paired and not paired with light. |
1997-01-23 |
2023-08-12 |
rat |
| L Cervo, L Pozzi, R Samani. 5-HT3 receptor antagonists do not modify cocaine place conditioning or the rise in extracellular dopamine in the nucleus accumbens of rats. Pharmacology, biochemistry, and behavior. vol 55. issue 1. 1997-01-23. PMID:8870035. |
5-ht3 receptor antagonists do not modify cocaine place conditioning or the rise in extracellular dopamine in the nucleus accumbens of rats. |
1997-01-23 |
2023-08-12 |
rat |
| L Cervo, L Pozzi, R Samani. 5-HT3 receptor antagonists do not modify cocaine place conditioning or the rise in extracellular dopamine in the nucleus accumbens of rats. Pharmacology, biochemistry, and behavior. vol 55. issue 1. 1997-01-23. PMID:8870035. |
at 0.1 mg/kg sc ondansetron did not modify the increase of extracellular dopamine caused by 10 mg/kg cocaine in the nucleus accumbens. |
1997-01-23 |
2023-08-12 |
rat |
| E Tirelli, J M Witki. Pharmacological characterization of the enhancement of apomorphine-induced gnawing in mice by cocaine. Pharmacology, biochemistry, and behavior. vol 55. issue 1. 1997-01-23. PMID:8870049. |
rather, this effect may be due to blockade of dopamine uptake and/or the local anesthetic actions of cocaine. |
1997-01-23 |
2023-08-12 |
mouse |
| W J Houlihan, J W Boja, V A Parrino, T A Kopajtic, M J Kuha. Halogenated mazindol analogs as potential inhibitors of the cocaine binding site at the dopamine transporter. Journal of medicinal chemistry. vol 39. issue 25. 1997-01-23. PMID:8960553. |
halogenated mazindol analogs as potential inhibitors of the cocaine binding site at the dopamine transporter. |
1997-01-23 |
2023-08-12 |
rat |
| M S Kleven, W Koe. Differential effects of direct and indirect dopamine agonists on eye blink rate in cynomolgus monkeys. The Journal of pharmacology and experimental therapeutics. vol 279. issue 3. 1997-01-23. PMID:8968343. |
spontaneous eye blink rate was assessed in cynomolgus monkeys treated intramuscularly with the high-efficacy dopamine (da) agonists, (-)-apomorphine, naxagolide, pd 128,907, 2-(n-phenylethyl-n-propyl)amino-5-hydroxytetralin (+/-)-ppht, quinpirole, skf 81297 and skf 82958; the low-efficacy da agonists, (-)-3-ppp, roxindole, sdz 208-912, skf 75670 and terguride; and the indirect da agonists, d-amphetamine, cocaine, gbr 12935 and methylphenidate. |
1997-01-23 |
2023-08-12 |
monkey |
| P D Mozley, H J Kim, R C Gur, K Tatsch, L R Muenz, W T McElgin, M P Kung, M Mu, A M Myers, H F Kun. Iodine-123-IPT SPECT imaging of CNS dopamine transporters: nonlinear effects of normal aging on striatal uptake values. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 37. issue 12. 1997-01-23. PMID:8970515. |
iodine-123-labeled ipt (n-(3-iodopropen-2-yl)-2 beta-carbomethoxy-3 beta-(4-chlorophenyl)tropane) is an analog of cocaine that selectively binds the presynaptic dopamine transporter. |
1997-01-23 |
2023-08-12 |
Not clear |
| G Palladini, S Ruggeri, F Stocchi, M F De Pandis, G Venturini, V Margott. A pharmacological study of cocaine activity in planaria. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology. vol 115. issue 1. 1997-01-23. PMID:8983168. |
the dose-related effects of cocaine on planaria motility and the response to cocaine treatment associated with the administration of specific d1 or d2 dopamine agonists and antagonists were investigated. |
1997-01-23 |
2023-08-12 |
Not clear |
| b' A Kankaanp\\xc3\\xa4\\xc3\\xa4, P Lillsunde, M Ruotsalainen, L Ahtee, T Sepp\\xc3\\xa2l\\xc3\\xa. 5-HT3 receptor antagonist MDL 72222 dose-dependently attenuates cocaine- and amphetamine-induced elevations of extracellular dopamine in the nucleus accumbens and the dorsal striatum. Pharmacology & toxicology. vol 78. issue 5. 1997-01-21. PMID:8737967.' |
cocaine elevated extracellular dopamine in the nucleus accumbens and to a lesser extent in the dorsal striatum, but it did not affect dopamine metabolites, 3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acid. |
1997-01-21 |
2023-08-12 |
rat |
| b' A Kankaanp\\xc3\\xa4\\xc3\\xa4, P Lillsunde, M Ruotsalainen, L Ahtee, T Sepp\\xc3\\xa2l\\xc3\\xa. 5-HT3 receptor antagonist MDL 72222 dose-dependently attenuates cocaine- and amphetamine-induced elevations of extracellular dopamine in the nucleus accumbens and the dorsal striatum. Pharmacology & toxicology. vol 78. issue 5. 1997-01-21. PMID:8737967.' |
the different potencies of the interactions of the 5-ht3 receptor antagonist with cocaine and amphetamine could be related to the different mechanisms by which these drugs primarily elevate extracellular dopamine. |
1997-01-21 |
2023-08-12 |
rat |
| b' B Przew\\xc5\\x82ocka, W Laso\\xc5\\x8. Adaptive changes in the proenkephalin and D2 dopamine receptor mRNA expression after chronic cocaine in the nucleus accumbens and striatum of the rat. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 5. issue 4. 1997-01-17. PMID:8998398.' |
hence, these data provide further evidence for the significance of the penk and dopamine systems in the neurochemical mechanism of cocaine. |
1997-01-17 |
2023-08-12 |
rat |
| B A Mattingly, J K Rowlett, T Ellison, K Ras. Cocaine-induced behavioral sensitization: effects of haloperidol and SCH 23390 treatments. Pharmacology, biochemistry, and behavior. vol 53. issue 3. 1997-01-15. PMID:8866944. |
these findings suggest that cocaine-induced behavioral sensitization may develop as a result of repeated dopamine d1- or d2-type receptor stimulation, and that brief dopamine antagonist treatments enhance subsequent behavioral sensitivity to cocaine. |
1997-01-15 |
2023-08-12 |
rat |