| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Deveroux Ferguson, Ningyi Shao, Elizabeth Heller, Jian Feng, Rachael Neve, Hee-Dae Kim, Tanessa Call, Samantha Magazu, Li Shen, Eric J Nestle. SIRT1-FOXO3a regulate cocaine actions in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 7. 2015-04-13. PMID:25698746. |
previous studies have shown that chronic cocaine administration induces sirt1, a class iii histone deacetylase, in the nucleus accumbens (nac), a key brain reward region, and that such induction influences the gene regulation and place conditioning effects of cocaine. |
2015-04-13 |
2023-08-13 |
mouse |
| Vinay Parikh, Sean X Naughton, Xiangdang Shi, Leslie K Kelley, Brittney Yegla, Christopher S Tallarida, Scott M Rawls, Ellen M Unterwal. Cocaine-induced neuroadaptations in the dorsal striatum: glutamate dynamics and behavioral sensitization. Neurochemistry international. vol 75. 2015-03-30. PMID:24911954. |
recent evidence suggests that diminished ability to control cocaine seeking arises from perturbations in glutamate homeostasis in the nucleus accumbens. |
2015-03-30 |
2023-08-13 |
rat |
| Shaun Yon-Seng Khoo, Robyn Mary Brow. Orexin/hypocretin based pharmacotherapies for the treatment of addiction: DORA or SORA? CNS drugs. vol 28. issue 8. 2015-03-30. PMID:24942635. |
the orexins have been shown to have a role in mediating the effects of several drugs of abuse, such as cocaine, morphine and alcohol via projections to key brain regions such as the ventral tegmental area, nucleus accumbens and prefrontal cortex. |
2015-03-30 |
2023-08-13 |
Not clear |
| Ana Weiland, Steven Garcia, Lori A Knacksted. Ceftriaxone and cefazolin attenuate the cue-primed reinstatement of alcohol-seeking. Frontiers in pharmacology. vol 6. 2015-03-25. PMID:25805996. |
cefaz had no effect on cocaine reinstatement, a behavior that has been strongly tied to altered glutamate homeostasis in the nucleus accumbens. |
2015-03-25 |
2023-08-13 |
rat |
| In Soo Ryu, Eun Sang Cho. Cocaine challenge increases the expression of immunoglobulin heavy chain binding protein in the rat nucleus accumbens. Neuroscience letters. vol 577. 2015-03-09. PMID:24970755. |
cocaine challenge increases the expression of immunoglobulin heavy chain binding protein in the rat nucleus accumbens. |
2015-03-09 |
2023-08-13 |
rat |
| In Soo Ryu, Eun Sang Cho. Cocaine challenge increases the expression of immunoglobulin heavy chain binding protein in the rat nucleus accumbens. Neuroscience letters. vol 577. 2015-03-09. PMID:24970755. |
this study was performed to investigate that cocaine challenge after cocaine abstinence is associated with the er stress response in the nucleus accumbens (nac). |
2015-03-09 |
2023-08-13 |
rat |
| Susan K Grotewold, Vanessa L Wall, Dayton J Goodell, Cassandra Hayter, Sondra T Blan. Effects of cocaine combined with a social cue on conditioned place preference and nucleus accumbens monoamines after isolation rearing in rats. Psychopharmacology. vol 231. issue 15. 2015-03-03. PMID:24553577. |
effects of cocaine combined with a social cue on conditioned place preference and nucleus accumbens monoamines after isolation rearing in rats. |
2015-03-03 |
2023-08-12 |
rat |
| Ken T Wakabayashi, Eugene A Kiyatki. Central and peripheral contributions to dynamic changes in nucleus accumbens glucose induced by intravenous cocaine. Frontiers in neuroscience. vol 9. 2015-03-02. PMID:25729349. |
central and peripheral contributions to dynamic changes in nucleus accumbens glucose induced by intravenous cocaine. |
2015-03-02 |
2023-08-13 |
rat |
| Ken T Wakabayashi, Eugene A Kiyatki. Central and peripheral contributions to dynamic changes in nucleus accumbens glucose induced by intravenous cocaine. Frontiers in neuroscience. vol 9. 2015-03-02. PMID:25729349. |
here, we used enzyme-based glucose sensors coupled with high-speed amperometry in freely moving rats to examine how intravenous cocaine at a behaviorally active dose affects extracellular glucose levels in the nucleus accumbens (nac), a critical structure within the motivation-reinforcement circuit. |
2015-03-02 |
2023-08-13 |
rat |
| M Behnam Ghasemzadeh, Preethi Vasudevan, Christopher R Mueller, Chad Seubert, John R Mantsc. Region-specific alterations in glutamate receptor expression and subcellular distribution following extinction of cocaine self-administration. Brain research. vol 1267. 2015-02-23. PMID:19368820. |
a role for glutamatergic signaling in the nucleus accumbens (na) in both the expression and extinction of cocaine seeking has been suggested. |
2015-02-23 |
2023-08-12 |
rat |
| Carolina P Ramôa, Susan E Doyle, Matthew D Lycas, Andrea K Chernau, Wendy J Lync. Diminished role of dopamine D1-receptor signaling with the development of an addicted phenotype in rats. Biological psychiatry. vol 76. issue 1. 2015-02-19. PMID:24199666. |
