| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Chen, S E Robinso. The effect of cobrotoxin on cholinergic neurons in the mouse. Life sciences. vol 51. issue 13. 1992-10-09. PMID:1522750. |
there were no obvious changes in the concentrations of ach and choline (ch) in the cortex, hippocampus, hypothalamus, midbrain, striatum, or thalamus of the mouse after injection of an analgesic dose of ct (2 micrograms, i.c.v.). |
1992-10-09 |
2023-08-11 |
mouse |
| R Bertorelli, D Amoroso, P Girotti, S Consol. Effect of tianeptine on the central cholinergic system: involvement of serotonin. Naunyn-Schmiedeberg's archives of pharmacology. vol 345. issue 3. 1992-08-05. PMID:1620232. |
the drug did not alter choline-o-acetyltransferase and acetylcholinesterase activities suggesting that it did not influence the cholinergic system through direct action on the ach metabolism; furthermore, it did not influence the sodium-dependent high-affinity uptake of choline in striatum, cortex and hippocampus. |
1992-08-05 |
2023-08-11 |
rat |
| I H Ulus, R L Buyukuysal, R J Wurtma. N-methyl-D-aspartate increases acetylcholine release from rat striatum and cortex: its effect is augmented by choline. The Journal of pharmacology and experimental therapeutics. vol 261. issue 3. 1992-07-14. PMID:1602377. |
n-methyl-d-aspartate increases acetylcholine release from rat striatum and cortex: its effect is augmented by choline. |
1992-07-14 |
2023-08-11 |
rat |
| G Maura, G C Andrioli, P Cavazzani, M Raiter. 5-Hydroxytryptamine3 receptors sited on cholinergic axon terminals of human cerebral cortex mediate inhibition of acetylcholine release. Journal of neurochemistry. vol 58. issue 6. 1992-06-04. PMID:1533419. |
synaptosomes prepared from freshly obtained human cerebral cortex and labeled with [3h]choline have been used to investigate the modulation of [3h]acetylcholine ([3h]ach) release by 5-hydroxytryptamine (5-ht). |
1992-06-04 |
2023-08-11 |
human |
| C Nardella, L Terracina, M Brunetti, L Avellini, G E De Medio, A Gaiti, P Belfiore, O Marian. Choline incorporation into phospholipids in brain areas from spontaneously hypertensive rats: effect of oxiracetam treatment. Farmaco (Societa chimica italiana : 1989). vol 46. issue 9. 1992-05-19. PMID:1807290. |
we tested both choline uptake into the cells and incorporation into choline phosphoglyceride (cpg) by incubating slices from hippocampus and cortex. |
1992-05-19 |
2023-08-11 |
rat |
| L Garofalo, A Ribeiro-da-Silva, A C Cuell. Nerve growth factor-induced synaptogenesis and hypertrophy of cortical cholinergic terminals. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 7. 1992-05-06. PMID:1557368. |
rats that had received vehicle showed a significantly reduced cortical choline acetyl-transferase-immunoreactive fiber network in the remaining cortex when compared with control animals. |
1992-05-06 |
2023-08-11 |
rat |
| K A Sherman, G E Gibson, P Perrino, K Garret. Acetylcholine formation from glucose following acute choline supplementation. Neurochemical research. vol 16. issue 9. 1992-03-19. PMID:1784327. |
a two to three fold elevation of brain choline did not alter ach levels or [u-14c]glucose incorporation into ach in the cortex, hippocampus or striatum. |
1992-03-19 |
2023-08-11 |
Not clear |
| T Arendt, M M Schugens, V Big. The cholinergic system and memory: amelioration of ethanol-induced memory deficiency by physostigmine in rat. Acta neurobiologiae experimentalis. vol 50. issue 4-5. 1991-11-13. PMID:2130647. |
profound reductions of acetylcholine content, the activities of choline acetyltransferase and acetylcholinesterase and choline uptake were observed in the cortex, hippocampus, substantia innominata and striatum four weeks after withdrawal from ethanol. |
1991-11-13 |
2023-08-11 |
rat |
| G Hasey, I Hani. Plasma corticosterone is increased and correlated with brain acetylcholine in physostigmine- but not in neostigmine-treated rats. Psychoneuroendocrinology. vol 15. issue 5-6. 1991-09-13. PMID:2101961. |
either 15 or 30 min later the number and intensity of observable cholinomimetic effects (oce) was determined, plasma was collected for corticosterone (cst) measurement, and the cerebral cortex, striatum, hippocampus and hypothalamus were removed after microwave treatment for the measurement of tissue acetylcholine (ach) and choline (ch) concentrations. |
1991-09-13 |
2023-08-11 |
rat |
| A Ueki, K Miyosh. Reversal of learning impairment in ventral globus pallidus-lesioned rats by combination of continuous intracerebroventricular choline infusion and oral cholinergic drug administration. Brain research. vol 547. issue 1. 1991-09-05. PMID:1860076. |
intracerebroventricular choline infusion (100 mumol/day) and oral tha or nik-247 administration (0.5 mg/kg) had no effect on the acquisition of the passive avoidance response, while the combination of oral tha or nik-247 administration (0.5 mg/kg) and intracerebroventricular choline infusion (100 mumol/day) elicited good acquisition of passive avoidance learning and produced a significant increase of choline and acetylcholine in the cerebral cortex of the bilateral ventral globus pallidus-lesioned rat. |
1991-09-05 |
2023-08-11 |
rat |
| M Kishi, S Ohkuma, F H Ma, K Kuriyam. Pharmacological characteristics of choline transport system in mouse cerebral cortical neurons in primary culture. Japanese journal of pharmacology. vol 55. issue 2. 1991-08-15. PMID:2067141. |
