| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S E Hemby, C Co, T R Koves, J E Smith, S I Dworki. Differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat. Psychopharmacology. vol 133. issue 1. 1997-11-14. PMID:9335075. |
differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat. |
1997-11-14 |
2023-08-12 |
human |
| S E Hemby, C Co, T R Koves, J E Smith, S I Dworki. Differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat. Psychopharmacology. vol 133. issue 1. 1997-11-14. PMID:9335075. |
studies indicate that nucleus accumbens (nacc) dopamine neurotransmission is involved in the reinforcing and direct effects of cocaine. |
1997-11-14 |
2023-08-12 |
human |
| S E Hemby, C Co, T R Koves, J E Smith, S I Dworki. Differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat. Psychopharmacology. vol 133. issue 1. 1997-11-14. PMID:9335075. |
the present study was initiated to explore further the relationship of nacc extracellular dopamine concentrations ([da]e) and cocaine self-administration using a yoked littermate design. |
1997-11-14 |
2023-08-12 |
human |
| A Hitri, R J Wyat. Regional differences in rat brain dopamine transporter binding: function of time after chronic cocaine. Clinical neuropharmacology. vol 16. issue 6. 1997-11-10. PMID:9377588. |
regional differences in rat brain dopamine transporter binding: function of time after chronic cocaine. |
1997-11-10 |
2023-08-12 |
rat |
| A Hitri, R J Wyat. Regional differences in rat brain dopamine transporter binding: function of time after chronic cocaine. Clinical neuropharmacology. vol 16. issue 6. 1997-11-10. PMID:9377588. |
chronic administration of cocaine to rats has been shown to produce a persistent decrease in dopamine (da) and its metabolites in the brain and periphery. |
1997-11-10 |
2023-08-12 |
rat |
| M Jaber, S Jones, B Giros, M G Caro. The dopamine transporter: a crucial component regulating dopamine transmission. Movement disorders : official journal of the Movement Disorder Society. vol 12. issue 5. 1997-11-07. PMID:9380041. |
our results establish not only the central importance of the transporter as the key element controlling dopamine levels in the brain, but also its role as an obligatory target for the behavioral and biochemical action of amphetamine and cocaine. |
1997-11-07 |
2023-08-12 |
mouse |
| B Geter-Douglass, J L Katz, K Alling, J B Acri, J M Witki. Characterization of unconditioned behavioral effects of dopamine D3/D2 receptor agonists. The Journal of pharmacology and experimental therapeutics. vol 283. issue 1. 1997-11-03. PMID:9336302. |
the effects of these drugs with selectivity for d3/d2 receptors over d1 receptors were compared with those produced by the selective d1 agonists [(+/-)-phenyl-2,3,4,5-tetrahydro-(1h)-3-benzazepine-7,8-diol hydrochloride (skf 38393), (+/-)-6-chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1h-3-be nzazepine hydrobromide (skf 82958)], a nonselective dopaminergic agonist (apomorphine), and an indirect dopamine agonist (cocaine). |
1997-11-03 |
2023-08-12 |
mouse |
| B Geter-Douglass, J L Katz, K Alling, J B Acri, J M Witki. Characterization of unconditioned behavioral effects of dopamine D3/D2 receptor agonists. The Journal of pharmacology and experimental therapeutics. vol 283. issue 1. 1997-11-03. PMID:9336302. |
the indirect dopamine agonist, cocaine, produced increases in locomotor activity and climbing, but had no effect on climbing or gnawing in mice and did not produce scratching in squirrel monkeys. |
1997-11-03 |
2023-08-12 |
mouse |
| R H Mach, M A Nader, R L Ehrenkaufer, S W Line, C R Smith, H D Gage, T E Morto. Use of positron emission tomography to study the dynamics of psychostimulant-induced dopamine release. Pharmacology, biochemistry, and behavior. vol 57. issue 3. 1997-10-23. PMID:9218272. |
methamphetamine and amphetamine had more pronounced effects on the washout kinetics of [18f]fcp relative to cocaine and methylphenidate, a result that is consistent with the ability of each drug to elevate synaptic dopamine levels. |
1997-10-23 |
2023-08-12 |
monkey |
| J L Katz, A H Newman, S Izenwasse. Relations between heterogeneity of dopamine transporter binding and function and the behavioral pharmacology of cocaine. Pharmacology, biochemistry, and behavior. vol 57. issue 3. 1997-10-23. PMID:9218275. |
relations between heterogeneity of dopamine transporter binding and function and the behavioral pharmacology of cocaine. |
1997-10-23 |
