| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Abe, C Takeyama, K Yoshimur. Effects of S-8510, a novel benzodiazepine receptor partial inverse agonist, on basal forebrain lesioning-induced dysfunction in rats. European journal of pharmacology. vol 347. issue 2-3. 1998-09-17. PMID:9653874. |
in addition, it increased acetylcholine release and high-affinity choline uptake from the cortex, a region closely associated with memory, in basal forebrain-lesioned rats. |
1998-09-17 |
2023-08-12 |
rat |
| Z Henderson, P S Harrison, E Jagger, J H Beeb. Density of choline acetyltransferase-immunoreactive terminals in the rat dentate gyrus after entorhinal cortex lesions: a quantitative light microscope study. Experimental neurology. vol 152. issue 1. 1998-08-17. PMID:9682012. |
density of choline acetyltransferase-immunoreactive terminals in the rat dentate gyrus after entorhinal cortex lesions: a quantitative light microscope study. |
1998-08-17 |
2023-08-12 |
rat |
| Z Li, R Yang, Z Che. [Effects of iodine and thyroid hormone deficiency during brain development on activities of cholinergic neurone-related enzymes in central nervous system of rats]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. vol 30. issue 6. 1998-01-20. PMID:9388907. |
to study the effects of iodine and thyroid hormone deficiency during brain development on activities of enzymes of central acetyl choline metabolism, activities of choline acetylcholinetransferase (chat) and acetylcholinesterase (ache) in hippocampus and cerebral cortex, basal forebrain and cerebellum in 20-day-old rats were determined. |
1998-01-20 |
2023-08-12 |
rat |
| W Sihver, P Günther, R Schliebs, V Big. Repeated administration of tacrine to normal rats: effects on cholinergic, glutamatergic, and GABAergic receptor subtypes in rat brain using receptor autoradiography. Neurochemistry international. vol 31. issue 5. 1997-12-22. PMID:9364455. |
repeated administration of tacrine resulted in decreased binding to high-affinity choline uptake, nicotinic and m2-muscarinic acetylcholine receptor sites in a number of cortical regions, while reductions in m1-muscarinic receptor binding were restricted to the cingulate and entorhinal cortex as well as caudate-putamen. |
1997-12-22 |
2023-08-12 |
rat |
| M Q Holmes-McNary, R Loy, M H Mar, C D Albright, S H Zeise. Apoptosis is induced by choline deficiency in fetal brain and in PC12 cells. Brain research. Developmental brain research. vol 101. issue 1-2. 1997-10-01. PMID:9263575. |
a similar inverse relationship between dietary intake of choline and tunel positive cells was detected in an area of cerebral cortex from these fetal brain slices. |
1997-10-01 |
2023-08-12 |
rat |
| H Kobayashi, T Watanabe, T Yasufuku, T Suzuki, S Saitoh, K Taken. Effects of systemic administration of 2-(4-phenyl-piperidino)-cyclohexanol (vesamicol) and an organophosphate DDVP on the cholinergic system in brain regions of rats. Brain research bulletin. vol 43. issue 1. 1997-09-04. PMID:9205789. |
to assess the effect of vesamicol in vivo, we examined cholinergic parameters, such as the subcellular distribution of ach, activities of enzymes, uptake of choline, and muscarinic receptor binding in the striatum, hippocampus, and cerebral cortex of rats 30 and 60 min after intraperitoneal injection of vesamicol (3 mg/kg) or of vesamicol in combination with ddvp (5 mg/kg), which was administered 10 min before vasamicol. |
1997-09-04 |
2023-08-12 |
rat |
| N Takagi, K Miyake, T Taguchi, N Sugita, K Takagi, H Tamada, S Take. Changes in cholinergic neurons and failure in learning function after microsphere embolism-induced cerebral ischemia. Brain research bulletin. vol 43. issue 1. 1997-09-04. PMID:9205800. |
