| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kadir Ertem, Alpay Alkan, Kaya Sarac, Cagatay Onal, Haci Bostan, Saim Yologlu, Arslan Bor. Magnetic resonance spectroscopy study of proton metabolite level changes in sensorimotor cortex after upper limb replantation-revascularization. Magnetic resonance imaging. vol 23. issue 1. 2005-07-14. PMID:15733795. |
metabolite ratios [naa (n-acetyl aspartate)/cr (creatine) and cho (choline)/cr] of the motor and somatosensory cortex were calculated. |
2005-07-14 |
2023-08-12 |
Not clear |
| L Descarries, N Aznavour, E Hame. The acetylcholine innervation of cerebral cortex: new data on its normal development and its fate in the hAPP(SW,IND) mouse model of Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 1. 2005-06-07. PMID:15599613. |
to follow on prior studies of the cerebral cortex, we examined the acetylcholine innervation in the developing hippocampus of rat, by means of light and electron microscopic immunocytochemistry with a highly sensitive antibody against choline acetyltransferease. |
2005-06-07 |
2023-08-12 |
mouse |
| b' Z Kristofikov\\xc3\\xa1, O Benesov\\xc3\\xa1, H Tejkalov\\xc3\\xa. Comparison of the effects of aging in vivo and of oxygen free radicals in vitro on high-affinity choline uptake and hemicholinium-3 binding in the rat brain. Archives of gerontology and geriatrics. vol 17. issue 3. 2005-03-10. PMID:15374317.' |
the effects of aging in vivo (wistar rats aged 3-26 months) and of an oxygen free-radical generating system in vitro (fe(2+)/ascorbic acid) on high-affinity choline uptake in the hippocampus and on (3h)hemicholinium-3 binding sites in the cortex and hippocampus are compared. |
2005-03-10 |
2023-08-12 |
rat |
| b' Z Kristofikov\\xc3\\xa1, O Benesov\\xc3\\xa1, H Tejkalov\\xc3\\xa. Comparison of the effects of aging in vivo and of oxygen free radicals in vitro on high-affinity choline uptake and hemicholinium-3 binding in the rat brain. Archives of gerontology and geriatrics. vol 17. issue 3. 2005-03-10. PMID:15374317.' |
the decrease in high-affinity choline uptake values is probably more influenced by the impairment of correct function of carriers (the fall in the turnover rate of each carrier) than by a decrease in the number of transport sites (no change of the density of the carriers in the hippocampus and cortex). |
2005-03-10 |
2023-08-12 |
rat |
| Vinay Parikh, Francois Pomerleau, Peter Huettl, Greg A Gerhardt, Martin Sarter, John P Brun. Rapid assessment of in vivo cholinergic transmission by amperometric detection of changes in extracellular choline levels. The European journal of neuroscience. vol 20. issue 6. 2004-12-20. PMID:15355321. |
in an effort to overcome these constraints, we investigated a ceramic-based microelectrode array designed to measure amperometrically rapid changes in extracellular choline as a marker for cholinergic transmission in the frontoparietal cortex of anesthetized rats. |
2004-12-20 |
2023-08-12 |
rat |
| Yael Abreu-Villaça, Frederic J Seidler, Dan Qiao, Charlotte A Tate, Mandy M Cousins, Indira Thillai, Theodore A Slotki. Short-term adolescent nicotine exposure has immediate and persistent effects on cholinergic systems: critical periods, patterns of exposure, dose thresholds. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 11. 2004-01-28. PMID:12784097. |
in the cerebral cortex, midbrain, and hippocampus, we assessed nicotinic cholinergic receptor (nachr) binding, choline acetyltransferase (chat) activity, a constitutive marker for cholinergic nerve terminals, and [(3)h]hemicholinium-3 (hc-3) binding to the high-affinity choline transporter, which responds to cholinergic synaptic stimulation. |
2004-01-28 |
2023-08-12 |
rat |
| A Birthelmer, A Lazaris, T Schweizer, R Jackisch, J-C Casse. Presynaptic regulation of neurotransmitter release in the cortex of aged rats with differential memory impairments. Pharmacology, biochemistry, and behavior. vol 75. issue 1. 2004-01-07. PMID:12759123. |
