| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simon Lovestone, Richard Killick, Marta Di Forti, Robin Murra. Schizophrenia as a GSK-3 dysregulation disorder. Trends in neurosciences. vol 30. issue 4. 2007-06-21. PMID:17324475. |
if, as we suggest, gsk-3 regulation is crucial to schizophrenia, the wnt and insulin signalling pathways become targets for therapy. |
2007-06-21 |
2023-08-12 |
Not clear |
| Na Zhang, Yongjun Jiang, Jianwei Zou, Shulin Zhuang, Haixiao Jin, Qingsen Y. Insights into unbinding mechanisms upon two mutations investigated by molecular dynamics study of GSK3beta-axin complex: role of packing hydrophobic residues. Proteins. vol 67. issue 4. 2007-06-07. PMID:17380482. |
glycogen synthase kinase 3beta (gsk 3beta) is a key component of several cellular processes including wnt and insulin signalling pathways. |
2007-06-07 |
2023-08-12 |
Not clear |
| Nicole I zur Nieden, Feodor D Price, Lesley A Davis, Rebecca E Everitt, Derrick E Rancour. Gene profiling on mixed embryonic stem cell populations reveals a biphasic role for beta-catenin in osteogenic differentiation. Molecular endocrinology (Baltimore, Md.). vol 21. issue 3. 2007-05-22. PMID:17170073. |
in addition to five other families of signaling molecules (insulin growth factors, prostaglandin, follistatin, tgfbeta2, and wnt molecules), we identified an endogenous expression pattern for bmps and ra that differed from our previous exogenous administration of these molecules. |
2007-05-22 |
2023-08-12 |
Not clear |
| Wayne B Rowe, Eric M Blalock, Kuey-Chu Chen, Inga Kadish, Daguang Wang, James E Barrett, Olivier Thibault, Nada M Porter, Gregory M Rose, Philip W Landfiel. Hippocampal expression analyses reveal selective association of immediate-early, neuroenergetic, and myelinogenic pathways with cognitive impairment in aged rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 12. 2007-04-12. PMID:17376971. |
selectively, in ai, there was downregulation at 5t of immediate-early gene, wnt (wingless integration site), insulin, and g-protein signaling, lipogenesis, and glucose utilization pathways, whereas notch2 (oligodendrocyte development) and myelination pathways were upregulated, particularly at 21pt. |
2007-04-12 |
2023-08-12 |
rat |
| Pamela A Lochhead, Ross Kinstrie, Gary Sibbet, Teeara Rawjee, Nick Morrice, Vaughn Clegho. A chaperone-dependent GSK3beta transitional intermediate mediates activation-loop autophosphorylation. Molecular cell. vol 24. issue 4. 2007-01-30. PMID:17188038. |
glycogen synthase kinase 3 (gsk3), a key component of the insulin and wnt signaling pathways, is unusual, as it is constitutively active and is inhibited in response to upstream signals. |
2007-01-30 |
2023-08-12 |
Not clear |
| Timothy P Bonnert, James G Bilsland, Paul C Guest, Robert Heavens, Donna McLaren, Charlotte Dale, Matthew Thakur, George McAllister, Ignacio Munoz-Sanjua. Molecular characterization of adult mouse subventricular zone progenitor cells during the onset of differentiation. The European journal of neuroscience. vol 24. issue 3. 2006-11-01. PMID:16930398. |
pathway analysis highlights alterations in insulin growth factor, wnt and transforming growth factor beta signalling cascades. |
2006-11-01 |
2023-08-12 |
mouse |
| Fawzia Bardag-Gorce, Barbara A French, Jennifer Dedes, Jun Li, Samuel W Frenc. Gene expression patterns of the liver in response to alcohol: in vivo and in vitro models compared. Experimental and molecular pathology. vol 80. issue 3. 2006-07-05. PMID:16770850. |
these included the insulin signaling pathway, tgfbeta signaling pathway, apoptosis, mapk signaling pathway, wnt signaling pathway and apoptosis. |
2006-07-05 |
2023-08-12 |
Not clear |
| Edward J McManus, Kei Sakamoto, Laura J Armit, Leah Ronaldson, Natalia Shpiro, Rodolfo Marquez, Dario R Aless. Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis. The EMBO journal. vol 24. issue 8. 2005-07-12. PMID:15791206. |
role that phosphorylation of gsk3 plays in insulin and wnt signalling defined by knockin analysis. |
2005-07-12 |
2023-08-12 |
mouse |
| Edward J McManus, Kei Sakamoto, Laura J Armit, Leah Ronaldson, Natalia Shpiro, Rodolfo Marquez, Dario R Aless. Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis. The EMBO journal. vol 24. issue 8. 2005-07-12. PMID:15791206. |
the inactivation of glycogen synthase kinase (gsk)3 has been proposed to play important roles in insulin and wnt signalling. |
2005-07-12 |
2023-08-12 |
mouse |
| Yasuyoshi Naishiro, Tesshi Yamada, Masashi Idogawa, Kazufumi Honda, Mizuho Takada, Tadashi Kondo, Kohzoh Imai, Setsuo Hirohash. Morphological and transcriptional responses of untransformed intestinal epithelial cells to an oncogenic beta-catenin protein. Oncogene. vol 24. issue 19. 2005-05-31. PMID:15735679. |
