| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J H Gordon, K O Perr. Pre- and postsynaptic neurochemical alterations following estrogen-induced striatal dopamine hypo- and hypersensitivity. Brain research bulletin. vol 10. issue 4. 1983-08-26. PMID:6134572. |
the decreased km for the cofactor was retained in the hypersensitive animals, however the vmax for tyrosine hydroxylase was decreased during the hypersensitive phase of the eb-induced changes in dopamine sensitivity. |
1983-08-26 |
2023-08-12 |
Not clear |
| J H Gordon, K O Perr. Pre- and postsynaptic neurochemical alterations following estrogen-induced striatal dopamine hypo- and hypersensitivity. Brain research bulletin. vol 10. issue 4. 1983-08-26. PMID:6134572. |
the presynaptic or autoreceptor sensitivity of the dopamine neurons projecting to the striatum was assessed by determining the apomorphine ic50 value for the inhibition of synaptosomal tyrosine hydroxylase activity. |
1983-08-26 |
2023-08-12 |
Not clear |
| I R Katz, D Smith, M H Makma. Forskolin stimulates the conversion of tyrosine to dopamine in catecholaminergic neural tissue. Brain research. vol 264. issue 1. 1983-07-29. PMID:6303497. |
in striatal synaptosomes, there is an approximately 80% stimulation of dopamine formation from tyrosine, but no effect with dopa as substrate, suggesting that the effect is on tyrosine hydroxylase. |
1983-07-29 |
2023-08-12 |
rat |
| J P Gagner, S Gauthier, T L Sourke. Participation of spinal monoaminergic and cholinergic systems in the regulation of adrenal tyrosine hydroxylase. Neuropharmacology. vol 22. issue 1. 1983-06-23. PMID:6133231. |
clonidine and several dopamine agonists did not affect tyrosine hydroxylase activity. |
1983-06-23 |
2023-08-12 |
rat |
| M F Mineyeva, D Tümmler, E A Kuznetsova, A E Vasiliev, K S Rayevsk. Changes in kinetic properties of tyrosine hydroxylase due to dopamine effect on the external synaptosomal membrane. Annali dell'Istituto superiore di sanita. vol 18. issue 1. 1983-06-23. PMID:6133490. |
changes in kinetic properties of tyrosine hydroxylase due to dopamine effect on the external synaptosomal membrane. |
1983-06-23 |
2023-08-12 |
Not clear |
| B A McMillen, C C McDonal. Selective effects of buspirone and molindone on dopamine metabolism and function in the striatum and frontal cortex of the rat. Neuropharmacology. vol 22. issue 3. 1983-06-10. PMID:6133232. |
the hypothesis that the nerve endings of the dopamine projection of the frontal cortex lack autoreceptors for regulation of tyrosine hydroxylase was tested by using the preferential inhibitors of dopamine autoreceptors, molindole and buspirone. |
1983-06-10 |
2023-08-12 |
rat |
| H Baker, T H Joh, D A Ruggiero, D J Rei. Variations in number of dopamine neurons and tyrosine hydroxylase activity in hypothalamus of two mouse strains. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 3. issue 4. 1983-05-27. PMID:6131950. |
variations in number of dopamine neurons and tyrosine hydroxylase activity in hypothalamus of two mouse strains. |
1983-05-27 |
2023-08-12 |
mouse |
| M A Peat, P F Warren, J W Gib. Effects of a single dose of methamphetamine and iprindole on the serotonergic and dopaminergic system of the rat brain. The Journal of pharmacology and experimental therapeutics. vol 225. issue 1. 1983-05-27. PMID:6187915. |
neostriatal tyrosine hydroxylase activity and dopamine concentrations were significantly depressed at all time points examined. |
1983-05-27 |
2023-08-12 |
rat |
| K L O'Malley, A Mauron, J Raese, J D Barchas, L Kede. Genes for catecholamine biosynthesis: cloning by expression and identification of the cDNA for rat dopamine beta-hydroxylase. Proceedings of the National Academy of Sciences of the United States of America. vol 80. issue 8. 1983-05-27. PMID:6572968. |
shared antigenic determinants between tyrosine hydroxylase and dopamine beta-hydroxylase allowed us to obtain enriched fractions of dopamine beta-hydroxylase mrna by immunoprecipitating translated mrna products with tyrosine hydroxylase antisera. |
1983-05-27 |
2023-08-12 |
rat |
| H Azuma, K Iwai, K Sato, M Kikuta, H J Liu, N Oshin. [Suppressive effects of lisuride on the synthesis, release and metabolism of dopamine in rat brain]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 80. issue 5. 1983-05-05. PMID:6131854. |
it was concluded from these results that lisuride administered at low dosage interacts preferentially with the presynaptic dopamine receptor, hereby causing the suppressive effects on the tyrosine hydroxylase reaction and the dopamine release mechanism in the dopamine nerve terminals of the brain. |
1983-05-05 |
2023-08-12 |
rat |
| C A Brass, O Greengar. Modulation of cerebral catecholamine concentrations during hyperphenylalaninaemia. The Biochemical journal. vol 208. issue 3. 1983-04-21. PMID:7165732. |
the fact that the inhibition of tyrosine hydroxylase by phenylalanine (or alpha-methylphenylalanine) in vitro was overcome by tyrosine concentrations similar to those effective in vivo further implicates the tyrosine hydroxylase inhibition as the mechanism underlying the dopamine depletion in hyperphenylalaninaemia. |
