| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J L Katz, A H Newman, S Izenwasse. Relations between heterogeneity of dopamine transporter binding and function and the behavioral pharmacology of cocaine. Pharmacology, biochemistry, and behavior. vol 57. issue 3. 1997-10-23. PMID:9218275. |
recently, some benztropine analogs have been discovered that bind to the dopamine transporter and inhibit dopamine uptake monophasically but have behavioral effects that are dissimilar to those of cocaine. |
1997-10-23 |
2023-08-12 |
Not clear |
| P M Callahan, R De La Garza, K A Cunningha. Mediation of the discriminative stimulus properties of cocaine by mesocorticolimbic dopamine systems. Pharmacology, biochemistry, and behavior. vol 57. issue 3. 1997-10-23. PMID:9218282. |
mediation of the discriminative stimulus properties of cocaine by mesocorticolimbic dopamine systems. |
1997-10-23 |
2023-08-12 |
rat |
| P M Callahan, R De La Garza, K A Cunningha. Mediation of the discriminative stimulus properties of cocaine by mesocorticolimbic dopamine systems. Pharmacology, biochemistry, and behavior. vol 57. issue 3. 1997-10-23. PMID:9218282. |
this paper provides a brief review of the scientific evidence implicating the mesocorticolimbic dopamine (da) system in modulating the discriminative stimulus properties of cocaine in rats. |
1997-10-23 |
2023-08-12 |
rat |
| P M Callahan, R De La Garza, K A Cunningha. Mediation of the discriminative stimulus properties of cocaine by mesocorticolimbic dopamine systems. Pharmacology, biochemistry, and behavior. vol 57. issue 3. 1997-10-23. PMID:9218282. |
dopamine d1 and d2 receptor antagonists attenuate this behavioral property of cocaine. |
1997-10-23 |
2023-08-12 |
rat |
| N H Chen, J H Ding, Y L Wang, M E Reit. Potential misconceptions in dopamine transporter assays arising from the binding of [125I]RTI-121 to filters: effect of ions and cocaine. Journal of neuroscience methods. vol 75. issue 2. 1997-10-23. PMID:9288650. |
potential misconceptions in dopamine transporter assays arising from the binding of [125i]rti-121 to filters: effect of ions and cocaine. |
1997-10-23 |
2023-08-12 |
rat |
| N H Chen, J H Ding, Y L Wang, M E Reit. Potential misconceptions in dopamine transporter assays arising from the binding of [125I]RTI-121 to filters: effect of ions and cocaine. Journal of neuroscience methods. vol 75. issue 2. 1997-10-23. PMID:9288650. |
binding of the cocaine analog 3 beta-(4-[125i]iodophenyl)tropane-2 beta-carboxylic acid isopropyl ester ([125i]rti-121) to filters was studied in order to assess its contribution to labeling dopamine transporters on rat striatal synaptosomal membranes in filtration assays. |
1997-10-23 |
2023-08-12 |
rat |
| N H Chen, J H Ding, Y L Wang, M E Reit. Potential misconceptions in dopamine transporter assays arising from the binding of [125I]RTI-121 to filters: effect of ions and cocaine. Journal of neuroscience methods. vol 75. issue 2. 1997-10-23. PMID:9288650. |
at 10 mm na+, rti-121 (1 microm) displaced the fb to the same degree as cocaine (100 microm); mazindol (10 microm), btcp (1 microm), and dopamine (1 mm) did so to a lesser degree; and gbr12935 (1 microm) did not. |
1997-10-23 |
2023-08-12 |
rat |
| M S Reid, K Hsu, S P Berge. Cocaine and amphetamine preferentially stimulate glutamate release in the limbic system: studies on the involvement of dopamine. Synapse (New York, N.Y.). vol 27. issue 2. 1997-10-21. PMID:9266771. |
cocaine and amphetamine preferentially stimulate glutamate release in the limbic system: studies on the involvement of dopamine. |
1997-10-21 |
2023-08-12 |
rat |
| M S Reid, K Hsu, S P Berge. Cocaine and amphetamine preferentially stimulate glutamate release in the limbic system: studies on the involvement of dopamine. Synapse (New York, N.Y.). vol 27. issue 2. 1997-10-21. PMID:9266771. |
the increase in nucleus accumbens glutamate levels following cocaine (30 mg/kg) was calcium-dependent and was blocked by pretreatment with dopamine antagonists; haloperidol (0.2 mg/kg, i.p. |
1997-10-21 |
2023-08-12 |
rat |
| L J Porrino, M Miller, A A Hedgecock, C Thornley, J J Matasi, H M Davie. Local cerebral metabolic effects of the novel cocaine analog, WF-31: comparisons to fluoxetine. Synapse (New York, N.Y.). vol 27. issue 1. 1997-10-21. PMID:9268062. |