those genes included known negative regulators of the wnt signaling pathway, sfrp4 and axin2; extracellular matrix and related molecule, hxb and crtl1; cell adhesion and cytoskeletal proteins, podxl, igaf4, and itab6; and molecules involved in the insulin and insulin-like growth factor (igf) signaling pathways, enpp1, igfbp2, and sgk. |
2005-05-31 |
2023-08-12 |
rat |
| S Patel, B Doble, J R Woodget. Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword? Biochemical Society transactions. vol 32. issue Pt 5. 2005-04-08. PMID:15494020. |
glycogen synthase kinase-3 in insulin and wnt signalling: a double-edged sword? |
2005-04-08 |
2023-08-12 |
human |
| Laurent Meijer, Marc Flajolet, Paul Greengar. Pharmacological inhibitors of glycogen synthase kinase 3. Trends in pharmacological sciences. vol 25. issue 9. 2005-02-10. PMID:15559249. |
three closely related forms of glycogen synthase kinase 3 (gsk-3alpha, gsk-3beta and gsk-3beta2) have a major role in wnt and hedgehog signaling pathways and regulate the cell-division cycle, stem-cell renewal and differentiation, apoptosis, circadian rhythm, transcription and insulin action. |
2005-02-10 |
2023-08-12 |
Not clear |
| Juro Saka. [Wnt coreceptor low density lipoprotein receptor related protein 5 (LRP5) mediates the bone formation and glucose induced insulin secretion]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics. vol 41. issue 6. 2005-02-01. PMID:15651377. |
[wnt coreceptor low density lipoprotein receptor related protein 5 (lrp5) mediates the bone formation and glucose induced insulin secretion]. |
2005-02-01 |
2023-08-12 |
Not clear |
| Akio Kanazawa, Syuuichi Tsukada, Akihiro Sekine, Tatsuhiko Tsunoda, Atsushi Takahashi, Atsunori Kashiwagi, Yasushi Tanaka, Tetsuya Babazono, Masafumi Matsuda, Kohei Kaku, Yasuhiko Iwamoto, Ryuzo Kawamori, Ryuichi Kikkawa, Yusuke Nakamura, Shiro Maed. Association of the gene encoding wingless-type mammary tumor virus integration-site family member 5B (WNT5B) with type 2 diabetes. American journal of human genetics. vol 75. issue 5. 2005-01-03. PMID:15386214. |
recent reports have suggested that wnt signaling is an important regulator for adipogenesis or insulin secretion and might be involved in the pathogenesis of type 2 diabetes. |
2005-01-03 |
2023-08-12 |
mouse |
| Sunny Z Hussain, Tamara Sneddon, Xinping Tan, Amanda Micsenyi, George K Michalopoulos, Satdarshan P S Mong. Wnt impacts growth and differentiation in ex vivo liver development. Experimental cell research. vol 292. issue 1. 2004-02-27. PMID:14720515. |
hgf, insulin and wnt combination provided no additional benefits rather had an overall deleterious effect. |
2004-02-27 |
2023-08-12 |
mouse |
| Sunny Z Hussain, Tamara Sneddon, Xinping Tan, Amanda Micsenyi, George K Michalopoulos, Satdarshan P S Mong. Wnt impacts growth and differentiation in ex vivo liver development. Experimental cell research. vol 292. issue 1. 2004-02-27. PMID:14720515. |
the addition of insulin to the combination of hgf and wnt provided no growth or differentiation advantage. |
2004-02-27 |
2023-08-12 |
mouse |
| Laurence H Pearl, David Barfor. Regulation of protein kinases in insulin, growth factor and Wnt signalling. Current opinion in structural biology. vol 12. issue 6. 2003-09-16. PMID:12504681. |
regulation of protein kinases in insulin, growth factor and wnt signalling. |
2003-09-16 |
2023-08-12 |
Not clear |
| Hiroto Yamazaki, Shin ichi Yanagaw. Axin and the Axin/Arrow-binding protein DCAP mediate glucose-glycogen metabolism. Biochemical and biophysical research communications. vol 304. issue 2. 2003-06-18. PMID:12711303. |
human lrp5 was originally found as a candidate gene of insulin dependent diabetes mellitus (iddm), but its drosophila homolog, arrow, works as a co-receptor of the canonical wnt signal. |
2003-06-18 |
2023-08-12 |
human |
| Hiroto Yamazaki, Shin ichi Yanagaw. Axin and the Axin/Arrow-binding protein DCAP mediate glucose-glycogen metabolism. Biochemical and biophysical research communications. vol 304. issue 2. 2003-06-18. PMID:12711303. |
in addition, the interaction among axin, arrow, and dcap implies a possible cross-talk between wnt signal and insulin signal. |
2003-06-18 |
2023-08-12 |
human |
| Rana Dajani, Elizabeth Fraser, S Mark Roe, Maggie Yeo, Valerie M Good, Vivienne Thompson, Trevor C Dale, Laurence H Pear. Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex. The EMBO journal. vol 22. issue 3. 2003-03-26. PMID:12554650. |
glycogen synthase kinase 3beta (gsk3beta) is a serine/threonine kinase involved in insulin, growth factor and wnt signalling. |
2003-03-26 |
2023-08-12 |
Not clear |