1983-04-21 |
2023-08-12 |
rat |
| A E Lang, C D Marsde. Alpha methylparatyrosine and tetrabenazine in movement disorders. Clinical neuropharmacology. vol 5. issue 4. 1983-04-15. PMID:6130839. |
clinical and experimental evidence suggests that alpha methylparatyrosine (ampt), an inhibitor of tyrosine hydroxylase, can potentiate the effects of other dopamine antagonists. |
1983-04-15 |
2023-08-12 |
Not clear |
| J R Perez-Polo, E Tiffany-Castiglioni, M G Ziegler, K Werrbach-Pere. Effect of nerve growth factor on catecholamine metabolism in a human neuroblastoma clone (SY5Y). Developmental neuroscience. vol 5. issue 5-6. 1983-04-15. PMID:6130933. |
careful examination of catecholamine synthesizing enzyme specific activities and catecholamine concentrations in nerve growth factor-treated sy5y cells showed a small elevation of tyrosine hydroxylase, no change in dopamine-beta-hydroxylase or in dopamine or norepinephrine intracellular concentrations. |
1983-04-15 |
2023-08-12 |
human |
| Z Huszti, G Szilágyi, E Kasztreine. Tyrosine hydroxylase and dopamine beta-hydroxylase inhibiting properties of a new series of pyridazinyl hydrazones. Biochemical pharmacology. vol 32. issue 4. 1983-04-15. PMID:6131675. |
tyrosine hydroxylase and dopamine beta-hydroxylase inhibiting properties of a new series of pyridazinyl hydrazones. |
1983-04-15 |
2023-08-12 |
Not clear |
| R M Ridley, H F Baker, F Owen, A J Cross, T J Cro. Behavioural and biochemical effects of chronic amphetamine treatment in the vervet monkey. Psychopharmacology. vol 78. issue 3. 1983-03-24. PMID:6130556. |
at post-mortem, by comparison with controls, amphetamine-treated monkeys showed marked depletions of the monoamines dopamine (da), noradrenaline (na) and serotonin (5-ht) in corpus striatum and cerebral cortex and reductions in the activities of tyrosine hydroxylase and dopa decarboxylase in striatum. |
1983-03-24 |
2023-08-12 |
monkey |
| J Price, A W Mudg. A subpopulation of rat dorsal root ganglion neurones is catecholaminergic. Nature. vol 301. issue 5897. 1983-03-17. PMID:6130474. |
we have used here antisera against tyrosine hydroxylase (th; ec 1.14.16.2) and dopamine-beta-hydroxylase (dbh; ec 1.14.17.1), two enzymes specific to catecholaminergic cells, to show that a subpopulation of rat drg neurones is catecholaminergic and that the neurotransmitter they make is probably dopamine. |
1983-03-17 |
2023-08-12 |
rat |
| H Baker, T Kawano, F L Margolis, T H Jo. Transneuronal regulation of tyrosine hydroxylase expression in olfactory bulb of mouse and rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 3. issue 1. 1983-03-11. PMID:6130133. |
lesions of the olfactory receptor neurons produced in the mouse by intranasal irrigation with either znso4 or triton x-100 and in the rat by surgical deafferentation or axotomy are associated with a decrease in the levels of dopamine (da), the da metabolite 3,4-dihydroxyphenylacetic acid (dopac), the activity of the enzyme tyrosine hydroxylase (th), bulb weight and an increase in norepinephrine (ne) levels in the olfactory bulb. |
1983-03-11 |
2023-08-12 |
mouse |
| N E Andén, K Pauksens, K Svensso. Selective blockade of brain alpha 2-autoreceptors by yohimbine: effects on motor activity and on turnover of noradrenaline and dopamine. Journal of neural transmission. vol 55. issue 2. 1983-02-25. PMID:6294237. |
the turnover of dopamine and noradrenaline in the mouse brain, as assessed by the disappearance of catecholamines following treatment with the tyrosine hydroxylase inhibitor alpha-methyltyrosine, was accelerated by yohimbine with a peak effect after 10 mg/kg intraperitoneally. |
1983-02-25 |
2023-08-12 |
mouse |
| L E Dyck, C W Kazakof. Acceleration of the biosynthesis of rat striatal dopamine by incubation and by administration of gamma-butyrolactone. Journal of neuroscience research. vol 8. issue 1. 1983-02-14. PMID:7175978. |
in conclusion, the effect of incubating striatal slices on their dopamine levels was similar to that of administering gbl in that the incubation enhanced the activity of tyrosine hydroxylase that in turn produced an accelerated synthesis of dopamine. |
1983-02-14 |
2023-08-12 |
rat |
| A V Juori. The effects of amfonelic acid and some other central stimulants on mouse striatal tyramine, dopamine and homovanillic acid. British journal of pharmacology. vol 77. issue 3. 1983-01-27. PMID:7139200. |
by increasing the dose to 20 mg/kg, nomifensine produced an increase in p-tyramine and homovanillic acid.5 the present results support the view that amfonelic acid and (+)-amphetamine would respectively release granular or newly synthesized dopamine, both actions being accompanied by an increase in tyrosine hydroxylase activity and dopamine turnover which in turn reduces p-tyramine but produces no change or an increase in m-tyramine.6 the effects of nomifensine were observed after the administration of a relatively high dose (20 mg/kg), that was lethal to some mice (about 20%, at 2 h), and more likely to posses unspecific actions. |
1983-01-27 |
2023-08-12 |
mouse |