| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A V Juori. The effects of amfonelic acid and some other central stimulants on mouse striatal tyramine, dopamine and homovanillic acid. British journal of pharmacology. vol 77. issue 3. 1983-01-27. PMID:7139200. |
by increasing the dose to 20 mg/kg, nomifensine produced an increase in p-tyramine and homovanillic acid.5 the present results support the view that amfonelic acid and (+)-amphetamine would respectively release granular or newly synthesized dopamine, both actions being accompanied by an increase in tyrosine hydroxylase activity and dopamine turnover which in turn reduces p-tyramine but produces no change or an increase in m-tyramine.6 the effects of nomifensine were observed after the administration of a relatively high dose (20 mg/kg), that was lethal to some mice (about 20%, at 2 h), and more likely to posses unspecific actions. |
1983-01-27 |
2023-08-12 |
mouse |
| N Autissier, L Rochette, P Dumas, A Beley, A Loireau, J Brale. Dopamine and norepinephrine turnover in various regions of the rat brain after chronic manganese chloride administration. Toxicology. vol 24. issue 2. 1982-12-21. PMID:7135412. |
the turnover of dopamine (da) and norepinephrine (ne) was measured in several brain regions (brain stem, hypothalamus, corpus striatum and "rest of the brain") by the decay in endogenous da and ne after inhibition of tyrosine hydroxylase by alpha-methylparatyrosine. |
1982-12-21 |
2023-08-12 |
rat |
| P Siltanen, O Penttilä, E Merikallio, K Kyösola, E Klinge, J Pisp. Myocardial catecholamines and their biosynthetic enzymes in various human heart diseases. Acta medica Scandinavica. Supplementum. vol 660. 1982-12-16. PMID:6127908. |
myocardial noradrenaline (na) content, together with the activities of the enzymes tyrosine hydroxylase (th) and dopamine beta-hydroxylase (dbh) was measured in biopsy specimens taken during cardiac surgery from patients with various heart diseases. |
1982-12-16 |
2023-08-12 |
human |
| B A McMille. Striatal synaptosomal tyrosine hydroxylase activity. A model system for study of presynaptic dopamine receptors. Biochemical pharmacology. vol 31. issue 16. 1982-12-16. PMID:6128002. |
tyrosine hydroxylase activity determined in striatal synaptosomes by the formation of [3h]h2o from [3,5-3h]tyrosine was used as a system for determining receptor affinities of neuroleptic drugs for the dopamine autoreceptor. |
1982-12-16 |
2023-08-12 |
Not clear |
| M Goldstein, A Lieberman, J Pearso. Relatively high levels of dopamine in nucleus accumbens of levodopa treated patients with Parkinson's disease. Journal of neural transmission. vol 54. issue 1-2. 1982-10-29. PMID:6125563. |
tyrosine hydroxylase immunocytochemistry revealed a severe degeneration of the nigro-striatal dopamine neuronal system in both postmortem brains. |
1982-10-29 |
2023-08-12 |
Not clear |
| H Baker, T H Joh, D J Rei. Time of appearance during development of differences in nigrostriatal tyrosine hydroxylase activity in two inbred mouse strains. Brain research. vol 256. issue 2. 1982-10-21. PMID:6125248. |
the greater activity of tyrosine hydroxylase (th) in substantia nigra and corpus striata of adult balb/cj than cba/j mice, is attributable to differences in the number of dopamine neurons in the ventral midbrain tegmentum. |
1982-10-21 |
2023-08-12 |
mouse |
| L Iacovitti, T H Joh, D H Park, R P Bung. Dual expression of neurotransmitter synthesis in cultured autonomic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 1. issue 7. 1982-10-21. PMID:6125574. |
we report here data which demonstrate that sympathetic neurons, cultured under conditions which foster the accrual of cholinergic properties, exhibit parallel increases in the activities and amounts of the specific adrenergic enzymes, tyrosine hydroxylase and dopamine beta-hydroxylase, as well as the specific cholinergic enzyme, choline acetyltransferase. |
1982-10-21 |
2023-08-12 |
rat |
| G Kapatos, M J Zigmon. Influence of calcium on dopamine synthesis and tyrosine hydroxylase activity in rat striatum. Journal of neurochemistry. vol 39. issue 2. 1982-08-26. PMID:6123555. |
influence of calcium on dopamine synthesis and tyrosine hydroxylase activity in rat striatum. |
1982-08-26 |
2023-08-12 |
rat |
| G Chamba, L Denoroy, B Renau. Comparative microdistribution of the activity of catecholamine-synthesizing enzymes in horizontal sections of the rat lower brainstem. Journal of neurochemistry. vol 39. issue 2. 1982-08-26. PMID:6123560. |
the difference was most important in the a2-c2 region where the maximal activity of phenylethanolamine-n-methyltransferase (ec 2.1.1.28) was located 1.5 mm more rostrally than the maximal activities of the tyrosine hydroxylase (ec 1.14.16.2) and dopamine beta-hydroxylase (ec1.14.17.1). |
1982-08-26 |
2023-08-12 |
rat |
| M Bräutigam, R Dreesen, C W Flosbach, H Herke. Mouse neuroblastoma clone N1E-115: a suitable model for studying the action of dopamine agonists of tyrosine hydroxylase activity. Biochemical pharmacology. vol 31. issue 7. 1982-08-07. PMID:6124255. |
mouse neuroblastoma clone n1e-115: a suitable model for studying the action of dopamine agonists of tyrosine hydroxylase activity. |
1982-08-07 |
