| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jonathan A Galli, Ronald Andari Sawaya, Frank K Friedenber. Cannabinoid hyperemesis syndrome. Current drug abuse reviews. vol 4. issue 4. 2012-04-27. PMID:22150623. |
cannabinoid hyperemesis syndrome is characterized by chronic cannabis use, cyclic episodes of nausea and vomiting, and frequent hot bathing. |
2012-04-27 |
2023-08-12 |
Not clear |
| Jonathan A Galli, Ronald Andari Sawaya, Frank K Friedenber. Cannabinoid hyperemesis syndrome. Current drug abuse reviews. vol 4. issue 4. 2012-04-27. PMID:22150623. |
tetrahydrocannabinol, cannabidiol, and cannabigerol are three cannabinoids found in the cannabis plant with opposing effects on the emesis response. |
2012-04-27 |
2023-08-12 |
Not clear |
| Dénes Kleiner, Kálmán Ditró. [The potential use of cannabidiol in the therapy of metabolic syndrome]. Orvosi hetilap. vol 153. issue 13. 2012-04-25. PMID:22430005. |
cannabidiol, a cannabinoid and serotonin receptor antagonist, may alleviate hyperphagia without the side effects of rimonabant (for example depression and reduced insulin sensitivity). |
2012-04-25 |
2023-08-12 |
Not clear |
| Jing Han, Philip Kesner, Mathilde Metna-Laurent, Tingting Duan, Lin Xu, Francois Georges, Muriel Koehl, Djoher Nora Abrous, Juan Mendizabal-Zubiaga, Pedro Grandes, Qingsong Liu, Guang Bai, Wei Wang, Lize Xiong, Wei Ren, Giovanni Marsicano, Xia Zhan. Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD. Cell. vol 148. issue 5. 2012-04-20. PMID:22385967. |
acute cannabinoids impair working memory through astroglial cb1 receptor modulation of hippocampal ltd. impairment of working memory is one of the most important deleterious effects of marijuana intoxication in humans, but its underlying mechanisms are presently unknown. |
2012-04-20 |
2023-08-12 |
mouse |
| Jing Han, Philip Kesner, Mathilde Metna-Laurent, Tingting Duan, Lin Xu, Francois Georges, Muriel Koehl, Djoher Nora Abrous, Juan Mendizabal-Zubiaga, Pedro Grandes, Qingsong Liu, Guang Bai, Wei Wang, Lize Xiong, Wei Ren, Giovanni Marsicano, Xia Zhan. Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD. Cell. vol 148. issue 5. 2012-04-20. PMID:22385967. |
we conclude that the impairment of working memory by marijuana and cannabinoids is due to the activation of astroglial cb(1)r and is associated with astroglia-dependent hippocampal ltd in vivo. |
2012-04-20 |
2023-08-12 |
mouse |
| Andrés Uribe-Mariño, Audrey Francisco, Maria Angélica Castiblanco-Urbina, André Twardowschy, Carlos José Salgado-Rohner, José Alexandre S Crippa, Jaime Eduardo Cecílio Hallak, Antônio Waldo Zuardi, Norberto Cysne Coimbr. Anti-aversive effects of cannabidiol on innate fear-induced behaviors evoked by an ethological model of panic attacks based on a prey vs the wild snake Epicrates cenchria crassus confrontation paradigm. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 2. 2012-04-17. PMID:21918503. |
recent attention has been given to the potential anxiolytic properties of cannabidiol, because of its complex actions on the endocannabinoid system together with its effects on other neurotransmitter systems. |
2012-04-17 |
2023-08-12 |
mouse |
| Chia-En A Chang, Rizi Ai, Michael Gutierrez, Michael J Marsell. Homology modeling of cannabinoid receptors: discovery of cannabinoid analogues for therapeutic use. Methods in molecular biology (Clifton, N.J.). vol 819. 2012-04-13. PMID:22183560. |
since the isolation and identification of the major psychoactive component Δ(9)-thc in cannabis sativa in the 1960s, numerous analogues of the classical plant cannabinoids have been synthesized and tested for their biological activity. |
2012-04-13 |
2023-08-12 |
Not clear |
| Andrew J Hill, Claire M Williams, Benjamin J Whalley, Gary J Stephen. Phytocannabinoids as novel therapeutic agents in CNS disorders. Pharmacology & therapeutics. vol 133. issue 1. 2012-04-10. PMID:21924288. |
in the past two decades, characterisation of the body's endogenous cannabinoid (cb) (endocannabinoid, ecb) system (ecs) has highlighted activation of central cb(1) receptors by the major pcb, Δ(9)-tetrahydrocannabinol (Δ(9)-thc) as the primary mediator of the psychoactive, hyperphagic and some of the potentially therapeutic properties of ingested cannabis. |
2012-04-10 |
2023-08-12 |
Not clear |
| Lisa K Brents, Anna Gallus-Zawada, Anna Radominska-Pandya, Tamara Vasiljevik, Thomas E Prisinzano, William E Fantegrossi, Jeffery H Moran, Paul L Prathe. Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity. Biochemical pharmacology. vol 83. issue 7. 2012-04-10. PMID:22266354. |
k2 and several similar purported "incense products" spiked with synthetic cannabinoids are abused as cannabis substitutes. |
2012-04-10 |
2023-08-12 |
mouse |
| Hemant Lata, Suman Chandra, Natascha Techen, Ikhlas A Khan, Mahmoud A ElSohl. Molecular analysis of genetic fidelity in Cannabis sativa L. plants grown from synthetic (encapsulated) seeds following in vitro storage. Biotechnology letters. vol 33. issue 12. 2012-04-06. PMID:21805186. |
