| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K A Albert, E Helmer-Matyjek, A C Nairn, T H Müller, J W Haycock, L A Greene, M Goldstein, P Greengar. Calcium/phospholipid-dependent protein kinase (protein kinase C) phosphorylates and activates tyrosine hydroxylase. Proceedings of the National Academy of Sciences of the United States of America. vol 81. issue 24. 1985-02-21. PMID:6151178. |
this phosphorylation of tyrosine hydroxylase reduced the km for the cofactor 6-methyltetrahydropterine from 0.45 mm to 0.11 mm, increased the ki for dopamine from 4.2 microm to 47.5 microm, and produced no change in the km for tyrosine. |
1985-02-21 |
2023-08-12 |
Not clear |
| S Caroldi, J A Jarvis, L Mago. In vivo inhibition of dopamine-beta-hydroxylase in rat adrenals during exposure to carbon disulphide. Archives of toxicology. vol 55. issue 4. 1985-02-19. PMID:6517704. |
after inhibition of tyrosine hydroxylase by alpha-methyl-p-tyrosine, adrenal dopamine contents declined at a slower rate in rats exposed to carbon disulphide than in controls. |
1985-02-19 |
2023-08-12 |
rat |
| G Toffano, G Savoini, F Aporti, S Calzolari, A Consolazione, G Maura, M Marchi, M Raiteri, L F Agnat. The functional recovery of damaged brain: the effect of GM1 monosialoganglioside. Journal of neuroscience research. vol 12. issue 2-3. 1985-01-09. PMID:6150119. |
gm1 enhances 3h-dopamine uptake in striatal synaptosomes of the lesioned side, and the enhancement of dopamine uptake precedes that of striatal tyrosine hydroxylase activity. |
1985-01-09 |
2023-08-12 |
rat |
| b' M F Mineeva, K S Raevski\\xc4\\xa. [Effect of butaclamol enantiomers on hypothalamic tyrosine hydroxylase in the rat brain]. Biulleten\' eksperimental\'noi biologii i meditsiny. vol 98. issue 10. 1985-01-04. PMID:6208950.' |
the authors demonstrate stereospecificity of the action of butaclamol enantiomers on substrate inhibition of hypothalamic tyrosine hydroxylase (th) and regulation of the tyrosine hydroxylase response by the presynaptic membrane (presynaptic receptors) of rat hypothalamus synaptosomes under membrane activation with dopamine. |
1985-01-04 |
2023-08-12 |
rat |
| A Dravid, A L Jaton, A Enz, P Fre. Spontaneous recovery from motor asymmetry in adult rats with 6-hydroxydopamine-induced partial lesions of the substantia nigra. Brain research. vol 311. issue 2. 1984-12-28. PMID:6149789. |
animals with 6-hydroxydopamine-induced partial unilateral lesions of the substantia nigra exhibit spontaneous recovery from motor asymmetry, a transitory increase in dopamine turnover and an increase in tyrosine hydroxylase activity in the denervated striatum. |
1984-12-28 |
2023-08-12 |
rat |
| A Dravid, A L Jaton, A Enz, P Fre. Spontaneous recovery from motor asymmetry in adult rats with 6-hydroxydopamine-induced partial lesions of the substantia nigra. Brain research. vol 311. issue 2. 1984-12-28. PMID:6149789. |
the recovery of function in these animals seems to be due to the compensatory increase in dopamine metabolism as well as due to the time-dependent increase in tyrosine hydroxylase resulting from either enzyme activation or following reinnervation of the denervated striatum by nigral efferents spared by the partial lesions. |
1984-12-28 |
2023-08-12 |
rat |
| T H Joh, E E Baetge, D J Rei. Molecular biology of catecholamine neurons. Similar gene hypothesis. Hypertension (Dallas, Tex. : 1979). vol 6. issue 5 Pt 2. 1984-12-28. PMID:6149999. |
we have postulated that the catecholamine-synthesizing enzymes tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbh), and phenylethanolamine n-methyltransferase (pnmt) are coded for by similar genes. |
1984-12-28 |
2023-08-12 |
Not clear |
| E L Sabban, M Goldstei. Subcellular site of biosynthesis of the catecholamine biosynthetic enzymes in bovine adrenal medulla. Journal of neurochemistry. vol 43. issue 6. 1984-12-20. PMID:6149268. |
immunoprecipitation of cell-free products with specific antisera localized the biosynthesis of the subunits of tyrosine hydroxylase (th) (apparent mr = 61,000) and of phenylethanolamine n-methyltransferase (pnmt) (apparent mr = 32,000) on free polysomes, compared with biosynthesis of subunits of dopamine beta-hydroxylase (dbh) (apparent mr = 67,000) on membrane-bound polysomes. |
1984-12-20 |
2023-08-12 |
cattle |
| M Kalia, K Fuxe, M Goldstein, A Harfstrand, L F Agnati, J T Coyl. Evidence for the existence of putative dopamine-, adrenaline- and noradrenaline-containing vagal motor neurons in the brainstem of the rat. Neuroscience letters. vol 50. issue 1-3. 1984-12-20. PMID:6149507. |
a combined technique utilizing retrograde transport of horseradish peroxidase (hrp) combined with immunocytochemistry using antibodies raised against tyrosine hydroxylase (th), dopamine beta-hydroxylase (dbh) and phenylethanolamine n-methyl transferase (pnmt) has been used to characterize monoaminergic neurons located within the region of the brainstem vagal motor nucleus. |
1984-12-20 |
2023-08-12 |
rat |
| A J Drake-Holland, P Cummins, T A English, J Wallwork, P J Birc. Metabolic changes in the autotransplanted baboon heart. Transplantation. vol 38. issue 5. 1984-12-20. PMID:6149639. |
