| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard L Hilderbran. High-performance sport, marijuana, and cannabimimetics. Journal of analytical toxicology. vol 35. issue 9. 2012-03-07. PMID:22080902. |
this article reviews some of the history of marijuana in olympic and collegiate sport, summarizes the guidelines by which a substance is added to the world anti-doping agency prohibited list, and updates information on the pharmacologic effects of cannabinoids and their mechanism of action. |
2012-03-07 |
2023-08-12 |
Not clear |
| M P Lim, L A Devi, R Rozenfel. Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis. Cell death & disease. vol 2. 2012-03-01. PMID:21654828. |
here we demonstrate that cannabidiol (cbd), a major non-psychoactive component of the plant cannabis sativa, induces apoptosis in activated hscs through a cannabinoid receptor-independent mechanism. |
2012-03-01 |
2023-08-12 |
mouse |
| Nahoko Uchiyama, Ruri Kikura-Hanajiri, Takuji Shoda, Kiyoshi Fukuhara, Yukihiro God. [Isomeric analysis of synthetic cannabinoids detected as designer drugs]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 131. issue 7. 2012-02-27. PMID:21720146. |
among those, two derivatives of Δ(9)-tetrahydrocannabinol (Δ(9)-thc), which is major psychotropic cannabinoid of marijuana, cannabicyclohexanol (cch, 3-[2-hydroxy-4-(2-methylnonan-2-yl)phenyl]cyclohexan-1-ol) and cp-47,497 (3-[2-hydroxy-4-(2-methyloctan-2-yl)phenyl]cyclohexan-1-ol), have been controlled as designated substances (shitei-yakubutsu) under the pharmaceutical affairs law since november 2009. |
2012-02-27 |
2023-08-12 |
Not clear |
| Kim Wild, Hugh Wilso. Cannabinoid hyperemesis. Emergency medicine journal : EMJ. vol 29. issue 1. 2012-02-21. PMID:22186263. |
a diagnosis of cannabinoid hyperemesis was made and her symptoms resolved after treatment with intravenous fluids, antiemetics and abstinence from cannabis. |
2012-02-21 |
2023-08-12 |
Not clear |
| Seraina M Schmid, Olav Lapaire, Dorothy J Huang, Frank Edwin Jürgens, Uwe Güt. Cannabinoid hyperemesis syndrome: an underreported entity causing nausea and vomiting of pregnancy. Archives of gynecology and obstetrics. vol 284. issue 5. 2012-02-15. PMID:21170540. |
cannabinoid hyperemesis syndrome, which seems to be a rare paradoxical reaction in individuals with a particular predisposition, is characterized by cyclic severe nausea and vomiting in long-term cannabis users. |
2012-02-15 |
2023-08-12 |
Not clear |
| Philip Robso. Abuse potential and psychoactive effects of δ-9-tetrahydrocannabinol and cannabidiol oromucosal spray (Sativex), a new cannabinoid medicine. Expert opinion on drug safety. vol 10. issue 5. 2012-02-15. PMID:21542664. |
abuse potential and psychoactive effects of δ-9-tetrahydrocannabinol and cannabidiol oromucosal spray (sativex), a new cannabinoid medicine. |
2012-02-15 |
2023-08-12 |
Not clear |
| Anna-Maria Szczesniak, Yehoshua Maor, Harold Robertson, Orlando Hung, Melanie E M Kell. Nonpsychotropic cannabinoids, abnormal cannabidiol and canabigerol-dimethyl heptyl, act at novel cannabinoid receptors to reduce intraocular pressure. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. vol 27. issue 5. 2012-02-10. PMID:21770780. |
nonpsychotropic cannabinoids, abnormal cannabidiol and canabigerol-dimethyl heptyl, act at novel cannabinoid receptors to reduce intraocular pressure. |
2012-02-10 |
2023-08-12 |
rat |
| Anna-Maria Szczesniak, Yehoshua Maor, Harold Robertson, Orlando Hung, Melanie E M Kell. Nonpsychotropic cannabinoids, abnormal cannabidiol and canabigerol-dimethyl heptyl, act at novel cannabinoid receptors to reduce intraocular pressure. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. vol 27. issue 5. 2012-02-10. PMID:21770780. |
the objective of our study was to examine the pharmacology of the intraocular pressure (iop)-lowering actions of the behaviorally inactive cannabinoids, abnormal cannabidiol (abn-cbd), and a cannabigerol analog, cannabigerol-dimethyl heptyl (cbg-dmh), in comparison to that of the nonselective cannabinoid 1 receptor (cb(1)r) and cb(2)r agonist, win55,212-2, in brown norway rats. |
2012-02-10 |
2023-08-12 |
rat |
| Mary E Lynch, Fiona Campbel. Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials. British journal of clinical pharmacology. vol 72. issue 5. 2012-02-09. PMID:21426373. |
cannabinoids studied included smoked cannabis, oromucosal extracts of cannabis based medicine, nabilone, dronabinol and a novel thc analogue. |
2012-02-09 |
2023-08-12 |
Not clear |
| Hanan El Marroun, James J Hudziak, Henning Tiemeier, Hanneke Creemers, Eric A P Steegers, Vincent W V Jaddoe, Albert Hofman, Frank C Verhulst, Wim van den Brink, Anja C Huizin. Intrauterine cannabis exposure leads to more aggressive behavior and attention problems in 18-month-old girls. Drug and alcohol dependence. vol 118. issue 2-3. 2012-02-09. PMID:21470799. |
