| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Tatsch, J Schwarz, P D Mozley, R Linke, O Pogarell, W H Oertel, R S Fieber, K Hahn, H F Kun. Relationship between clinical features of Parkinson's disease and presynaptic dopamine transporter binding assessed with [123I]IPT and single-photon emission tomography. European journal of nuclear medicine. vol 24. issue 4. 1997-06-24. PMID:9096093. |
ipt [n-(3-iodopropen-2-yl)- 2beta-carbomethoxy-3beta-(4-chlorophenyl) tropane] is a new cocaine analogue which allows the presynaptic dopamine transporters to be imaged with single-photon emission tomography (spet) as early as 1-2 h post injection. |
1997-06-24 |
2023-08-12 |
Not clear |
| M C Ritz, F R Georg. Cocaine toxicity: concurrent influence of dopaminergic, muscarinic and sigma receptors in mediating cocaine-induced lethality. Psychopharmacology. vol 129. issue 4. 1997-06-19. PMID:9085400. |
the dopamine reuptake inhibitor bupropion increased the number of occurrences of lethality produced by (-) cocaine, while the dopaminergic d1 antagonist sch 23390, the muscarinic m1 antagonist pirenzepine, and the sigma ligand (+) skf 10047 all significantly, but only partially, antagonized (-) cocaine-induced lethality. |
1997-06-19 |
2023-08-12 |
mouse |
| W J Chen, S E Maier, J R Wes. Prenatal alcohol treatment attenuated postnatal cocaine-induced elevation of dopamine concentration in nucleus accumbens: a preliminary study. Neurotoxicology and teratology. vol 19. issue 1. 1997-06-19. PMID:9088009. |
the present study investigated one of the functional aspects of dopaminergic system in neonatal rats exposed prenatally to a binge-like alcohol paradigm by measuring dopamine concentrations following a single postnatal cocaine challenge. |
1997-06-19 |
2023-08-12 |
rat |
| W J Chen, S E Maier, J R Wes. Prenatal alcohol treatment attenuated postnatal cocaine-induced elevation of dopamine concentration in nucleus accumbens: a preliminary study. Neurotoxicology and teratology. vol 19. issue 1. 1997-06-19. PMID:9088009. |
basal dopamine levels (0 mg/kg cocaine group) did not alter as a function of prenatal alcohol treatment in either region. |
1997-06-19 |
2023-08-12 |
rat |
| W J Chen, S E Maier, J R Wes. Prenatal alcohol treatment attenuated postnatal cocaine-induced elevation of dopamine concentration in nucleus accumbens: a preliminary study. Neurotoxicology and teratology. vol 19. issue 1. 1997-06-19. PMID:9088009. |
however, acute cocaine injection increased the dopamine content in nac, but not in sn/vta, in ad lib-fed animals, and this elevation in dopamine level was significantly attenuated by prenatal alcohol treatment in both female and male animals, and by prenatal pair-fed treatment in male animals. |
1997-06-19 |
2023-08-12 |
rat |
| H Nakamura, T Hishinuma, Y Tomioka, S Ishiwata, T Ido, R Iwata, Y Funaki, M Itoh, T Fujiwara, K Yanai, M Sato, Y Numachi, S Yoshida, M Mizugak. Effects of haloperidol and cocaine pretreatments on brain distribution and kinetics of [11C]methamphetamine in methamphetamine sensitized dog: application of PET to drug pharmacokinetic study. Nuclear medicine and biology. vol 24. issue 2. 1997-06-19. PMID:9190247. |
in behavioral studies, haloperidol (a dopamine d2 receptor antagonist) prevents map-induced behavioral sensitization, and cocaine (a dopamine reuptake blocker) has the cross-behavioral sensitization with map. |
1997-06-19 |
2023-08-12 |
dog |
| S R Letchworth, J B Daunais, A A Hedgecock, L J Porrin. Effects of chronic cocaine administration on dopamine transporter mRNA and protein in the rat. Brain research. vol 750. issue 1-2. 1997-06-17. PMID:9098547. |
effects of chronic cocaine administration on dopamine transporter mrna and protein in the rat. |
1997-06-17 |
2023-08-12 |
rat |
| S R Letchworth, J B Daunais, A A Hedgecock, L J Porrin. Effects of chronic cocaine administration on dopamine transporter mRNA and protein in the rat. Brain research. vol 750. issue 1-2. 1997-06-17. PMID:9098547. |
chronic cocaine administration resulted in dose-dependent decreases in the density of dopamine transporter (dat) mrna in both the substantia nigra pars compacta and ventral tegmental area as shown by in situ hybridization histochemistry. |
1997-06-17 |
2023-08-12 |
rat |
| B P Bowman, B Blatt, C M Kuh. Ontogeny of the behavioral response to dopamine agonists after chronic cocaine. Psychopharmacology. vol 129. issue 2. 1997-06-16. PMID:9040117. |
ontogeny of the behavioral response to dopamine agonists after chronic cocaine. |
1997-06-16 |
2023-08-12 |
rat |
| B P Bowman, B Blatt, C M Kuh. Ontogeny of the behavioral response to dopamine agonists after chronic cocaine. Psychopharmacology. vol 129. issue 2. 1997-06-16. PMID:9040117. |
the behavioral response to separate and combined administration of dopamine d1 and d2 receptor agonists was assessed acutely and after chronic cocaine exposure (30 mg/kg s.c. b.i.d. |