in the frontoparietal cortex, we subsequently assessed the electrically evoked release of tritium in slices preloaded with [3h]choline, [3h]noradrenaline (na), or [3h]serotonin (5-ht) and the effects of an agonist (oxotremorine, uk 14,304, and cp 93,129) of the respective autoreceptors. |
2004-01-07 |
2023-08-12 |
rat |
| Ivan Tkác, Raghavendra Rao, Michael K Georgieff, Rolf Gruette. Developmental and regional changes in the neurochemical profile of the rat brain determined by in vivo 1H NMR spectroscopy. Magnetic resonance in medicine. vol 50. issue 1. 2003-11-20. PMID:12815675. |
the most sensitive markers for developmental and regional variations between hippocampus, striatum, and cerebral cortex were n-acetylaspartate, myo-inositol, taurine, glutamate, and choline compounds. |
2003-11-20 |
2023-08-12 |
rat |
| Nilkanta Chakrabarti, Arun K Ra. Stimulation of AChE activity in relation to changes in electronmicroscopic structure of adult rat cerebrocortical synaptosomes pretreated with 3-5-3'-triiodo-L-thyronine. Neuroreport. vol 14. issue 11. 2003-11-20. PMID:12960772. |
triiodothyronine (t3) stimulated ache activity in depolarization-induced intact synaptosomes (isolated from adult rat cerebral cortex) suspended in calcium-supplemented choline chloride buffer in a time-dependent manner maximally 45-60 s after t3 administration and in a dose-dependent manner with an optimum at 10-100 nm. |
2003-11-20 |
2023-08-12 |
rat |
| C Scali, M G Giovannini, C Prosperi, A Bellucci, G Pepeu, F Casament. The selective cyclooxygenase-2 inhibitor rofecoxib suppresses brain inflammation and protects cholinergic neurons from excitotoxic degeneration in vivo. Neuroscience. vol 117. issue 4. 2003-06-10. PMID:12654342. |
seven days after injection, a marked reduction in the number of choline acetyltransferase-positive neurons was found, along with an intense glia reaction, selective activation of p38mapk at the injection site and a significant decrease in the extracellular levels of acetylcholine in the cortex ipsilateral to the injection site. |
2003-06-10 |
2023-08-12 |
rat |
| Toru Sasaki, Kazunori Kawamura, Yasukazu Tanaka, Susumu Ando, Michio Send. Assessment of choline uptake for the synthesis and release of acetylcholine in brain slices by a dynamic autoradiographic technique using [11C]choline. Brain research. Brain research protocols. vol 10. issue 1. 2003-01-03. PMID:12379431. |
[11c]choline uptake increased with the period of incubation and was 1.9 times higher in the striatum than cerebral cortex. |
2003-01-03 |
2023-08-12 |
Not clear |
| Rachel Katz-Brull, Alexei R Koudinov, Hadassa Degan. Choline in the aging brain. Brain research. vol 951. issue 2. 2002-11-25. PMID:12270493. |
the in vitro studies revealed that in the aged cortex and the aged hippocampus the activity of the low-affinity choline uptake increased, possibly compensating for a decrease in the high-affinity uptake activity and the rate of choline diffusion. |
2002-11-25 |
2023-08-12 |
rat |
| J Suhy, R G Miller, R Rule, N Schuff, J Licht, V Dronsky, D Gelinas, A A Maudsley, M W Weine. Early detection and longitudinal changes in amyotrophic lateral sclerosis by (1)H MRSI. Neurology. vol 58. issue 5. 2002-04-19. PMID:11889242. |
to determine 1) the reproducibility of metabolite measurements by (1)h mrs in the motor cortex; 2) the extent to which (1)h mrs imaging (mrsi) detects abnormal concentrations of n-acetylaspartate (naa)-, choline (cho)-, and creatine (cre)-containing compounds in early stages of als; and 3) the metabolite changes over time in als. |
2002-04-19 |
2023-08-12 |
Not clear |
