| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Karler, L D Calder, D K Thai, J B Bedingfiel. The role of dopamine and GABA in the frontal cortex of mice in modulating a motor-stimulant effect of amphetamine and cocaine. Pharmacology, biochemistry, and behavior. vol 60. issue 1. 1998-07-27. PMID:9610948. |
the present studies were designed to investigate the cortical influence of dopamine and gaba agonists and antagonists on the motor response to systemically administered amphetamine and cocaine in the mouse. |
1998-07-27 |
2023-08-12 |
mouse |
| M L'hirondel, A Chéramy, G Godeheu, F Artaud, A Saiardi, E Borrelli, J Glowinsk. Lack of autoreceptor-mediated inhibitory control of dopamine release in striatal synaptosomes of D2 receptor-deficient mice. Brain research. vol 792. issue 2. 1998-07-20. PMID:9593923. |
interestingly, while amphetamine-induced release of [3h]-da was not modified, a slight reduction of [3h]-da efflux induced by the dopamine (da) uptake inhibitor cocaine was observed in d2 receptor-deficient mice. |
1998-07-20 |
2023-08-12 |
mouse |
| L T Tran-Nguyen, R A Fuchs, G P Coffey, D A Baker, L E O'Dell, J L Neisewande. Time-dependent changes in cocaine-seeking behavior and extracellular dopamine levels in the amygdala during cocaine withdrawal. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 19. issue 1. 1998-07-20. PMID:9608576. |
time-dependent changes in cocaine-seeking behavior and extracellular dopamine levels in the amygdala during cocaine withdrawal. |
1998-07-20 |
2023-08-12 |
rat |
| C Zhang, S Izenwasser, J L Katz, P D Terry, M L Trudel. Synthesis and dopamine transporter affinity of the four stereoisomers of (+/-)-2-(methoxycarbonyl)-7-methyl-3-phenyl-7-azabicyclo[2.2.1]heptane. Journal of medicinal chemistry. vol 41. issue 13. 1998-07-09. PMID:9632375. |
1]heptane were synthesized and evaluated as cocaine binding site ligands at the dopamine transporter. |
1998-07-09 |
2023-08-12 |
rat |
| J W Tidey, J Bergma. Drug discrimination in methamphetamine-trained monkeys: agonist and antagonist effects of dopaminergic drugs. The Journal of pharmacology and experimental therapeutics. vol 285. issue 3. 1998-07-02. PMID:9618419. |
injections of 0.3 mg/kg methamphetamine from saline, methamphetamine (0.03-0.3 mg/kg), cocaine (0.1-1.0 mg/kg) and the selective dopamine uptake inhibitor, gbr 12909 (3.0-17.8 mg/kg) produced dose-related increases in responding on the methamphetamine-associated lever and, at the highest doses, full substitution. |
1998-07-02 |
2023-08-12 |
monkey |
| J B Daunais, S L Hart, H R Smith, S R Letchworth, H M Davies, T Sexton, B A Bennett, S R Childers, L J Porrin. Long-acting blockade of biogenic amine transporters in rat brain by administration of the potent novel tropane 2beta-propanoyl-3beta-(2-Naphthyl)-tropane. The Journal of pharmacology and experimental therapeutics. vol 285. issue 3. 1998-07-02. PMID:9618429. |
2beta-propanoyl-3beta-(2-naphthyl)-tropane (wf-23) is a potent cocaine analog with activity at dopamine and serotonin transporters. |
1998-07-02 |
2023-08-12 |
rat |
| A J Fischman, A A Bonab, J W Babich, E P Palmer, N M Alpert, D R Elmaleh, R J Callahan, S A Barrow, W Graham, P C Meltzer, R N Hanson, B K Madra. Rapid detection of Parkinson's disease by SPECT with altropane: a selective ligand for dopamine transporters. Synapse (New York, N.Y.). vol 29. issue 2. 1998-07-01. PMID:9593103. |
2beta-carbomethoxy-3beta-(4-fluorophenyl)-n-(1-iodoprop-1-en -3-yl) nortropane (iacft, altropane) is a cocaine analog with high affinity and selectivity for dopamine transporter (dat) sites in the striatum. |
1998-07-01 |
2023-08-12 |
human |
| U Scheffel, Z Szabo, W B Mathews, P A Finley, R F Dannals, H T Ravert, K Szabo, J Yuan, G A Ricaurt. In vivo detection of short- and long-term MDMA neurotoxicity--a positron emission tomography study in the living baboon brain. Synapse (New York, N.Y.). vol 29. issue 2. 1998-07-01. PMID:9593108. |
the present study evaluated short- and long-term effects of mdma (3,4-methylenedioxymethamphetamine) in the baboon brain using pet and [11c](+)mcn 5652, a potent 5-ht transporter ligand, as well as [11c]rti-55, a cocaine derivative which labels both 5-ht and dopamine transporters. |
1998-07-01 |
2023-08-12 |
human |
| M Froimowitz, C Georg. Conformational analysis and a crystal structure of bupropion, an antidepressant with dopamine reuptake blocking activity. Journal of chemical information and computer sciences. vol 38. issue 3. 1998-06-29. PMID:9611786. |
the three-dimensional structure of the preferred conformer of bupropion is consistent with the three-dimensional structures of other dopamine reuptake blockers such as cocaine, cft, and methylphenidate. |
1998-06-29 |
2023-08-12 |
Not clear |
| R T Malison, S E Best, C H van Dyck, E F McCance, E A Wallace, M Laruelle, R M Baldwin, J P Seibyl, L H Price, T R Kosten, R B Inni. Elevated striatal dopamine transporters during acute cocaine abstinence as measured by [123I] beta-CIT SPECT. The American journal of psychiatry. vol 155. issue 6. 1998-06-18. PMID:9619159. |