the development of the fetal endocannabinoid receptor system may be vulnerable to maternal cannabis use during pregnancy and may produce long-term consequences in children. |
2012-02-09 |
2023-08-12 |
Not clear |
| Christine Moore, Cynthia Coulter, Donald Uges, James Tuyay, Susanne van der Linde, Arthur van Leeuwen, Margaux Garnier, Jonathan Orbit. Cannabinoids in oral fluid following passive exposure to marijuana smoke. Forensic science international. vol 212. issue 1-3. 2012-02-02. PMID:21763088. |
cannabinoids in oral fluid following passive exposure to marijuana smoke. |
2012-02-02 |
2023-08-12 |
human |
| Luciano De Petrocellis, Alessia Ligresti, Aniello Schiano Moriello, Marco Allarà, Tiziana Bisogno, Stefania Petrosino, Colin G Stott, Vincenzo Di Marz. Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. British journal of pharmacology. vol 163. issue 7. 2012-01-18. PMID:21175579. |
effects of cannabinoids and cannabinoid-enriched cannabis extracts on trp channels and endocannabinoid metabolic enzymes. |
2012-01-18 |
2023-08-12 |
Not clear |
| Luciano De Petrocellis, Alessia Ligresti, Aniello Schiano Moriello, Marco Allarà, Tiziana Bisogno, Stefania Petrosino, Colin G Stott, Vincenzo Di Marz. Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes. British journal of pharmacology. vol 163. issue 7. 2012-01-18. PMID:21175579. |
cannabidiol (cbd) and Δ(9) -tetrahydrocannabinol (thc) interact with transient receptor potential (trp) channels and enzymes of the endocannabinoid system. |
2012-01-18 |
2023-08-12 |
Not clear |
| Ewa Kozela, Nirit Lev, Nathali Kaushansky, Raya Eilam, Neta Rimmerman, Rivka Levy, Avraham Ben-Nun, Ana Juknat, Zvi Voge. Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL/6 mice. British journal of pharmacology. vol 163. issue 7. 2012-01-18. PMID:21449980. |
cannabis extracts and several cannabinoids have been shown to exert broad anti-inflammatory activities in experimental models of inflammatory cns degenerative diseases. |
2012-01-18 |
2023-08-12 |
mouse |
| Javier Fernández-Ruiz, Miguel Moreno-Martet, Carmen Rodríguez-Cueto, Cristina Palomo-Garo, María Gómez-Cañas, Sara Valdeolivas, Carmen Guaza, Julián Romero, Manuel Guzmán, Raphael Mechoulam, José A Ramo. Prospects for cannabinoid therapies in basal ganglia disorders. British journal of pharmacology. vol 163. issue 7. 2012-01-18. PMID:21545415. |
on the one hand, cannabinoids like Δ(9) -tetrahydrocannabinol or cannabidiol protect nigral or striatal neurons in experimental models of both disorders, in which oxidative injury is a prominent cytotoxic mechanism. |
2012-01-18 |
2023-08-12 |
Not clear |
| James Richard Burgdorf, Beau Kilmer, Rosalie Liccardo Pacul. Heterogeneity in the composition of marijuana seized in California. Drug and alcohol dependence. vol 117. issue 1. 2012-01-17. PMID:21288662. |
marijuana contains multiple cannabinoids. |
2012-01-17 |
2023-08-12 |
Not clear |
| James Richard Burgdorf, Beau Kilmer, Rosalie Liccardo Pacul. Heterogeneity in the composition of marijuana seized in California. Drug and alcohol dependence. vol 117. issue 1. 2012-01-17. PMID:21288662. |
research suggests that another cannabinoid, cannabidiol (cbd), may offset some of these effects. |
2012-01-17 |
2023-08-12 |
Not clear |
| Catherine Lombard, Venkatesh L Hegde, Mitzi Nagarkatti, Prakash S Nagarkatt. Perinatal exposure to Δ9-tetrahydrocannabinol triggers profound defects in T cell differentiation and function in fetal and postnatal stages of life, including decreased responsiveness to HIV antigens. The Journal of pharmacology and experimental therapeutics. vol 339. issue 2. 2012-01-16. PMID:21831965. |
although marijuana cannabinoids have been shown to exert immunosuppression in adults, virtually nothing is known about the effects of marijuana use during pregnancy on the developing immune system of the fetus and during postnatal life. |
2012-01-16 |
2023-08-12 |
mouse |
| Gerald T DeLong, Carl E Wolf, Alphonse Poklis, Aron Lichtma. Cannabichromene and tetrahydrocannabinol determination in mouse blood and brain by gas chromatography-mass spectrometry. Journal of analytical toxicology. vol 35. issue 7. 2012-01-12. PMID:21871159. |
cannabichromene (cbc) is a phytocannabinoid, the second most abundant cannabinoid quantitatively in marijuana. |
2012-01-12 |
2023-08-12 |
mouse |
| David M Schwope, Karl B Scheidweiler, Marilyn A Huesti. Direct quantification of cannabinoids and cannabinoid glucuronides in whole blood by liquid chromatography-tandem mass spectrometry. Analytical and bioanalytical chemistry. vol 401. issue 4. 2012-01-11. PMID:21727996. |
electrospray ionization was utilized for cannabinoid detection; both positive (Δ(9)-tetrahydrocannabinol [thc] and cannabinol [cbn]) and negative (11-hydroxy-thc [11-oh-thc], 11-nor-9-carboxy-thc [thccooh], cannabidiol [cbd], thc-glucuronide, and thccooh-glucuronide) polarity were employed with multiple reaction monitoring. |
2012-01-11 |
2023-08-12 |
Not clear |