2023-08-12 |
Not clear |
| J L Katz, A H Newman, S Izenwasse. Relations between heterogeneity of dopamine transporter binding and function and the behavioral pharmacology of cocaine. Pharmacology, biochemistry, and behavior. vol 57. issue 3. 1997-10-23. PMID:9218275. |
both in vitro binding studies and studies of dopamine uptake have indicated that there is a heterogeneity of action of cocaine and cocaine analogs. |
1997-10-23 |
2023-08-12 |
Not clear |
| J L Katz, A H Newman, S Izenwasse. Relations between heterogeneity of dopamine transporter binding and function and the behavioral pharmacology of cocaine. Pharmacology, biochemistry, and behavior. vol 57. issue 3. 1997-10-23. PMID:9218275. |
in addition, tolerance to the psychomotor stimulant effects of cocaine occurs with a concomitant change in only the high-affinity component for dopamine uptake. |
1997-10-23 |
2023-08-12 |
Not clear |
| J L Katz, A H Newman, S Izenwasse. Relations between heterogeneity of dopamine transporter binding and function and the behavioral pharmacology of cocaine. Pharmacology, biochemistry, and behavior. vol 57. issue 3. 1997-10-23. PMID:9218275. |
these drugs bind to the dopamine transporter and inhibit dopamine uptake; however, they do not have behavioral effects like those of cocaine. |
1997-10-23 |
2023-08-12 |
Not clear |
| J L Katz, A H Newman, S Izenwasse. Relations between heterogeneity of dopamine transporter binding and function and the behavioral pharmacology of cocaine. Pharmacology, biochemistry, and behavior. vol 57. issue 3. 1997-10-23. PMID:9218275. |
this finding is a critical point of inquiry for the dopamine hypothesis because, based on the neurochemical data, these drugs should have behavioral actions like those of cocaine. |
1997-10-23 |
2023-08-12 |
Not clear |
| J L Katz, A H Newman, S Izenwasse. Relations between heterogeneity of dopamine transporter binding and function and the behavioral pharmacology of cocaine. Pharmacology, biochemistry, and behavior. vol 57. issue 3. 1997-10-23. PMID:9218275. |
recently, some benztropine analogs have been discovered that bind to the dopamine transporter and inhibit dopamine uptake monophasically but have behavioral effects that are dissimilar to those of cocaine. |
1997-10-23 |
2023-08-12 |
Not clear |
| P M Callahan, R De La Garza, K A Cunningha. Mediation of the discriminative stimulus properties of cocaine by mesocorticolimbic dopamine systems. Pharmacology, biochemistry, and behavior. vol 57. issue 3. 1997-10-23. PMID:9218282. |
mediation of the discriminative stimulus properties of cocaine by mesocorticolimbic dopamine systems. |
1997-10-23 |
2023-08-12 |
rat |
| P M Callahan, R De La Garza, K A Cunningha. Mediation of the discriminative stimulus properties of cocaine by mesocorticolimbic dopamine systems. Pharmacology, biochemistry, and behavior. vol 57. issue 3. 1997-10-23. PMID:9218282. |
this paper provides a brief review of the scientific evidence implicating the mesocorticolimbic dopamine (da) system in modulating the discriminative stimulus properties of cocaine in rats. |
1997-10-23 |
2023-08-12 |
rat |
| P M Callahan, R De La Garza, K A Cunningha. Mediation of the discriminative stimulus properties of cocaine by mesocorticolimbic dopamine systems. Pharmacology, biochemistry, and behavior. vol 57. issue 3. 1997-10-23. PMID:9218282. |
dopamine d1 and d2 receptor antagonists attenuate this behavioral property of cocaine. |
1997-10-23 |
2023-08-12 |
rat |
| N H Chen, J H Ding, Y L Wang, M E Reit. Potential misconceptions in dopamine transporter assays arising from the binding of [125I]RTI-121 to filters: effect of ions and cocaine. Journal of neuroscience methods. vol 75. issue 2. 1997-10-23. PMID:9288650. |
potential misconceptions in dopamine transporter assays arising from the binding of [125i]rti-121 to filters: effect of ions and cocaine. |
1997-10-23 |
2023-08-12 |
rat |
| N H Chen, J H Ding, Y L Wang, M E Reit. Potential misconceptions in dopamine transporter assays arising from the binding of [125I]RTI-121 to filters: effect of ions and cocaine. Journal of neuroscience methods. vol 75. issue 2. 1997-10-23. PMID:9288650. |
binding of the cocaine analog 3 beta-(4-[125i]iodophenyl)tropane-2 beta-carboxylic acid isopropyl ester ([125i]rti-121) to filters was studied in order to assess its contribution to labeling dopamine transporters on rat striatal synaptosomal membranes in filtration assays. |
1997-10-23 |
2023-08-12 |
rat |