elevated striatal dopamine transporters during acute cocaine abstinence as measured by [123i] beta-cit spect. |
1998-06-18 |
2023-08-12 |
human |
| A P Kozikowski, G L Araldi, J Boja, W M Meil, K M Johnson, J L Flippen-Anderson, C George, E Saia. Chemistry and pharmacology of the piperidine-based analogues of cocaine. Identification of potent DAT inhibitors lacking the tropane skeleton. Journal of medicinal chemistry. vol 41. issue 11. 1998-06-15. PMID:9599245. |
this simple piperidine is thus 33-fold more potent than cocaine in binding affinity and 29-fold more potent in its inhibition of dopamine uptake. |
1998-06-15 |
2023-08-12 |
mouse |
| S H Lee, S S Kang, H Son, Y S Le. The region of dopamine transporter encompassing the 3rd transmembrane domain is crucial for function. Biochemical and biophysical research communications. vol 246. issue 2. 1998-06-15. PMID:9610361. |
bovine dopamine transporter (bdat) shows relatively low dopamine (da) uptake efficacy and scant mpp+ transport and cocaine binding, while all of these activities are avid in human dopamine transporter (hdat). |
1998-06-15 |
2023-08-12 |
human |
| E Przegaliński, M Fili. Nitric oxide (NO) pathway and locomotor hyperactivity towards dopaminomimetics in rats. Polish journal of pharmacology. vol 49. issue 5. 1998-05-27. PMID:9566027. |
the effects of the no donor molsidomine and the inhibitors of the no synthase (nos) 7-nitroindazole (7-ni) and ng-nitro-l-arginine methyl ester (l-name) on the motor hyperactivity induced by indirect (amphetamine and cocaine) or direct (skf 38393 and bromocriptine) dopamine (da) agonists were studied in rats. |
1998-05-27 |
2023-08-12 |
rat |
| L D Middaugh, K K McGroarty, C H Groseclose, B Adinof. Cocaine discrimination: relationship to local anesthetics and monoamine uptake inhibitors in C57BL/6 mice. Psychopharmacology. vol 136. issue 1. 1998-05-21. PMID:9537681. |
in addition, mazindol, a general monoamine uptake inhibitor similar to cocaine, and nomifensine, which is relatively specific for the dopamine transporter, substituted completely for cocaine, as described for rats. |
1998-05-21 |
2023-08-12 |
mouse |
| L D Middaugh, K K McGroarty, C H Groseclose, B Adinof. Cocaine discrimination: relationship to local anesthetics and monoamine uptake inhibitors in C57BL/6 mice. Psychopharmacology. vol 136. issue 1. 1998-05-21. PMID:9537681. |
these experiments emphasize the importance of the dopamine transporter in mediating the discriminative stimulus effects of cocaine in c57 mice. |
1998-05-21 |
2023-08-12 |
mouse |
| H Wayment, S M Meiergerd, J O Schen. Relationships between the catechol substrate binding site and amphetamine, cocaine, and mazindol binding sites in a kinetic model of the striatal transporter of dopamine in vitro. Journal of neurochemistry. vol 70. issue 5. 1998-05-18. PMID:9572278. |
relationships between the catechol substrate binding site and amphetamine, cocaine, and mazindol binding sites in a kinetic model of the striatal transporter of dopamine in vitro. |
1998-05-18 |
2023-08-12 |
Not clear |
| P M Kunko, D French, S Izenwasse. Alterations in locomotor activity during chronic cocaine administration: effect on dopamine receptors and interaction with opioids. The Journal of pharmacology and experimental therapeutics. vol 285. issue 1. 1998-05-12. PMID:9536022. |
alterations in locomotor activity during chronic cocaine administration: effect on dopamine receptors and interaction with opioids. |
1998-05-12 |
2023-08-12 |
Not clear |
| P M Kunko, D French, S Izenwasse. Alterations in locomotor activity during chronic cocaine administration: effect on dopamine receptors and interaction with opioids. The Journal of pharmacology and experimental therapeutics. vol 285. issue 1. 1998-05-12. PMID:9536022. |
thus, continuous cocaine administration produces a rapid sensitization that is lost over the course of the treatment period, yet does not produce any immediate alterations in dopamine receptors or regulation of adenylyl cyclase. |
1998-05-12 |
2023-08-12 |
Not clear |
| D R Woolfolk, S G Holtzma. mu-, delta- and kappa-opioid receptor agonists do not alter the discriminative stimulus effects of cocaine or d-amphetamine in rats. Drug and alcohol dependence. vol 48. issue 3. 1998-05-04. PMID:9449020. |
opioid receptor agonists can modulate the activity of dopamine neurons and could therefore, modify the behavioral effects of drugs that act through the dopamine systems, such as d-amphetamine and cocaine. |
1998-05-04 |
2023-08-12 |
rat |
| M B Bowers, R T Malison, J P Seibyl, T R Koste. Plasma homovanillic acid and the dopamine transporter during cocaine withdrawal. Biological psychiatry. vol 43. issue 4. 1998-04-30. PMID:9513737. |
plasma homovanillic acid and the dopamine transporter during cocaine withdrawal. |
1998-04-30 |
2023-08-12 |
human |