| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J A Miller, P A Chmielewsk. The regulation of high-affinity choline uptake in vitro in rat cortical and hippocampal synaptosomes by beta-carbolines administered in vivo. Neuroscience letters. vol 114. issue 3. 1990-10-24. PMID:2402344. |
the effects of several beta-carboline derivatives on sodium-dependent high-affinity choline uptake (hacu) were investigated in rat hippocampus and cerebral cortex. |
1990-10-24 |
2023-08-11 |
rat |
| V Luine, M Hearn. Spatial memory deficits in aged rats: contributions of the cholinergic system assessed by ChAT. Brain research. vol 523. issue 2. 1990-10-23. PMID:2400918. |
activity of choline acetylase (chat) was measured in basal forebrain cholinergic nuclei and in projection sites of these cells in the hippocampus and cortex of young rats and of aged rats who showed impaired performance on the radial arm maze. |
1990-10-23 |
2023-08-11 |
rat |
| J M Barnes, N M Barnes, B Costall, Z P Horovitz, J W Ironside, R J Naylor, T J William. Angiotensin II inhibits cortical cholinergic function: implications for cognition. Journal of cardiovascular pharmacology. vol 16. issue 2. 1990-10-04. PMID:1697379. |
in the present studies we have shown that angiotensin ii (at ii), in a concentration-dependent manner in rat tissue (10(-9)-10(-5) m) or at a single concentration in human tissue (10(-6) m), can inhibit potassium-stimulated release of [3h]acetylcholine ( [3h]ach) from slices of rat entorhinal cortex and human temporal cortex preloaded with [3h]choline for the biochemical analyses. |
1990-10-04 |
2023-08-11 |
human |
| D Maysinger, M Herrera-Marschitz, U Ungerstedt, A C Cuell. Acetylcholine release in vivo: effects of chronic treatment with monosialoganglioside GM1. Neuropharmacology. vol 29. issue 2. 1990-05-30. PMID:2330073. |
the release of acetylcholine and choline was studied in the cortex and striatum of the rat under nonstimulated (basal) and kcl (100 mm)-stimulating conditions. |
1990-05-30 |
2023-08-11 |
rat |
| Z Qian, P V Reddy, L R Drewe. Guanine nucleotide-binding protein regulation of microsomal phospholipase D activity of canine cerebral cortex. Journal of neurochemistry. vol 54. issue 5. 1990-05-18. PMID:2109044. |
the hydrolytic activity of microsomal phospholipase d from canine cerebral cortex was measured by a radiochemical assay using 1,2-dipalmitoyl-sn-glycerol-3-phosphoryl[3h]choline and 1-palmitoyl-2-[9,10(n)-3h]palmitoyl-sn-glycerol-3-phosphorylcholine as the exogenous substrates. |
1990-05-18 |
2023-08-11 |
Not clear |
| Z Qian, P V Reddy, L R Drewe. Guanine nucleotide-binding protein regulation of microsomal phospholipase D activity of canine cerebral cortex. Journal of neurochemistry. vol 54. issue 5. 1990-05-18. PMID:2109044. |
these results indicate that regulation of microsomal phosphatidylcholine phospholipase d activity by the guanine nucleotide-binding protein(s) in canine cerebral cortex may play an important role in signal transduction processes as well as in brain choline metabolism. |
1990-05-18 |
2023-08-11 |
Not clear |
| K Toide, T Arim. Effects of cholinergic drugs on extracellular levels of acetylcholine and choline in rat cortex, hippocampus and striatum studied by brain dialysis. European journal of pharmacology. vol 173. issue 2-3. 1990-04-12. PMID:2625133. |
effects of cholinergic drugs on extracellular levels of acetylcholine and choline in rat cortex, hippocampus and striatum studied by brain dialysis. |
1990-04-12 |
2023-08-11 |
rat |
| H A Navarro, F J Seidler, J P Eylers, F E Baker, S S Dobbins, S E Lappi, T A Slotki. Effects of prenatal nicotine exposure on development of central and peripheral cholinergic neurotransmitter systems. Evidence for cholinergic trophic influences in developing brain. The Journal of pharmacology and experimental therapeutics. vol 251. issue 3. 1990-01-30. PMID:2600820. |
the cerebral cortex displayed a unique maturational pattern of choline acetyltransferase (chat) activity and high-affinity synaptosomal [3h]choline uptake capabilities, characterized by increases in the concentration of these components and a postnatal spike of neuronal activity as assessed with the uptake/chat ratio; the peak of activity coincided with the time at which neurogenesis declines and synaptogenesis rises. |
1990-01-30 |
2023-08-11 |
rat |
| C J Pirola, A L Alvarez, M S Balda, S Finkielman, V E Nahmo. Evidence for cholinergic innervation in dog renal tissue. The American journal of physiology. vol 257. issue 5 Pt 2. 1989-12-28. PMID:2589481. |
denervation did not change either [3h]qnb binding parameters or the ability of inner and outer cortex cells to perform the hemicholinium-3-inhibitable, sodium-dependent choline uptake and conversion of [3h]choline to [3h]acetylcholine. |
1989-12-28 |
2023-08-11 |
dog |
| O U Scremin, D J Jende. Effects of middle cerebral artery occlusion on cerebral cortex choline and acetylcholine in rats. Stroke. vol 20. issue 11. 1989-12-11. PMID:2815187. |
effects of middle cerebral artery occlusion on cerebral cortex choline and acetylcholine in rats. |