gc analysis of six major cannabinoids [Δ(9)-tetrahydrocannabinol, tetrahydrocannabivarin, cannabidiol, cannabichromene, cannabigerol and cannabinol] showed homogeneity in the re-grown clones and the mother plant with insignificant differences in cannabinoids content, thereby confirming the stability of plants derived from synthetic seeds following 6 months storage. |
2012-04-06 |
2023-08-12 |
Not clear |
| S Fleig, R Brunkhors. Hyperemesis and a high water bill. Zeitschrift fur Gastroenterologie. vol 49. issue 11. 2012-04-02. PMID:22069047. |
he reported regular cannabis use and showed abnormal bathing behavior taking hot showers several times a day for more than one hour each, which was the only measure to ease his nausea; on the basis of these clinical findings, the diagnosis of cannabinoid hyperemesis syndrome was made. |
2012-04-02 |
2023-08-12 |
Not clear |
| Mikael A Kowal, Lorenza S Colzato, Bernhard Homme. Decreased spontaneous eye blink rates in chronic cannabis users: evidence for striatal cannabinoid-dopamine interactions. PloS one. vol 6. issue 11. 2012-04-02. PMID:22125599. |
chronic cannabis use has been shown to block long-term depression of gaba-glutamate synapses in the striatum, which is likely to reduce the extent to which endogenous cannabinoids modulate gaba- and glutamate-related neuronal activity. |
2012-04-02 |
2023-08-12 |
Not clear |
| Krishna C Chimalakonda, Stacie M Bratton, Vi-Huyen Le, Kan Hui Yiew, Anna Dineva, Cindy L Moran, Laura P James, Jeffery H Moran, Anna Radominska-Pandy. Conjugation of synthetic cannabinoids JWH-018 and JWH-073, metabolites by human UDP-glucuronosyltransferases. Drug metabolism and disposition: the biological fate of chemicals. vol 39. issue 10. 2012-03-29. PMID:21746969. |
k2, a synthetic cannabinoid (sc), is an emerging drug of abuse touted as "legal marijuana" and marketed to young teens and first-time drug users. |
2012-03-29 |
2023-08-12 |
human |
| J Michael Bostwic. Blurred boundaries: the therapeutics and politics of medical marijuana. Mayo Clinic proceedings. vol 87. issue 2. 2012-03-26. PMID:22305029. |
pubmed searches were conducted using the following keywords: medical marijuana, medical cannabis, endocannabinoid system, cb1 receptors, cb2 receptors, thc, cannabidiol, nabilone, dronabinol, nabiximols, rimonabant, marijuana legislation, marijuana abuse, marijuana dependence, and marijuana and schizophrenia. |
2012-03-26 |
2023-08-12 |
human |
| Béla Horváth, Partha Mukhopadhyay, György Haskó, Pál Pache. The endocannabinoid system and plant-derived cannabinoids in diabetes and diabetic complications. The American journal of pathology. vol 180. issue 2. 2012-03-25. PMID:22155112. |
the therapeutic potential of targeting the endocannabinoid system and certain plant-derived cannabinoids, such as cannabidiol and Δ9-tetrahydrocannabivarin, which are devoid of psychotropic effects and possess potent anti-inflammatory and/or antioxidant properties, in diabetes and diabetic complications is also discussed. |
2012-03-25 |
2023-08-12 |
Not clear |
| Mark Asbridge, Jill A Hayden, Jennifer L Cartwrigh. Acute cannabis consumption and motor vehicle collision risk: systematic review of observational studies and meta-analysis. BMJ (Clinical research ed.). vol 344. 2012-03-20. PMID:22323502. |
to determine whether the acute consumption of cannabis (cannabinoids) by drivers increases the risk of a motor vehicle collision. |
2012-03-20 |
2023-08-12 |
Not clear |
| R Maldonado, F Berrendero, A Ozaita, P Robled. Neurochemical basis of cannabis addiction. Neuroscience. vol 181. 2012-03-16. PMID:21334423. |
the psychoactive compounds contained in cannabis induce their pharmacological effects by the activation of at least two different receptors, cb1 and cb2 cannabinoid receptors. |
2012-03-16 |
2023-08-12 |
Not clear |
| R Maldonado, F Berrendero, A Ozaita, P Robled. Neurochemical basis of cannabis addiction. Neuroscience. vol 181. 2012-03-16. PMID:21334423. |
this review describes the experimental methods now available to study the pharmacological responses of cannabinoids related to their addictive effects and how these methods have contributed to advance the knowledge of the specific contribution of different neurochemical systems in cannabis addiction. |
2012-03-16 |
2023-08-12 |
Not clear |
| Ronny Berkovitz, Mickey Arieli, Eli Maro. [Synthetic cannabinoids--the new "legal high" drugs]. Harefuah. vol 150. issue 12. 2012-03-15. PMID:22352277. |
the synthetic cannabinoids do not resemble the chemical structure of tetrahydrocannabinol (thc] which appears in marijuana or hashish, but affects the body in the same manner and according to the literature, are five times more potent. |
2012-03-15 |
2023-08-12 |
Not clear |
| Richard L Hilderbran. High-performance sport, marijuana, and cannabimimetics. Journal of analytical toxicology. vol 35. issue 9. 2012-03-07. PMID:22080902. |
information continues to accumulate on the adverse health effects of smoked marijuana and the decrement of performance caused by the use of cannabinoids. |
2012-03-07 |
2023-08-12 |
Not clear |