| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Toumane, T Durkin, A Marighetto, R Jaffar. The durations of hippocampal and cortical cholinergic activation induced by spatial discrimination testing of mice in an eight-arm radial maze decrease as a function of acquisition. Behavioral and neural biology. vol 52. issue 2. 1989-11-01. PMID:2803178. |
sodium-dependent high-affinity choline uptake velocities in p2 fractions of the hippocampus and cortex of mice were analyzed at different times following both the first (day 1) and last (day 9) daily sessions of a spatial discrimination testing procedure in an eight-arm radial maze. |
1989-11-01 |
2023-08-11 |
mouse |
| K Toid. Effects of scopolamine on extracellular acetylcholine and choline levels and on spontaneous motor activity in freely moving rats measured by brain dialysis. Pharmacology, biochemistry, and behavior. vol 33. issue 1. 1989-10-26. PMID:2550972. |
the present study demonstrates the feasibility of measuring acetylcholine (ach) and choline in perfusate samples collected by in vivo brain dialysis in the frontal cortex and hippocampus of freely moving rats in which spontaneous motor activity could be measured simultaneously. |
1989-10-26 |
2023-08-11 |
rat |
| H Lai, M A Carino, A Horita, A W Gu. Low-level microwave irradiation and central cholinergic systems. Pharmacology, biochemistry, and behavior. vol 33. issue 1. 1989-10-26. PMID:2675124. |
our previous research showed that 45 min of exposure to low-level, pulsed microwaves (2450-mhz, 2-microseconds pulses, 500 pps, whole-body average specific absorption rate 0.6 w/kg) decreased sodium-dependent high-affinity choline uptake in the frontal cortex and hippocampus of the rat. |
1989-10-26 |
2023-08-11 |
rat |
| H Lai, M A Carino, A Horita, A W Gu. Low-level microwave irradiation and central cholinergic systems. Pharmacology, biochemistry, and behavior. vol 33. issue 1. 1989-10-26. PMID:2675124. |
increases in choline uptake activity in the frontal cortex, hippocampus, and hypothalamus were observed after 20 min of acute microwave exposure, and tolerance to the effect of microwaves developed in the hypothalamus, but not in the frontal cortex and hippocampus, of rats subjected to ten daily 20-min exposure sessions. |
1989-10-26 |
2023-08-11 |
rat |
| C E Whalley, T M Shi. Effects of soman and sarin on high affinity choline uptake by rat brain synaptosomes. Brain research bulletin. vol 22. issue 5. 1989-10-03. PMID:2765946. |
following soman injection, sodium-dependent, high affinity choline uptake (sdhacu) was decreased from 1 to 4 hr in the cortex and from 1 to 2 hr in the hippocampus, but increased from 2 to 24 hr in the striatum. |
1989-10-03 |
2023-08-11 |
rat |
| M Kakihana, N Yamazaki, A Nagaok. Effects of idebenone on the levels of acetylcholine, choline, free fatty acids, and energy metabolites in the brains of rats with cerebral ischemia. Archives of gerontology and geriatrics. vol 8. issue 3. 1989-09-14. PMID:2764642. |
in the ischemic rats, a significant decrease in acetylcholine (ach) and a marked increase in choline were observed in the cerebral cortex, hippocampus, striatum, and diencephalon. |
1989-09-14 |
2023-08-11 |
rat |
| R Nakov, E Habermann, G Hertting, S Wurster, C Allgaie. Effects of botulinum A toxin on presynaptic modulation of evoked transmitter release. European journal of pharmacology. vol 164. issue 1. 1989-09-07. PMID:2568939. |
rabbit hippocampal slices prelabelled with [3h]noradrenaline ([3h]na), [3h]5-hydroxytryptamine ([3h]5-ht) or [3h]choline were superfused with physiological medium and were stimulated electrically during superfusion. |
1989-09-07 |
2023-08-11 |
rabbit |
| K Toid. Effects of aniracetam on one-trial passive avoidance tests and cholinergic neurons in discrete brain regions of rats. Archives internationales de pharmacodynamie et de therapie. vol 298. 1989-09-01. PMID:2757465. |
ach content in the hippocampus was increased by doses of 100-300 mg/kg, p.o., but choline was not significantly increased by any doses, while in the cerebral cortex ach content was significantly increased by a dose of 300 mg/kg, p.o. |
1989-09-01 |
2023-08-11 |
rat |
| K Toid. Effects of aniracetam on one-trial passive avoidance tests and cholinergic neurons in discrete brain regions of rats. Archives internationales de pharmacodynamie et de therapie. vol 298. 1989-09-01. PMID:2757465. |
in addition, the decrease in hippocampal ach and choline content following an injection of scopolamine was lessened by aniracetam 100 mg/kg, p.o. |
1989-09-01 |
2023-08-11 |
rat |
| K Toid. Effects of aniracetam on one-trial passive avoidance tests and cholinergic neurons in discrete brain regions of rats. Archives internationales de pharmacodynamie et de therapie. vol 298. 1989-09-01. PMID:2757465. |
in order to elucidate the mechanism of these actions of aniracetam, the ach-releasing action and changes in choline content of the extracellular spaces in the hippocampus were investigated, but no effects were observed. |
1989-09-01 |
2023-08-11 |
rat |
