| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X H Wang, P Levitt, A O'Brien Jenkins, E H Murph. Normal development of tyrosine hydroxylase and serotonin immunoreactive fibers innervating anterior cingulate cortex and visual cortex in rabbits exposed prenatally to cocaine. Brain research. vol 715. issue 1-2. 1997-01-14. PMID:8739642. |
the interactions of cocaine with the dopamine, norepinephrine and serotonin systems makes each a potential candidate for influencing these developmental effects. |
1997-01-14 |
2023-08-12 |
Not clear |
| R Weissenborn, V Deroche, G F Koob, F Weis. Effects of dopamine agonists and antagonists on cocaine-induced operant responding for a cocaine-associated stimulus. Psychopharmacology. vol 126. issue 4. 1997-01-10. PMID:8878347. |
the present study examined the effects of receptor subtype-selective dopamine agonists and antagonists on (i) cocaine-induced responding for a cocaine-associated stimulus and (ii) on responding for food and cocaine reinforcement. |
1997-01-10 |
2023-08-12 |
rat |
| S R Jones, T H Lee, R M Wightman, E H Ellinwoo. Effects of intermittent and continuous cocaine administration on dopamine release and uptake regulation in the striatum: in vitro voltammetric assessment. Psychopharmacology. vol 126. issue 4. 1997-01-10. PMID:8878349. |
effects of intermittent and continuous cocaine administration on dopamine release and uptake regulation in the striatum: in vitro voltammetric assessment. |
1997-01-10 |
2023-08-12 |
rat |
| S R Jones, T H Lee, R M Wightman, E H Ellinwoo. Effects of intermittent and continuous cocaine administration on dopamine release and uptake regulation in the striatum: in vitro voltammetric assessment. Psychopharmacology. vol 126. issue 4. 1997-01-10. PMID:8878349. |
following a 7-day withdrawal period, we examined the effects of these two dosing regimens on: (1) baseline dopamine efflux and uptake following single-pulse electrical stimulation, (2) inhibition of uptake by cocaine; and (3) inhibition of efflux by autoreceptor activation. |
1997-01-10 |
2023-08-12 |
rat |
| S R Jones, T H Lee, R M Wightman, E H Ellinwoo. Effects of intermittent and continuous cocaine administration on dopamine release and uptake regulation in the striatum: in vitro voltammetric assessment. Psychopharmacology. vol 126. issue 4. 1997-01-10. PMID:8878349. |
in the absence of pharmacological agents, no group differences were found in the amount of baseline dopamine released or in the uptake kinetics; the potency of bath-applied cocaine (0.03-60 microm) in inhibiting the uptake was also unaltered in either group. |
1997-01-10 |
2023-08-12 |
rat |
| C L Monitto, P Feuer, M O'Rourke, L Shaw, C D Kurt. Effect of dopamine antagonism on the behavioral and hemodynamic responses to cocaine in piglets. Biology of the neonate. vol 70. issue 1. 1997-01-09. PMID:8853847. |
effect of dopamine antagonism on the behavioral and hemodynamic responses to cocaine in piglets. |
1997-01-09 |
2023-08-12 |
Not clear |
| C L Monitto, P Feuer, M O'Rourke, L Shaw, C D Kurt. Effect of dopamine antagonism on the behavioral and hemodynamic responses to cocaine in piglets. Biology of the neonate. vol 70. issue 1. 1997-01-09. PMID:8853847. |
was administered to awake newborn piglets that were pretreated with either intravenous saline (placebo) or sch23390, a dopamine antagonist, to study dopamine's role in cocaine's vascular and behavioral actions. |
1997-01-09 |
2023-08-12 |
Not clear |
| C L Monitto, P Feuer, M O'Rourke, L Shaw, C D Kurt. Effect of dopamine antagonism on the behavioral and hemodynamic responses to cocaine in piglets. Biology of the neonate. vol 70. issue 1. 1997-01-09. PMID:8853847. |
these data indicate that the behavioral and blood flow responses to cocaine in cerebellum, choroid plexus, heart, and kidneys are mediated by dopamine, whereas the arterial pressor response to cocaine is not. |
1997-01-09 |
2023-08-12 |
Not clear |
| S J Gatley, N D Volkow, A N Gifford, Y S Ding, J Logan, G J Wan. Model for estimating dopamine transporter occupancy and subsequent increases in synaptic dopamine using positron emission tomography and carbon-11-labeled cocaine. Biochemical pharmacology. vol 53. issue 1. 1997-01-09. PMID:8960062. |
model for estimating dopamine transporter occupancy and subsequent increases in synaptic dopamine using positron emission tomography and carbon-11-labeled cocaine. |
1997-01-09 |
2023-08-12 |
human |
| S J Gatley, N D Volkow, A N Gifford, Y S Ding, J Logan, G J Wan. Model for estimating dopamine transporter occupancy and subsequent increases in synaptic dopamine using positron emission tomography and carbon-11-labeled cocaine. Biochemical pharmacology. vol 53. issue 1. 1997-01-09. PMID:8960062. |
although increases in dopamine secondary to the inhibition of the dopamine transporter appear to underlie the reinforcing properties of cocaine, there is presently no model that relates the elevation of synaptic dopamine to the transporter occupancy by cocaine. |
1997-01-09 |
2023-08-12 |
human |
