| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Giustino, V Cuomo, C A Marsde. Maternal cocaine exposure alters mesolimbic dopaminergic function in rat offspring. European journal of pharmacology. vol 345. issue 2. 1998-07-27. PMID:9600634. |
in vivo microdialysis has shown that maternal cocaine exposure significantly decreases basal extracellular concentrations of dopamine in the nucleus accumbens of young-adult offspring (4 weeks after cessation of cocaine treatment). |
1998-07-27 |
2023-08-12 |
rat |
| A Giustino, V Cuomo, C A Marsde. Maternal cocaine exposure alters mesolimbic dopaminergic function in rat offspring. European journal of pharmacology. vol 345. issue 2. 1998-07-27. PMID:9600634. |
moreover, the increase in extracellular dopamine levels induced by a challenge dose of k+ (intracerebral 60 mm k+ artificial cerebrospinal fluid (acsf) infusion) or cocaine (15 mg/kg i.p.) |
1998-07-27 |
2023-08-12 |
rat |
| A Giustino, V Cuomo, C A Marsde. Maternal cocaine exposure alters mesolimbic dopaminergic function in rat offspring. European journal of pharmacology. vol 345. issue 2. 1998-07-27. PMID:9600634. |
the alterations in mesolimbic dopamine transmission observed in these experiments might underlie behavioral abnormalities induced in rat offspring by maternal exposure to cocaine at dose levels which do not produce gross malformations and/or overt neurotoxic effects. |
1998-07-27 |
2023-08-12 |
rat |
| N A Darman. Cocaine and selective monoamine uptake blockers (sertraline, nisoxetine, and GBR 12935) prevent the d-fenfluramine-induced head-twitch response in mice. Pharmacology, biochemistry, and behavior. vol 60. issue 1. 1998-07-27. PMID:9610928. |
because a dramatic differential potentiation in htr frequency is obtained when cocaine is administered prior relative to after l-tryptophan injection, the effects of varying doses of cocaine and the selective serotonin (sertraline), dopamine (da) (gbr 12935), and norepinephrine (ne) (nisoxetine) uptake blockers were investigated on the d-fenfluramine-induced behavior in two experimental protocols. |
1998-07-27 |
2023-08-12 |
mouse |
| A Saitoh, K Morita, M Sodeyama, J Kame. Effects of the experimental diabetes on dopamine D1 receptor-mediated locomotor-enhancing activity in mice. Pharmacology, biochemistry, and behavior. vol 60. issue 1. 1998-07-27. PMID:9610938. |
although spontaneous locomotor activity in diabetic mice was significantly greater than that in nondiabetic mice, the locomotor-enhancing effects of methamphetamine (4 mg/kg, s.c.), cocaine (20 mg/kg, s.c.) and skf82958 (1 mg/kg, s.c.), a selective dopamine d1-receptor agonist, in diabetic mice were significantly lower than those in nondiabetic mice. |
1998-07-27 |
2023-08-12 |
mouse |
| R Karler, L D Calder, D K Thai, J B Bedingfiel. The role of dopamine and GABA in the frontal cortex of mice in modulating a motor-stimulant effect of amphetamine and cocaine. Pharmacology, biochemistry, and behavior. vol 60. issue 1. 1998-07-27. PMID:9610948. |
the role of dopamine and gaba in the frontal cortex of mice in modulating a motor-stimulant effect of amphetamine and cocaine. |
1998-07-27 |
2023-08-12 |
mouse |
| R Karler, L D Calder, D K Thai, J B Bedingfiel. The role of dopamine and GABA in the frontal cortex of mice in modulating a motor-stimulant effect of amphetamine and cocaine. Pharmacology, biochemistry, and behavior. vol 60. issue 1. 1998-07-27. PMID:9610948. |