| S Perini, M Brunetti, L Parnetti, G E De Medio, G Trovarelli, S Banfi, L Dorigotti, A Gait. The effect of oxiracetam treatment on alterations of lipid metabolism in brain areas from spontaneously hypertensive rats. Pharmacological research. vol 21. issue 3. 1989-08-17. PMID:2748513. |
we have now assayed the incorporation of labelled choline, ethanolamine, glycerol and arachidonic acid into the phospholipids from the cortex and hippocampus of shr-water and shr-nacl at different time intervals from injection into the lateral ventricle of the brain. |
1989-08-17 |
2023-08-11 |
rat |
| S Perini, M Brunetti, L Parnetti, G E De Medio, G Trovarelli, S Banfi, L Dorigotti, A Gait. The effect of oxiracetam treatment on alterations of lipid metabolism in brain areas from spontaneously hypertensive rats. Pharmacological research. vol 21. issue 3. 1989-08-17. PMID:2748513. |
a noticeable decrease of both choline and arachidonate specific activity (sa) in the phospholipids was found in the cortex and hippocampus (where the effect is most evident) from shr-nacl. |
1989-08-17 |
2023-08-11 |
rat |
| A Horita, M A Carino, J Zabawska, H La. TRH analog MK-771 reverses neurochemical and learning deficits in medial septal-lesioned rats. Peptides. vol 10. issue 1. 1989-08-14. PMID:2501767. |
microinjection of ibotenic acid into medial septum of rats decreased choline acetyltransferase (cat) and high-affinity choline uptake (hacu) activities in hippocampus and retarded the learning of a spatial memory task in the radial-arm maze. |
1989-08-14 |
2023-08-11 |
rat |
| R Schliebs, M Zivin, J Steinbach, T Roth. Changes in cholinergic but not in GABAergic markers in amygdala, piriform cortex, and nucleus basalis of the rat brain following systemic administration of kainic acid. Journal of neurochemistry. vol 53. issue 1. 1989-07-13. PMID:2542459. |
three days after systemic administration of kainic acid (15 mg/kg, s.c.), selected cholinergic markers (choline acetyltransferase, acetylcholinesterase, muscarinic acetylcholine receptor, and high-affinity choline uptake) and gabaergic parameters [benzodiazepine and gamma-aminobutyric acid (gaba) receptors] were studied in the frontal and piriform cortex, dorsal hippocampus, amygdaloid complex, and nucleus basalis. |
1989-07-13 |
2023-08-11 |
rat |
| A Horita, M A Carino, C Chin. Fentanyl produces cholinergically-mediated analeptic and EEG arousal effects in rats. Neuropharmacology. vol 28. issue 5. 1989-07-11. PMID:2566949. |
fentanyl also increased sodium-dependent high affinity uptake of choline activity in the hippocampus and cortex that had been depressed by the barbiturate. |
1989-07-11 |
2023-08-11 |
rat |
| P L Di Patre, A Abbamondi, L Bartolini, G Pepe. GM1 ganglioside counteracts cholinergic and behavioral deficits induced in the rat by intracerebral injection of vincristine. European journal of pharmacology. vol 162. issue 1. 1989-07-06. PMID:2721563. |
the intracerebroventricular injection of 0.5 mg of vincristine sulphate in adult male wistar rats caused within 11 days the impairment of motor and reflexive behavior, evaluated by the elevated platform and hanging wire tests, a decrease in food consumption and loss of body weight, a 45% decrease in hippocampal choline acetyltransferase (chat) activity and a 35% decrease in the rate of high-affinity choline uptake (hacu) in the injected side. |
1989-07-06 |
2023-08-11 |
rat |
| D Curti, F Dagani, M R Galmozzi, F Marzatic. Effect of aging and acetyl-L-carnitine on energetic and cholinergic metabolism in rat brain regions. Mechanisms of ageing and development. vol 47. issue 1. 1989-07-03. PMID:2542702. |
the treatment caused also an increase in cytochrome oxidase activity in all the three cerebral regions and in choline uptake in the hippocampus, parameters that were not directly affected by aging processes. |
1989-07-03 |
2023-08-11 |
rat |
| Z Pittel, A Fisher, E Heldma. Cholinotoxicity induced by ethylcholine aziridinium ion after intracarotid and intracerebroventricular administration. Life sciences. vol 44. issue 20. 1989-06-30. PMID:2725177. |
high-affinity choline transport was reduced significantly 11 days after an icv injection of af64a in all the above mentioned brain regions, and recovered 60 days post injection in the cerebral cortex and in the corpus striatum but not in the hippocampus. |
1989-06-30 |
2023-08-11 |
rat |
| H Lai, M A Carino, A Horita, A W Gu. Low-level microwave irradiation and central cholinergic activity: a dose-response study. Bioelectromagnetics. vol 10. issue 2. 1989-06-08. PMID:2712849. |
immediately after exposure, sodium-dependent high-affinity choline uptake, an indicator of cholinergic activity in neural tissue, was measured in the striatum, frontal cortex, hippocampus, and hypothalamus. |
1989-06-08 |
2023-08-11 |
rat |
| H Lai, M A Carino, A Horita, A W Gu. Low-level microwave irradiation and central cholinergic activity: a dose-response study. Bioelectromagnetics. vol 10. issue 2. 1989-06-08. PMID:2712849. |
decrease in choline uptake was observed in the striatum at a sar of 0.75 w/kg and above, whereas for the frontal cortex and hippocampus, decreases in choline uptake were observed at a sar of 0.45 w/kg and above. |
1989-06-08 |
2023-08-11 |
rat |