| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Lorente, S Torres, M Salazar, A Carracedo, S Hernández-Tiedra, F Rodríguez-Fornés, E García-Taboada, B Meléndez, M Mollejo, Y Campos-Martín, S A Lakatosh, J Barcia, M Guzmán, G Velasc. Stimulation of the midkine/ALK axis renders glioma cells resistant to cannabinoid antitumoral action. Cell death and differentiation. vol 18. issue 6. 2011-08-22. PMID:21233844. |
Δ(9)-tetrahydrocannabinol (thc), the major active ingredient of marijuana, and other cannabinoids inhibit tumor growth in animal models of cancer, including glioma, an effect that relies, at least in part, on the stimulation of autophagy-mediated apoptosis in tumor cells. |
2011-08-22 |
2023-08-12 |
human |
| Bogna Geppert, Artur Tezyk, Ewa Florek, Czesław Zab. [Plants' materials and synthetic agonists of cannabinoid receptors use as a substitute of Marihuana, appearing in a current forensic toxicology practice of evidence materials]. Przeglad lekarski. vol 67. issue 10. 2011-08-17. PMID:21360966. |
the substitutes of marihuana occurring on the market are of natural or synthetic origins, for example different species of raw plants' materials having action similar to cannabis or raw plants' materials with no psychoactive properities but with an addition of components so called synthetic cannabinoids. |
2011-08-17 |
2023-08-12 |
Not clear |
| Yuki Hashimotodani, Asami Tanimura, Masanobu Kan. [Lipid mediator endocannabinoids in modulating synaptic transmission]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 31. issue 3. 2011-08-16. PMID:21800700. |
marijuana smoking elicits various psychoactive effects through type 1 cannabinoid receptors (cb(1)rs) in the brain. |
2011-08-16 |
2023-08-12 |
Not clear |
| Mark D Black, Rachel J Stevens, Nancy Rogacki, Robert E Featherstone, Yaw Senyah, Odessa Giardino, Beth Borowsky, Jeanne Stemmelin, Caroline Cohen, Philippe Pichat, Michal Arad, Segev Barak, Amaya De Levie, Ina Weiner, Guy Griebel, Geoffrey B Vart. AVE1625, a cannabinoid CB1 receptor antagonist, as a co-treatment with antipsychotics for schizophrenia: improvement in cognitive function and reduction of antipsychotic-side effects in rodents. Psychopharmacology. vol 215. issue 1. 2011-08-15. PMID:21181124. |
the psychotomimetic effects of cannabis are believed to be mediated via cannabinoid cb1 receptors. |
2011-08-15 |
2023-08-12 |
Not clear |
| T Karasu, T H Marczylo, M Maccarrone, J C Konj. The role of sex steroid hormones, cytokines and the endocannabinoid system in female fertility. Human reproduction update. vol 17. issue 3. 2011-08-12. PMID:21227997. |
endogenous cannabinoids (also called endocannabinoids) bind to the same receptors as those of Δ(9)-tetrahydrocannabinol (thc), the psychoactive component of cannabis sativa. |
2011-08-12 |
2023-08-12 |
human |
| Laxmikant S Deshpande, Robert E Blair, Robert J DeLorenz. Prolonged cannabinoid exposure alters GABA(A) receptor mediated synaptic function in cultured hippocampal neurons. Experimental neurology. vol 229. issue 2. 2011-08-05. PMID:21324315. |
developing cannabinoid-based medication along with marijuana's recreational use makes it important to investigate molecular adaptations the endocannabinoid system undergoes following prolonged use and withdrawal. |
2011-08-05 |
2023-08-12 |
Not clear |
| Ana María Martín-Moreno, David Reigada, Belén G Ramírez, R Mechoulam, Nadia Innamorato, Antonio Cuadrado, María L de Ceballo. Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer's disease. Molecular pharmacology. vol 79. issue 6. 2011-08-01. PMID:21350020. |
cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to alzheimer's disease. |
2011-08-01 |
2023-08-12 |
mouse |
| Kathryn A Seely, Paul L Prather, Laura P James, Jeffery H Mora. Marijuana-based drugs: innovative therapeutics or designer drugs of abuse? Molecular interventions. vol 11. issue 1. 2011-07-29. PMID:21441120. |
the principal psychoactive component of marijuana, Δ(9)-tetrahydrocannabinol (thc), activates cb1 cannabinoid receptors (cb1rs). |
2011-07-29 |
2023-08-12 |
Not clear |
| Sofía Torres, Mar Lorente, Fátima Rodríguez-Fornés, Sonia Hernández-Tiedra, María Salazar, Elena García-Taboada, Juan Barcia, Manuel Guzmán, Guillermo Velasc. A combined preclinical therapy of cannabinoids and temozolomide against glioma. Molecular cancer therapeutics. vol 10. issue 1. 2011-07-28. PMID:21220494. |
administration of submaximal doses of thc and cannabidiol (cbd; another plant-derived cannabinoid that also induces glioma cell death through a mechanism of action different from that of thc) remarkably reduces the growth of glioma xenografts. |
2011-07-28 |
2023-08-12 |
Not clear |
| Sabatino Maione, Fabiana Piscitelli, Luisa Gatta, Daniela Vita, Luciano De Petrocellis, Enza Palazzo, Vito de Novellis, Vincenzo Di Marz. Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action. British journal of pharmacology. vol 162. issue 3. 2011-07-26. PMID:20942863. |
two non-psychoactive cannabinoids, cannabidiol (cbd) and cannabichromene (cbc), are known to modulate in vitro the activity of proteins involved in nociceptive mechanisms, including transient receptor potential (trp) channels of vanilloid type-1 (trpv1) and of ankyrin type-1 (trpa1), the equilibrative nucleoside transporter and proteins facilitating endocannabinoid inactivation. |