1989-12-11 |
2023-08-11 |
rat |
| O U Scremin, D J Jende. Effects of middle cerebral artery occlusion on cerebral cortex choline and acetylcholine in rats. Stroke. vol 20. issue 11. 1989-12-11. PMID:2815187. |
a large increase in tissue choline concentration was observed in the ischemic cortex. |
1989-12-11 |
2023-08-11 |
rat |
| A Toumane, T Durkin, A Marighetto, R Jaffar. The durations of hippocampal and cortical cholinergic activation induced by spatial discrimination testing of mice in an eight-arm radial maze decrease as a function of acquisition. Behavioral and neural biology. vol 52. issue 2. 1989-11-01. PMID:2803178. |
sodium-dependent high-affinity choline uptake velocities in p2 fractions of the hippocampus and cortex of mice were analyzed at different times following both the first (day 1) and last (day 9) daily sessions of a spatial discrimination testing procedure in an eight-arm radial maze. |
1989-11-01 |
2023-08-11 |
mouse |
| M Raiteri, M Marchi, G Bonanno, P Melchiorri, V Erspame. Facilitation of [3H]acetylcholine and [3H]5-hydroxytryptamine release from rat cerebral cortex synaptosomes by a factor extracted from the skin of the Australian frog Pseudophryne coriacea. European journal of pharmacology. vol 172. issue 3. 1989-10-23. PMID:2776843. |
a partly purified extract of the skin of the australian frog pseudophryne coriacea (psc) evoked the release of [3h]acetylcholine [( 3h]ach) and of [3h]5-hydroxytryptamine [( 3h]5-ht) from superfused rat cerebral cortex synaptosomes prelabeled with [3h]choline or [3h]5-ht, respectively. |
1989-10-23 |
2023-08-11 |
rat |
| J R O'Kusky, E G McGee. Methylmercury-induced movement and postural disorders in developing rat: high-affinity uptake of choline, glutamate, and gamma-aminobutyric acid in the cerebral cortex and caudate-putamen. Journal of neurochemistry. vol 53. issue 4. 1989-10-12. PMID:2570131. |
methylmercury-induced movement and postural disorders in developing rat: high-affinity uptake of choline, glutamate, and gamma-aminobutyric acid in the cerebral cortex and caudate-putamen. |
1989-10-12 |
2023-08-11 |
rat |
| J R O'Kusky, E G McGee. Methylmercury-induced movement and postural disorders in developing rat: high-affinity uptake of choline, glutamate, and gamma-aminobutyric acid in the cerebral cortex and caudate-putamen. Journal of neurochemistry. vol 53. issue 4. 1989-10-12. PMID:2570131. |
sodium-dependent high-affinity uptake of radiolabeled choline, glutamate, and gamma-aminobutyric acid (gaba) was measured in homogenates of cerebral cortex and caudate-putamen. |
1989-10-12 |
2023-08-11 |
rat |
| J R O'Kusky, E G McGee. Methylmercury-induced movement and postural disorders in developing rat: high-affinity uptake of choline, glutamate, and gamma-aminobutyric acid in the cerebral cortex and caudate-putamen. Journal of neurochemistry. vol 53. issue 4. 1989-10-12. PMID:2570131. |
there was a significant decrease in the uptake of [3h]choline in the cerebral cortex, but not in the caudate-putamen, at the onset of neurological impairment (73-75%) and at one subclinical stage of toxicity (58-64%). |
1989-10-12 |
2023-08-11 |
rat |
| J R O'Kusky, E G McGee. Methylmercury-induced movement and postural disorders in developing rat: high-affinity uptake of choline, glutamate, and gamma-aminobutyric acid in the cerebral cortex and caudate-putamen. Journal of neurochemistry. vol 53. issue 4. 1989-10-12. PMID:2570131. |
because the high-affinity uptake of choline is the rate-limiting step for acetylcholine synthesis by cholinergic neurons, the decrease in [3h]choline uptake may reflect an abnormal development of cholinergic innervation of the cerebral cortex. |
1989-10-12 |
2023-08-11 |
rat |
| C E Whalley, T M Shi. Effects of soman and sarin on high affinity choline uptake by rat brain synaptosomes. Brain research bulletin. vol 22. issue 5. 1989-10-03. PMID:2765946. |
following soman injection, sodium-dependent, high affinity choline uptake (sdhacu) was decreased from 1 to 4 hr in the cortex and from 1 to 2 hr in the hippocampus, but increased from 2 to 24 hr in the striatum. |
1989-10-03 |
2023-08-11 |
rat |
| M Kakihana, N Yamazaki, A Nagaok. Effects of idebenone on the levels of acetylcholine, choline, free fatty acids, and energy metabolites in the brains of rats with cerebral ischemia. Archives of gerontology and geriatrics. vol 8. issue 3. 1989-09-14. PMID:2764642. |
in the ischemic rats, a significant decrease in acetylcholine (ach) and a marked increase in choline were observed in the cerebral cortex, hippocampus, striatum, and diencephalon. |
1989-09-14 |
2023-08-11 |
rat |
| K Toid. Effects of aniracetam on one-trial passive avoidance tests and cholinergic neurons in discrete brain regions of rats. Archives internationales de pharmacodynamie et de therapie. vol 298. 1989-09-01. PMID:2757465. |
ach content in the hippocampus was increased by doses of 100-300 mg/kg, p.o., but choline was not significantly increased by any doses, while in the cerebral cortex ach content was significantly increased by a dose of 300 mg/kg, p.o. |
1989-09-01 |
2023-08-11 |
rat |