| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wilfred Ip, Yu-Ting Alex Chiang, Tianru Ji. The involvement of the wnt signaling pathway and TCF7L2 in diabetes mellitus: The current understanding, dispute, and perspective. Cell & bioscience. vol 2. issue 1. 2012-10-12. PMID:22892353. |
we then expanded our view into the crosstalk among wnt, insulin and foxo signaling cascades, which further illustrates the complexity of the wnt signaling pathway in metabolic homeostasis. |
2012-10-12 |
2023-08-12 |
drosophila_melanogaster |
| Xiaofeng Li, Jufang Shan, Woochul Chang, Ingyu Kim, Ju Bao, Ho-Jin Lee, Xinxin Zhang, Varman T Samuel, Gerald I Shulman, Dakai Liu, Jie J Zheng, Dianqing W. Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 28. 2012-10-05. PMID:22733757. |
dkk2 deficiency did not cause in increase in insulin production but resulted in increased wnt activity and glp1 production in the intestines. |
2012-10-05 |
2023-08-12 |
mouse |
| Toru Yamaguch. Bone fragility in type 2 diabetes mellitus. World journal of orthopedics. vol 1. issue 1. 2012-08-23. PMID:22474621. |
moreover, several studies have shown that antagonism of wnt signaling by oxidative stress contributes to the development of osteoporosis, as well as insulin resistance and hyperlipidemia. |
2012-08-23 |
2023-08-12 |
mouse |
| Jiwon Shim, Tina Mukherjee, Utpal Banerje. Direct sensing of systemic and nutritional signals by haematopoietic progenitors in Drosophila. Nature cell biology. vol 14. issue 4. 2012-06-07. PMID:22407365. |
here, we show that the haematopoietic progenitors of drosophila are direct targets of systemic (insulin) and nutritional (essential amino acid) signals, and that these systemic signals maintain the progenitors by promoting wingless (wnt in mammals) signalling. |
2012-06-07 |
2023-08-12 |
drosophila_melanogaster |
| Jane Palsgaard, Brice Emanuelli, Jonathon N Winnay, Grzegorz Sumara, Gerard Karsenty, C Ronald Kah. Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5). The Journal of biological chemistry. vol 287. issue 15. 2012-06-06. PMID:22337886. |
cross-talk between insulin and wnt signaling in preadipocytes: role of wnt co-receptor low density lipoprotein receptor-related protein-5 (lrp5). |
2012-06-06 |
2023-08-12 |
Not clear |
| Jane Palsgaard, Brice Emanuelli, Jonathon N Winnay, Grzegorz Sumara, Gerard Karsenty, C Ronald Kah. Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5). The Journal of biological chemistry. vol 287. issue 15. 2012-06-06. PMID:22337886. |
in the present study, we have investigated cross-talk between insulin and wnt signaling pathways using preadipocytes with and without knockdown of the wnt co-receptors lrp5 and lrp6 and with and without knock-out of insulin and igf-1 receptors. |
2012-06-06 |
2023-08-12 |
Not clear |
| Jane Palsgaard, Brice Emanuelli, Jonathon N Winnay, Grzegorz Sumara, Gerard Karsenty, C Ronald Kah. Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5). The Journal of biological chemistry. vol 287. issue 15. 2012-06-06. PMID:22337886. |
we find that wnt stimulation leads to phosphorylation of insulin signaling key mediators, including akt, gsk3β, and erk1/2, although with a lower fold stimulation and slower time course than observed for insulin. |
2012-06-06 |
2023-08-12 |
Not clear |
| Jane Palsgaard, Brice Emanuelli, Jonathon N Winnay, Grzegorz Sumara, Gerard Karsenty, C Ronald Kah. Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5). The Journal of biological chemistry. vol 287. issue 15. 2012-06-06. PMID:22337886. |
these data demonstrate that wnt and insulin signaling pathways exhibit cross-talk at multiple levels. |
2012-06-06 |
2023-08-12 |
Not clear |
| Jane Palsgaard, Brice Emanuelli, Jonathon N Winnay, Grzegorz Sumara, Gerard Karsenty, C Ronald Kah. Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5). The Journal of biological chemistry. vol 287. issue 15. 2012-06-06. PMID:22337886. |
insulin signaling also involves the wnt co-receptor lrp5, which has a positive effect on insulin signaling. |
2012-06-06 |
2023-08-12 |
Not clear |
| Jane Palsgaard, Brice Emanuelli, Jonathon N Winnay, Grzegorz Sumara, Gerard Karsenty, C Ronald Kah. Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5). The Journal of biological chemistry. vol 287. issue 15. 2012-06-06. PMID:22337886. |
thus, altered wnt and lrp5 activity can serve as modifiers of insulin action and insulin resistance in the pathophysiology of diabetes and metabolic syndrome. |
2012-06-06 |
2023-08-12 |
Not clear |
| Yuta Enami, Brigid Joseph, Sriram Bandi, Juan Lin, Sanjeev Gupt. Molecular perturbations restrict potential for liver repopulation of hepatocytes isolated from non-heart-beating donor rats. Hepatology (Baltimore, Md.). vol 55. issue 4. 2012-05-22. PMID:21993967. |
gene expression profiling in hepatocytes isolated from non-heart-beating donors showed far greater perturbations compared with corresponding liver tissue, including representation of pathways in focal adhesion, actin cytoskeleton, extracellular matrix-receptor interactions, multiple ligand-receptor interactions, and signaling in insulin, calcium, wnt, jak-stat, or other cascades. |