in the biochemical study, acetylcholine and choline contents, and choline acetyltransferase activity were measured in the cerebral cortex and hippocampus. |
1997-09-04 |
2023-08-12 |
rat |
| A Itoh, A Nitta, M Hirose, T Hasegawa, T Nabeshim. Effects of metrifonate on impairment of learning and dysfunction of cholinergic neuronal system in basal forebrain-lesioned rats. Behavioural brain research. vol 83. issue 1-2. 1997-07-09. PMID:9062677. |
in vivo brain microdialysis studies showed that mtf significantly increased the release of ach, but decreased that of choline (ch) in the cerebral cortex of bf-lesioned rats. |
1997-07-09 |
2023-08-12 |
rat |
| A Itoh, A Nitta, Y Katono, M Usui, K Naruhashi, R Iida, T Hasegawa, T Nabeshim. Effects of metrifonate on memory impairment and cholinergic dysfunction in rats. European journal of pharmacology. vol 322. issue 1. 1997-07-07. PMID:9088864. |
metrifonate (50 and 100 mg/kg) also significantly increased extracellular acetylcholine levels but decreased choline levels in the cerebral cortex of the basal forebrain-lesioned rats. |
1997-07-07 |
2023-08-12 |
rat |
| G W Moeckel, Y H Lie. Distribution of de novo synthesized betaine in rat kidney: role of renal synthesis on medullary betaine accumulation. The American journal of physiology. vol 272. issue 1 Pt 2. 1997-03-31. PMID:9039054. |
the trimethylamine glycine-betaine is accumulated to high concentrations in medullary cells of mammalian kidneys, whereas betaine synthesis from choline is predominant in the renal cortex. |
1997-03-31 |
2023-08-12 |
rat |
| T J Walsh, C D Herzog, C Gandhi, R W Stackman, R G Wile. Injection of IgG 192-saporin into the medial septum produces cholinergic hypofunction and dose-dependent working memory deficits. Brain research. vol 726. issue 1-2. 1997-02-13. PMID:8836547. |
the behavioral deficits were associated with dose-dependent decreases in pre-synaptic cholinergic parameters (ie., high affinity choline uptake) in the terminal fields of the medial septum (hippocampus, cingulate, entorhinal cortex). |
1997-02-13 |
2023-08-12 |
Not clear |
| F Amenta, E Bronzetti, A Ricci, S Sagratella, A Scotti de Carolis, D Zacche. Nucleus basalis magnocellularis lesions decrease histochemically reactive zinc stores in the rat brain: effect of choline alphoscerate treatment. European journal of histochemistry : EJH. vol 39. issue 4. 1996-12-13. PMID:8835182. |
treatment with choline alphoscerate, which is a precursor in the biosynthesis of brain phospholipids that increases the bioavailability of acetylcholine in the nervous tissue, restored, in part, the density and pattern of sulphide-silver positive fibres in the fronto-parietal cortex and in the hippocampus. |
1996-12-13 |
2023-08-12 |
rat |
| M Imagawa, H Mimata, S Takahashi, M Nakagawa, Y Nomura, J Ogat. Modulation of platelet-activating factor synthesis by recombinant interferon-alpha in human renal cell carcinoma. Urologia internationalis. vol 57. issue 1. 1996-12-12. PMID:8840484. |
to evaluate the role of paf and the effect of interferon-alpha (ifn-alpha) on paf production in rcc, we measured paf content and the activity of choline phosphotransferase (cpt), an enzyme involved in the de novo biosynthesis of paf, in rcc specimens obtained from 30 patients who had undergone radical nephrectomy for rcc, and in specimens of normal renal cortex and normal renal medulla. |
1996-12-12 |
2023-08-12 |
human |
| T J Walsh, R M Kelly, K D Dougherty, R W Stackman, R G Wiley, C L Kutsche. Behavioral and neurobiological alterations induced by the immunotoxin 192-IgG-saporin: cholinergic and non-cholinergic effects following i.c.v. injection. Brain research. vol 702. issue 1-2. 1996-10-22. PMID:8846082. |
