| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Enrico Gaffo, Paolo Zambonelli, Andrea Bisognin, Stefania Bortoluzzi, Roberta Davol. miRNome of Italian Large White pig subcutaneous fat tissue: new miRNAs, isomiRs and moRNAs. Animal genetics. vol 45. issue 5. 2015-03-02. PMID:25039998. |
porcine transcripts targeted by the most expressed mirnas were predicted, showing that these mirnas may have an impact on wnt, insulin signalling and axon guidance pathways. |
2015-03-02 |
2023-08-13 |
human |
| Linkai Mou, Molin Li, Shao-Yong Lu, Shuai Li, Qiancheng Shen, Jian Zhang, Chuangang Li, Xuefeng L. Unraveling the role of Arg4 and Arg6 in the auto-inhibition mechanism of GSK3β from molecular dynamics simulation. Chemical biology & drug design. vol 83. issue 6. 2015-02-12. PMID:24444018. |
glycogen synthase kinase 3β (gsk3β) is a multifunctional serine/threonine protein kinase that is involved in several biological processes including insulin and wnt signaling pathways. |
2015-02-12 |
2023-08-12 |
Not clear |
| Yi Ju Wu, Yen Hsin Fang, Hsiang Cheng Chi, Li Chiung Chang, Shih Ying Chung, Wei Chieh Huang, Xiao Wen Wang, Kuan Wei Lee, Shen Liang Che. Insulin and LiCl synergistically rescue myogenic differentiation of FoxO1 over-expressed myoblasts. PloS one. vol 9. issue 2. 2014-10-14. PMID:24551104. |
although over-expression of wildtype foxo1 in c2c12 myoblasts significantly blocked their myogenic differentiation under serum withdrawal condition, application of insulin and licl, an activator of wnt signaling pathway, to these cells successfully rescued their myogenic differentiation and generated myotubes with larger diameters. |
2014-10-14 |
2023-08-12 |
Not clear |
| Yi Ju Wu, Yen Hsin Fang, Hsiang Cheng Chi, Li Chiung Chang, Shih Ying Chung, Wei Chieh Huang, Xiao Wen Wang, Kuan Wei Lee, Shen Liang Che. Insulin and LiCl synergistically rescue myogenic differentiation of FoxO1 over-expressed myoblasts. PloS one. vol 9. issue 2. 2014-10-14. PMID:24551104. |
these results suggest that foxo1 inhibits myogenesis in serum withdrawal condition but turns into a hypertrophy potentiator when other myogenic signals, such as wnt and insulin, are available. |
2014-10-14 |
2023-08-12 |
Not clear |
| Colleen M Bartman, Jennifer Egelston, Sravya Kattula, Leigh C Zeidner, Anthony D'Ippolito, Bradley W Doble, Christopher J Phie. Gene Expression Profiling in Mouse Embryonic Stem Cells Reveals Glycogen Synthase Kinase-3-Dependent Targets of Phosphatidylinositol 3-Kinase and Wnt/β-Catenin Signaling Pathways. Frontiers in endocrinology. vol 5. 2014-08-28. PMID:25165462. |
however, in addition to wnt signaling, all gsk-3-regulated pathways, such as insulin signaling, are also affected simultaneously in gsk-3α(-) (/) (-); gsk-3β(-) (/) (-)escs. |
2014-08-28 |
2023-08-13 |
mouse |
| Colleen M Bartman, Jennifer Egelston, Sravya Kattula, Leigh C Zeidner, Anthony D'Ippolito, Bradley W Doble, Christopher J Phie. Gene Expression Profiling in Mouse Embryonic Stem Cells Reveals Glycogen Synthase Kinase-3-Dependent Targets of Phosphatidylinositol 3-Kinase and Wnt/β-Catenin Signaling Pathways. Frontiers in endocrinology. vol 5. 2014-08-28. PMID:25165462. |
our results show that wnt signaling has a greater effect on up-regulated genes in the gsk-3α(-) (/) (-); gsk-3β(-) (/) (-)escs, whereas pi3k-dependent insulin signaling is more responsible for the down-regulation of genes in the same cells. |
