| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S L Povlock, J O Schen. A multisubstrate kinetic mechanism of dopamine transport in the nucleus accumbens and its inhibition by cocaine. Journal of neurochemistry. vol 69. issue 3. 1997-09-25. PMID:9282932. |
however, the dopamine transporter in the nacc is more tightly regulated by na+, possesses a higher kinetic turnover rate, is four times more sensitive to cocaine than the striatal transporter, and exhibits cocaine inhibition independent of [substrate]. |
1997-09-25 |
2023-08-12 |
Not clear |
| J D Stekete. Intra-ventral tegmental area administration of H7 delays, but does not prevent the development of cocaine-induced sensitization. Brain research bulletin. vol 43. issue 6. 1997-09-23. PMID:9254028. |
pretreatment with h7 in the vta attenuated the acute motor stimulant response to cocaine as well as the cocaine-induced increase in extracellular dopamine in the nucleus accumbens. |
1997-09-23 |
2023-08-12 |
Not clear |
| J D Stekete. Intra-ventral tegmental area administration of H7 delays, but does not prevent the development of cocaine-induced sensitization. Brain research bulletin. vol 43. issue 6. 1997-09-23. PMID:9254028. |
in addition, the augmented increase in dopamine in the nucleus accumbens of cocaine-sensitized animals was prevented in animals pretreated with h7 before each of their daily cocaine injections, when tested after a 24 h withdrawal. |
1997-09-23 |
2023-08-12 |
Not clear |
| J D Stekete. Intra-ventral tegmental area administration of H7 delays, but does not prevent the development of cocaine-induced sensitization. Brain research bulletin. vol 43. issue 6. 1997-09-23. PMID:9254028. |
however, when tested after a 1 week withdrawal, animals demonstrated sensitization to both the cocaine-induced increase in motor activity and the cocaine-induced increase in dopamine in the nucleus accumbens regardless of whether they received intra-vta saline or h7 before each of their daily cocaine injections. |
1997-09-23 |
2023-08-12 |
Not clear |
| S Koch, M F Piercey, M P Galloway, K A Svensso. Interactions between cocaine and (-)-DS 121: studies with 2-deoxyglucose autoradiography and microdialysis in the rat brain. European journal of pharmacology. vol 319. issue 2-3. 1997-09-22. PMID:9042588. |
when rats were pretreated with (-)-ds 121, a subsequent dose of cocaine augmented the increase in extracellular striatal dopamine to 870% of controls. |
1997-09-22 |
2023-08-12 |
rat |
| S Koch, M F Piercey, M P Galloway, K A Svensso. Interactions between cocaine and (-)-DS 121: studies with 2-deoxyglucose autoradiography and microdialysis in the rat brain. European journal of pharmacology. vol 319. issue 2-3. 1997-09-22. PMID:9042588. |
the results support the contention that (-)-ds 121 possesses weak cocaine-mimetic effects and that its antagonism of cocaine's subjective effects are due to interactions with dopamine at postsynaptic sites. |
1997-09-22 |
2023-08-12 |
rat |
| A L Bittencourt, R N Takahash. Mazindol and lidocaine are antinociceptives in the mouse formalin model: involvement of dopamine receptor. European journal of pharmacology. vol 330. issue 2-3. 1997-09-22. PMID:9253942. |
), a dopamine d2 receptor antagonist, reduced the antinociceptive actions of mazindol and cocaine, while sch 23390, r(+)-7-chloro 8-hydroxy-3methyl-1-phenyl-2,3,4,5-tetrahydro-1h-3 benzazepine (0.03 mg/kg, i.p. |
1997-09-22 |
2023-08-12 |
mouse |
| T E Schlaepfer, G D Pearlson, D F Wong, S Marenco, R F Dannal. PET study of competition between intravenous cocaine and [11C]raclopride at dopamine receptors in human subjects. The American journal of psychiatry. vol 154. issue 9. 1997-09-18. PMID:9286178. |
pet study of competition between intravenous cocaine and [11c]raclopride at dopamine receptors in human subjects. |
1997-09-18 |
2023-08-12 |
human |
| T E Schlaepfer, G D Pearlson, D F Wong, S Marenco, R F Dannal. PET study of competition between intravenous cocaine and [11C]raclopride at dopamine receptors in human subjects. The American journal of psychiatry. vol 154. issue 9. 1997-09-18. PMID:9286178. |
animal data suggest that the strong euphoriant effects of cocaine are related to the drug's enhancement of available dopamine at the synaptic cleft. |
1997-09-18 |
2023-08-12 |
human |
| A E Morgan, B Horan, S L Dewey, C R Ashb. Repeated administration of 3,4-methylenedioxymethamphetamine augments cocaine's action on dopamine in the nucleus accumbens: a microdialysis study. European journal of pharmacology. vol 331. issue 1. 1997-09-12. PMID:9274936. |
repeated administration of 3,4-methylenedioxymethamphetamine augments cocaine's action on dopamine in the nucleus accumbens: a microdialysis study. |
