| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O K Rønnekleiv, Y Fang, W S Choi, L Cha. Changes in the midbrain-rostral forebrain dopamine circuitry in the cocaine-exposed primate fetal brain. Annals of the New York Academy of Sciences. vol 846. 1998-07-31. PMID:9668406. |
however, by day 60 the midbrain of monkeys exposed to cocaine had significantly reduced expression of tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis. |
1998-07-31 |
2023-08-12 |
monkey |
| O K Rønnekleiv, Y Fang, W S Choi, L Cha. Changes in the midbrain-rostral forebrain dopamine circuitry in the cocaine-exposed primate fetal brain. Annals of the New York Academy of Sciences. vol 846. 1998-07-31. PMID:9668406. |
these findings suggest that in utero cocaine exposure has profound effects on the developing dopamine neurocircuitry. |
1998-07-31 |
2023-08-12 |
monkey |
| E Friedman, H Y Wan. Prenatal cocaine exposure alters signal transduction in the brain D1 dopamine receptor system. Annals of the New York Academy of Sciences. vol 846. 1998-07-31. PMID:9668411. |
this selective reduction in d1 dopamine receptor-mediated activation of gs protein increased in severity as the dose of cocaine administered to the pregnant dams was increased. |
1998-07-31 |
2023-08-12 |
rabbit |
| E Friedman, H Y Wan. Prenatal cocaine exposure alters signal transduction in the brain D1 dopamine receptor system. Annals of the New York Academy of Sciences. vol 846. 1998-07-31. PMID:9668411. |
the data also indicate that in utero cocaine exposure causes persistent uncoupling of the d1 dopamine receptors from their associated gs protein which appears as early as gestational day 22 and persists to postnatal day 100. |
1998-07-31 |
2023-08-12 |
rabbit |
| E Friedman, H Y Wan. Prenatal cocaine exposure alters signal transduction in the brain D1 dopamine receptor system. Annals of the New York Academy of Sciences. vol 846. 1998-07-31. PMID:9668411. |
the resultant attenuated d1 dopamine receptor-mediated signaling may ultimately underlie both long-lasting behavioral dysfunction and morphologic changes which are associated with prenatal cocaine exposure in the rabbit. |
1998-07-31 |
2023-08-12 |
rabbit |
| R M Costanza, P Terr. The dopamine D4 receptor antagonist L-745,870: effects in rats discriminating cocaine from saline. European journal of pharmacology. vol 345. issue 2. 1998-07-27. PMID:9600627. |
the dopamine d4 receptor antagonist l-745,870: effects in rats discriminating cocaine from saline. |
1998-07-27 |
2023-08-12 |
rat |
| R M Costanza, P Terr. The dopamine D4 receptor antagonist L-745,870: effects in rats discriminating cocaine from saline. European journal of pharmacology. vol 345. issue 2. 1998-07-27. PMID:9600627. |
the contribution of dopamine d4 receptors to the discriminative stimulus effects of cocaine was evaluated by testing the selective dopamine d4 receptor antagonist, l-745,870 (3-([4-(4-chlororphenyl) piperazin-1-yl] methyl)-1 h-pyrrolo[2,3-b] pyridine), alone and in combination with cocaine, in rats trained to discriminate cocaine (10 mg/kg) from saline. |
1998-07-27 |
2023-08-12 |
rat |
| R M Costanza, P Terr. The dopamine D4 receptor antagonist L-745,870: effects in rats discriminating cocaine from saline. European journal of pharmacology. vol 345. issue 2. 1998-07-27. PMID:9600627. |
results suggest that dopamine d4 receptors play a negligible role in cocaine's discriminative stimulus effects, and further support a critical involvement of dopamine d1-like receptors. |
1998-07-27 |
2023-08-12 |
rat |
| A Giustino, V Cuomo, C A Marsde. Maternal cocaine exposure alters mesolimbic dopaminergic function in rat offspring. European journal of pharmacology. vol 345. issue 2. 1998-07-27. PMID:9600634. |
in vivo microdialysis has shown that maternal cocaine exposure significantly decreases basal extracellular concentrations of dopamine in the nucleus accumbens of young-adult offspring (4 weeks after cessation of cocaine treatment). |
1998-07-27 |
2023-08-12 |
rat |
| A Giustino, V Cuomo, C A Marsde. Maternal cocaine exposure alters mesolimbic dopaminergic function in rat offspring. European journal of pharmacology. vol 345. issue 2. 1998-07-27. PMID:9600634. |
moreover, the increase in extracellular dopamine levels induced by a challenge dose of k+ (intracerebral 60 mm k+ artificial cerebrospinal fluid (acsf) infusion) or cocaine (15 mg/kg i.p.) |
1998-07-27 |
2023-08-12 |
rat |
| A Giustino, V Cuomo, C A Marsde. Maternal cocaine exposure alters mesolimbic dopaminergic function in rat offspring. European journal of pharmacology. vol 345. issue 2. 1998-07-27. PMID:9600634. |
the alterations in mesolimbic dopamine transmission observed in these experiments might underlie behavioral abnormalities induced in rat offspring by maternal exposure to cocaine at dose levels which do not produce gross malformations and/or overt neurotoxic effects. |
