| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| B A Sorg, D L Davidson, P W Kalivas, B M Prasa. Repeated daily cocaine alters subsequent cocaine-induced increase of extracellular dopamine in the medial prefrontal cortex. The Journal of pharmacology and experimental therapeutics. vol 281. issue 1. 1997-05-02. PMID:9103480. |
repeated daily cocaine alters subsequent cocaine-induced increase of extracellular dopamine in the medial prefrontal cortex. |
1997-05-02 |
2023-08-12 |
rat |
| B A Sorg, D L Davidson, P W Kalivas, B M Prasa. Repeated daily cocaine alters subsequent cocaine-induced increase of extracellular dopamine in the medial prefrontal cortex. The Journal of pharmacology and experimental therapeutics. vol 281. issue 1. 1997-05-02. PMID:9103480. |
were subsequently challenged with an injection of cocaine, and extracellular dopamine content in the medial prefrontal cortex (mpfc) was measured using in vivo microdialysis. |
1997-05-02 |
2023-08-12 |
rat |
| B A Sorg, D L Davidson, P W Kalivas, B M Prasa. Repeated daily cocaine alters subsequent cocaine-induced increase of extracellular dopamine in the medial prefrontal cortex. The Journal of pharmacology and experimental therapeutics. vol 281. issue 1. 1997-05-02. PMID:9103480. |
cocaine challenge increased extracellular dopamine levels from base line in all three groups of rats, but the augmentation was significantly reduced in the cocaine-pretreated group, compared with the saline-pretreated group. |
1997-05-02 |
2023-08-12 |
rat |
| B A Sorg, D L Davidson, P W Kalivas, B M Prasa. Repeated daily cocaine alters subsequent cocaine-induced increase of extracellular dopamine in the medial prefrontal cortex. The Journal of pharmacology and experimental therapeutics. vol 281. issue 1. 1997-05-02. PMID:9103480. |
to test whether repeated cocaine treatment led to altered releasability of dopamine from mpfc terminals, challenge with kci (10, 30 or 100 mm) or d-amphetamine (3, 30 or 300 microm) was made via infusion through the dialysis probe into the mpfc. |
1997-05-02 |
2023-08-12 |
rat |
| B A Sorg, D L Davidson, P W Kalivas, B M Prasa. Repeated daily cocaine alters subsequent cocaine-induced increase of extracellular dopamine in the medial prefrontal cortex. The Journal of pharmacology and experimental therapeutics. vol 281. issue 1. 1997-05-02. PMID:9103480. |
to determine whether the effects of cocaine were mediated by local actions within mpfc dopamine terminals, a cocaine challenge was administered through the microdialysis probe (1, 10 or 100 microm). |
1997-05-02 |
2023-08-12 |
rat |
| B A Sorg, D L Davidson, P W Kalivas, B M Prasa. Repeated daily cocaine alters subsequent cocaine-induced increase of extracellular dopamine in the medial prefrontal cortex. The Journal of pharmacology and experimental therapeutics. vol 281. issue 1. 1997-05-02. PMID:9103480. |
in summary, daily cocaine-pretreated rats demonstrated a suppressed mpfc dopamine response to subsequent systemic, but not local, cocaine challenge. |
1997-05-02 |
2023-08-12 |
rat |
| S R Tella, B Ladenheim, J L Cade. Differential regulation of dopamine transporter after chronic self-administration of bupropion and nomifensine. The Journal of pharmacology and experimental therapeutics. vol 281. issue 1. 1997-05-02. PMID:9103538. |
inhibition of dopamine (da) transporter function is thought to be the principal mechanism underlying cocaine's addictive effects. |
1997-05-02 |
2023-08-12 |
rat |
| S J Gatley, N D Volkow, R Chen, J S Fowler, F I Carroll, M J Kuha. Displacement of RTI-55 from the dopamine transporter by cocaine. European journal of pharmacology. vol 296. issue 2. 1997-05-01. PMID:8838450. |
displacement of rti-55 from the dopamine transporter by cocaine. |
1997-05-01 |
2023-08-12 |
mouse |
| S J Gatley, N D Volkow, R Chen, J S Fowler, F I Carroll, M J Kuha. Displacement of RTI-55 from the dopamine transporter by cocaine. European journal of pharmacology. vol 296. issue 2. 1997-05-01. PMID:8838450. |
the cocaine analog 3 beta-(4-iodophenyl)tropane-2 beta-carboxylic acid methyl ester (rti-55 or beta cit) has a higher affinity for the dopamine transporter and may be potentially useful in interfering with cocaine's actions in brain. |
1997-05-01 |
2023-08-12 |
mouse |
| S J Gatley, N D Volkow, R Chen, J S Fowler, F I Carroll, M J Kuha. Displacement of RTI-55 from the dopamine transporter by cocaine. European journal of pharmacology. vol 296. issue 2. 1997-05-01. PMID:8838450. |
the reduction in dopamine transporter availability, assessed in vivo in mouse striatum using [3h]cocaine, caused by pretreatment with rti-55 was significantly mitigated by subsequent administration of cocaine. |
1997-05-01 |
2023-08-12 |
mouse |
| R H Kline, S Izenwasser, J L Katz, D B Joseph, W D Bowen, A H Newma. 3'-Chloro-3 alpha-(diphenylmethoxy)tropane but not 4'-chloro-3 alpha-(diphenylmethoxy)tropane produces a cocaine-like behavioral profile. Journal of medicinal chemistry. vol 40. issue 6. 1997-05-01. PMID:9083473. |
