| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicholas D Leach, Fernando R Nodal, Patricia M Cordery, Andrew J King, Victoria M Baj. Cortical cholinergic input is required for normal auditory perception and experience-dependent plasticity in adult ferrets. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 15. 2013-06-05. PMID:23575862. |
this produced a substantial loss of both p75 neurotrophin receptor (p75(ntr))-positive and choline acetyltransferase-positive cells in this region and of acetylcholinesterase-positive fibers throughout the auditory cortex. |
2013-06-05 |
2023-08-12 |
Not clear |
| Pravinkumar Bhutada, Yogita Mundhada, Vishwas Humane, Anand Rahigude, Prashant Deshmukh, Sandeep Latad, Kishor Jai. Agmatine, an endogenous ligand of imidazoline receptor protects against memory impairment and biochemical alterations in streptozotocin-induced diabetic rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 37. issue 1. 2012-11-08. PMID:22300747. |
lipid peroxidation and glutathione levels as parameters of oxidative stress and choline esterase (che) activity as a marker of cholinergic function were assessed in the cerebral cortex and hippocampus. |
2012-11-08 |
2023-08-12 |
rat |
| C Moret, I Pastrie, M Brile. Effects of scopolamine treatment and lesion of the nucleus basalis upon various cholinergic markers in the rat brain cortex. Neurochemistry international. vol 15. issue 3. 2012-10-02. PMID:20504503. |
after bilateral lesion with ibotenic acid at the level of nucleus basalis of meynert, there was a significant decrease of about 50% in the high affinity uptake of choline and choline acetyltransferase activity in the frontoparietal cortex. |
2012-10-02 |
2023-08-12 |
rat |
| M K Schulz, J A McNulty, T P Hogan, J Zimmer, A J Castr. Biochemical and anatomical analysis of cholinergic, noradrenergic and serotonergic innervation of fetal neocortical transplants placed in excitotoxin-induced neocortical lesions of adult rats. Restorative neurology and neuroscience. vol 7. issue 3. 2012-10-02. PMID:21551780. |
cholinergic fiber innervation was examined at 3 months post grafting by measuring acetylcholinesterase (ache) and choline acetyl-transferase (chat) enzyme activities within the grafts and within the corresponding host cortex by radiochemical enzyme assays as well as by ache histochemistry for the visualization of ache positive fibers. |
2012-10-02 |
2023-08-12 |
rat |
| Francesco Saccà, Mario Quarantelli, Carlo Rinaldi, Tecla Tucci, Raffaele Piro, Gaetano Perrotta, Barbara Carotenuto, Angela Marsili, Vincenzo Palma, Giuseppe De Michele, Arturo Brunetti, Vincenzo Brescia Morra, Alessandro Filla, Marco Salvator. A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: clinical, neuroimaging, and hormonal results. Journal of neurology. vol 259. issue 1. 2012-05-01. PMID:21706151. |
primary endpoint was n-acetylaspartate/(creatine + choline) (naa/cre + cho) ratio in motor cortex assessed by magnetic resonance spectroscopy performed at months 0, 6, and 12. |
2012-05-01 |
2023-08-12 |
Not clear |
| Izabela Kowalczyk, Neil Duggal, Robert Barth. Proton magnetic resonance spectroscopy of the motor cortex in cervical myelopathy. Brain : a journal of neurology. vol 135. issue Pt 2. 2012-04-27. PMID:22180462. |
this prospective study characterizes differences in metabolite levels in the motor cortex, specifically n-acetylaspartate, creatine, choline, myo-inositol and glutamate plus glutamine, due to alterations in cortical function in patients with reversible spinal cord compression compared with healthy controls. |
2012-04-27 |
2023-08-12 |
Not clear |
| André Luis Nunes-Freitas, Anderson Ribeiro-Carvalho, Carla Soares Lima, Ana Carolina Dutra-Tavares, Alex C Manhães, Patricia C Lisboa, Elaine Oliveira, Egberto Gaspar de Moura, Cláudio C Filgueiras, Yael Abreu-Villaç. Nicotine exposure during the third trimester equivalent of human gestation: time course of effects on the central cholinergic system of rats. Toxicological sciences : an official journal of the Society of Toxicology. vol 123. issue 1. 2011-12-20. PMID:21633116. |
