| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ami Cohen, Timothy W Whitfield, Max Kreifeldt, Pascale Koebel, Brigitte L Kieffer, Candice Contet, Olivier George, George F Koo. Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. PloS one. vol 9. issue 5. 2015-06-08. PMID:24816773. |
these results suggest that dynorphin in a very specific area of the nucleus accumbens contributes to depressive-like states and may be involved in neuroadaptations in the nacc that contribute to the development of cocaine addiction as a persistent and lasting condition. |
2015-06-08 |
2023-08-13 |
rat |
| Jian Feng, Ningyi Shao, Keith E Szulwach, Vincent Vialou, Jimmy Huynh, Chun Zhong, Thuc Le, Deveroux Ferguson, Michael E Cahill, Yujing Li, Ja Wook Koo, Efrain Ribeiro, Benoit Labonte, Benjamin M Laitman, David Estey, Victoria Stockman, Pamela Kennedy, Thomas Couroussé, Isaac Mensah, Gustavo Turecki, Kym F Faull, Guo-li Ming, Hongjun Song, Guoping Fan, Patrizia Casaccia, Li Shen, Peng Jin, Eric J Nestle. Role of Tet1 and 5-hydroxymethylcytosine in cocaine action. Nature neuroscience. vol 18. issue 4. 2015-06-08. PMID:25774451. |
we found that ten-eleven translocation protein 1 (tet1) was downregulated in mouse nucleus accumbens (nac), a key brain reward structure, by repeated cocaine administration, which enhanced behavioral responses to cocaine. |
2015-06-08 |
2023-08-13 |
mouse |
| N D Volkow, D Tomasi, G-J Wang, J Logan, D L Alexoff, M Jayne, J S Fowler, C Wong, P Yin, C D. Stimulant-induced dopamine increases are markedly blunted in active cocaine abusers. Molecular psychiatry. vol 19. issue 9. 2015-06-05. PMID:24912491. |
dopamine signaling in nucleus accumbens is essential for cocaine reward. |
2015-06-05 |
2023-08-13 |
human |
| J Hamilton, J Lee, J J Canale. Chronic unilateral stimulation of the nucleus accumbens at high or low frequencies attenuates relapse to cocaine seeking in an animal model. Brain stimulation. vol 8. issue 1. 2015-05-20. PMID:25457212. |
chronic unilateral stimulation of the nucleus accumbens at high or low frequencies attenuates relapse to cocaine seeking in an animal model. |
2015-05-20 |
2023-08-13 |
Not clear |
| Jun-Jun Wang, Wen-Qing Yao, Yue-Jun Chen, Lan Ma, Ye-Zheng Ta. [Neurons in NAc core and BLA are activated during cocaine context-associated reward memory retrieval in mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 66. issue 5. 2015-05-16. PMID:25332000. |
the results showed that: neuronal c-fos, zif268 protein expression levels in nucleus accumbens (nac) core both were elevated in cocaine retrieval group compared with those in saline retrieval (control) group during cocaine context-associated reward memory retrieval. |
2015-05-16 |
2023-08-13 |
mouse |
| James E McCutcheon, Jackson J Cone, Christopher G Sinon, Samantha M Fortin, Pranish A Kantak, Ilana B Witten, Karl Deisseroth, Garret D Stuber, Mitchell F Roitma. Optical suppression of drug-evoked phasic dopamine release. Frontiers in neural circuits. vol 8. 2015-05-15. PMID:25278845. |
here, we used in vivo fast-scan cyclic voltammetry to record transients evoked by cocaine and raclopride in nucleus accumbens (nac) of urethane-anesthetized rats. |
2015-05-15 |
2023-08-13 |
rat |
| Juan-Carlos Bustamante, Alfonso Barrós-Loscertales, Víctor Costumero, Paola Fuentes-Claramonte, Patricia Rosell-Negre, Noelia Ventura-Campos, Juan-José Llopis, César Ávil. Abstinence duration modulates striatal functioning during monetary reward processing in cocaine patients. Addiction biology. vol 19. issue 5. 2015-05-11. PMID:23445167. |
in conclusion, caudate and nucleus accumbens show a different brain response pattern to non-drug rewards during cocaine addiction, which can be modulated by treatment success. |
2015-05-11 |
2023-08-12 |
Not clear |
| Lindsey P Pattison, Scot McIntosh, Tammy Sexton, Steven R Childers, Scott E Hemb. Changes in dopamine transporter binding in nucleus accumbens following chronic self-administration cocaine: heroin combinations. Synapse (New York, N.Y.). vol 68. issue 10. 2015-05-11. PMID:24916769. |
changes in dopamine transporter binding in nucleus accumbens following chronic self-administration cocaine: heroin combinations. |
2015-05-11 |
2023-08-13 |
rat |
| Lindsey P Pattison, Scot McIntosh, Tammy Sexton, Steven R Childers, Scott E Hemb. Changes in dopamine transporter binding in nucleus accumbens following chronic self-administration cocaine: heroin combinations. Synapse (New York, N.Y.). vol 68. issue 10. 2015-05-11. PMID:24916769. |
concurrent use of cocaine and heroin (speedball) has been shown to exert synergistic effects on dopamine neurotransmission in the nucleus accumbens (nac), as observed by significant increases in extracellular dopamine levels and compensatory elevations in the maximal reuptake rate of dopamine. |
2015-05-11 |
2023-08-13 |
rat |