further evaluation of compound 5c and the other benztropine analogs will undoubtedly prove useful in the elucidation of the role of the dopamine transporter in the reinforcing effects of cocaine and the ultimate identification of a cocaine-abuse treatment. |
1997-05-01 |
2023-08-12 |
rat |
| L Xu, S V Kelkar, S A Lomenzo, S Izenwasser, J L Katz, R H Kline, M L Trudel. Synthesis, dopamine transporter affinity, dopamine uptake inhibition, and locomotor stimulant activity of 2-substituted 3 beta-phenyltropane derivatives. Journal of medicinal chemistry. vol 40. issue 6. 1997-05-01. PMID:9083474. |
a series of 2 beta-substituted 3 beta-phenyltropanes were synthesized as analogs of cocaine and tested in vitro for their ability to displace bound [3h]win 35,428 (2b) and inhibit dopamine uptake in rat caudate-putamen tissue. |
1997-05-01 |
2023-08-12 |
rat |
| L Xu, S V Kelkar, S A Lomenzo, S Izenwasser, J L Katz, R H Kline, M L Trudel. Synthesis, dopamine transporter affinity, dopamine uptake inhibition, and locomotor stimulant activity of 2-substituted 3 beta-phenyltropane derivatives. Journal of medicinal chemistry. vol 40. issue 6. 1997-05-01. PMID:9083474. |
the structure-activity relationships of this series of cocaine analogs supports a pharmacophore model in which lipophilic interactions between the beta-c(2)-position of 3 beta-phenyltropanes and the cocaine binding site on the dopamine transporter lead to enhanced potency while electrostatic interactions have a nonspecific effect. |
1997-05-01 |
2023-08-12 |
rat |
| T Brücke, S Asenbaum, W Pirker, S Djamshidian, S Wenger, C Wöber, C Müller, I Podrek. Measurement of the dopaminergic degeneration in Parkinson's disease with [123I] beta-CIT and SPECT. Correlation with clinical findings and comparison with multiple system atrophy and progressive supranuclear palsy. Journal of neural transmission. Supplementum. vol 50. 1997-04-24. PMID:9120429. |
the cocaine derivative [123i] beta-cit binds with high affinity to dopamine uptake sites in the striatum and can be used to visualize dopaminergic nerve terminals in vivo in the human brain with spect. |
1997-04-24 |
2023-08-12 |
human |
| K Y Little, J Gorebig, F I Carroll, J Mapili, J H Meador-Woodruf. Lack of dopamine receptor agonists effect on striatal dopamine transporter binding sites. Brain research. vol 742. issue 1-2. 1997-04-22. PMID:9117410. |
depending on experimental conditions, chronic cocaine exposure can induce an increase in binding to the dopamine transporter (dat). |
1997-04-22 |
2023-08-12 |
rat |
| R W Keller, K S Johnson, A M Snyder-Keller, J N Carlson, S D Glic. Effects of prenatal cocaine exposure on the mesocorticolimbic dopamine system: an in vivo microdialysis study in the rat. Brain research. vol 742. issue 1-2. 1997-04-22. PMID:9117423. |
microdialysis studies were conducted on prenatally saline-treated and prenatally cocaine-treated rats, either as pups (10-30 days old) or young adults (40-190 days old), to study the effects of prenatal cocaine exposure on the mesolimbic dopamine (da) system. |
1997-04-22 |
2023-08-12 |
rat |
| G Le Pen, D Duterte-Boucher, J Costenti. Place conditioning with cocaine and the dopamine uptake inhibitor GBR12783. Neuroreport. vol 7. issue 18. 1997-04-18. PMID:9116192. |
place conditioning with cocaine and the dopamine uptake inhibitor gbr12783. |
1997-04-18 |
2023-08-12 |
Not clear |
| J R Glowa, F H Wojnick. Effects of drugs on food- and cocaine-maintained responding, III: Dopaminergic antagonists. Psychopharmacology. vol 128. issue 4. 1997-04-16. PMID:8986005. |
the effects of three dopamine (da) antagonists (sch23390, pimozide, and chlorpromazine), with various degrees of selectivity for d1 and d2 receptors, and an agonist (the cocaine analog, cft) were studied on responding maintained under a multiple fixed-ratio (fr) 30 food, fr30 cocaine (1-100 micrograms/kg per injection) delivery, with an interposed 10-min time-out (to), schedule in rhesus monkeys. |
1997-04-16 |
2023-08-12 |
monkey |
| T H Lee, W Y Gao, E H Ellinwoo. Differential effects of SCH 23390 on the apomorphine subsensitivity in the substantia nigra and ventral tegmental area 1 day following withdrawal from continuous or intermittent cocaine pretreatment. Brain research. vol 744. issue 2. 1997-04-16. PMID:9027389. |
using extracellular single-unit recordings in rats, the effects of chronic intermittent injections and continuous infusion of cocaine on single dopamine neurons were directly compared in the substantia nigra and ventral tegmental area. |
1997-04-16 |
2023-08-12 |
rat |
| H Sershen, A Hashim, A Lajth. Ibogaine and cocaine abuse: pharmacological interactions at dopamine and serotonin receptors. Brain research bulletin. vol 42. issue 3. 1997-04-15. PMID:8995326. |
ibogaine and cocaine abuse: pharmacological interactions at dopamine and serotonin receptors. |
1997-04-15 |
2023-08-12 |
Not clear |