| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wen Luo, Shumao Lin, Guihuan Li, Qinghua Nie, Xiquan Zhan. Integrative Analyses of miRNA-mRNA Interactions Reveal let-7b, miR-128 and MAPK Pathway Involvement in Muscle Mass Loss in Sex-Linked Dwarf Chickens. International journal of molecular sciences. vol 17. issue 3. 2016-11-04. PMID:26927061. |
additionally, we also found some genes and mirnas involved in chicken skeletal muscle development, through the mapk, pi3k-akt, wnt and insulin signaling pathways. |
2016-11-04 |
2023-08-13 |
chicken |
| Berta Victoria, Joseph M Dhahbi, Yury O Nunez Lopez, Lina Spinel, Hani Atamna, Stephen R Spindler, Michal M Masterna. Circulating microRNA signature of genotype-by-age interactions in the long-lived Ames dwarf mouse. Aging cell. vol 14. issue 6. 2016-10-25. PMID:26176567. |
functional enrichment analysis of putative and validated mirna targets highlighted cellular processes such as tumor suppression, anti-inflammatory response, and modulation of wnt, insulin, mtor, and mapk signaling pathways, among others. |
2016-10-25 |
2023-08-13 |
mouse |
| Jinjin Wang, Guoli Yan, Jianfeng Zhang, Kaiping Gao, Ming Zhang, Linlin Li, Yan Wang, Qian Wang, Yujia Zhai, Haifei You, Yongcheng Ren, Bingyuan Wang, Dongsheng H. Association of LRP5, TCF7L2, and GCG variants and type 2 diabetes mellitus as well as fasting plasma glucose and lipid metabolism indexes. Human immunology. vol 76. issue 5. 2016-02-23. PMID:25863010. |
recent data puts wnt signaling pathway in a pivotal role in regulating pancreas development as well as islet function, insulin production and secretion. |
2016-02-23 |
2023-08-13 |
Not clear |
| Pei-Wen Cheng, Ying-Ying Chen, Wen-Han Cheng, Pei-Jung Lu, Hsin-Hung Chen, Bo-Rong Chen, Tung-Chen Yeh, Gwo-Ching Sun, Michael Hsiao, Ching-Jiunn Tsen. Wnt Signaling Regulates Blood Pressure by Downregulating a GSK-3β-Mediated Pathway to Enhance Insulin Signaling in the Central Nervous System. Diabetes. vol 64. issue 10. 2016-01-04. PMID:25883115. |
wnt signaling regulates blood pressure by downregulating a gsk-3β-mediated pathway to enhance insulin signaling in the central nervous system. |
2016-01-04 |
2023-08-13 |
rat |
| Pei-Wen Cheng, Ying-Ying Chen, Wen-Han Cheng, Pei-Jung Lu, Hsin-Hung Chen, Bo-Rong Chen, Tung-Chen Yeh, Gwo-Ching Sun, Michael Hsiao, Ching-Jiunn Tsen. Wnt Signaling Regulates Blood Pressure by Downregulating a GSK-3β-Mediated Pathway to Enhance Insulin Signaling in the Central Nervous System. Diabetes. vol 64. issue 10. 2016-01-04. PMID:25883115. |
nevertheless, the relationships between wnt signaling and the insulin pathway and the related modulation of blood pressure (bp) in the central nervous system have yet to be established. |
2016-01-04 |
2023-08-13 |
rat |
| Yuechi Xu, Zhongjie Su. Molecular basis of Klotho: from gene to function in aging. Endocrine reviews. vol 36. issue 2. 2015-12-31. PMID:25695404. |
recent evidence suggests that α-klotho suppresses the insulin and wnt signaling pathways, inhibits oxidative stress, and regulates phosphatase and calcium absorption. |
2015-12-31 |
2023-08-13 |
mouse |
| R U Almario, S E Karaka. Roles of circulating WNT-signaling proteins and WNT-inhibitors in human adiposity, insulin resistance, insulin secretion, and inflammation. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 47. issue 2. 2015-09-25. PMID:25089371. |