2023-08-12 |
mouse |
| D Engler, D Chad, I M Jackso. Thyrotropin-releasing hormone in the pancreas and brain of the rat is regulated by central noradrenergic and dopaminergic pathways. The Journal of clinical investigation. vol 69. issue 6. 1982-08-07. PMID:6806317. |
however, when cns stores of both ne and dopamine (da) were depleted by the subcutaneous administration of the tyrosine hydroxylase inhibitor alpha-methyl-rho-tyrosine (alpha-mt), trh concentrations in the brain were not significantly altered.fla-63 and alpha-mt did not significantly reduce pancreatic catecholamine concentrations, indicating that in the basal state, these agents predominantly deplete central catecholamine stores. |
1982-08-07 |
2023-08-12 |
rat |
| S Chaudhuri, H Parvez, L Marzouki, S Parve. Role of a non-ionic detergent upon maintenance and radioisotopic determination of enzymes catechol-O-methyltransferase and monoamine oxidase in brain and adrenal tissues. Journal de pharmacologie. vol 13. issue 1. 1982-06-24. PMID:7070096. |
therefore, different homogenization medias are required for the assay of enzymes of metabolism (mao and comt) and synthesis (tyrosine hydroxylase, phenylethano-l-amine-n-methyltransferase and dopamine beta hydroxylase). |
1982-06-24 |
2023-08-12 |
Not clear |
| A V Juori. The effect of gamma-hydroxybutyrate on mouse striatal tyramine, dopamine and homovanillic acid. British journal of pharmacology. vol 75. issue 3. 1982-06-21. PMID:7066598. |
3 there experiments strongly suggest that the increases in dopamine turnover produced by gamma-hydroxybutyrate caused reciprocal changes in striatal tyramine that are similar to those produced by drug or treatment that increase dopamine turnover and tyrosine hydroxylase activity. |
1982-06-21 |
2023-08-12 |
mouse |
| E Melamed, F Hefti, R J Wurtma. Compensatory mechanisms in the nigrostriatal dopaminergic system in Parkinson's disease: studies in an animal model. Israel journal of medical sciences. vol 18. issue 1. 1982-06-14. PMID:6121770. |
in such rats, surviving nigrostriatal neurons accelerated their rates of dopamine (da) synthesis and release (estimated by the ratio of homovanillic acid to tyrosine hydroxylase) only when 60% of more of da neurons had been destroyed. |
1982-06-14 |
2023-08-12 |
rat |
| R B Rastogi, R L Singhal, Y D Lapierr. Comparative effects of short- and long-term treatment with neuroleptics on behavioural activity as well as dopamine turnover in striatum. General pharmacology. vol 13. issue 1. 1982-05-27. PMID:6120880. |
produced an activation of dopamine synthesis and turnover as evidenced by increased activity of tyrosine hydroxylase and higher levels of homovanillic acid in the striatum of rats. |
1982-05-27 |
2023-08-12 |
rat |
| D R Liston, D N Franz, J W Gib. Biochemical evidence for alteration of neostriatal dopaminergic function by 5,7-dihydroxytryptamine. Journal of neurochemistry. vol 38. issue 5. 1982-05-27. PMID:6121011. |
unilateral injection of 5,7-dihydroxytryptamine (dht) into the rat neostriatum markedly reduced not only striatal tryptophan hydroxylase (tph) activity but also striatal tyrosine hydroxylase (th) activity and dopamine (da) concentration measured 10--15 days later. |
1982-05-27 |
2023-08-12 |
rat |
| E Meller, E Friedma. Differential dose- and time-dependent effects of molindone on dopamine neurons of rat brain: mediation by irreversible inhibition of monoamine oxidase. The Journal of pharmacology and experimental therapeutics. vol 220. issue 3. 1982-05-27. PMID:6121048. |
the effects of molindone (2.5, 10 and 40 mg/kg) on striatal tyrosine hydroxylase activity and dopamine (da), 3,4-dihydroxyphenylacetic acid and homovanillic acid levels were measured as a function of time (0-72 hr). |
1982-05-27 |
2023-08-12 |
rat |
| M Messripour, J B Clar. Tyrosine hydroxylase activity in rat brain synaptosomes: direct measurement using high performance liquid chromatography. Journal of neurochemistry. vol 38. issue 4. 1982-05-21. PMID:6121003. |
by use of high performance liquid chromatography with electrochemical detection to measure dopamine production, tyrosine hydroxylase (ec 1.14.16.2) activity has been measured in rat brain synaptosomes from striatum and forebrain. |
1982-05-21 |
2023-08-12 |
rat |
| C Vadasz, H Baker, T H Joh, A Lajtha, D J Rei. The inheritance and genetic correlation of tyrosine hydroxylase activities in the substantia nigra and corpus striatum in the C x B recombinant inbred mouse strains. Brain research. vol 234. issue 1. 1982-05-12. PMID:6120745. |
in mouse, strain differences in the activity of tyrosine hydroxylase (th) in ventral midbrain dopamine systems of substantia nigra-a10 (sn) region of mouse brain and in a terminal field, the striatum (cs), can be entirely attributed to variations in the number of dopaminergic neurons2. |
1982-05-12 |
2023-08-12 |
mouse |
| P M Iuvone, P B Marshbur. Regulation of tyrosine hydroxylase activity in retinal cell suspensions: effects of potassium and 8-bromo cyclic AMP. Life sciences. vol 30. issue 1. 1982-03-26. PMID:6119599. |
tyrosine hydroxylase (th) contained in dopamine (da) neurons of rat retina is activated in vivo as a consequence of photic stimulation. |
1982-03-26 |
2023-08-12 |
rat |