| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J B Daunais, S L Hart, A Hedgecock-Rowe, J J Matasi, C Thornley, H M Davies, L J Porrin. Alterations in behavior and opioid gene expression induced by the novel tropane analog WF-31. Brain research. Molecular brain research. vol 50. issue 1-2. 1998-02-19. PMID:9406946. |
the effects of the acute administration of the serotonin-selective tropane analog, [2beta-propanoyl-3beta-(4-isopropylphenyl)-tropane, wf-31, on spontaneous locomotor activity were measured and compared to those of the highly selective serotonin uptake inhibitor, fluoxetine and cocaine, a non-selective re-uptake inhibitor of dopamine and serotonin. |
1998-02-19 |
2023-08-12 |
rat |
| N D Volkow, G J Wang, J S Fowler, R Hitzemann, S J Gatley, S S Dewey, N Pappa. Enhanced sensitivity to benzodiazepines in active cocaine-abusing subjects: a PET study. The American journal of psychiatry. vol 155. issue 2. 1998-02-19. PMID:9464198. |
because cocaine enhances dopamine brain activity and dopamine signals are transferred through gamma-aminobutyric acid pathways, the authors hypothesized gaba-ergic disruption in cocaine-abusing subjects. |
1998-02-19 |
2023-08-12 |
human |
| G Skuza, Z Rogóz, A Wieczore. Neuropsychopharmacological profile of remoxipride in comparison with clozapine. Polish journal of pharmacology. vol 49. issue 1. 1998-02-18. PMID:9431546. |
moreover, it markedly decreased quinpirole (dopamine d2/3 receptor agonist)-induced hyperactivity of rats, and less potently inhibited stimulatory activity induced by cocaine and mk-801 (non-competitive nmda receptor antagonist). |
1998-02-18 |
2023-08-12 |
mouse |
| M Filip, E Przegalińsk. The role of dopamine receptor subtypes in the discriminative stimulus effects of amphetamine and cocaine in rats. Polish journal of pharmacology. vol 49. issue 1. 1998-02-18. PMID:9431548. |
the role of dopamine (da) receptor subtypes in the discriminative stimuli of the psychostimulant drugs of abuse amphetamine and cocaine was evaluated by the ability of da d1, d2 and d3 receptor subtype ligands to either substitute for or antagonize these effects. |
1998-02-18 |
2023-08-12 |
rat |
| G E Agoston, J H Wu, S Izenwasser, C George, J Katz, R H Kline, A H Newma. Novel N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues: selective ligands for the dopamine transporter. Journal of medicinal chemistry. vol 40. issue 26. 1998-02-13. PMID:9435902. |
additionally, the most potent and selective analogue in this series at the dopamine transporter, n-(4"-phenyl-n-butyl)-3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogue failed to substitute for cocaine in rats trained to discriminate cocaine from saline. |
1998-02-13 |
2023-08-12 |
rat |
| G E Agoston, J H Wu, S Izenwasser, C George, J Katz, R H Kline, A H Newma. Novel N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues: selective ligands for the dopamine transporter. Journal of medicinal chemistry. vol 40. issue 26. 1998-02-13. PMID:9435902. |
potentially, new leads toward the development of a pharmacotherapeutic for cocaine abuse and other disorders affecting the dopamine transporter may be discovered. |
1998-02-13 |
2023-08-12 |
rat |
| S M Husbands, S Izenwasser, R J Loeloff, J L Katz, W D Bowen, B J Vilner, A H Newma. Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole): irreversible ligands for the dopamine transporter. Journal of medicinal chemistry. vol 40. issue 26. 1998-02-13. PMID:9435903. |
cocaine has been reported to bind to the dopamine transporter in a biphasic fashion, and it has been hypothesized that the low-affinity component may play a modulatory role in cocaine's psychomotor stimulant effects. |
1998-02-13 |
2023-08-12 |
Not clear |
| S A Lomenzo, S Izenwasser, J L Katz, P D Terry, N Zhu, C L Klein, M L Trudel. Synthesis, structure, dopamine transporter affinity, and dopamine uptake inhibition of 6-alkyl-3-benzyl-2-[(methoxycarbonyl)methyl]tropane derivatives. Journal of medicinal chemistry. vol 40. issue 26. 1998-02-13. PMID:9435910. |
a series of 6-alkyl-3 beta-benzyl-2-[(methoxycarbonyl)methyl]tropane analogues were synthesized and evaluated as cocaine binding site ligands at the dopamine transporter (dat). |
1998-02-13 |
2023-08-12 |
rat |
| S A Lomenzo, S Izenwasser, J L Katz, P D Terry, N Zhu, C L Klein, M L Trudel. Synthesis, structure, dopamine transporter affinity, and dopamine uptake inhibition of 6-alkyl-3-benzyl-2-[(methoxycarbonyl)methyl]tropane derivatives. Journal of medicinal chemistry. vol 40. issue 26. 1998-02-13. PMID:9435910. |
the unsubstituted enantiopure analogues (-)-19a (ki = 33 nm) and surprisingly (+)-20a (ki = 60 nm) were found to be almost equipotent with the high-affinity binding components of cocaine and win 35,065-2 and exhibited slightly more potent dopamine uptake inhibition than both cocaine and win 35,065-2. |
1998-02-13 |
2023-08-12 |
rat |
