| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xue Liu, Bi-Yun Luo, Jian-Bin Feng, Ling-Xia Zhou, Ke-Yi Ma, Gao-Feng Qi. Identification and profiling of microRNAs during gonadal development in the giant freshwater prawn Macrobrachium rosenbergii. Scientific reports. vol 9. issue 1. 2020-09-08. PMID:30787336. |
furthermore, the putative target genes of the sex-biased mirnas, such as cyclin l1, mitogen-activated protein kinase 7 (mapk 7), heat shock protein (hsp), and zinc finger protein, were significantly enriched in many reproduction-related pathways including the gonadotropin-releasing hormone (gnrh) pathway, glycolysis, gluconeogenesis pathway, ovarian steroidogenesis, estrogen signaling pathway, mapk pathway, wnt pathway, and insulin signaling pathway, implicating potential regulatory roles of mirnas in reproduction. |
2020-09-08 |
2023-08-13 |
Not clear |
| Indira Rojo Báez, Daniel Omar Rivera Castro, Sarahí Salas Gutiérrez, Edgar Dehesa López, Adriana Aguilar Lemarroy, Luis Felipe Jave Suarez, Hipólito Castillo Ureta, Edith Hilario Torres Montoya, Vicente Olimón Andaló. Association of serum levels of secreted frizzled-related protein 5 and Wnt member 5a with glomerular filtration rate in patients with type 2 diabetes mellitus and chronic renal disease: a cross-sectional study. Sao Paulo medical journal = Revista paulista de medicina. vol 138. issue 2. 2020-08-31. PMID:32491086. |
wnt member 5a (wnt5a) and secreted frizzled-related protein 5 (sfrp5) are proinflammatory proteins associated with insulin resistance and chronic low-grade adipose tissue inflammation. |
2020-08-31 |
2023-08-13 |
Not clear |
| Mujib Ullah, Zhongjie Su. Klotho Deficiency Accelerates Stem Cells Aging by Impairing Telomerase Activity. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 74. issue 9. 2020-06-11. PMID:30452555. |
this suggests that both kl and telomeres regulate the stem cell aging process through telomerase subunits terf1, pot1, and tert using the tgfβ, insulin, and wnt signaling. |
2020-06-11 |
2023-08-13 |
Not clear |
| Daniela A Maschio, Valquíria A Matheus, Carla B Collares-Buzat. Islet cells are the source of Wnts that can induce beta-cell proliferation in vitro. Journal of cellular physiology. vol 234. issue 11. 2020-06-02. PMID:30963563. |
the aim of this work was threefold: (a) to screen for wnt expressed by murine pancreas/islet cells, (b) to investigate whether the wnt gene expression profile can be changed in hyperplastic islets from type 2 prediabetic mice (fed a high-fat diet), and (c) to verify whether soluble factors (namely wnts) released by pancreatic islets affect insulin secretion and proliferation of a beta-cell line in vitro condition. |
2020-06-02 |
2023-08-13 |
mouse |
| Habib Yaribeygi, Stephen L Atkin, Amirhossein Sahebka. Wingless-type inducible signaling pathway protein-1 (WISP1) adipokine and glucose homeostasis. Journal of cellular physiology. vol 234. issue 10. 2020-05-26. PMID:30807659. |
wingless-type (wnt) inducible signaling pathway protein-1 (wisp1) is a newly identified adipokine that has important roles in many molecular pathways and cellular events, with the suggestion that wisp1 adipokine is closely correlated to the progression of insulin resistance. |
2020-05-26 |
2023-08-13 |
Not clear |
| Xin-Yong Wang, Xian-Zhao Zhang, Feng Li, Qing-Rong J. MiR-128-3p accelerates cardiovascular calcification and insulin resistance through ISL1-dependent Wnt pathway in type 2 diabetes mellitus rats. Journal of cellular physiology. vol 234. issue 4. 2020-03-18. PMID:30341898. |