| M A Silver, M Fagiolini, D C Gillespie, C L Howe, M G Frank, N P Issa, A Antonini, M P Stryke. Infusion of nerve growth factor (NGF) into kitten visual cortex increases immunoreactivity for NGF, NGF receptors, and choline acetyltransferase in basal forebrain without affecting ocular dominance plasticity or column development. Neuroscience. vol 108. issue 4. 2002-03-14. PMID:11738495. |
immunohistochemical analysis of the basal forebrain regions of the same animals demonstrated that the ngf infused into cortex was biologically active, producing an increase in the number of ngf-, trka-, p75(ntr)-, and choline acetyltransferase-positive neurons in basal forebrain nuclei in the hemisphere ipsilateral to the ngf minipump compared to the contralateral basal forebrain neurons. |
2002-03-14 |
2023-08-12 |
human |
| S Vielhaber, J Kaufmann, M Kanowski, M Sailer, H Feistner, C Tempelmann, C E Elger, H J Heinze, W S Kun. Effect of creatine supplementation on metabolite levels in ALS motor cortices. Experimental neurology. vol 172. issue 2. 2002-02-06. PMID:11716561. |
these data are compatible with the interpretation that creatine supplementation causes an increase in the diminished naa levels in als motor cortex as well as an increase of choline levels in both als and control motor cortices. |
2002-02-06 |
2023-08-12 |
Not clear |
| C Lucetti, P Del Dotto, G Gambaccini, S Bernardini, M C Bianchi, M Tosetti, U Bonuccell. Proton magnetic resonance spectroscopy (1H-MRS) of motor cortex and basal ganglia in de novo Parkinson's disease patients. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 22. issue 1. 2001-12-13. PMID:11487206. |
proton mr spectroscopy (1h-mrs) has been previously performed in parkinson's disease (pd) and parkinsonian syndromes to evaluate in vivo concentrations of basal ganglia and cerebral cortex metabolites such as n-acetylaspartate (naa), choline (cho), and creatine (cr). |
2001-12-13 |
2023-08-12 |
Not clear |
| H Misawa, K Nakata, J Matsuura, M Nagao, T Okuda, T Hag. Distribution of the high-affinity choline transporter in the central nervous system of the rat. Neuroscience. vol 105. issue 1. 2001-09-27. PMID:11483303. |
noticeably, high densities of high-affinity choline transporter-positive axonal fibers and puncta were encountered in many brain regions such as cerebral cortex, hippocampus, amygdala, striatum, several thalamic nuclei, and brainstem. |
2001-09-27 |
2023-08-12 |
mouse |
| C L Yen, M H Mar, R B Meeker, A Fernandes, S H Zeise. Choline deficiency induces apoptosis in primary cultures of fetal neurons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 15. issue 10. 2001-08-30. PMID:11481217. |
we now examine whether choline deprivation induces apoptosis in nondividing primary neuronal cultures of fetal rat cortex and hippocampus. |
2001-08-30 |
2023-08-12 |
rat |
| N Schuff, W D Rooney, R Miller, D F Gelinas, D L Amend, A A Maudsley, M W Weine. Reanalysis of multislice (1)H MRSI in amyotrophic lateral sclerosis. Magnetic resonance in medicine. vol 45. issue 3. 2001-06-28. PMID:11241711. |
in the motor cortex of als, n-acetyl aspartate (naa) was 23% (p = 0.004) lower than in controls, and in the posterior internal capsule of als choline compounds (cho) were 20% (p = 0.02) higher. |
2001-06-28 |
2023-08-12 |
human |
| M B Abou-Donia, L B Goldstein, K H Jones, A A Abdel-Rahman, T V Damodaran, A M Dechkovskaia, S L Bullman, B E Amir, W A Kha. Locomotor and sensorimotor performance deficit in rats following exposure to pyridostigmine bromide, DEET, and permethrin, alone and in combination. Toxicological sciences : an official journal of the Society of Toxicology. vol 60. issue 2. 2001-06-07. PMID:11248143. |
no effect was observed on choline acetyl transferase activity in brainstem or cortex, except combined exposure to pb, deet, and permethrin caused a slight but significant increase in cortical choline acetyltransferase activity. |
2001-06-07 |
2023-08-12 |
rat |