both doses of 192-saporin produced a 60-80% decrease in high affinity choline transport in the hippocampus and cortex without altering this parameter in the striatum. |
1996-10-22 |
2023-08-12 |
rat |
| S Rossner, R Schliebs, W Härtig, V Big. 192IGG-saporin-induced selective lesion of cholinergic basal forebrain system: neurochemical effects on cholinergic neurotransmission in rat cerebral cortex and hippocampus. Brain research bulletin. vol 38. issue 4. 1996-02-08. PMID:8535860. |
intracerebroventricular injection of 4 micrograms 192igg-saporin conjugate resulted in a selective loss of cholinergic cells in the basal forebrain nuclei 1 week after application, which was accompanied by decreased activities of choline acetyltransferase and by reduced high-affinity uptake of [3h]choline into cholinergic nerve terminals in the cerebral cortex and hippocampus, as well as by a significant activation of micro- and to a lesser extent of astroglial cells in the hippocampus, but hardly in the cerebral cortex.. |
1996-02-08 |
2023-08-12 |
rat |
| A Wawrzeńczyk, K A Nałecz, M J Nałec. Effect of externally added carnitine on the synthesis of acetylcholine in rat cerebral cortex cells. Neurochemistry international. vol 26. issue 6. 1995-10-17. PMID:7670366. |
together with choline (20 microm), carnitine was found to stimulate acetylcholine synthesis in a synergistic way in cortex cells from adult rats (18%). |
1995-10-17 |
2023-08-12 |
rat |
| A Wawrzeńczyk, K A Nałecz, M J Nałec. Effect of externally added carnitine on the synthesis of acetylcholine in rat cerebral cortex cells. Neurochemistry international. vol 26. issue 6. 1995-10-17. PMID:7670366. |
choline, however, was incapable of reversing an inhibitory effect exerted by carnitine on acetylcholine synthesis in cortex cells from suckling animals. |
1995-10-17 |
2023-08-12 |
rat |
| P P Gonçalves, A P Carvalh. Characterization of the carrier-mediated [3H]GABA release from isolated synaptic plasma membrane vesicles. Neurochemical research. vol 20. issue 2. 1995-07-20. PMID:7783842. |
in this work, we utilized spm vesicles isolated from sheep brain cortex to investigate the process of [3h]gaba release induced by ouabain, veratridine and na+ substitution by other monovalent cations (k+, rb+, li+, and choline). |
1995-07-20 |
2023-08-12 |
Not clear |
| S Y Chung, T Moriyama, E Uezu, K Uezu, R Hirata, N Yohena, Y Masuda, T Kokubu, S Yamamot. Administration of phosphatidylcholine increases brain acetylcholine concentration and improves memory in mice with dementia. The Journal of nutrition. vol 125. issue 6. 1995-07-18. PMID:7782901. |
we administered egg phosphatidylcholine to mice with dementia and to normal mice and compared the differences in memory and serum choline concentration, and choline and acetylcholine concentrations and choline acetyltransferase activities of three forebrain regions (cortex, hippocampus and the remaining forebrain). |
1995-07-18 |
2023-08-12 |
mouse |
| S Y Chung, T Moriyama, E Uezu, K Uezu, R Hirata, N Yohena, Y Masuda, T Kokubu, S Yamamot. Administration of phosphatidylcholine increases brain acetylcholine concentration and improves memory in mice with dementia. The Journal of nutrition. vol 125. issue 6. 1995-07-18. PMID:7782901. |
we administered 100 mg of egg phosphatidylcholine (phosphatidylcholine group) or water (control group) by gavage to each mouse daily for about 45 d. control mice with dementia had poorer memory in passive avoidance performance and lower brain choline (cortex and hippocampus) and acetylcholine (hippocampus and forebrain excluding cortex and hippocampus) concentrations and lower cortex choline acetyltransferase activity than the control normal mice (p < 0.05). |
1995-07-18 |
2023-08-12 |
mouse |