wingless-type mmtv integration site family member (wnt) signaling and wnt-inhibitors have been implicated in regulation of adipogenesis, insulin resistance, pancreatic function, and inflammation. |
2015-09-25 |
2023-08-13 |
human |
| R U Almario, S E Karaka. Roles of circulating WNT-signaling proteins and WNT-inhibitors in human adiposity, insulin resistance, insulin secretion, and inflammation. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 47. issue 2. 2015-09-25. PMID:25089371. |
our goal was to determine serum proteins involved in wnt signaling (wnt5 and wisp2) and wnt inhibition (sfrp4 and sfrp5) as they relate to obesity, serum adipokines, insulin resistance, insulin secretion, and inflammation in humans. |
2015-09-25 |
2023-08-13 |
human |
| R U Almario, S E Karaka. Roles of circulating WNT-signaling proteins and WNT-inhibitors in human adiposity, insulin resistance, insulin secretion, and inflammation. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 47. issue 2. 2015-09-25. PMID:25089371. |
better understanding of the role of wnt signaling in obesity, insulin resistance, insulin secretion, lipoprotein metabolism, and inflammation is important for prevention and treatment of metabolic syndrome, diabetes and cardiovascular disease. |
2015-09-25 |
2023-08-13 |
human |
| Pooja Ganguly, Niladri Gangul. Transcriptomic analyses of genes differentially expressed by high-risk and low-risk human papilloma virus E6 oncoproteins. Virusdisease. vol 26. issue 3. 2015-09-23. PMID:26396976. |
gene ontology mapping of 44 genes according cellular pathways revealed 13 pathways namely angiogenesis, alzhemier's, wnt, p53, interleukin, tgf-β, cadherin, integrin, pi3-kinase, catennin, insulin, chemokine and g protein signalling pathways. |
2015-09-23 |
2023-08-13 |
human |
| Kangxing Song, Shuxia Wang, Mitra Mani, Arya Man. Wnt signaling, de novo lipogenesis, adipogenesis and ectopic fat. Oncotarget. vol 5. issue 22. 2015-08-25. PMID:25526027. |
following we will describe our most pertinent findings related to wnt/lrp6 regulation of de novo lipogenesis and adipogenesis and the role of impaired wnt signaling in generation of ectopic fat, insulin resistance, elevated plasma lipids and non-alcoholic fatty liver disease (nafld). |
2015-08-25 |
2023-08-13 |
Not clear |
| Q He, S Z Wang, L Leng, W Na, Q G Wang, H L. Differentially expressed genes in the liver of lean and fat chickens. Genetics and molecular research : GMR. vol 13. issue 4. 2015-08-06. PMID:25526202. |
the differentially expressed genes were involved in wnt, insulin signaling, and cell cycle pathways. |
2015-08-06 |
2023-08-13 |
chicken |
| Binggui Zhang, Rongqi Wang, Jinghua Du, Jingya Niu, Rui Zhang, Shunjiang Xu, Xuemin Niu, Qingfu Zhang, Yuemin Na. Upregulated microRNA-199a-5p inhibits nuclear receptor corepressor 1 translation in mice with non‑alcoholic steatohepatitis. Molecular medicine reports. vol 10. issue 6. 2015-06-19. PMID:25269746. |
in the bioinformatic analysis, mir‑199a‑5p was identified to be predominantly involved in transcription, protein serine/threonine kinase activity, insulin signaling, and the wnt and mitogen‑activated protein kinase signaling pathways. |
2015-06-19 |
2023-08-13 |
mouse |
| A E Zielak-Steciwko, J A Browne, P A McGettigan, M Gajewska, M Dzięcioł, T Szulc, A C O Evan. Expression of microRNAs and their target genes and pathways associated with ovarian follicle development in cattle. Physiological genomics. vol 46. issue 19. 2015-06-08. PMID:25096366. |
