| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Samantha Gardner, Adam J Pawso. Emerging targets of the GnRH receptor: novel interactions with Wnt signalling mediators. Neuroendocrinology. vol 89. issue 3. 2009-07-14. PMID:18946197. |
these include the targeting of mediators of classical insulin signalling, and wnt signalling pathways. |
2009-07-14 |
2023-08-12 |
Not clear |
| Tianru Ji. Mechanisms underlying proglucagon gene expression. The Journal of endocrinology. vol 198. issue 1. 2009-07-07. PMID:18577568. |
investigations have also revealed that gcg expression is controlled by both protein kinase a and epac signaling pathways in response to camp elevation, and cell-type specifically controlled by insulin and the effectors of the wnt signaling pathway. |
2009-07-07 |
2023-08-12 |
mouse |
| Lisa Longato, Suzanne de la Monte, Noriyoshi Kuzushita, Masayoshi Horimoto, Arlin B Rogers, Betty L Slagle, Jack R Wand. Overexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant alterations in the liver. Hepatology (Baltimore, Md.). vol 49. issue 6. 2009-07-01. PMID:19475691. |
all three transgenic lines had significantly increased insulin growth factor 1 (igf-1), wnt 1 and wnt 3 mrna levels, and evidence of dna damage and oxidative stress. |
2009-07-01 |
2023-08-12 |
mouse |
| Klelia D Salpea, David R Gable, Jackie A Cooper, Jeffrey W Stephens, Steven J Hurel, Helen A Ireland, Michael D Feher, Ian F Godsland, Steve E Humphrie. The effect of WNT5B IVS3C>G on the susceptibility to type 2 diabetes in UK Caucasian subjects. Nutrition, metabolism, and cardiovascular diseases : NMCD. vol 19. issue 2. 2009-04-30. PMID:18555673. |
the wnt signaling pathway regulates adipogenesis and insulin secretion. |
2009-04-30 |
2023-08-12 |
human |
| Hannah J Welters, Rohit N Kulkarn. Wnt signaling: relevance to beta-cell biology and diabetes. Trends in endocrinology and metabolism: TEM. vol 19. issue 10. 2009-04-29. PMID:18926717. |
here, we review emerging new evidence that wnt signaling influences endocrine pancreas development and modulates mature beta-cell functions including insulin secretion, survival and proliferation. |
2009-04-29 |
2023-08-12 |
Not clear |
| Marc S Dionne, David S Schneide. Models of infectious diseases in the fruit fly Drosophila melanogaster. Disease models & mechanisms. vol 1. issue 1. 2009-04-14. PMID:19048052. |
the physiological response of the fly was modified further by eiger, insulin, wnt inhibitor of dorsal (wntd) and nitric oxide (no) signaling. |
2009-04-14 |
2023-08-12 |
drosophila_melanogaster |
| S Muruganandan, A A Roman, C J Sina. Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: cross talk with the osteoblastogenic program. Cellular and molecular life sciences : CMLS. vol 66. issue 2. 2009-02-27. PMID:18854943. |
this occurs through the cross talk between complex signaling pathways including those derived from bone morphogenic proteins (bmps), winglesstype mmtv integration site (wnt) proteins, hedgehogs, delta/jagged proteins, fibroblastic growth factors (fgf), insulin, insulin-like growth factors (igf), and transcriptional regulators of adipocyte and osteoblast differentiation including peroxisome proliferator-activated receptor-gamma (ppar gamma) and runt-related transcription factor 2 (runx2). |
2009-02-27 |
2023-08-12 |
Not clear |
| Andrei V Ougolkov, Daniel D Billadea. Inhibition of glycogen synthase kinase-3. Methods in molecular biology (Clifton, N.J.). vol 468. 2009-01-22. PMID:19099246. |
there are two homologous forms of glycogen synthase kinase (gsk)-3, gsk-3alpha and gsk-3beta, which play overlapping roles in the regulation of wnt, hedgehog, and insulin pathways, as well as the activation of nuclear factor (nf)-kappab-mediated gene transcription. |
2009-01-22 |
2023-08-12 |
human |
| Tianru Jin, I George Fantus, Jane Su. Wnt and beyond Wnt: multiple mechanisms control the transcriptional property of beta-catenin. Cellular signalling. vol 20. issue 10. 2008-11-14. PMID:18555664. |
extensive examination in different cell lineages has shown that the activity of cat/tcf can be stimulated by mechanisms other than via the wnt glycoproteins, including the stimulation of beta-cat nuclear translocation and enhanced binding of cat/tcf to the wnt target gene promoters by insulin and insulin-like growth factor-1 (igf-1). |
2008-11-14 |
2023-08-12 |
human |
| S Schinner, F Ulgen, C Papewalis, M Schott, A Woelk, A Vidal-Puig, W A Scherbau. Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules. Diabetologia. vol 51. issue 1. 2008-10-17. PMID:17994217. |
regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived wnt signalling molecules. |
2008-10-17 |
2023-08-12 |
Not clear |