mir-128-3p accelerates cardiovascular calcification and insulin resistance through isl1-dependent wnt pathway in type 2 diabetes mellitus rats. |
2020-03-18 |
2023-08-13 |
rat |
| Xin-Yong Wang, Xian-Zhao Zhang, Feng Li, Qing-Rong J. MiR-128-3p accelerates cardiovascular calcification and insulin resistance through ISL1-dependent Wnt pathway in type 2 diabetes mellitus rats. Journal of cellular physiology. vol 234. issue 4. 2020-03-18. PMID:30341898. |
we hypothesized that mir-128-3p is associated with cardiovascular calcification and insulin resistance (ir) in rats with t2dm by targeting isl1 via the wnt pathway. |
2020-03-18 |
2023-08-13 |
rat |
| Sharad S Singhal, Ravi Salgia, Nisan Verma, David Horne, Sanjay Awasth. RLIP controls receptor-ligand signaling by regulating clathrin-dependent endocytosis. Biochimica et biophysica acta. Reviews on cancer. vol 1873. issue 1. 2020-02-20. PMID:31904398. |
cde is an essential mechanism for internalizing ligand-receptor complexes that signal proliferation (egf, insulin, igf1), apoptosis (tnfα, trail, fas-l), and differentiation and morphogenesis (tgfβ, wnt, notch, shh). |
2020-02-20 |
2023-08-13 |
Not clear |
| Maren Carstensen-Kirberg, Karin Röhrig, Corinna Niersmann, D Margriet Ouwens, Bengt F Belgardt, Michael Roden, Christian Herde. Sfrp5 increases glucose-stimulated insulin secretion in the rat pancreatic beta cell line INS-1E. PloS one. vol 14. issue 3. 2019-12-26. PMID:30921355. |
this study examined effects of sfrp5 on (i) beta cell viability and proliferation, (ii) basal and glucose-stimulated insulin secretion and (iii) canonical and non-canonical wnt signalling pathways. |
2019-12-26 |
2023-08-13 |
rat |
| Benedikt M Mortzfeld, Jan Taubenheim, Alexander V Klimovich, Sebastian Fraune, Philip Rosenstiel, Thomas C G Bosc. Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways. Nature communications. vol 10. issue 1. 2019-12-16. PMID:31332174. |
temperature and insulin signaling regulate body size in hydra by the wnt and tgf-beta pathways. |
2019-12-16 |
2023-08-13 |
Not clear |
| Shouyi Wang, Pin Liu, Pu Yang, Junwen Zheng, Dongchi Zha. Peripheral blood microRNAs expression is associated with infant respiratory syncytial virus infection. Oncotarget. vol 8. issue 57. 2019-11-20. PMID:29228557. |
pathway analysis indicated that the dysregulated micrornas were involved in inflammatory and immune responses, including wnt, tgf-β, insulin, and t and b cell receptor signaling. |
2019-11-20 |
2023-08-13 |
Not clear |
| Michael A Kalwat, In Hyun Hwang, Jocelyn Macho, Magdalena G Grzemska, Jonathan Z Yang, Kathleen McGlynn, John B MacMillan, Melanie H Cob. Chromomycin A The Journal of general physiology. vol 150. issue 12. 2019-10-24. PMID:30352794. |
in this study, using multiple phenotypic analyses, we found that one of the top natural product hits, chromomycin a2 (cma2), potently inhibited insulin secretion by at least three potential mechanisms: disruption of wnt signaling, interference of β cell gene expression, and partial suppression of ca |
2019-10-24 |
2023-08-13 |
Not clear |
| María A Zuriaga, José J Fuster, Melissa G Farb, Susan MacLauchlan, Rosa Bretón-Romero, Shakun Karki, Donald T Hess, Caroline M Apovian, Naomi M Hamburg, Noyan Gokce, Kenneth Wals. Activation of non-canonical WNT signaling in human visceral adipose tissue contributes to local and systemic inflammation. Scientific reports. vol 7. issue 1. 2019-07-15. PMID:29229927. |
wnt5a, a non-canonical wnt ligand, has been shown to promote adipose tissue inflammation and insulin resistance in animal studies. |