| S J Gatley, N D Volkow, A N Gifford, Y S Ding, J Logan, G J Wan. Model for estimating dopamine transporter occupancy and subsequent increases in synaptic dopamine using positron emission tomography and carbon-11-labeled cocaine. Biochemical pharmacology. vol 53. issue 1. 1997-01-09. PMID:8960062. |
we propose such a model based on positron emission tomographic (pet) measurements of the brain concentration of cocaine and the assumption of rapid equilibrium between free cocaine and cocaine bound to the dopamine transporter. |
1997-01-09 |
2023-08-12 |
human |
| S J Gatley, N D Volkow, A N Gifford, Y S Ding, J Logan, G J Wan. Model for estimating dopamine transporter occupancy and subsequent increases in synaptic dopamine using positron emission tomography and carbon-11-labeled cocaine. Biochemical pharmacology. vol 53. issue 1. 1997-01-09. PMID:8960062. |
if reuptake of dopamine is reduced in proportion to the fraction of transporters occupied by cocaine, our model indicates that synaptic dopamine rises supra-linearly with occupancy, so that 5 and 40 mg doses of cocaine give about 2- and 10-fold increases, respectively. |
1997-01-09 |
2023-08-12 |
human |
| S J Gatley, N D Volkow, A N Gifford, Y S Ding, J Logan, G J Wan. Model for estimating dopamine transporter occupancy and subsequent increases in synaptic dopamine using positron emission tomography and carbon-11-labeled cocaine. Biochemical pharmacology. vol 53. issue 1. 1997-01-09. PMID:8960062. |
a consequence is that a given dose of cocaine produces a similar degree of elevation of dopamine regardless of the prior level of occupation of the transporters by cocaine. |
1997-01-09 |
2023-08-12 |
human |
| S J Gatley, N D Volkow, A N Gifford, Y S Ding, J Logan, G J Wan. Model for estimating dopamine transporter occupancy and subsequent increases in synaptic dopamine using positron emission tomography and carbon-11-labeled cocaine. Biochemical pharmacology. vol 53. issue 1. 1997-01-09. PMID:8960062. |
it could also explain why attempts to block the psychostimulant-induced "high" by pretreating subjects with drugs that block the dopamine transporter have been unsuccessful, and why the use of methylphenidate to treat cocaine addicts led to increased cocaine consumption. |
1997-01-09 |
2023-08-12 |
human |
| P Jatlow, E F McCance, C W Bradberry, J D Elsworth, J R Taylor, R H Rot. Alcohol plus cocaine: the whole is more than the sum of its parts. Therapeutic drug monitoring. vol 18. issue 4. 1997-01-08. PMID:8857569. |
cocaethylene is similar to cocaine in its properties as an indirect dopamine agonist, and human subjects cannot distinguish its effects from those of cocaine. |
1997-01-08 |
2023-08-12 |
human |
| P Jatlow, E F McCance, C W Bradberry, J D Elsworth, J R Taylor, R H Rot. Alcohol plus cocaine: the whole is more than the sum of its parts. Therapeutic drug monitoring. vol 18. issue 4. 1997-01-08. PMID:8857569. |
cocaethylene, and especially its isopropyl analog, are more selective indirect dopamine agonists than cocaine, with relatively weak potency at the serotonin transporter. |
1997-01-08 |
2023-08-12 |
human |
| M Xu, X T Hu, D C Cooper, F J White, S Tonegaw. A genetic approach to study mechanisms of cocaine action. Annals of the New York Academy of Sciences. vol 801. 1997-01-08. PMID:8959023. |
extracellular single unit recording of dopamine sensitive nucleus accumbens neurons in the d1 receptor mutant mice and control mice revealed a marked reduction in the inhibitory effects of cocaine and dopamine on the generation of action potentials, suggesting that d1 receptors play a fundamental role in cocaine- and dopamine-mediated neurophysiological effects within the nucleus accumbens. |
1997-01-08 |
2023-08-12 |
mouse |
| M Xu, X T Hu, D C Cooper, F J White, S Tonegaw. A genetic approach to study mechanisms of cocaine action. Annals of the New York Academy of Sciences. vol 801. 1997-01-08. PMID:8959023. |
in the future, the use of this powerful genetic approach will be essential for elucidating the molecular components of the signal transduction pathway leading to anatomical, cellular and behavioral changes upon cocaine administration and dopamine neurotransmission. |
1997-01-08 |
2023-08-12 |
mouse |
| A Shimada, K Yamaguchi, T Yanagit. Neurochemical analysis of the psychotoxicity of methamphetamine and cocaine by microdialysis in the rat brain. Annals of the New York Academy of Sciences. vol 801. 1997-01-08. PMID:8959048. |
to examine the neurochemical mechanism underlying the development of psychotoxicity by methamphetamine and cocaine, the levels of dopamine, serotonin and their metabolites were determined by in vivo microdialysis in the brains of freely moving rats. |
1997-01-08 |
2023-08-12 |
rat |
| A Shimada, K Yamaguchi, T Yanagit. Neurochemical analysis of the psychotoxicity of methamphetamine and cocaine by microdialysis in the rat brain. Annals of the New York Academy of Sciences. vol 801. 1997-01-08. PMID:8959048. |
cocaine increased dopamine to about 4 times along with a slight decrease in dopac. |
1997-01-08 |
2023-08-12 |
rat |