| Victoria Lutgen, Linghai Kong, Kristen S Kau, Aric Madayag, John R Mantsch, David A Bake. Time course of cocaine-induced behavioral and neurochemical plasticity. Addiction biology. vol 19. issue 4. 2015-04-20. PMID:22970924. |
after 1, 21 or 60 days of withdrawal, drug seeking and extracellular glutamate levels in the nucleus accumbens were measured before and after a cocaine injection. |
2015-04-20 |
2023-08-12 |
rat |
| Elena Martín-García, Julien Courtin, Prisca Renault, Jean-François Fiancette, Hélène Wurtz, Amélie Simonnet, Florian Levet, Cyril Herry, Véronique Deroche-Gamone. Frequency of cocaine self-administration influences drug seeking in the rat: optogenetic evidence for a role of the prelimbic cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 10. 2015-04-15. PMID:24633559. |
the medial prefrontal cortex (mpfc), basolateral amygdala (bla), and nucleus accumbens (nac) have been shown to have a role in cocaine seeking. |
2015-04-15 |
2023-08-12 |
human |
| Deveroux Ferguson, Ningyi Shao, Elizabeth Heller, Jian Feng, Rachael Neve, Hee-Dae Kim, Tanessa Call, Samantha Magazu, Li Shen, Eric J Nestle. SIRT1-FOXO3a regulate cocaine actions in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 7. 2015-04-13. PMID:25698746. |
sirt1-foxo3a regulate cocaine actions in the nucleus accumbens. |
2015-04-13 |
2023-08-13 |
mouse |
| Deveroux Ferguson, Ningyi Shao, Elizabeth Heller, Jian Feng, Rachael Neve, Hee-Dae Kim, Tanessa Call, Samantha Magazu, Li Shen, Eric J Nestle. SIRT1-FOXO3a regulate cocaine actions in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 7. 2015-04-13. PMID:25698746. |
previous studies have shown that chronic cocaine administration induces sirt1, a class iii histone deacetylase, in the nucleus accumbens (nac), a key brain reward region, and that such induction influences the gene regulation and place conditioning effects of cocaine. |
2015-04-13 |
2023-08-13 |
mouse |
| Vinay Parikh, Sean X Naughton, Xiangdang Shi, Leslie K Kelley, Brittney Yegla, Christopher S Tallarida, Scott M Rawls, Ellen M Unterwal. Cocaine-induced neuroadaptations in the dorsal striatum: glutamate dynamics and behavioral sensitization. Neurochemistry international. vol 75. 2015-03-30. PMID:24911954. |
recent evidence suggests that diminished ability to control cocaine seeking arises from perturbations in glutamate homeostasis in the nucleus accumbens. |
2015-03-30 |
2023-08-13 |
rat |
| Shaun Yon-Seng Khoo, Robyn Mary Brow. Orexin/hypocretin based pharmacotherapies for the treatment of addiction: DORA or SORA? CNS drugs. vol 28. issue 8. 2015-03-30. PMID:24942635. |
the orexins have been shown to have a role in mediating the effects of several drugs of abuse, such as cocaine, morphine and alcohol via projections to key brain regions such as the ventral tegmental area, nucleus accumbens and prefrontal cortex. |
2015-03-30 |
2023-08-13 |
Not clear |
| Ana Weiland, Steven Garcia, Lori A Knacksted. Ceftriaxone and cefazolin attenuate the cue-primed reinstatement of alcohol-seeking. Frontiers in pharmacology. vol 6. 2015-03-25. PMID:25805996. |
cefaz had no effect on cocaine reinstatement, a behavior that has been strongly tied to altered glutamate homeostasis in the nucleus accumbens. |
2015-03-25 |
2023-08-13 |
rat |
| In Soo Ryu, Eun Sang Cho. Cocaine challenge increases the expression of immunoglobulin heavy chain binding protein in the rat nucleus accumbens. Neuroscience letters. vol 577. 2015-03-09. PMID:24970755. |
cocaine challenge increases the expression of immunoglobulin heavy chain binding protein in the rat nucleus accumbens. |
2015-03-09 |
2023-08-13 |
rat |
| In Soo Ryu, Eun Sang Cho. Cocaine challenge increases the expression of immunoglobulin heavy chain binding protein in the rat nucleus accumbens. Neuroscience letters. vol 577. 2015-03-09. PMID:24970755. |
this study was performed to investigate that cocaine challenge after cocaine abstinence is associated with the er stress response in the nucleus accumbens (nac). |
2015-03-09 |
2023-08-13 |
rat |
| Susan K Grotewold, Vanessa L Wall, Dayton J Goodell, Cassandra Hayter, Sondra T Blan. Effects of cocaine combined with a social cue on conditioned place preference and nucleus accumbens monoamines after isolation rearing in rats. Psychopharmacology. vol 231. issue 15. 2015-03-03. PMID:24553577. |
effects of cocaine combined with a social cue on conditioned place preference and nucleus accumbens monoamines after isolation rearing in rats. |
2015-03-03 |
2023-08-12 |
rat |
| Ken T Wakabayashi, Eugene A Kiyatki. Central and peripheral contributions to dynamic changes in nucleus accumbens glucose induced by intravenous cocaine. Frontiers in neuroscience. vol 9. 2015-03-02. PMID:25729349. |
central and peripheral contributions to dynamic changes in nucleus accumbens glucose induced by intravenous cocaine. |
2015-03-02 |
2023-08-13 |
rat |