2019-07-15 |
2023-08-13 |
human |
| Abrar E Al-Shaer, George R Flentke, Mark E Berres, Ana Garic, Susan M Smit. Exon level machine learning analyses elucidate novel candidate miRNA targets in an avian model of fetal alcohol spectrum disorder. PLoS computational biology. vol 15. issue 4. 2019-05-28. PMID:30973878. |
other pathways are crucial to facial morphogenesis and represent both novel (focal adhesion, foxo signaling, insulin signaling) and known (wnt signaling) alcohol targets. |
2019-05-28 |
2023-08-13 |
chicken |
| Ye Hou, Liangliang Fu, Jingjin Li, Jingxuan Li, Yunxia Zhao, Yu Luan, An Liu, Huiying Liu, Xinyun Li, Shuhong Zhao, Changchun L. Transcriptome Analysis of Potential miRNA Involved in Adipogenic Differentiation of C2C12 Myoblasts. Lipids. vol 53. issue 4. 2019-04-29. PMID:29766503. |
functional annotation indicated that the target genes of de mirna were mostly enriched in adipogenic transdifferentiation and fat metabolism-related pathways, including wnt, mitogen-activated protein kinase (mapk), and insulin signaling. |
2019-04-29 |
2023-08-13 |
Not clear |
| Ye Hou, Liangliang Fu, Jingjin Li, Jingxuan Li, Yunxia Zhao, Yu Luan, An Liu, Huiying Liu, Xinyun Li, Shuhong Zhao, Changchun L. Transcriptome Analysis of Potential miRNA Involved in Adipogenic Differentiation of C2C12 Myoblasts. Lipids. vol 53. issue 4. 2019-04-29. PMID:29766503. |
the insulin signaling pathway was further analyzed for its close connections to wnt and mapk signaling pathways as well as for the containing of thymoma viral proto-oncogene-3 (akt3) and glycogen synthase kinase-3 beta (gsk3b), which were both target genes predicted by most de mirna. |
2019-04-29 |
2023-08-13 |
Not clear |
| Jun-Ha Hwang, A Rum Kim, Kyung Min Kim, Jung Il Park, Ho Taek Oh, Sung A Moon, Mi Ran Byun, Hana Jeong, Hyo Kyung Kim, Michael B Yaffe, Eun Sook Hwang, Jeong-Ho Hon. TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression. Nature communications. vol 10. issue 1. 2019-02-22. PMID:30679431. |
furthermore, taz is required for wnt signalling-induced irs1 expression, as observed by decreased irs1 expression and insulin sensitivity in muscle-specific apc- and taz-double-knockout mice. |
2019-02-22 |
2023-08-13 |
mouse |
| Yu Qin, Min Chen, Yan Yang, Xin-Rong Zhou, Shi-Ying Shao, Dao-Wen Wang, Gang Yua. Liraglutide improves hepatic insulin resistance via the canonical Wnt signaling pathway. Molecular medicine reports. vol 17. issue 5. 2018-09-21. PMID:29568881. |
liraglutide improves hepatic insulin resistance via the canonical wnt signaling pathway. |
2018-09-21 |
2023-08-13 |
mouse |
| Yu Qin, Min Chen, Yan Yang, Xin-Rong Zhou, Shi-Ying Shao, Dao-Wen Wang, Gang Yua. Liraglutide improves hepatic insulin resistance via the canonical Wnt signaling pathway. Molecular medicine reports. vol 17. issue 5. 2018-09-21. PMID:29568881. |
using in vivo and in vitro models of diabetes and insulin resistance, it was investigated whether the beneficial effects of liraglutide on liver glucose metabolism are mediated by the wnt signaling pathway. |
2018-09-21 |
2023-08-13 |
mouse |
| Yu Qin, Min Chen, Yan Yang, Xin-Rong Zhou, Shi-Ying Shao, Dao-Wen Wang, Gang Yua. Liraglutide improves hepatic insulin resistance via the canonical Wnt signaling pathway. Molecular medicine reports. vol 17. issue 5. 2018-09-21. PMID:29568881. |
the wnt signaling pathway may be a potential therapeutic target for the treatment of altered hepatic physiology in insulin resistance. |
2018-09-21 |
2023-08-13 |
mouse |