the present studies were designed to investigate the cortical influence of dopamine and gaba agonists and antagonists on the motor response to systemically administered amphetamine and cocaine in the mouse. |
1998-07-27 |
2023-08-12 |
mouse |
| M L'hirondel, A Chéramy, G Godeheu, F Artaud, A Saiardi, E Borrelli, J Glowinsk. Lack of autoreceptor-mediated inhibitory control of dopamine release in striatal synaptosomes of D2 receptor-deficient mice. Brain research. vol 792. issue 2. 1998-07-20. PMID:9593923. |
interestingly, while amphetamine-induced release of [3h]-da was not modified, a slight reduction of [3h]-da efflux induced by the dopamine (da) uptake inhibitor cocaine was observed in d2 receptor-deficient mice. |
1998-07-20 |
2023-08-12 |
mouse |
| L T Tran-Nguyen, R A Fuchs, G P Coffey, D A Baker, L E O'Dell, J L Neisewande. Time-dependent changes in cocaine-seeking behavior and extracellular dopamine levels in the amygdala during cocaine withdrawal. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 19. issue 1. 1998-07-20. PMID:9608576. |
time-dependent changes in cocaine-seeking behavior and extracellular dopamine levels in the amygdala during cocaine withdrawal. |
1998-07-20 |
2023-08-12 |
rat |
| C Zhang, S Izenwasser, J L Katz, P D Terry, M L Trudel. Synthesis and dopamine transporter affinity of the four stereoisomers of (+/-)-2-(methoxycarbonyl)-7-methyl-3-phenyl-7-azabicyclo[2.2.1]heptane. Journal of medicinal chemistry. vol 41. issue 13. 1998-07-09. PMID:9632375. |
1]heptane were synthesized and evaluated as cocaine binding site ligands at the dopamine transporter. |
1998-07-09 |
2023-08-12 |
rat |
| J W Tidey, J Bergma. Drug discrimination in methamphetamine-trained monkeys: agonist and antagonist effects of dopaminergic drugs. The Journal of pharmacology and experimental therapeutics. vol 285. issue 3. 1998-07-02. PMID:9618419. |
injections of 0.3 mg/kg methamphetamine from saline, methamphetamine (0.03-0.3 mg/kg), cocaine (0.1-1.0 mg/kg) and the selective dopamine uptake inhibitor, gbr 12909 (3.0-17.8 mg/kg) produced dose-related increases in responding on the methamphetamine-associated lever and, at the highest doses, full substitution. |
1998-07-02 |
2023-08-12 |
monkey |
| J B Daunais, S L Hart, H R Smith, S R Letchworth, H M Davies, T Sexton, B A Bennett, S R Childers, L J Porrin. Long-acting blockade of biogenic amine transporters in rat brain by administration of the potent novel tropane 2beta-propanoyl-3beta-(2-Naphthyl)-tropane. The Journal of pharmacology and experimental therapeutics. vol 285. issue 3. 1998-07-02. PMID:9618429. |
2beta-propanoyl-3beta-(2-naphthyl)-tropane (wf-23) is a potent cocaine analog with activity at dopamine and serotonin transporters. |
1998-07-02 |
2023-08-12 |
rat |
| A J Fischman, A A Bonab, J W Babich, E P Palmer, N M Alpert, D R Elmaleh, R J Callahan, S A Barrow, W Graham, P C Meltzer, R N Hanson, B K Madra. Rapid detection of Parkinson's disease by SPECT with altropane: a selective ligand for dopamine transporters. Synapse (New York, N.Y.). vol 29. issue 2. 1998-07-01. PMID:9593103. |
2beta-carbomethoxy-3beta-(4-fluorophenyl)-n-(1-iodoprop-1-en -3-yl) nortropane (iacft, altropane) is a cocaine analog with high affinity and selectivity for dopamine transporter (dat) sites in the striatum. |
1998-07-01 |
2023-08-12 |
human |