2012-05-22 |
2023-08-12 |
rat |
| Yujiro Tanaka, Aya Nakamura, Masaki Suimye Morioka, Shoko Inoue, Mimi Tamamori-Adachi, Kazuhiko Yamada, Kenji Taketani, Junya Kawauchi, Miki Tanaka-Okamoto, Jun Miyoshi, Hiroshi Tanaka, Shigetaka Kitajim. Systems analysis of ATF3 in stress response and cancer reveals opposing effects on pro-apoptotic genes in p53 pathway. PloS one. vol 6. issue 10. 2012-03-26. PMID:22046379. |
further analysis of effects of atf3 knockdown on these targets revealed that stress-induced atf3 regulates genes in metabolic pathways, cell cycle, apoptosis, cell adhesion, and signalling including insulin, p53, wnt, and vegf pathways. |
2012-03-26 |
2023-08-12 |
human |
| Miao Jiang, Cheng Xiao, Gao Chen, Cheng Lu, Qinglin Zha, Xiaoping Yan, Weiping Kong, Shijie Xu, Dahong Ju, Pu Xu, Youwen Zou, Aiping L. Correlation between cold and hot pattern in traditional Chinese medicine and gene expression profiles in rheumatoid arthritis. Frontiers of medicine. vol 5. issue 2. 2011-11-22. PMID:21695629. |
mapk signalling pathway, wnt signaling pathway, and insulin signaling pathway were found to be related to hot pattern. |
2011-11-22 |
2023-08-12 |
Not clear |
| Jinbiao Peng, Geoffrey N Gobert, Yang Hong, Weibin Jiang, Hongxiao Han, Donald P McManus, Xinzhi Wang, Jinming Liu, Zhiqiang Fu, Yaojun Shi, Jiaojiao Li. Apoptosis governs the elimination of Schistosoma japonicum from the non-permissive host Microtus fortis. PloS one. vol 6. issue 6. 2011-11-02. PMID:21731652. |
genes that were down-regulated in schistosomula from m. fortis included apoptosis-inhibited genes encoding a baculoviral iap repeat-containing protein (sjiap) and cytokine-induced apoptosis inhibitor (sjciap), genes encoding molecules involved in insulin metabolism, long-chain fatty acid metabolism, signal transduction, the transforming growth factor (tgf) pathway, the wnt pathway and in development. |
2011-11-02 |
2023-08-12 |
mouse |
| Shaoyong Lu, Yongjun Jiang, Jing Lv, Jianwei Zou, Tianxing W. Mechanism of kinase inactivation and nonbinding of FRATide to GSK3β due to K85M mutation: molecular dynamics simulation and normal mode analysis. Biopolymers. vol 95. issue 10. 2011-09-30. PMID:21442609. |
as a serine/threonine protein kinase, glycogen synthase kinase 3β (gsk3β) is an essential component of several cellular processes, including insulin, growth factor, and wnt signaling. |
2011-09-30 |
2023-08-12 |
Not clear |
| Claudie Hooper, Richard Killick, Cathy Fernandes, G Cocks, David Sugden, Simon Loveston. Transcriptomic profiles of Wnt3a and insulin in primary cultured rat cortical neurones. Journal of neurochemistry. vol 118. issue 4. 2011-09-16. PMID:21668888. |
glycogen synthase kinase 3 (gsk3) is a widely expressed, constitutively active, serine/threonine kinase that is negatively regulated by both wnt and insulin via two independent signalling pathways. |
2011-09-16 |
2023-08-12 |
rat |
| Claudie Hooper, Richard Killick, Cathy Fernandes, G Cocks, David Sugden, Simon Loveston. Transcriptomic profiles of Wnt3a and insulin in primary cultured rat cortical neurones. Journal of neurochemistry. vol 118. issue 4. 2011-09-16. PMID:21668888. |
in this study, we sought to determine the neuronal genes regulated by both wnt and insulin in an in vitro cell culture model to further elucidate the signalling roles gsk3 plays in the cns. |
2011-09-16 |
2023-08-12 |
rat |
| Claudie Hooper, Richard Killick, Cathy Fernandes, G Cocks, David Sugden, Simon Loveston. Transcriptomic profiles of Wnt3a and insulin in primary cultured rat cortical neurones. Journal of neurochemistry. vol 118. issue 4. 2011-09-16. PMID:21668888. |
these data demonstrate that the wnt and insulin pathways exhibit both divergent and overlapping signalling activities in neuronal cells. |
2011-09-16 |
2023-08-12 |
rat |
| Claudie Hooper, Richard Killick, Cathy Fernandes, G Cocks, David Sugden, Simon Loveston. Transcriptomic profiles of Wnt3a and insulin in primary cultured rat cortical neurones. Journal of neurochemistry. vol 118. issue 4. 2011-09-16. PMID:21668888. |
these findings have ramifications for neurodevelopment and neurological diseases, in which the wnt and insulin signalling pathways are implicated. |
2011-09-16 |
2023-08-12 |
rat |
| Ana Richelia Jara-Lazaro, Puay Hoon Ta. Molecular pathogenesis of progression and recurrence in breast phyllodes tumors. American journal of translational research. vol 1. issue 1. 2011-07-14. PMID:19966935. |
inverse correlations between epithelial and stromal overexpression for various biological markers like estrogen receptor, p53, c-kit, ki-67, endothelin-1, epidermal growth factor receptor, heparan sulfate, in addition to findings of epithelial wnt signalling with stromal insulin growth factors and beta-catenin expression, suggest an initial epithelial-stromal interdependence at the benign phase. |
2011-07-14 |
2023-08-12 |
Not clear |