1997-06-16 |
2023-08-12 |
rat |
| R P Hammer, Y Egilmez, M W Emmett-Oglesb. Neural mechanisms of tolerance to the effects of cocaine. Behavioural brain research. vol 84. issue 1-2. 1997-06-13. PMID:9079787. |
the mechanism underlying this effect may involve an absolute or relative attenuation of dopamine response to cocaine challenge after frequent or repeated treatment in the nucleus accumbens (nac). |
1997-06-13 |
2023-08-12 |
human |
| R P Hammer, Y Egilmez, M W Emmett-Oglesb. Neural mechanisms of tolerance to the effects of cocaine. Behavioural brain research. vol 84. issue 1-2. 1997-06-13. PMID:9079787. |
thus, a combination of various pharmacodynamic mechanisms and the attenuation of dopamine response induced by sufficient dose, duration and frequency of cocaine exposure ultimately invoke the transient development of tolerance to the reinforcing effects of cocaine. |
1997-06-13 |
2023-08-12 |
human |
| X F Zhang, X T Hu, F J White, M E Wol. Increased responsiveness of ventral tegmental area dopamine neurons to glutamate after repeated administration of cocaine or amphetamine is transient and selectively involves AMPA receptors. The Journal of pharmacology and experimental therapeutics. vol 281. issue 2. 1997-06-12. PMID:9152375. |
increased responsiveness of ventral tegmental area dopamine neurons to glutamate after repeated administration of cocaine or amphetamine is transient and selectively involves ampa receptors. |
1997-06-12 |
2023-08-12 |
rat |
| J Q Wang, J F McGint. The full D1 dopamine receptor agonist SKF-82958 induces neuropeptide mRNA in the normosensitive striatum of rats: regulation of D1/D2 interactions by muscarinic receptors. The Journal of pharmacology and experimental therapeutics. vol 281. issue 2. 1997-06-12. PMID:9152408. |
neuropeptide and immediate early gene expression in striatonigral neurons of the normosensitive striatum is induced by mixed d1/d2 receptor agonists and indirect dopamine agonists, such as cocaine and amphetamine. |
1997-06-12 |
2023-08-12 |
rat |
| M J Nirenberg, J Chan, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 11. 1997-06-10. PMID:9151720. |
dat is also a major binding site for cocaine and other stimulants, the psychoactive effects of which are associated primarily with the inhibition of dopamine reuptake within mesocorticolimbic dopaminergic neurons. |
1997-06-10 |
2023-08-12 |
rat |
| M J Nirenberg, J Chan, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 11. 1997-06-10. PMID:9151720. |
these findings suggest that intermediate and distal dendrites are both the primary sites of dopamine reuptake and the principal targets of cocaine and related psychostimulants within dopaminergic neurons in the vta. |
1997-06-10 |
2023-08-12 |
rat |
| C Xu, L L Coffey, M E Reit. Binding domains for blockers and substrates on the dopamine transporter in rat striatal membranes studied by protection against N-ethylmaleimide-induced reduction of [3H]WIN 35,428 binding. Naunyn-Schmiedeberg's archives of pharmacology. vol 355. issue 1. 1997-06-09. PMID:9007844. |
binding sites for 2 beta-carbomethoxy-3 beta-(4-fluorophenyl)[3h]tropane ([3h]win 35,428) on rat striatal membranes were alkylated with n-ethylmaleimide (nem), and the protective potency was measured of the blockers cocaine, n[1-(2-benzo[b]thiophenyl) cyclohexyl]piperidine (btcp), benztropine, win 35,428; and nomifensine, and of the substrates dopamine, norepinephrine, s(+)-amphetamine, tyramine, and metaraminol. |
1997-06-09 |
2023-08-12 |
rat |
| C S Norton, M P Gallowa. Repeated cocaine exposure attenuates the ability of 5-hydroxytryptamine to release striatal dopamine in vivo. European journal of pharmacology. vol 318. issue 2-3. 1997-05-29. PMID:9016921. |
repeated cocaine exposure attenuates the ability of 5-hydroxytryptamine to release striatal dopamine in vivo. |
1997-05-29 |
2023-08-12 |
rat |
| C S Norton, M P Gallowa. Repeated cocaine exposure attenuates the ability of 5-hydroxytryptamine to release striatal dopamine in vivo. European journal of pharmacology. vol 318. issue 2-3. 1997-05-29. PMID:9016921. |
the 5-ht effect on dopamine release returned to control levels 21 days after cocaine exposure and was not altered by acute cocaine treatment (30 mg/kg, i.p. |
1997-05-29 |
2023-08-12 |
rat |
| S Das, M Grunert, L Williams, S R Vincen. NMDA and D1 receptors regulate the phosphorylation of CREB and the induction of c-fos in striatal neurons in primary culture. Synapse (New York, N.Y.). vol 25. issue 3. 1997-05-27. PMID:9068120. |
numerous in vivo studies have demonstrated that psychostimulant drugs such as amphetamine and cocaine can induce the expression of the immediate early gene c-fos in striatal neurons via the activation of d1 dopamine receptors. |
1997-05-27 |
2023-08-12 |
Not clear |