| U Scheffel, Z Szabo, W B Mathews, P A Finley, R F Dannals, H T Ravert, K Szabo, J Yuan, G A Ricaurt. In vivo detection of short- and long-term MDMA neurotoxicity--a positron emission tomography study in the living baboon brain. Synapse (New York, N.Y.). vol 29. issue 2. 1998-07-01. PMID:9593108. |
the present study evaluated short- and long-term effects of mdma (3,4-methylenedioxymethamphetamine) in the baboon brain using pet and [11c](+)mcn 5652, a potent 5-ht transporter ligand, as well as [11c]rti-55, a cocaine derivative which labels both 5-ht and dopamine transporters. |
1998-07-01 |
2023-08-12 |
human |
| M Froimowitz, C Georg. Conformational analysis and a crystal structure of bupropion, an antidepressant with dopamine reuptake blocking activity. Journal of chemical information and computer sciences. vol 38. issue 3. 1998-06-29. PMID:9611786. |
the three-dimensional structure of the preferred conformer of bupropion is consistent with the three-dimensional structures of other dopamine reuptake blockers such as cocaine, cft, and methylphenidate. |
1998-06-29 |
2023-08-12 |
Not clear |
| R T Malison, S E Best, C H van Dyck, E F McCance, E A Wallace, M Laruelle, R M Baldwin, J P Seibyl, L H Price, T R Kosten, R B Inni. Elevated striatal dopamine transporters during acute cocaine abstinence as measured by [123I] beta-CIT SPECT. The American journal of psychiatry. vol 155. issue 6. 1998-06-18. PMID:9619159. |
elevated striatal dopamine transporters during acute cocaine abstinence as measured by [123i] beta-cit spect. |
1998-06-18 |
2023-08-12 |
human |
| A P Kozikowski, G L Araldi, J Boja, W M Meil, K M Johnson, J L Flippen-Anderson, C George, E Saia. Chemistry and pharmacology of the piperidine-based analogues of cocaine. Identification of potent DAT inhibitors lacking the tropane skeleton. Journal of medicinal chemistry. vol 41. issue 11. 1998-06-15. PMID:9599245. |
this simple piperidine is thus 33-fold more potent than cocaine in binding affinity and 29-fold more potent in its inhibition of dopamine uptake. |
1998-06-15 |
2023-08-12 |
mouse |
| S H Lee, S S Kang, H Son, Y S Le. The region of dopamine transporter encompassing the 3rd transmembrane domain is crucial for function. Biochemical and biophysical research communications. vol 246. issue 2. 1998-06-15. PMID:9610361. |
bovine dopamine transporter (bdat) shows relatively low dopamine (da) uptake efficacy and scant mpp+ transport and cocaine binding, while all of these activities are avid in human dopamine transporter (hdat). |
1998-06-15 |
2023-08-12 |
human |
| E Przegaliński, M Fili. Nitric oxide (NO) pathway and locomotor hyperactivity towards dopaminomimetics in rats. Polish journal of pharmacology. vol 49. issue 5. 1998-05-27. PMID:9566027. |
the effects of the no donor molsidomine and the inhibitors of the no synthase (nos) 7-nitroindazole (7-ni) and ng-nitro-l-arginine methyl ester (l-name) on the motor hyperactivity induced by indirect (amphetamine and cocaine) or direct (skf 38393 and bromocriptine) dopamine (da) agonists were studied in rats. |
1998-05-27 |
2023-08-12 |
rat |
| L D Middaugh, K K McGroarty, C H Groseclose, B Adinof. Cocaine discrimination: relationship to local anesthetics and monoamine uptake inhibitors in C57BL/6 mice. Psychopharmacology. vol 136. issue 1. 1998-05-21. PMID:9537681. |
in addition, mazindol, a general monoamine uptake inhibitor similar to cocaine, and nomifensine, which is relatively specific for the dopamine transporter, substituted completely for cocaine, as described for rats. |
1998-05-21 |
2023-08-12 |
mouse |