| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Y Little, D P McLaughlin, L Zhang, P R McFinton, G W Dalack, E H Cook, B J Cassin, S J Watso. Brain dopamine transporter messenger RNA and binding sites in cocaine users: a postmortem study. Archives of general psychiatry. vol 55. issue 9. 1998-09-16. PMID:9736005. |
results of recent radioligand binding experiments suggest that chronic cocaine exposure increases dopamine transporter (dat) synthesis throughout the striatum of humans. |
1998-09-16 |
2023-08-12 |
Not clear |
| J V Ferrer, J A Javitc. Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 16. 1998-09-08. PMID:9689064. |
cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter. |
1998-09-08 |
2023-08-12 |
human |
| J V Ferrer, J A Javitc. Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 16. 1998-09-08. PMID:9689064. |
cocaine and other psychostimulants act by blocking the dopamine transporter. |
1998-09-08 |
2023-08-12 |
human |
| J V Ferrer, J A Javitc. Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 16. 1998-09-08. PMID:9689064. |
binding of the cocaine analog, [3h]2-beta-carbomethoxy-3-beta-(4-fluorophenyl) tropane (cft) to the dopamine transporter is sensitive to polar sulfhydryl-specific derivatives of methanethiosulfonate (mts). |
1998-09-08 |
2023-08-12 |
human |
| G Le Pen, D Duterte-Boucher, J Costenti. Sensitization to the rewarding effects of the specific dopamine uptake inhibitor GBR12783. The Journal of pharmacology and experimental therapeutics. vol 286. issue 2. 1998-09-02. PMID:9694922. |
the conditioned place preference (cpp) induced by increasing doses (1.25-40 mg/kg) of cocaine or the specific dopamine uptake inhibitor gbr12783 was investigated in rats previously treated with cocaine (10 or 20 mg/kg), gbr12783 (10 mg/kg) or morphine (10 mg/kg) for 15 days. |
1998-09-02 |
2023-08-12 |
rat |
| G Le Pen, D Duterte-Boucher, J Costenti. Sensitization to the rewarding effects of the specific dopamine uptake inhibitor GBR12783. The Journal of pharmacology and experimental therapeutics. vol 286. issue 2. 1998-09-02. PMID:9694922. |
however, prior exposure to morphine sensitized the rats to the rewarding effects of cocaine (2.5 mg/kg) but not to those of gbr12783, suggesting that other mechanisms working in concert with dopamine may facilitate the rewarding effect of cocaine without affecting that of gbr12783. |
1998-09-02 |
2023-08-12 |
rat |
| M Jabe. [Dopamine control of neuroendocrine functions. New findings based on the study of transgenic animals]. Annales d'endocrinologie. vol 58. issue 6. 1998-09-01. PMID:9686001. |
a special emphasis is made on the consequences of the knock out of the dopamine transporter where our results establish not only the central importance of the transporter as the key element controlling da levels in the brain and pituitary, but also its role as an obligatory target for the behavioral and biochemical action of amphetamine and cocaine. |
1998-09-01 |
2023-08-12 |
mouse |
| T Lenhard, K Marheineke, B Lingen, W Haase, R Hammermann, H Michel, H Reilände. Characterization of the human dopamine transporter heterologously expressed in BHK-21 cells. Cellular and molecular neurobiology. vol 18. issue 3. 1998-08-31. PMID:9590564. |
electroporation of in vitro transcribed mrna from this plasmid into bhk-21 cells resulted in production of the transporter as measured by [3h]dopamine uptake (km = 2.0 +/- 0.4 microm), which was specifically inhibited in the presence of cocaine. |
1998-08-31 |
2023-08-12 |
human |
| K Y Little, F I Carroll, J D Butt. Striatal [125I]RTI-55 binding sites in cocaine-abusing humans. Progress in neuro-psychopharmacology & biological psychiatry. vol 22. issue 3. 1998-08-31. PMID:9612843. |
evidence from the present and earlier experiments suggests that cocaine exposure may induce conformational changes in the dopamine transporter. |
1998-08-31 |
2023-08-12 |
human |
| S M Antelman, A R Caggiula, B J Kucinski, H Fowler, S Gershon, D J Edwards, M C Austin, R Stiller, S Kiss, D Koca. The effects of lithium on a potential cycling model of bipolar disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 22. issue 3. 1998-08-31. PMID:9612846. |
in order to test whether such cycling might be of potential relevance to bipolar disorder, the authors examined whether cocaine-induced cyclicity of amphetamine-evoked efflux of dopamine from slices of rat nucleus accumbens and striatum and/or cocaine induced oscillation of a behavior, stress-induced hypoalgesia, could be prevented by lithium, the agent of choice in treating this disease. |
1998-08-31 |
2023-08-12 |
rat |
| C E Maggos, H Tsukada, T Kakiuchi, S Nishiyama, J E Myers, J Kreuter, S D Schlussman, E M Unterwald, A Ho, M J Kree. Sustained withdrawal allows normalization of in vivo [11C]N-methylspiperone dopamine D2 receptor binding after chronic binge cocaine: a positron emission tomography study in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 19. issue 2. 1998-08-21. PMID:9629568. |