the predicted targets for these mirnas were enriched for pathways involving oocyte meiosis, wnt, tgf-beta, erbb, insulin, p13k-akt, and mapk signaling pathways. |
2015-06-08 |
2023-08-13 |
cattle |
| Juvenal A Ríos, Pedro Cisternas, Marco Arrese, Salesa Barja, Nibaldo C Inestros. Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum. Progress in neurobiology. vol 121. 2015-06-02. PMID:25084549. |
we also discuss relevant issues such as the role of leptin, insulin and renin-angiotensin signaling in the brain and the possible role of wnt signaling in both ms and ad. |
2015-06-02 |
2023-08-13 |
mouse |
| José J Fuster, María A Zuriaga, Doan Thi-Minh Ngo, Melissa G Farb, Tamar Aprahamian, Terry P Yamaguchi, Noyan Gokce, Kenneth Wals. Noncanonical Wnt signaling promotes obesity-induced adipose tissue inflammation and metabolic dysfunction independent of adipose tissue expansion. Diabetes. vol 64. issue 4. 2015-05-22. PMID:25352637. |
taken together, these results demonstrate that noncanonical wnt signaling contributes to obesity-induced insulin resistance independent of adipose tissue expansion. |
2015-05-22 |
2023-08-13 |
mouse |
| Dragana Nikitovic, Katerina Kouvidi, Kallirroi Voudouri, Aikaterini Berdiaki, Evgenia Karousou, Alberto Passi, George N Tzanakaki. The motile breast cancer phenotype roles of proteoglycans/glycosaminoglycans. BioMed research international. vol 2014. 2015-05-11. PMID:25140302. |
thus, gags/pgs may modulate downstream signaling of key cellular mediators including insulin growth factor receptor (igfr), epidermal growth factor receptor (egfr), estrogen receptors (ers), or wnt members. |
2015-05-11 |
2023-08-13 |
Not clear |
| D M Schulte, D Kragelund, N Müller, I Hagen, G Elke, A Titz, D Schädler, J Schumacher, N Weiler, B Bewig, S Schreiber, M Laude. The wingless-related integration site-5a/secreted frizzled-related protein-5 system is dysregulated in human sepsis. Clinical and experimental immunology. vol 180. issue 1. 2015-05-08. PMID:25382802. |
in type 2 diabetes we and others have recently provided evidence that alterations of the proinflammatory wingless-related integration site (wnt)-5a/anti-inflammatory secreted frizzled-related protein (sfrp)-5 system are involved in the pathogenesis of insulin resistance. |
2015-05-08 |
2023-08-13 |
human |
| Dandan Liu, Changqing Yi, Chi-Chun Fong, Qinghui Jin, Zuankai Wang, Wai-Kin Yu, Dong Sun, Jianlong Zhao, Mengsu Yan. Activation of multiple signaling pathways during the differentiation of mesenchymal stem cells cultured in a silicon nanowire microenvironment. Nanomedicine : nanotechnology, biology, and medicine. vol 10. issue 6. 2015-03-30. PMID:24566272. |
the results showed that the microenvironment of sinw array activated a number of mechanosensitive pathways (including integrin, tgf-β/bmp, akt, mapk, insulin, and wnt pathways) in mscs, which converged to stimulate the osteogenesis and chondrogenesis via the ras-raf-mek-erk cascade. |
2015-03-30 |
2023-08-12 |
Not clear |
| Z Musavi, N Azarpira, M H Sangtarash, M Kordi, K Kazemi, B Geramizadeh, S A Malek-Hossein. Polymorphism of Transcription Factor-7-Like 2 (TCF7L2) Gene and New-Onset Diabetes after Liver Transplantation. International journal of organ transplantation medicine. vol 6. issue 1. 2015-03-04. PMID:25737773. |
transcription factor-7-like 2 (tcf7l2) is a wnt signaling-associated transcription factor that plays an important role in β-cell proliferation and insulin secretion. |
2015-03-04 |
2023-08-13 |
Not clear |