although considerable evidence implicates dopamine d1-receptor signaling in the nucleus accumbens in motivation for cocaine during early stages of addiction, less is known with regard to its role after the development of addiction. |
2015-02-19 |
2023-08-12 |
rat |
| Joanna Miszkiel, Jan Detka, Joanna Cholewa, Małgorzata Frankowska, Ewa Nowak, Bogusława Budziszewska, Edmund Przegaliński, Małgorzata Fili. The effect of active and passive intravenous cocaine administration on the extracellular signal-regulated kinase (ERK) activity in the rat brain. Pharmacological reports : PR. vol 66. issue 4. 2015-02-12. PMID:24948065. |
on the 3rd day the reduction in the erk activity (25-34%) was observed in the hippocampus for both cocaine-treated groups, and also in the nucleus accumbens for "yoked" cocaine group (40%). |
2015-02-12 |
2023-08-13 |
rat |
| Alexander C W Smith, Yonatan M Kupchik, Michael D Scofield, Cassandra D Gipson, Armina Wiggins, Charles A Thomas, Peter W Kaliva. Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases. Nature neuroscience. vol 17. issue 12. 2015-02-06. PMID:25326689. |
relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens and synaptic reorganization requires matrix metalloproteinase (mmp) degradation of the extracellular matrix proteins. |
2015-02-06 |
2023-08-13 |
rat |
| Gunnar Sørensen, Henriette Husum, Lise T Brennum, Christoffer Bundgaard, Liliana C P Montezinho, Arne Mørk, Gitta Wörtwein, David P D Woldby. Addiction-related effects of DOV 216,303 and cocaine: A comparative study in the mouse. Basic & clinical pharmacology & toxicology. vol 114. issue 6. 2015-02-02. PMID:24314270. |
the addictive drug cocaine has similar mechanism of action and exerts rewarding effects by blocking reuptake of dopamine, leading to increased extracellular concentrations of dopamine in the nucleus accumbens. |
2015-02-02 |
2023-08-12 |
mouse |
| Yao-Ying Ma, Brian R Lee, Xiusong Wang, Changyong Guo, Lei Liu, Ranji Cui, Yan Lan, Judith J Balcita-Pedicino, Marina E Wolf, Susan R Sesack, Yavin Shaham, Oliver M Schlüter, Yanhua H Huang, Yan Don. Bidirectional modulation of incubation of cocaine craving by silent synapse-based remodeling of prefrontal cortex to accumbens projections. Neuron. vol 83. issue 6. 2015-01-21. PMID:25199705. |
glutamatergic projections from the medial prefrontal cortex (mpfc) to nucleus accumbens (nac) contribute to cocaine relapse. |
2015-01-21 |
2023-08-13 |
rat |
| Julie A Kauer, Abigail M Polte. Yin and Yang: unsilencing synapses to control cocaine seeking. Neuron. vol 83. issue 6. 2015-01-21. PMID:25233302. |
(2014) show that long-term depression of two independent prefrontal cortical inputs to nucleus accumbens modifies behavioral responses controlling incubation of cocaine craving. |
2015-01-21 |
2023-08-13 |
Not clear |
| Hagit Turm, Diptendu Mukherjee, Doron Haritan, Maayan Tahor, Ami Citr. Comprehensive analysis of transcription dynamics from brain samples following behavioral experience. Journal of visualized experiments : JoVE. issue 90. 2015-01-09. PMID:25225819. |
the protocol is demonstrated in the context of analysis of gene expression dynamics in the nucleus accumbens following acute cocaine experience. |
2015-01-09 |
2023-08-13 |
mouse |
| Francesca Felicia Caputi, Manuela Di Benedetto, Donatella Carretta, Sussy Bastias del Carmen Candia, Claudio D'Addario, Chiara Cavina, Sanzio Candeletti, Patrizia Romuald. Dynorphin/KOP and nociceptin/NOP gene expression and epigenetic changes by cocaine in rat striatum and nucleus accumbens. Progress in neuro-psychopharmacology & biological psychiatry. vol 49. 2014-12-31. PMID:24184686. |
dynorphin/kop and nociceptin/nop gene expression and epigenetic changes by cocaine in rat striatum and nucleus accumbens. |
2014-12-31 |
2023-08-12 |
rat |
| Francesca Felicia Caputi, Manuela Di Benedetto, Donatella Carretta, Sussy Bastias del Carmen Candia, Claudio D'Addario, Chiara Cavina, Sanzio Candeletti, Patrizia Romuald. Dynorphin/KOP and nociceptin/NOP gene expression and epigenetic changes by cocaine in rat striatum and nucleus accumbens. Progress in neuro-psychopharmacology & biological psychiatry. vol 49. 2014-12-31. PMID:24184686. |
the aim of this study was to investigate possible changes of gene expression of the dynorphinergic and nociceptinergic system components in the nucleus accumbens (na) and in medial and lateral caudate putamen (mcpu and lcpu, respectively) of rats, following chronic subcutaneous infusion of cocaine. |
2014-12-31 |
2023-08-12 |
rat |
| Morgan H James, Rikki K Quinn, Lin Kooi Ong, Emily M Levi, Janine L Charnley, Doug W Smith, Phillip W Dickson, Christopher V Daya. mTORC1 inhibition in the nucleus accumbens 'protects' against the expression of drug seeking and 'relapse' and is associated with reductions in GluA1 AMPAR and CAMKIIα levels. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 7. 2014-12-29. PMID:24469593. |
we found that withdrawal from cocaine self-administration increased indices of mtorc1 activity in the nucleus accumbens (nac). |
2014-12-29 |
2023-08-12 |
rat |