in the cerebral cortex, midbrain, and hippocampus, we assessed nicotinic acetylcholine receptor (nachr) binding, [(3)h]hemicholinium-3 (hc-3) binding to the high-affinity choline transporter, choline acetyltransferase (chat), and acetylcholinesterase (ache) activities. |
2011-12-20 |
2023-08-12 |
human |
| Pravinkumar Bhutada, Yogita Mundhada, Kuldeep Bansod, Santosh Tawari, Shaktipal Patil, Pankaj Dixit, Sudhir Umathe, Dharmendra Mundhad. Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes. Behavioural brain research. vol 220. issue 1. 2011-07-15. PMID:21262264. |
lipid peroxidation and glutathione levels as parameters of oxidative stress and choline esterase (che) activity as marker of cholinergic function were assessed in the cerebral cortex and hippocampus. |
2011-07-15 |
2023-08-12 |
rat |
| Roland Kreis, Kevin Wingeier, Peter Vermathen, Elisabeth Giger, Franziska Joncourt, Karin Zwygart, Franz Kaufmann, Chris Boesch, Maja Steinli. Brain metabolite composition in relation to cognitive function and dystrophin mutations in boys with Duchenne muscular dystrophy. NMR in biomedicine. vol 24. issue 3. 2011-06-17. PMID:21404337. |
quantitative mrs showed consistent choline deficits, in both cerebellar white matter and temporo-parietal cortex, as well as small, but significant, metabolic abnormalities for glutamate and total n-acetyl compounds in the temporo-parietal region. |
2011-06-17 |
2023-08-12 |
human |
| Bethany K Bracken, J Eric Jensen, Andrew P Prescot, Bruce M Cohen, Perry F Renshaw, Dost Ongü. Brain metabolite concentrations across cortical regions in healthy adults. Brain research. vol 1369. 2011-04-21. PMID:21081116. |
this study used mrs to examine concentrations of n-acetylaspartate (naa), a marker of neuronal integrity and function, and choline (cho), which is related to the amount of cell membrane per unit volume, in anterior cingulate cortex (acc) and parieto-occipital cortex (poc) in healthy individuals. |
2011-04-21 |
2023-08-12 |
human |
| T Peeyush Kumar, Sherin Antony, Smijin Soman, Korah P Kuruvilla, Naijil George, C S Paulos. Role of curcumin in the prevention of cholinergic mediated cortical dysfunctions in streptozotocin-induced diabetic rats. Molecular and cellular endocrinology. vol 331. issue 1. 2011-02-28. PMID:20637830. |
our study revealed decreased gene expression of muscarinic m1, insulin receptor, sod, choline acetyl transferase and increased gene expression of muscarinic m3, α7-nicotinic acetylcholine receptor, acetylcholine esterase and glut3 in cerebral cortex of diabetic rats. |
2011-02-28 |
2023-08-12 |
rat |
| Natalia A Crivello, Jan K Blusztajn, James A Joseph, Barbara Shukitt-Hale, Donald E Smit. Short-term nutritional folate deficiency in rats has a greater effect on choline and acetylcholine metabolism in the peripheral nervous system than in the brain, and this effect escalates with age. Nutrition research (New York, N.Y.). vol 30. issue 10. 2011-02-09. PMID:21056288. |
in adult rats, fd consumption markedly decreased choline levels in the liver, kidneys, and heart; furthermore, choline levels in the cortex and striatum were moderately elevated, although hippocampal choline levels were not affected. |
2011-02-09 |
2023-08-12 |
rat |
| Reza M Salek, Jing Xia, Amy Innes, Brian C Sweatman, Robert Adalbert, Suzanne Randle, Eileen McGowan, Piers C Emson, Julian L Griffi. A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease. Neurochemistry international. vol 56. issue 8. 2010-11-29. PMID:20398713. |
the analysis of the corresponding loading plots for these brain regions indicated a decrease in n-acetyl-l-aspartate, glutamate, glutamine, taurine (exception hippocampus), gamma-amino butyric acid, choline and phosphocholine (combined resonances), creatine, phosphocreatine and succinate in hippocampus, cortex, frontal cortex (exception gamma-amino butyric acid) and midbrain of affected animals. |
2010-11-29 |
2023-08-12 |
mouse |