2014-08-28 |
2023-08-13 |
mouse |
| Xinhui Wang, Xin Gen Lei, Jufang Wan. Malondialdehyde regulates glucose-stimulated insulin secretion in murine islets via TCF7L2-dependent Wnt signaling pathway. Molecular and cellular endocrinology. vol 382. issue 1. 2014-08-26. PMID:24035868. |
malondialdehyde regulates glucose-stimulated insulin secretion in murine islets via tcf7l2-dependent wnt signaling pathway. |
2014-08-26 |
2023-08-12 |
Not clear |
| F Conti, D T Wolosinska, G Puglies. Diabetes and bone fragility: a dangerous liaison. Aging clinical and experimental research. vol 25 Suppl 1. 2014-07-17. PMID:23907773. |
diabetes leads to impaired bone formation through many mechanisms: insulin deficiency and hyperglycemia, prevalently by age/rage axis alteration, insulin growth factors reduction, and alterations in osteocalcin and/or wnt signaling pathways. |
2014-07-17 |
2023-08-12 |
Not clear |
| Qiping Shi, Simin Luo, Haiying Jia, Lie Feng, Xiaohua Lu, Lixin Zhou, Jiye Ca. Wnt/β-catenin signaling may be involved with the maturation, but not the differentiation, of insulin-producing cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 67. issue 8. 2014-06-26. PMID:23680408. |
interestingly, the inhibition of wnt signaling did not block ipc differentiation; instead, it resulted in the upregulation of ipc-specific markers, including pdx-1, insulin, irs-1, and irs-2. |
2014-06-26 |
2023-08-12 |
human |
| Hui-Min Chen, Yan-Wei Lin, Ji-Lin Wang, Xuan Kong, Jie Hong, Jing-Yuan Fan. Identification of potential target genes of butyrate in dimethylhydrazine-induced colorectal cancer in mice. Nutrition and cancer. vol 65. issue 8. 2014-06-26. PMID:24099273. |
the results revealed that most of the tumor-related signaling pathways (e.g., mapk pathway, wnt pathway, insulin pathway, and vegf pathway) were downregulated by butyrate. |
2014-06-26 |
2023-08-12 |
mouse |
| Jie Qiu, Xiao-guang Zhou, Xiao-yu Zhou, Chun Zhu, Chun-mei Shi, Chen-bo Ji, Rui Cheng, Yong Li, Xi-rong Gu. Characterization of microRNA expression profiles in 3T3-L1 adipocytes overexpressing C10orf116. Molecular biology reports. vol 40. issue 11. 2014-06-11. PMID:24052233. |
the target genes of differentially expressed mirnas were found to be involved in multiple signalling pathways, such as wnt, tgf-beta, mapk, jak-stat, insulin signalling pathway, et al. |
2014-06-11 |
2023-08-12 |
Not clear |
| Mi-Hyun Kim, Jae-Hwan Jee, Sunyoung Park, Myung-Shik Lee, Kwang-Won Kim, Moon-Kyu Le. Metformin enhances glucagon-like peptide 1 via cooperation between insulin and Wnt signaling. The Journal of endocrinology. vol 220. issue 2. 2014-03-11. PMID:24233023. |
metformin enhances glucagon-like peptide 1 via cooperation between insulin and wnt signaling. |
2014-03-11 |
2023-08-12 |
mouse |
| Mi-Hyun Kim, Jae-Hwan Jee, Sunyoung Park, Myung-Shik Lee, Kwang-Won Kim, Moon-Kyu Le. Metformin enhances glucagon-like peptide 1 via cooperation between insulin and Wnt signaling. The Journal of endocrinology. vol 220. issue 2. 2014-03-11. PMID:24233023. |
one aspect of the effects of metformin on glucagon-like peptide (glp)-1 might be associated with the mechanism by which the cross talk between insulin and wnt signaling enhances glp1 secretion, due to the action of metformin as an insulin sensitizer. |