sustained withdrawal allows normalization of in vivo [11c]n-methylspiperone dopamine d2 receptor binding after chronic binge cocaine: a positron emission tomography study in rats. |
1998-08-21 |
2023-08-12 |
rat |
| C E Maggos, H Tsukada, T Kakiuchi, S Nishiyama, J E Myers, J Kreuter, S D Schlussman, E M Unterwald, A Ho, M J Kree. Sustained withdrawal allows normalization of in vivo [11C]N-methylspiperone dopamine D2 receptor binding after chronic binge cocaine: a positron emission tomography study in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 19. issue 2. 1998-08-21. PMID:9629568. |
we have found that [11c]sch23390 binding to dopamine d1 receptors returns to saline control levels within ten days withdrawal from chronic binge cocaine and remains at control levels after 21 days withdrawal. |
1998-08-21 |
2023-08-12 |
rat |
| C E Maggos, H Tsukada, T Kakiuchi, S Nishiyama, J E Myers, J Kreuter, S D Schlussman, E M Unterwald, A Ho, M J Kree. Sustained withdrawal allows normalization of in vivo [11C]N-methylspiperone dopamine D2 receptor binding after chronic binge cocaine: a positron emission tomography study in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 19. issue 2. 1998-08-21. PMID:9629568. |
the apparent recovery of dopamine d2 receptors after prolonged abstinence from chronic cocaine and the different rates of normalization for dopamine d1 versus d2 receptors may be critical information for development of pharmacotherapies for cocaine dependent patients. |
1998-08-21 |
2023-08-12 |
rat |
| L H Parsons, T M Kerr, F Weis. Simple microbore high-performance liquid chromatographic method for the determination of dopamine and cocaine from a single in vivo brain microdialysis sample. Journal of chromatography. B, Biomedical sciences and applications. vol 709. issue 1. 1998-08-21. PMID:9653924. |
simple microbore high-performance liquid chromatographic method for the determination of dopamine and cocaine from a single in vivo brain microdialysis sample. |
1998-08-21 |
2023-08-12 |
rat |
| L H Parsons, T M Kerr, F Weis. Simple microbore high-performance liquid chromatographic method for the determination of dopamine and cocaine from a single in vivo brain microdialysis sample. Journal of chromatography. B, Biomedical sciences and applications. vol 709. issue 1. 1998-08-21. PMID:9653924. |
a microbore chromatographic method for the analysis of both dopamine and cocaine from in vivo brain microdialysis samples is described. |
1998-08-21 |
2023-08-12 |
rat |
| L H Parsons, T M Kerr, F Weis. Simple microbore high-performance liquid chromatographic method for the determination of dopamine and cocaine from a single in vivo brain microdialysis sample. Journal of chromatography. B, Biomedical sciences and applications. vol 709. issue 1. 1998-08-21. PMID:9653924. |
estimates of dialysate dopamine and cocaine concentrations after 5, 10 and 20 mg/kg cocaine (i.p.) |
1998-08-21 |
2023-08-12 |
rat |
| G D Borasio, R Linke, J Schwarz, V Schlamp, A Abel, P D Mozley, K Tatsc. Dopaminergic deficit in amyotrophic lateral sclerosis assessed with [I-123] IPT single photon emission computed tomography. Journal of neurology, neurosurgery, and psychiatry. vol 65. issue 2. 1998-08-20. PMID:9703186. |
dopamine transporter imaging was performed in 18 patients with sporadic amyotrophic lateral sclerosis (als) and 11 age matched controls with [i-123] ipt (n-(3-iodopropen-2-yl)-2beta-carbomethoxy-3beta(4-chlorophen yl)-tropane), a new cocaine analogue that selectively binds to the dopamine transporter located on dopaminergic nerve terminals. |
1998-08-20 |
2023-08-12 |
Not clear |
| N Chen, C G Trowbridge, J B Justic. Voltammetric studies on mechanisms of dopamine efflux in the presence of substrates and cocaine from cells expressing human norepinephrine transporter. Journal of neurochemistry. vol 71. issue 2. 1998-08-19. PMID:9681456. |
voltammetric studies on mechanisms of dopamine efflux in the presence of substrates and cocaine from cells expressing human norepinephrine transporter. |
1998-08-19 |
2023-08-12 |
human |
| T J De Vries, A R Cools, T S Shippenber. Infusion of a D-1 receptor agonist into the nucleus accumbens enhances cocaine-induced behavioural sensitization. Neuroreport. vol 9. issue 8. 1998-08-13. PMID:9665597. |
the present study was designed to evaluate the effect of dopamine (da) d-1 receptor activation in the nucleus accumbens (nac) on the locomotor sensitizing effects of repeated intra-accumbens (intra-nac) infusions of cocaine. |
1998-08-13 |
2023-08-12 |
Not clear |
| R B Rothman, G I Elmer, T S Shippenberg, W Rea, M H Bauman. Phentermine and fenfluramine. Preclinical studies in animal models of cocaine addiction. Annals of the New York Academy of Sciences. vol 844. 1998-08-13. PMID:9668665. |
combined dopamine (da) and 5-hydroxytryptamine (5-ht) releases such as phentermine (phen) and fenfluramine (fen) are reported, in open label studies, to reduce craving for alcohol and cocaine and to prevent relapse. |
1998-08-13 |
2023-08-12 |
mouse |