| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kamil Kozinski, Magdalena Jazurek, Pawel Dobrzyn, Justyna Janikiewicz, Katarzyna Kolczynska, Anna Gajda, Agnieszka Dobrzy. Adipose- and muscle-derived Wnts trigger pancreatic β-cell adaptation to systemic insulin resistance. Scientific reports. vol 6. 2018-07-03. PMID:27527335. |
here, we show that two wnt proteins, wnt3a and wnt4, are specifically secreted by skeletal muscle and adipose tissue during the development of insulin resistance and play an important role in cross-talk between insulin-resistant tissues and pancreatic beta cells. |
2018-07-03 |
2023-08-13 |
Not clear |
| Kamil Kozinski, Magdalena Jazurek, Pawel Dobrzyn, Justyna Janikiewicz, Katarzyna Kolczynska, Anna Gajda, Agnieszka Dobrzy. Adipose- and muscle-derived Wnts trigger pancreatic β-cell adaptation to systemic insulin resistance. Scientific reports. vol 6. 2018-07-03. PMID:27527335. |
the activation of frizzled receptor and wnt signaling in pancreatic islets via circulating wnt3a in blood resulted in higher insulin secretion and an increase in beta cell proliferation, thus leading to islet adaptation in a pre-diabetic state. |
2018-07-03 |
2023-08-13 |
Not clear |
| Chengyi Tu, Robert Xu, Meghana Koleti, Janet Zolda. Glycogen synthase kinase-3 inhibition sensitizes human induced pluripotent stem cells to thiol-containing antioxidants induced apoptosis. Stem cell research. vol 23. 2018-05-30. PMID:28772167. |
however, the effects of such inhibition on pscs, besides upregulating the wnt pathway, have rarely been investigated despite that gsk3 is broadly involved in other cellular activities such as insulin signaling and cell growth/survival regulation. |
2018-05-30 |
2023-08-13 |
mouse |
| Noemie Ammeux, Benjamin E Housden, Andrew Georgiadis, Yanhui Hu, Norbert Perrimo. Mapping signaling pathway cross-talk in Drosophila cells. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 35. 2018-03-26. PMID:27528688. |
our study, focusing on seven core pathways, epidermal growth factor receptor (egfr), bone morphogenetic protein (bmp), jun kinase (jnk), jak/stat, notch, insulin, and wnt, revealed that many ligands and receptors are primary targets of signaling pathways, highlighting that transcriptional regulation of genes encoding pathway components is a major level of signaling cross-talk. |
2018-03-26 |
2023-08-13 |
drosophila_melanogaster |
| Mukesh Gautam, Indrashis Bhattacharya, Umesh Rai, Subeer S Majumda. Hormone induced differential transcriptome analysis of Sertoli cells during postnatal maturation of rat testes. PloS one. vol 13. issue 1. 2018-02-21. PMID:29342173. |
our data revealed that immature sc express genes involved in cellular growth, metabolism, chemokines, cell division, mapk and wnt pathways, while mature sc are more specialized expressing genes involved in glucose metabolism, phagocytosis, insulin signaling and cytoskeleton structuring. |
2018-02-21 |
2023-08-13 |
rat |
| Chad Pope, Stephanie C Piekos, Liming Chen, Shashank Mishra, Xiao-Bo Zhon. The role of H19, a long non-coding RNA, in mouse liver postnatal maturation. PloS one. vol 12. issue 11. 2017-12-29. PMID:29099871. |
using an h19 knockout mouse model to determine the role of h19 in liver development, we quantified gene expression for insulin growth factor signaling, wnt signaling, key cytochrome p450 (p450) enzymes known to change as the liver develops, and fetal and adult plasma protein produced in liver. |
2017-12-29 |
2023-08-13 |
mouse |
| Kathryn G V Anderson, William B Hamilton, Fabian V Roske, Ajuna Azad, Teresa E Knudsen, Maurice A Canham, Lesley M Forrester, Joshua M Brickma. Insulin fine-tunes self-renewal pathways governing naive pluripotency and extra-embryonic endoderm. Nature cell biology. vol 19. issue 10. 2017-10-24. PMID:28945231. |