the characteristics of [3h]choline transport with high affinity were investigated using primary cultured neurons obtained from the mouse cerebral cortex. |
1991-08-15 |
2023-08-11 |
mouse |
| G Bonanno, A Ruelle, G C Andrioli, M Raiter. Cholinergic nerve terminals of human cerebral cortex possess a GABA transporter whose activation induces release of acetylcholine. Brain research. vol 539. issue 2. 1991-07-31. PMID:2054596. |
the effect of gamma-aminobutyric acid (gaba) on the release of [3h]acetylcholine [( 3h]ach) from human cerebral cortex nerve terminals was investigated using synaptosomes prepared from neurosurgical specimens (which had to be removed to reach deeply located tumors) prelabeled with [3h]choline and exposed in superfusion to varying concentrations of gaba. |
1991-07-31 |
2023-08-11 |
human |
| E Wülfer. [Pharmaceutical research strategies in Alzheimer's disease]. Journal de pharmacie de Belgique. vol 46. issue 1. 1991-07-25. PMID:2051302. |
the hypothesis that the symptomatology of alzheimer's disease is attributable to loss of cortical cholinergic innervation is supported by post-mortem studies demonstrating both reduced choline acetyltransferase (cat) activity and reduced high-affinity choline uptake (hacht) in the cortex, and neuron cell loss in the basal forebrain nucleus basalis of meynert. |
1991-07-25 |
2023-08-11 |
cat |
| T Rothe, U K Hanisch, K Krohn, R Schliebs, W Härtig, H H Webster, D Biesol. Changes in choline acetyltransferase activity and high-affinity choline uptake, but not in acetylcholinesterase activity and muscarinic cholinergic receptors, in rat somatosensory cortex after sciatic nerve injury. Somatosensory & motor research. vol 7. issue 4. 1991-03-29. PMID:1963253. |
changes in choline acetyltransferase activity and high-affinity choline uptake, but not in acetylcholinesterase activity and muscarinic cholinergic receptors, in rat somatosensory cortex after sciatic nerve injury. |
1991-03-29 |
2023-08-11 |
rat |
| T Rothe, U K Hanisch, K Krohn, R Schliebs, W Härtig, H H Webster, D Biesol. Changes in choline acetyltransferase activity and high-affinity choline uptake, but not in acetylcholinesterase activity and muscarinic cholinergic receptors, in rat somatosensory cortex after sciatic nerve injury. Somatosensory & motor research. vol 7. issue 4. 1991-03-29. PMID:1963253. |
selected cholinergic markers (choline acetyltransferase, acetylcholinesterase, muscarinic acetylcholine receptor, high-affinity choline uptake) were studied in the hindlimb representation areas of the rat somatosensory cortex and within the visual cortex 1 to 63 days after unilateral transection of the sciatic nerve. |
1991-03-29 |
2023-08-11 |
rat |
| T Rothe, U K Hanisch, K Krohn, R Schliebs, W Härtig, H H Webster, D Biesol. Changes in choline acetyltransferase activity and high-affinity choline uptake, but not in acetylcholinesterase activity and muscarinic cholinergic receptors, in rat somatosensory cortex after sciatic nerve injury. Somatosensory & motor research. vol 7. issue 4. 1991-03-29. PMID:1963253. |
in the contralateral somatosensory cortex, peripheral deafferentation resulted in a significant reduction of choline acetyltransferase activity (by 15%) 3 days after sciatic nerve injury, and in a significant reduction of high-affinity choline uptake (by 30%) 1 day after nerve transection, in comparison to untreated control rats. |
1991-03-29 |
2023-08-11 |
rat |
| K A Sherman, E Friedma. Pre- and post-synaptic cholinergic dysfunction in aged rodent brain regions: new findings and an interpretative review. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 8. issue 6. 1991-03-25. PMID:2288244. |
this study therefore compared choline acetyltransferase activity (as a structural marker) and sodium-dependent high affinity choline uptake (which reflects both ongoing cholinergic neuronal activity and structural integrity) in the hippocampus, cortex and straitum of male c57bl mice at 3-4, 10-12 or 28-32 months of age. |
1991-03-25 |
2023-08-11 |
mouse |
| D Maysinger, M Herrera-Marschitz, U Ungerstedt, A C Cuell. Effects of treatment with microencapsulated monosialoganglioside GM1 on cortical and striatal acetylcholine release in rats with cortical devascularizing lesions. Neuroscience letters. vol 118. issue 2. 1991-02-28. PMID:2274279. |
the effects of microencapsulated gm1 on extracellular levels of acetylcholine, choline and dopamine in the cortex and in the striatum were analyzed using in vivo microdialysis. |
1991-02-28 |
2023-08-11 |
human |
| R B Illin. A subtype of cerebellar Golgi cells may be cholinergic. Brain research. vol 522. issue 2. 1990-12-07. PMID:2224528. |
in cerebellar sections of the feline brain processed for choline acetyltransferase-like immunoreactivity, a population of distinctly stained cells was discovered in the granular layer of the cortex in both vermis and hemispheres. |
1990-12-07 |
2023-08-11 |
Not clear |
| M Marchi, A Ruelle, G C Andrioli, M Raiter. Pirenzepine-insensitive muscarinic autoreceptors regulate acetylcholine release in human neocortex. Brain research. vol 520. issue 1-2. 1990-11-14. PMID:2207644. |
the release of [3h]acetylcholine ([3h]ach) and its modulation mediated by autoreceptors were investigated in synaptosomes prepared from fresh human cerebral cortex prelabelled with [3h]choline ([3h]ch) and depolarized in superfusion with 15 mm kcl. |
1990-11-14 |
2023-08-11 |
human |