2014-03-11 |
2023-08-12 |
mouse |
| Mi-Hyun Kim, Jae-Hwan Jee, Sunyoung Park, Myung-Shik Lee, Kwang-Won Kim, Moon-Kyu Le. Metformin enhances glucagon-like peptide 1 via cooperation between insulin and Wnt signaling. The Journal of endocrinology. vol 220. issue 2. 2014-03-11. PMID:24233023. |
in this study, we have investigated the mechanisms of the action of metformin on cross talk between insulin and wnt signaling. |
2014-03-11 |
2023-08-12 |
mouse |
| Mi-Hyun Kim, Jae-Hwan Jee, Sunyoung Park, Myung-Shik Lee, Kwang-Won Kim, Moon-Kyu Le. Metformin enhances glucagon-like peptide 1 via cooperation between insulin and Wnt signaling. The Journal of endocrinology. vol 220. issue 2. 2014-03-11. PMID:24233023. |
our findings indicate that the cooperation between wnt and its upstream insulin signaling pathways might be a novel and important mechanism underlying the effects of metformin on glp1 production. |
2014-03-11 |
2023-08-12 |
mouse |
| Mi-Hyun Kim, Seung-Hyun Hong, Moon-Kyu Le. Insulin receptor-overexpressing β-cells ameliorate hyperglycemia in diabetic rats through Wnt signaling activation. PloS one. vol 8. issue 7. 2014-02-24. PMID:23874448. |
insulin receptor-overexpressing β-cells ameliorate hyperglycemia in diabetic rats through wnt signaling activation. |
2014-02-24 |
2023-08-12 |
human |
| Mi-Hyun Kim, Seung-Hyun Hong, Moon-Kyu Le. Insulin receptor-overexpressing β-cells ameliorate hyperglycemia in diabetic rats through Wnt signaling activation. PloS one. vol 8. issue 7. 2014-02-24. PMID:23874448. |
in addition, the promotion of cell proliferation and insulin secretion by wnt signaling activation was shown by 100 nm insulin treatment, and to a similar degree, was shown in ins-ir cells. |
2014-02-24 |
2023-08-12 |
human |
| Mi-Hyun Kim, Seung-Hyun Hong, Moon-Kyu Le. Insulin receptor-overexpressing β-cells ameliorate hyperglycemia in diabetic rats through Wnt signaling activation. PloS one. vol 8. issue 7. 2014-02-24. PMID:23874448. |
additionally, this study demonstrates that the novel mechanism of cross-talk between insulin and wnt signaling plays a primary role in the higher therapeutic efficacy of ir-overexpressing β-cells. |
2014-02-24 |
2023-08-12 |
human |
| Haytham Aly, Nidhi Rohatgi, Connie A Marshall, Tiffani C Grossenheider, Hiroyuki Miyoshi, Thaddeus S Stappenbeck, Scot J Matkovich, Michael L McDanie. A novel strategy to increase the proliferative potential of adult human β-cells while maintaining their differentiated phenotype. PloS one. vol 8. issue 6. 2014-01-23. PMID:23776620. |
direct inhibition of gsk-3, that engages wnt signaling downstream of the wnt receptor, increases β-catenin nuclear translocation and β-cell proliferation but results in lower insulin content. |
2014-01-23 |
2023-08-12 |
human |
| Xiaojun Lian, Jianhua Zhang, Kexian Zhu, Timothy J Kamp, Sean P Palece. Insulin inhibits cardiac mesoderm, not mesendoderm, formation during cardiac differentiation of human pluripotent stem cells and modulation of canonical Wnt signaling can rescue this inhibition. Stem cells (Dayton, Ohio). vol 31. issue 3. 2014-01-07. PMID:23193013. |
insulin inhibits cardiac mesoderm, not mesendoderm, formation during cardiac differentiation of human pluripotent stem cells and modulation of canonical wnt signaling can rescue this inhibition. |
2014-01-07 |
2023-08-12 |
human |