2011-07-26 |
2023-08-12 |
rat |
| V Di Marzo, F Piscitell. Gut feelings about the endocannabinoid system. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 23. issue 5. 2011-07-20. PMID:21481098. |
stemming from the centuries-old and well known effects of cannabis on intestinal motility and secretion, research on the role of the endocannabinoid system in gut function and dysfunction has received ever increasing attention since the discovery of the cannabinoid receptors and their endogenous ligands, the endocannabinoids. |
2011-07-20 |
2023-08-12 |
Not clear |
| Gino Serra, Walter Fratt. A possible role for the endocannabinoid system in the neurobiology of depression. Clinical practice and epidemiology in mental health : CP & EMH. vol 3. 2011-07-14. PMID:18021439. |
no clinical trials carried out using cannabinoids in the treatment of affective disorders have been published to date, although anecdotal reports have described both antidepressant and antimanic properties of cannabis as well as the ability of cannabis to induce mania that has also been documented. |
2011-07-14 |
2023-08-12 |
Not clear |
| Ethan B Russ. Cannabinoids in the management of difficult to treat pain. Therapeutics and clinical risk management. vol 4. issue 1. 2011-07-14. PMID:18728714. |
sativex((r)), a cannabis derived oromucosal spray containing equal proportions of thc (partial cb(1) receptor agonist ) and cannabidiol (cbd, a non-euphoriant, anti-inflammatory analgesic with cb(1) receptor antagonist and endocannabinoid modulating effects) was approved in canada in 2005 for treatment of central neuropathic pain in multiple sclerosis, and in 2007 for intractable cancer pain. |
2011-07-14 |
2023-08-12 |
Not clear |
| Masood A Khan, Sailaja Akell. Cannabis-induced bipolar disorder with psychotic features: a case report. Psychiatry (Edgmont (Pa. : Township)). vol 6. issue 12. 2011-07-14. PMID:20104292. |
although there is good evidence to support this, the connections are complex and not fully understood.as the research in the endocannabinoid system is emerging, the neurobiological effects of cannabis are being evaluated in the development of psychiatric illness for those individuals who may be genetically vulnerable. |
2011-07-14 |
2023-08-12 |
Not clear |
| Gregory I Lio. Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation. World journal of diabetes. vol 1. issue 1. 2011-07-14. PMID:21537423. |
this review is focused on the therapeutic effects of cannabidiol (cbd), a non-psychoactive native cannabinoid, as an emerging and novel therapeutic modality in ophthalmology based on systematic studies in animal models of inflammatory retinal diseases including diabetic retinopathy - a retinal disease associated with vascular-neuroinflammation. |
2011-07-14 |
2023-08-12 |
Not clear |
| Prakash Nagarkatti, Rupal Pandey, Sadiye Amcaoglu Rieder, Venkatesh L Hegde, Mitzi Nagarkatt. Cannabinoids as novel anti-inflammatory drugs. Future medicinal chemistry. vol 1. issue 7. 2011-07-11. PMID:20191092. |
the discovery of Δ9-tetrahydrocannabinol (thc) as the major psychoactive principle in marijuana, as well as the identification of cannabinoid receptors and their endogenous ligands, has led to a significant growth in research aimed at understanding the physiological functions of cannabinoids. |
2011-07-11 |
2023-08-12 |
mouse |
| Uri Napchan, Dawn C Buse, Elizabeth W Lode. The use of marijuana or synthetic cannabinoids for the treatment of headache. Headache. vol 51. issue 3. 2011-07-07. PMID:21462433. |
the use of marijuana or synthetic cannabinoids for the treatment of headache. |
2011-07-07 |
2023-08-12 |
Not clear |
| Zhiqiang Liu, Jing Han, Lintao Jia, Jean-Christian Maillet, Guang Bai, Lin Xu, Zhengping Jia, Qiaohua Zheng, Wandong Zhang, Robert Monette, Zul Merali, Zhou Zhu, Wei Wang, Wei Ren, Xia Zhan. Synaptic neurotransmission depression in ventral tegmental dopamine neurons and cannabinoid-associated addictive learning. PloS one. vol 5. issue 12. 2011-07-05. PMID:21187978. |
it is unknown whether chronic exposure of cannabis (marijuana or cannabinoids), the most commonly used illicit drug worldwide, induce ltp or ltd at these synapses. |
2011-07-05 |
2023-08-12 |
rat |
| G Appendino, G Chianese, O Taglialatela-Scafat. Cannabinoids: occurrence and medicinal chemistry. Current medicinal chemistry. vol 18. issue 7. 2011-07-04. PMID:21254969. |
the biomedical relevance of hemp undoubtedly underlies the wealth of data on its constituents and their biological activities, and cannabinoids, a class of unique meroterpenoids derived from the alkylation of an olivetollike alkyl resorcinol with a monoterpene unit, are the most typical constituents of cannabis. |
2011-07-04 |
2023-08-12 |
Not clear |
| Patrizia Campolongo, Viviana Trezza, Patrizia Ratano, Maura Palmery, Vincenzo Cuom. Developmental consequences of perinatal cannabis exposure: behavioral and neuroendocrine effects in adult rodents. Psychopharmacology. vol 214. issue 1. 2011-06-20. PMID:20556598. |
since the endocannabinoid system plays a crucial role in brain development, maternal exposure to cannabis derivatives might result in long-lasting neurobehavioral abnormalities in the exposed offspring. |
2011-06-20 |
2023-08-12 |
Not clear |