| Yael Abreu-Villaça, Cláudio Carneiro Filgueiras, Monique Guthierrez, Ana Heloisa de Medeiros, Maria Angélica Mattos, Maurício Dos Santos Pereira, Alex Christian Manhães, Regina Célia Cussa Kubrusl. Exposure to tobacco smoke containing either high or low levels of nicotine during adolescence: differential effects on choline uptake in the cerebral cortex and hippocampus. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. vol 12. issue 7. 2010-10-18. PMID:20457645. |
exposure to tobacco smoke containing either high or low levels of nicotine during adolescence: differential effects on choline uptake in the cerebral cortex and hippocampus. |
2010-10-18 |
2023-08-12 |
Not clear |
| Can-Jun Ruan, Li Zhang, Di-Hua Chen, Zhan Li, Guan-Hua Du, Lan Su. Effects of trans-2,4-dimethoxystibene against the neurotoxicity induced by Abeta(25-35) both in vitro and in vivo. Neuroscience research. vol 67. issue 3. 2010-09-13. PMID:20346380. |
at the same time, the decreased superoxide dismutase (sod) and choline acetyl transferase (chat) were markedly increased, and the increased acetylcholine esterase (ache) activity was significantly decreased in hippocampus and cortex. |
2010-09-13 |
2023-08-12 |
mouse |
| Thomas Lescot, Laurence Fulla-Oller, Lawrence Fulla-Oller, Chrystelle Po, Xiao Ru Chen, Louis Puybasset, Brigitte Gillet, Michel Plotkine, Philippe Meric, Catherine Marchand-Lerou. Temporal and regional changes after focal traumatic brain injury. Journal of neurotrauma. vol 27. issue 1. 2010-05-10. PMID:19705964. |
ratios of n-acetylaspartate (naa), choline compounds (cho), and lactate (lac) over creatine (cr) were estimated by (1)h-mrs. t2 values were high in the contused cortex 24 h after tbi, suggesting edema development; adc was low, consistent with cytotoxic edema. |
2010-05-10 |
2023-08-12 |
rat |
| Can-Jun Ruan, Jian-Yong Si, Li Zhang, Di-Hua Chen, Guan-Hua Du, Lan S. Protective effect of stilbenes containing extract-fraction from Cajanus cajan L. on Abeta(25-35)-induced cognitive deficits in mice. Neuroscience letters. vol 467. issue 2. 2010-02-01. PMID:19833171. |
furthermore, superoxide dismutase (sod), choline acetyl transferase (chat) and acetylcholine esterase (ache) activity in hippocampus and cortex were analyzed by spectrophotometric method. |
2010-02-01 |
2023-08-12 |
mouse |
| K J A Rodrigues, M B Santana, J L M Do Nascimento, D L W Picanço-Diniz, L A L Maués, S N Santos, V M M Ferreira, M Alfonso, R Durán, L R F Far. Behavioral and biochemical effects of neonicotinoid thiamethoxam on the cholinergic system in rats. Ecotoxicology and environmental safety. vol 73. issue 1. 2010-01-12. PMID:19481804. |
therefore, we aimed to determine the potential effects of thiamethoxam on mammalian brain, testing the performance in the open field and elevated plus-maze of rats exposed to this insecticide and, in order to establish the neurochemical endpoints, we measured the acetylcholinesterase activity in different brain regions (hippocampus, striatum and cortex) and the high-affinity choline uptake (hacu) in synaptosomes from rat hippocampus. |
2010-01-12 |
2023-08-12 |
rat |
| Jan Johansson, Elena Formaggio, Guido Fumagalli, Christian Chiamuler. Choline up-regulates BDNF and down-regulates TrkB neurotrophin receptor in rat cortical cell culture. Neuroreport. vol 20. issue 9. 2009-08-21. PMID:19424097. |
primary cell cultures from rat cerebral cortex were exposed for 72 h to the alpha7 nachr selective agonist choline and protein expression levels of the neurotrophin receptors p75, trka, trkb and trkc were examined. |
2009-08-21 |
2023-08-12 |
rat |
| Chieh-Hsun Lee, Ping-Hong Lai, Chin-San Liu, Jie-Yuan L. Proton magnetic resonance spectroscopy in Kennedy disease. Journal of the neurological sciences. vol 277. issue 1-2. 2009-04-02. PMID:19019384. |
relative metabolite concentrations for n-acetyl-aspartate (naa), choline (cho) and phosphocreatine (cr) and lactate (lac) were measured in the motor cortex and the brainstem area. |
2009-04-02 |
2023-08-12 |
human |