the effects of the acute administration of the selective serotonin uptake inhibitor, fluoxetine, on rates of local cerebral glucose utilization in rats were compared to those of the novel cocaine analog, [2beta-propanoyl-3beta-(4-isopropylphenyl)-tropane, wf-31, which has greater affinity for serotonin than dopamine transporters, using the quantitative autoradiographic 2-[14c]deoxyglucose method. |
1997-10-21 |
2023-08-12 |
rat |
| M Rubinstein, T J Phillips, J R Bunzow, T L Falzone, G Dziewczapolski, G Zhang, Y Fang, J L Larson, J A McDougall, J A Chester, C Saez, T A Pugsley, O Gershanik, M J Low, D K Grand. Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell. vol 90. issue 6. 1997-10-20. PMID:9323127. |
mice lacking dopamine d4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. |
1997-10-20 |
2023-08-12 |
mouse |
| G F Koob, E J Nestle. The neurobiology of drug addiction. The Journal of neuropsychiatry and clinical neurosciences. vol 9. issue 3. 1997-10-16. PMID:9276849. |
the reinforcing effects of indirect sympathomimetics such as cocaine and amphetamine appear to depend on release of dopamine in the terminal fields of the mesocorticolimbic dopamine system. |
1997-10-16 |
2023-08-12 |
Not clear |
| G J Wang, N D Volkow, J S Fowler, M Fischman, R Foltin, N N Abumrad, J Logan, N R Pappa. Cocaine abusers do not show loss of dopamine transporters with age. Life sciences. vol 61. issue 11. 1997-10-15. PMID:9307051. |
cocaine abusers do not show loss of dopamine transporters with age. |
1997-10-15 |
2023-08-12 |
Not clear |
| G J Wang, N D Volkow, J S Fowler, M Fischman, R Foltin, N N Abumrad, J Logan, N R Pappa. Cocaine abusers do not show loss of dopamine transporters with age. Life sciences. vol 61. issue 11. 1997-10-15. PMID:9307051. |
cocaine blocks dopamine transporters (dat) and this effect is crucial to its reinforcing properties. |
1997-10-15 |
2023-08-12 |
Not clear |
| S B Caine, G F Koob, L H Parsons, B J Everitt, J C Schwartz, P Sokolof. D3 receptor test in vitro predicts decreased cocaine self-administration in rats. Neuroreport. vol 8. issue 9-10. 1997-10-07. PMID:9243643. |
the three dopamine agonists with highest reported d3 receptor selectivity in vitro, pramipexole, quinelorane and pd128,907, decreased self-administration of a high dose of cocaine in rats as a result of a leftward shift in the cocaine dose-effect function. |
1997-10-07 |
2023-08-12 |
rat |
| S B Caine, G F Koob, L H Parsons, B J Everitt, J C Schwartz, P Sokolof. D3 receptor test in vitro predicts decreased cocaine self-administration in rats. Neuroreport. vol 8. issue 9-10. 1997-10-07. PMID:9243643. |
moreover the relative potencies of these and other d2-like dopamine agonists (lisuride, 7-oh-dpat, quinpirole, apomorphine, bromocriptine) to modulate cocaine self-administration were highly correlated with their relative potencies for increasing mitogenesis in vitro in cell lines expressing d3 but not d2 receptors. |
1997-10-07 |
2023-08-12 |
rat |
| M J Nirenberg, J Chan, A Pohorille, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. The dopamine transporter: comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 18. 1997-10-03. PMID:9278525. |
the dopamine transporter (dat) regulates extracellular dopamine concentrations, transports neurotoxins, and acts as a substrate for cocaine reinforcement. |
1997-10-03 |
2023-08-12 |
Not clear |
| P C Meltzer, A Y Liang, P Blundell, M D Gonzalez, Z Chen, C George, B K Madra. 2-Carbomethoxy-3-aryl-8-oxabicyclo[3.2.1]octanes: potent non-nitrogen inhibitors of monoamine transporters. Journal of medicinal chemistry. vol 40. issue 17. 1997-09-25. PMID:9276012. |
in particular, the 8-amino function on the tropane skeleton of cocaine and cocaine analogs has been assumed to provide an ionic bond to the aspartic acid residue on the dopamine transporter (dat). |
1997-09-25 |
2023-08-12 |
Not clear |
| S L Povlock, J O Schen. A multisubstrate kinetic mechanism of dopamine transport in the nucleus accumbens and its inhibition by cocaine. Journal of neurochemistry. vol 69. issue 3. 1997-09-25. PMID:9282932. |
a multisubstrate kinetic mechanism of dopamine transport in the nucleus accumbens and its inhibition by cocaine. |
1997-09-25 |
2023-08-12 |
Not clear |
| S L Povlock, J O Schen. A multisubstrate kinetic mechanism of dopamine transport in the nucleus accumbens and its inhibition by cocaine. Journal of neurochemistry. vol 69. issue 3. 1997-09-25. PMID:9282932. |
cocaine inhibited dopamine transport and the influences of the other substrates allosterically with an overall ki of 0.30 microm. |
1997-09-25 |
2023-08-12 |
Not clear |