1997-09-12 |
2023-08-12 |
rat |
| A E Morgan, B Horan, S L Dewey, C R Ashb. Repeated administration of 3,4-methylenedioxymethamphetamine augments cocaine's action on dopamine in the nucleus accumbens: a microdialysis study. European journal of pharmacology. vol 331. issue 1. 1997-09-12. PMID:9274936. |
cocaine produced a 400% increase in extracellular nucleus accumbens dopamine levels in control rats, whereas in 3,4-methylenedioxymethamphetamine treated rats the increase produced by cocaine was 800%, which was significantly different from controls. |
1997-09-12 |
2023-08-12 |
rat |
| C Xu, M E Reit. WIN 35,428 and mazindol are mutually exclusive in binding to the cloned human dopamine transporter. The Journal of pharmacology and experimental therapeutics. vol 282. issue 2. 1997-09-11. PMID:9262359. |
it has been suggested that cocaine and mazindol bind to separate sites on the dopamine transporter. |
1997-09-11 |
2023-08-12 |
human |
| C Xu, M E Reit. WIN 35,428 and mazindol are mutually exclusive in binding to the cloned human dopamine transporter. The Journal of pharmacology and experimental therapeutics. vol 282. issue 2. 1997-09-11. PMID:9262359. |
in the present study, we address this issue by examining the inhibition by mazindol of the binding of [3h]win 35,428 ([3h]2beta-carbomethyoxy-3beta-(4-fluorophenyl)-tropane), a phenyltropane analog of cocaine, and the inhibition by win 35,428 of [3h]mazindol binding to the cloned human dopamine transporter expressed in c6 glioma cells. |
1997-09-11 |
2023-08-12 |
human |
| C Xu, M E Reit. WIN 35,428 and mazindol are mutually exclusive in binding to the cloned human dopamine transporter. The Journal of pharmacology and experimental therapeutics. vol 282. issue 2. 1997-09-11. PMID:9262359. |
the present results suggest that complex interactions reported between cocaine and mazindol in inhibiting dopamine transport are beyond the level of ligand recognition. |
1997-09-11 |
2023-08-12 |
human |
| S Singh, G P Basmadjian, K S Avor, B Pouw, T W Seal. Synthesis and ligand binding studies of 4'-iodobenzoyl esters of tropanes and piperidines at the dopamine transporter. Journal of medicinal chemistry. vol 40. issue 16. 1997-09-10. PMID:9258354. |
an iodo group substitution at the 4'-position of cocaine decreased dopamine transporter binding potency, while a hydroxy or acetoxy group at the 2'-position exhibited increased binding potency for the dopamine transporter compared to cocaine (10- and 3.58-fold, respectively). |
1997-09-10 |
2023-08-12 |
Not clear |
| A E Morgan, S P Porter, F A Clarkson, N D Volkow, J S Fowler, S L Dewe. Direct approach for attenuating cocaine's effects on extracellular dopamine: targeting the dopamine transporter. Synapse (New York, N.Y.). vol 26. issue 4. 1997-09-09. PMID:9215601. |
direct approach for attenuating cocaine's effects on extracellular dopamine: targeting the dopamine transporter. |
1997-09-09 |
2023-08-12 |
rat |
| A E Morgan, S P Porter, F A Clarkson, N D Volkow, J S Fowler, S L Dewe. Direct approach for attenuating cocaine's effects on extracellular dopamine: targeting the dopamine transporter. Synapse (New York, N.Y.). vol 26. issue 4. 1997-09-09. PMID:9215601. |
using in vivo microdialysis techniques, the effects of rti-55 and/or cocaine on extracellular dopamine (da) concentrations were measured in the nucleus accumbens (nacc) of freely moving rats. |
1997-09-09 |
2023-08-12 |
rat |
| A E Morgan, S P Porter, F A Clarkson, N D Volkow, J S Fowler, S L Dewe. Direct approach for attenuating cocaine's effects on extracellular dopamine: targeting the dopamine transporter. Synapse (New York, N.Y.). vol 26. issue 4. 1997-09-09. PMID:9215601. |
these findings indicate that rti-55, a drug that binds directly to the dopamine transporter (dat) with higher affinity than cocaine, does not appear to be effective in attenuating cocaine's effects on nacc dopamine levels. |
1997-09-09 |
2023-08-12 |
rat |
| N E Goeder. A neuroendocrine role in cocaine reinforcement. Psychoneuroendocrinology. vol 22. issue 4. 1997-09-05. PMID:9226728. |
in particular, the medial prefrontal cortex appears to be at least one brain region where dopamine and adrenocorticosteroids may interact to affect cocaine reinforcement. |
1997-09-05 |
2023-08-12 |
rat |
| S G Howard, R Fisher, C F Landr. Alterations in the spontaneous release of dopamine and the density of the DA D2 receptor mRNA after chronic postnatal exposure to cocaine. Brain research bulletin. vol 43. issue 1. 1997-09-04. PMID:9205803. |
alterations in the spontaneous release of dopamine and the density of the da d2 receptor mrna after chronic postnatal exposure to cocaine. |
1997-09-04 |
2023-08-12 |
rat |