in naive embryonic stem cell culture, we find that insulin complements lif signalling to support self-renewal; however, when it is removed, lif, acta and wnt signalling not only induce pre differentiation, but also support its expansion. |
2017-10-24 |
2023-08-13 |
Not clear |
| Salvatore Benvenga, Fabrizio Guarner. Conservation in the phylum of the local homology of apolipoproteins with the thyroid hormone plasma carriers. Reviews in endocrine & metabolic disorders. vol 17. issue 4. 2017-08-30. PMID:27549767. |
no occurrence of the motif was found in control proteins (alpha- and beta-tubulin, eosinophil cationic protein, endothelin-1, -2 and -3, igg receptor, tropomyosin, wnt inhibitory factor 1, erythropoietin, insulin and haptoglobin).maintenance of a th-binding domain in apolipoproteins throughout the phylum should be not less important that maintenance of the lipid binding domain. |
2017-08-30 |
2023-08-13 |
human |
| Peter J Meyers, Thomas H Q Powell, Kimberly K O Walden, Adam J Schieferecke, Jeffrey L Feder, Daniel A Hahn, Hugh M Robertson, Stewart H Berlocher, Gregory J Raglan. Divergence of the diapause transcriptome in apple maggot flies: winter regulation and post-winter transcriptional repression. The Journal of experimental biology. vol 219. issue Pt 17. 2017-08-09. PMID:27312473. |
expression and polymorphism analysis identify candidate genes in the wnt and insulin signaling pathways that contribute to population differences in seasonality. |
2017-08-09 |
2023-08-13 |
Not clear |
| Rik Mencke, Jan-Luuk Hillebrand. The role of the anti-ageing protein Klotho in vascular physiology and pathophysiology. Ageing research reviews. vol 35. 2017-08-02. PMID:27693241. |
klotho is an anti-ageing protein that functions in many pathways that govern ageing, like regulation of phosphate homeostasis, insulin signaling, and wnt signaling. |
2017-08-02 |
2023-08-13 |
human |
| Alp Aydos, Aykut Gurel, Yasemin Oztemur Islakoglu, Senem Noyan, Bagdagul Gokce, Tolga Ecemis, Cemil Kaya, Arif Tarik Aksu, Bala Gur Dedeogl. Identification of Polycystic Ovary Syndrome (PCOS) Specific Genes in Cumulus and Mural Granulosa Cells. PloS one. vol 11. issue 12. 2017-06-30. PMID:27997581. |
this study enabled us to reveal dysregulation in mapk (mitogen activated protein kinase), insulin and wnt signaling pathways between ccs and mgcs in pcos. |
2017-06-30 |
2023-08-13 |
Not clear |
| Monika Karczewska-Kupczewska, Magdalena Stefanowicz, Natalia Matulewicz, Agnieszka Nikołajuk, Marek Strączkowsk. Wnt Signaling Genes in Adipose Tissue and Skeletal Muscle of Humans With Different Degrees of Insulin Sensitivity. The Journal of clinical endocrinology and metabolism. vol 101. issue 8. 2017-06-26. PMID:27218273. |
wnt signaling genes in adipose tissue and skeletal muscle of humans with different degrees of insulin sensitivity. |
2017-06-26 |
2023-08-13 |
Not clear |
| Yan Wang, Xiuyun Zhang, Zhitao Zhao, Hui X. Preliminary Analysis of MicroRNAs Expression Profiling in MC3T3-E1 Cells Exposed to Fluoride. Biological trace element research. vol 176. issue 2. 2017-06-19. PMID:27580895. |
among them, the wnt, insulin, tgf-beta, hedgehog, vegf, and notch pathways in osteoblasts were those mainly affected by fluoride treatment. |
2017-06-19 |
2023-08-13 |
Not clear |
| Md Kamrul H Chowdhury, Lindsay E Wu, James L J Coleman, Nicola J Smith, Margaret J Morris, Peter R Shepherd, Greg C Smit. Niclosamide blocks glucagon phosphorylation of Ser552 on β-catenin in primary rat hepatocytes via PKA signalling. The Biochemical journal. vol 473. issue 9. 2017-06-08. PMID:26964897. |