1998-07-27 |
2023-08-12 |
rat |
| N A Darman. Cocaine and selective monoamine uptake blockers (sertraline, nisoxetine, and GBR 12935) prevent the d-fenfluramine-induced head-twitch response in mice. Pharmacology, biochemistry, and behavior. vol 60. issue 1. 1998-07-27. PMID:9610928. |
because a dramatic differential potentiation in htr frequency is obtained when cocaine is administered prior relative to after l-tryptophan injection, the effects of varying doses of cocaine and the selective serotonin (sertraline), dopamine (da) (gbr 12935), and norepinephrine (ne) (nisoxetine) uptake blockers were investigated on the d-fenfluramine-induced behavior in two experimental protocols. |
1998-07-27 |
2023-08-12 |
mouse |
| A Saitoh, K Morita, M Sodeyama, J Kame. Effects of the experimental diabetes on dopamine D1 receptor-mediated locomotor-enhancing activity in mice. Pharmacology, biochemistry, and behavior. vol 60. issue 1. 1998-07-27. PMID:9610938. |
although spontaneous locomotor activity in diabetic mice was significantly greater than that in nondiabetic mice, the locomotor-enhancing effects of methamphetamine (4 mg/kg, s.c.), cocaine (20 mg/kg, s.c.) and skf82958 (1 mg/kg, s.c.), a selective dopamine d1-receptor agonist, in diabetic mice were significantly lower than those in nondiabetic mice. |
1998-07-27 |
2023-08-12 |
mouse |
| R Karler, L D Calder, D K Thai, J B Bedingfiel. The role of dopamine and GABA in the frontal cortex of mice in modulating a motor-stimulant effect of amphetamine and cocaine. Pharmacology, biochemistry, and behavior. vol 60. issue 1. 1998-07-27. PMID:9610948. |
the role of dopamine and gaba in the frontal cortex of mice in modulating a motor-stimulant effect of amphetamine and cocaine. |
1998-07-27 |
2023-08-12 |
mouse |
| R Karler, L D Calder, D K Thai, J B Bedingfiel. The role of dopamine and GABA in the frontal cortex of mice in modulating a motor-stimulant effect of amphetamine and cocaine. Pharmacology, biochemistry, and behavior. vol 60. issue 1. 1998-07-27. PMID:9610948. |
the present studies were designed to investigate the cortical influence of dopamine and gaba agonists and antagonists on the motor response to systemically administered amphetamine and cocaine in the mouse. |
1998-07-27 |
2023-08-12 |
mouse |
| M L'hirondel, A Chéramy, G Godeheu, F Artaud, A Saiardi, E Borrelli, J Glowinsk. Lack of autoreceptor-mediated inhibitory control of dopamine release in striatal synaptosomes of D2 receptor-deficient mice. Brain research. vol 792. issue 2. 1998-07-20. PMID:9593923. |
interestingly, while amphetamine-induced release of [3h]-da was not modified, a slight reduction of [3h]-da efflux induced by the dopamine (da) uptake inhibitor cocaine was observed in d2 receptor-deficient mice. |
1998-07-20 |
2023-08-12 |
mouse |
| L T Tran-Nguyen, R A Fuchs, G P Coffey, D A Baker, L E O'Dell, J L Neisewande. Time-dependent changes in cocaine-seeking behavior and extracellular dopamine levels in the amygdala during cocaine withdrawal. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 19. issue 1. 1998-07-20. PMID:9608576. |
time-dependent changes in cocaine-seeking behavior and extracellular dopamine levels in the amygdala during cocaine withdrawal. |
1998-07-20 |
2023-08-12 |
rat |
| C Zhang, S Izenwasser, J L Katz, P D Terry, M L Trudel. Synthesis and dopamine transporter affinity of the four stereoisomers of (+/-)-2-(methoxycarbonyl)-7-methyl-3-phenyl-7-azabicyclo[2.2.1]heptane. Journal of medicinal chemistry. vol 41. issue 13. 1998-07-09. PMID:9632375. |
1]heptane were synthesized and evaluated as cocaine binding site ligands at the dopamine transporter. |
1998-07-09 |
2023-08-12 |
rat |
| J W Tidey, J Bergma. Drug discrimination in methamphetamine-trained monkeys: agonist and antagonist effects of dopaminergic drugs. The Journal of pharmacology and experimental therapeutics. vol 285. issue 3. 1998-07-02. PMID:9618419. |
injections of 0.3 mg/kg methamphetamine from saline, methamphetamine (0.03-0.3 mg/kg), cocaine (0.1-1.0 mg/kg) and the selective dopamine uptake inhibitor, gbr 12909 (3.0-17.8 mg/kg) produced dose-related increases in responding on the methamphetamine-associated lever and, at the highest doses, full substitution. |
1998-07-02 |
2023-08-12 |
monkey |
| J B Daunais, S L Hart, H R Smith, S R Letchworth, H M Davies, T Sexton, B A Bennett, S R Childers, L J Porrin. Long-acting blockade of biogenic amine transporters in rat brain by administration of the potent novel tropane 2beta-propanoyl-3beta-(2-Naphthyl)-tropane. The Journal of pharmacology and experimental therapeutics. vol 285. issue 3. 1998-07-02. PMID:9618429. |
2beta-propanoyl-3beta-(2-naphthyl)-tropane (wf-23) is a potent cocaine analog with activity at dopamine and serotonin transporters. |
1998-07-02 |
2023-08-12 |
rat |