| C Lundkvist, C Halldin, N Ginovart, C G Swahn, L Fard. [18F] beta-CIT-FP is superior to [11C] beta-CIT-FP for quantitation of the dopamine transporter. Nuclear medicine and biology. vol 24. issue 7. 1998-02-12. PMID:9352532. |
beta-cit-fp [n-(3-fluoropropyl)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)nortropane] is a cocaine analogue with high affinity for the dopamine transporter. |
1998-02-12 |
2023-08-12 |
human |
| S A Burchett, M J Banno. Serotonin, dopamine and norepinephrine transporter mRNAs: heterogeneity of distribution and response to 'binge' cocaine administration. Brain research. Molecular brain research. vol 49. issue 1-2. 1998-02-11. PMID:9387868. |
serotonin, dopamine and norepinephrine transporter mrnas: heterogeneity of distribution and response to 'binge' cocaine administration. |
1998-02-11 |
2023-08-12 |
rat |
| N K Mello, J H Mendelson, M Kelly, N Diaz-Migoyo, J W Shola. Dopamine infusion does not alter LH levels before or after chronic cocaine exposure in female rhesus monkeys. Pharmacology, biochemistry, and behavior. vol 58. issue 3. 1998-02-06. PMID:9329077. |
dopamine infusion does not alter lh levels before or after chronic cocaine exposure in female rhesus monkeys. |
1998-02-06 |
2023-08-12 |
monkey |
| N K Mello, J H Mendelson, M Kelly, N Diaz-Migoyo, J W Shola. Dopamine infusion does not alter LH levels before or after chronic cocaine exposure in female rhesus monkeys. Pharmacology, biochemistry, and behavior. vol 58. issue 3. 1998-02-06. PMID:9329077. |
cocaine stimulates release of luteinizing hormone (lh) in preclinical and clinical studies but the contribution of the indirect dopamine agonist actions of cocaine to its effects on lh are unclear. |
1998-02-06 |
2023-08-12 |
monkey |
| N K Mello, J H Mendelson, M Kelly, N Diaz-Migoyo, J W Shola. Dopamine infusion does not alter LH levels before or after chronic cocaine exposure in female rhesus monkeys. Pharmacology, biochemistry, and behavior. vol 58. issue 3. 1998-02-06. PMID:9329077. |
to determine whether chronic cocaine exposure influenced the effect of dopamine on lh, rhesus females were studied after more than 2 years of cocaine self-administration at an average dose of 6.5 +/- 0.2 mg/kg/day. |
1998-02-06 |
2023-08-12 |
monkey |
| N K Mello, J H Mendelson, M Kelly, N Diaz-Migoyo, J W Shola. Dopamine infusion does not alter LH levels before or after chronic cocaine exposure in female rhesus monkeys. Pharmacology, biochemistry, and behavior. vol 58. issue 3. 1998-02-06. PMID:9329077. |
similarly, during withdrawal from cocaine, baseline lh levels averaged 32.1 +/- 4.5 ng/ml, and lh did not change significantly during dopamine infusions (31.2 +/- 1.1 ng/ml) and infusion interruptions (32.1 +/- 1.1 ng/ml). |
1998-02-06 |
2023-08-12 |
monkey |
| N K Mello, J H Mendelson, M Kelly, N Diaz-Migoyo, J W Shola. Dopamine infusion does not alter LH levels before or after chronic cocaine exposure in female rhesus monkeys. Pharmacology, biochemistry, and behavior. vol 58. issue 3. 1998-02-06. PMID:9329077. |
moreover, these data suggest that the stimulation of lh by cocaine may not be explained by its indirect dopamine agonist actions. |
1998-02-06 |
2023-08-12 |
monkey |
| G Tanda, F E Pontieri, R Frau, G Di Chiar. Contribution of blockade of the noradrenaline carrier to the increase of extracellular dopamine in the rat prefrontal cortex by amphetamine and cocaine. The European journal of neuroscience. vol 9. issue 10. 1998-02-04. PMID:9421168. |
contribution of blockade of the noradrenaline carrier to the increase of extracellular dopamine in the rat prefrontal cortex by amphetamine and cocaine. |
1998-02-04 |
2023-08-12 |
rat |
| F J White, A Joshi, T E Koeltzow, X T H. Dopamine receptor antagonists fail to prevent induction of cocaine sensitization. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 18. issue 1. 1998-01-30. PMID:9408916. |
we investigated the ability of dopamine d1 and d2 class receptor antagonists to prevent the induction of behavioral sensitization to cocaine. |
1998-01-30 |
2023-08-12 |
Not clear |
| F J White, A Joshi, T E Koeltzow, X T H. Dopamine receptor antagonists fail to prevent induction of cocaine sensitization. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 18. issue 1. 1998-01-30. PMID:9408916. |
we conclude that dopamine receptors are either not involved in the induction of cocaine sensitization or that redundant mechanisms exist to produce the same neuroadaptations. |
1998-01-30 |
2023-08-12 |
Not clear |
| Y M Wang, R R Gainetdinov, F Fumagalli, F Xu, S R Jones, C B Bock, G W Miller, R M Wightman, M G Caro. Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine. Neuron. vol 19. issue 6. 1998-01-29. PMID:9427251. |
the observed changes in presynaptic homeostasis are accompanied by a pronounced supersensitivity of the mice to the locomotor effects of the dopamine agonist apomorphine, the psychostimulants cocaine and amphetamine, and ethanol. |
1998-01-29 |
2023-08-12 |
mouse |