| S Schinner, F Ulgen, C Papewalis, M Schott, A Woelk, A Vidal-Puig, W A Scherbau. Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules. Diabetologia. vol 51. issue 1. 2008-10-17. PMID:17994217. |
the aim of this study was to investigate the effect of adipocyte-derived wnt signalling molecules on insulin secretion and beta cell proliferation. |
2008-10-17 |
2023-08-12 |
Not clear |
| Tianru Ji. Why diabetes patients are more prone to the development of colon cancer? Medical hypotheses. vol 71. issue 2. 2008-09-19. PMID:18456417. |
this compensatory response involves the activation of wnt signaling pathway and the cross-talk between wnt and insulin signaling pathways. |
2008-09-19 |
2023-08-12 |
Not clear |
| Yoshiyuki Takahara, Tomoko Kobayashi, Kazuhisa Takemoto, Tetsuya Adachi, Ken Osaki, Kozo Kawahara, Gozoh Tsujimot. Pharmacogenomics of cardiovascular pharmacology: development of an informatics system for analysis of DNA microarray data with a focus on lipid metabolism. Journal of pharmacological sciences. vol 107. issue 1. 2008-09-09. PMID:18490852. |
clustered changes of molecules were apparent in the insulin, wnt, and ppargamma signaling pathways and in the lipogenesis, lipid oxidation, and lipid transport pathways during cell differentiation. |
2008-09-09 |
2023-08-12 |
Not clear |
| Jane Sun, Tianru Ji. Both Wnt and mTOR signaling pathways are involved in insulin-stimulated proto-oncogene expression in intestinal cells. Cellular signalling. vol 20. issue 1. 2008-06-11. PMID:17993259. |
our observations support the existence of crosstalk between insulin and wnt signaling pathways, and suggest that the crosstalk involves a pkb-independent mechanism. |
2008-06-11 |
2023-08-12 |
human |
| Fenghua Yi, Jane Sun, Gareth E Lim, I George Fantus, Patricia L Brubaker, Tianru Ji. Cross talk between the insulin and Wnt signaling pathways: evidence from intestinal endocrine L cells. Endocrinology. vol 149. issue 5. 2008-06-10. PMID:18258680. |
cross talk between the insulin and wnt signaling pathways: evidence from intestinal endocrine l cells. |
2008-06-10 |
2023-08-12 |
mouse |
| Fenghua Yi, Jane Sun, Gareth E Lim, I George Fantus, Patricia L Brubaker, Tianru Ji. Cross talk between the insulin and Wnt signaling pathways: evidence from intestinal endocrine L cells. Endocrinology. vol 149. issue 5. 2008-06-10. PMID:18258680. |
collectively, these findings indicate that enhancement of beta-catenin nuclear translocation and cat/tcf binding are among the mechanisms underlying cross talk between the insulin and wnt signaling pathways in intestinal endocrine l cells. |
2008-06-10 |
2023-08-12 |
mouse |
| Stéphane Cauchi, Philippe Frogue. TCF7L2 genetic defect and type 2 diabetes. Current diabetes reports. vol 8. issue 2. 2008-06-10. PMID:18445358. |
within only 2 years, an avalanche of studies identified several genes expressed in pancreatic beta cells and involved in the control of insulin secretion, such as transcription factor 7-like 2 (tcf7l2), a key element of the wnt signaling pathway. |
2008-06-10 |
2023-08-12 |
Not clear |
| Gene J Ahlborn, Gail M Nelson, William O Ward, Geremy Knapp, James W Allen, Ming Ouyang, Barbara C Roop, Yan Chen, Thomas O'Brien, Kirk T Kitchin, Don A Delke. Dose response evaluation of gene expression profiles in the skin of K6/ODC mice exposed to sodium arsenite. Toxicology and applied pharmacology. vol 227. issue 3. 2008-05-05. PMID:18191166. |
only the highest dose (10 ppm) resulted in significantly altered kegg (kyoto encyclopedia of genes and genomes) pathways, including mapk, regulation of actin cytoskeleton, wnt, jak-stat, tight junction, toll-like, phosphatidylinositol and insulin signaling pathways. |
2008-05-05 |
2023-08-12 |
mouse |
| Stavros C Manolagas, Maria Almeid. Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism. Molecular endocrinology (Baltimore, Md.). vol 21. issue 11. 2008-02-11. PMID:17622581. |
we hypothesize that antagonism of wnt signaling by oxidative stress with increasing age may be a common molecular mechanism contributing to the development not only of involutional osteoporosis, but several pathologies such as atherosclerosis, insulin resistance, and hyperlipidemia, all of which become more prevalent with advancing age. |
2008-02-11 |
2023-08-12 |
mouse |
| Ingrid C Rulifson, Satyajit K Karnik, Patrick W Heiser, Derk ten Berge, Hainan Chen, Xueying Gu, Makoto M Taketo, Roel Nusse, Matthias Hebrok, Seung K Ki. Wnt signaling regulates pancreatic beta cell proliferation. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 15. 2007-10-17. PMID:17404238. |
conditional pancreatic beta cell expression of activated beta-catenin, a crucial wnt signal transduction protein, produced similar phenotypes in vivo, leading to beta cell expansion, increased insulin production and serum levels, and enhanced glucose handling. |
2007-10-17 |
2023-08-12 |
Not clear |