| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takahiro Fujino, Hiroshi Asaba, Man-Jong Kang, Yukio Ikeda, Hideyuki Sone, Shinji Takada, Dong-Ho Kim, Ryoichi X Ioka, Masao Ono, Hiroko Tomoyori, Minoru Okubo, Toshio Murase, Akihisa Kamataki, Joji Yamamoto, Kenta Magoori, Sadao Takahashi, Yoshiharu Miyamoto, Hisashi Oishi, Masato Nose, Mitsuyo Okazaki, Shinichi Usui, Katsumi Imaizumi, Masashi Yanagisawa, Juro Sakai, Tokuo T Yamamot. Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 1. 2003-02-21. PMID:12509515. |
furthermore, exposure of lrp5++ islets to wnt-3a and wnt-5a stimulates glucose-induced insulin secretion and this stimulation was blocked by the addition of a soluble form of wnt receptor, secreted frizzled-related protein-1. |
2003-02-21 |
2023-08-12 |
mouse |
| Anita C Hall, Angela Brennan, Robert G Goold, Karen Cleverley, Fiona R Lucas, Phillip R Gordon-Weeks, Patricia C Salina. Valproate regulates GSK-3-mediated axonal remodeling and synapsin I clustering in developing neurons. Molecular and cellular neurosciences. vol 20. issue 2. 2002-08-29. PMID:12093158. |
recent studies suggest that lithium and vpa inhibit gsk-3beta, a serine/threonine kinase involved in the insulin and wnt signaling pathways. |
2002-08-29 |
2023-08-12 |
Not clear |
| Fumiko Mukai, Koichi Ishiguro, Yumiko Sano, Shinobu C Fujit. Alternative splicing isoform of tau protein kinase I/glycogen synthase kinase 3beta. Journal of neurochemistry. vol 81. issue 5. 2002-07-09. PMID:12065620. |
glycogen synthase kinase 3 (gsk3) plays important roles in wnt and insulin signaling, cell fate determination, and alzheimer-like tau phosphorylation. |
2002-07-09 |
2023-08-12 |
mouse |
| Elizabeth Fraser, Neville Young, Rana Dajani, Jonathan Franca-Koh, Jonathan Ryves, Robin S B Williams, Margaret Yeo, Marie-Therese Webster, Chris Richardson, Matthew J Smalley, Laurence H Pearl, Adrian Harwood, Trevor C Dal. Identification of the Axin and Frat binding region of glycogen synthase kinase-3. The Journal of biological chemistry. vol 277. issue 3. 2002-02-13. PMID:11707456. |
glycogen synthase kinase-3 (gsk-3) is a key component of several signaling pathways including those regulated by wnt and insulin ligands. |
2002-02-13 |
2023-08-12 |
xenopus_laevis |
| C Russ, S Lovestone, J F Powel. Identification of sequence variants and analysis of the role of the glycogen synthase kinase 3 beta gene and promoter in late onset Alzheimer's disease. Molecular psychiatry. vol 6. issue 3. 2001-07-26. PMID:11326302. |
gsk3 beta binds to presenilin 1 and plays a role in wnt and insulin signalling cascades, both of which have been proposed to be linked to ad. |
2001-07-26 |
2023-08-12 |
Not clear |
| R Dajani, E Fraser, S M Roe, N Young, V Good, T C Dale, L H Pear. Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition. Cell. vol 105. issue 6. 2001-07-26. PMID:11440715. |
glycogen synthase kinase 3 beta (gsk3 beta) plays a key role in insulin and wnt signaling, phosphorylating downstream targets by default, and becoming inhibited following the extracellular signaling event. |
2001-07-26 |
2023-08-12 |
human |
| V W Ding, R H Chen, F McCormic. Differential regulation of glycogen synthase kinase 3beta by insulin and Wnt signaling. The Journal of biological chemistry. vol 275. issue 42. 2000-11-20. PMID:10913153. |
differential regulation of glycogen synthase kinase 3beta by insulin and wnt signaling. |
2000-11-20 |
2023-08-12 |
Not clear |
| V W Ding, R H Chen, F McCormic. Differential regulation of glycogen synthase kinase 3beta by insulin and Wnt signaling. The Journal of biological chemistry. vol 275. issue 42. 2000-11-20. PMID:10913153. |
glycogen synthase kinase 3beta (gsk3beta) is a key component in many biological processes including insulin and wnt signaling. |
2000-11-20 |
2023-08-12 |
Not clear |
| V W Ding, R H Chen, F McCormic. Differential regulation of glycogen synthase kinase 3beta by insulin and Wnt signaling. The Journal of biological chemistry. vol 275. issue 42. 2000-11-20. PMID:10913153. |
we found that, unlike insulin, neither the phosphorylation status of the serine9 residue of gsk3beta nor the activity of protein kinase b is regulated by wnt. |
2000-11-20 |
2023-08-12 |
Not clear |
| V W Ding, R H Chen, F McCormic. Differential regulation of glycogen synthase kinase 3beta by insulin and Wnt signaling. The Journal of biological chemistry. vol 275. issue 42. 2000-11-20. PMID:10913153. |
our results suggest that the axin-conductin complexed gsk3beta may be dedicated to wnt rather than insulin signaling. |
2000-11-20 |
2023-08-12 |
Not clear |
| V W Ding, R H Chen, F McCormic. Differential regulation of glycogen synthase kinase 3beta by insulin and Wnt signaling. The Journal of biological chemistry. vol 275. issue 42. 2000-11-20. PMID:10913153. |
insulin and wnt pathways regulate gsk3beta through different mechanisms, and therefore lead to distinct downstream events. |
2000-11-20 |
2023-08-12 |
Not clear |
| S Ikeda, S Kishida, H Yamamoto, H Murai, S Koyama, A Kikuch. Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin. The EMBO journal. vol 17. issue 5. 1998-04-16. PMID:9482734. |
glycogen synthase kinase-3 (gsk-3) mediates epidermal growth factor, insulin and wnt signals to various downstream events such as glycogen metabolism, gene expression, proliferation and differentiation. |
1998-04-16 |
2023-08-12 |
mouse |