primary rat hepatocytes were incubated with insulin, glucagon or adrenaline (epinephrine) and a range of inhibitors of pi3k (phosphoinositide 3-kinase), wnt, mitochondrial uncoupler (niclosamide) or pka inhibitors to dissect out the pathway leading to increased ser(552) phosphorylation on β-catenin following glucagon exposure. |
2017-06-08 |
2023-08-13 |
rat |
| A Bowen, K Kos, J Whatmore, S Richardson, H J Welter. Wnt4 antagonises Wnt3a mediated increases in growth and glucose stimulated insulin secretion in the pancreatic beta-cell line, INS-1. Biochemical and biophysical research communications. vol 479. issue 4. 2017-06-02. PMID:27687546. |
investigating the impact of a non-canonical wnt ligand, wnt4, on beta-cell function we found that in ins-1 cells, wnt4 was able to completely block wnt3a stimulated cell growth and insulin secretion. |
2017-06-02 |
2023-08-13 |
Not clear |
| Qian Zhang, Xiaofang Sun, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Zhixin Wang, Cuijuan Qi, Tong Wang, Xiaojing Wan. Maternal Chromium Restriction Leads to Glucose Metabolism Imbalance in Mice Offspring through Insulin Signaling and Wnt Signaling Pathways. International journal of molecular sciences. vol 17. issue 10. 2017-03-23. PMID:27782077. |
maternal chromium restriction leads to glucose metabolism imbalance in mice offspring through insulin signaling and wnt signaling pathways. |
2017-03-23 |
2023-08-13 |
mouse |
| Z-Q D. Comparative transcriptome analysis reveals three potential antiviral signaling pathways in lymph organ tissue of the red swamp crayfish, Procambarus clarkii. Genetics and molecular research : GMR. vol 15. issue 4. 2017-02-27. PMID:27886336. |
the degs were then mapped to different signaling pathways; the janus kinase/signal transducers and activators of transcription, insulin, and wnt signaling pathways were predicted to be involved in crayfish antiviral innate immunity. |
2017-02-27 |
2023-08-13 |
Not clear |
| Chunjin Li, Lu Chen, Yun Zhao, Shuxiong Chen, Lulu Fu, Yanwen Jiang, Shan Gao, Zhuo Liu, Fengge Wang, Xiaoling Zhu, Jiahui Rao, Jing Zhang, Xu Zho. Altered expression of miRNAs in the uterus from a letrozole-induced rat PCOS model. Gene. vol 598. 2017-02-01. PMID:27777110. |
pathway analysis supported that target genes of mirnas were involved in insulin secretion and signaling pathways, such as wnt, ampk, pi3k-akt, and ras. |
2017-02-01 |
2023-08-13 |
rat |
| Yao-Zhong Liu, Lei Zhang, Astrid M Roy-Engel, Shigeki Saito, Joseph A Lasky, Guangdi Wang, He Wan. Carcinogenic effects of oil dispersants: A KEGG pathway-based RNA-seq study of human airway epithelial cells. Gene. vol 602. 2017-01-30. PMID:27866042. |
our results suggested a pattern of change towards carcinogenesis for the treated cells marked by upregulation of ribosomal biosynthesis (hsa03008) (p=1.97e-13), protein processing (hsa04141) (p=4.09e-7), wnt signaling (hsa04310) (p=6.76e-3), neurotrophin signaling (hsa04722) (p=7.73e-3) and insulin signaling (hsa04910) (p=1.16e-2) pathways under the dispersant corexit 9527 treatment, as identified by gage analysis. |
2017-01-30 |
2023-08-13 |
human |
| Z Wicik, M Gajewska, A Majewska, D Walkiewicz, E Osińska, T Moty. Characterization of microRNA profile in mammary tissue of dairy and beef breed heifers. Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie. vol 133. issue 1. 2016-12-13. PMID:26060050. |
enrichment analyses for targeted genes revealed that the major differences between mirna expression in the mammary gland of hf versus lm were associated with the regulation of signalling pathways that are crucial for mammary gland development, such as tgf-beta, insulin, wnt and inflammatory pathways. |
2016-12-13 |
2023-08-13 |
cattle |