the level of tyrosine hydroxylase activity shows that the denervated heart can synthesize dopamine. |
1984-12-20 |
2023-08-12 |
Not clear |
| H Hallman, E Sundström, G Jonsso. Effects of the noradrenaline neurotoxin DSP 4 on monoamine neurons and their transmitter turnover in rat CNS. Journal of neural transmission. vol 60. issue 2. 1984-12-12. PMID:6208323. |
analysis of catecholamine decline after tyrosine hydroxylase inhibition and metabolite/monoamine ratios, as indices for transmitter utilization rate, indicated an increased noradrenaline turnover in terminals spared by dsp 4, while dopamine turnover appeared to be reduced in many regions (i.a. |
1984-12-12 |
2023-08-12 |
rat |
| L F Agnati, K Fuxe, L Calza, M Goldstein, G Toffano, L Giardino, M Zol. Further studies on the effects of the GM1 ganglioside on the degenerative and regenerative features of mesostriatal dopamine neurons. Acta physiologica Scandinavica. Supplementum. vol 532. 1984-12-05. PMID:6594030. |
in the rostrocaudal analysis it was demonstrated that chronic gm-1 treatment preferentially protected the caudally located dopamine nerve cells from degeneration after partial hemitransection, while instead this chronic gm-1 treatment increased tyrosine hydroxylase immunoreactivity mainly within the rostrally located da nerve cells present close to the site of the lesion. |
1984-12-05 |
2023-08-12 |
rat |
| P C Waldmeier, P A Baumann, B Fehr, P De Herdt, L Maitr. Carbamazepine decreases catecholamine turnover in the rat brain. The Journal of pharmacology and experimental therapeutics. vol 231. issue 1. 1984-11-28. PMID:6491972. |
the depletion of brain norepinephrine after inhibition of tyrosine hydroxylase or dopamine (da) beta-hydroxylase rather tended to be decreased and the accumulation of da in the rat heart after da beta-hydroxylase inhibition was diminished. |
1984-11-28 |
2023-08-12 |
rat |
| A Mutti, M Falzoi, A Romanelli, I Franchin. Regional alterations of brain catecholamines by styrene exposure in rabbits. Archives of toxicology. vol 55. issue 3. 1984-11-26. PMID:6497650. |
the turnover of dopamine and norepinephrine was also measured in several brain regions by the decay in endogenous catecholamines after inhibition of tyrosine hydroxylase by alpha-methyl-p-tyrosine. |
1984-11-26 |
2023-08-12 |
Not clear |
| K Anderson, K Fuxe, P Eneroth, L F Agnat. Differential effects of mecamylamine on the nicotine induced changes in amine levels and turnover in hypothalamic dopamine and noradrenaline nerve terminal systems and in the secretion of adenohypophyseal hormones in the castrated female rat. Evidence for involvement of cholinergic nicotine-like receptors. Acta physiologica Scandinavica. vol 120. issue 4. 1984-11-21. PMID:6148837. |
the nicotine treatment induced a significant depletion of amine stores and an increase of amine turnover in dopamine (da) and noradrenaline (na) nerve terminals of the median eminence and of the peri- and paraventricular and dorsomedial na systems of the hypothalamus using the tyrosine hydroxylase (th) inhibition model. |
1984-11-21 |
2023-08-12 |
rat |
| L Jennes, W E Stumpf, G Bissette, C B Nemerof. Monosodium glutamate lesions in rat hypothalamus studied by immunohistochemistry for gonadotropin releasing hormone, neurotensin, tyrosine hydroxylase, and glutamic acid decarboxylase and by autoradiography for [3H] estradiol. Brain research. vol 308. issue 2. 1984-11-14. PMID:6148123. |
immunohistochemical analysis of the distribution of tyrosine hydroxylase (th), glutamic acid decarboxylase (gad), neurotensin (nt) and gonadotropin-releasing hormone (gnrh) reveals substantial destructions of tuberoinfundibular dopamine and nt systems accompanied by a marked reduction of immunoreactivity in the median eminence. |
1984-11-14 |
2023-08-12 |
rat |
| J Ballesta, G Terenghi, J Thibault, J M Pola. Putative dopamine-containing cells in the retina of seven species demonstrated by tyrosine hydroxylase immunocytochemistry. Neuroscience. vol 12. issue 4. 1984-11-09. PMID:6148714. |
immunocytochemistry with antibodies to catecholamine synthesizing enzymes has revealed cells in the retina of chick, mouse, hamster, rat, guinea-pig, piglet and marmoset which contain tyrosine hydroxylase but not dopamine beta-hydroxylase. |
1984-11-09 |
2023-08-12 |
mouse |
| J C David, A Cavoy, J F Coulon, J Delacou. Prenatal ontogenesis of p-, m-octopamine and phenylethanolamine in relation to catecholamines and their metabolizing enzymes in the developing rat brain and heart. Neuroscience. vol 12. issue 4. 1984-11-09. PMID:6148717. |
the activities of tyrosine hydroxylase, dopa decarboxylase, dopamine beta-hydroxylase and monoamine oxidase were determined in parallel. |
1984-11-09 |
2023-08-12 |
rat |
| J C David, A Cavoy, J F Coulon, J Delacou. Prenatal ontogenesis of p-, m-octopamine and phenylethanolamine in relation to catecholamines and their metabolizing enzymes in the developing rat brain and heart. Neuroscience. vol 12. issue 4. 1984-11-09. PMID:6148717. |
dopa decarboxylase, dopamine beta-hydroxylase and tyrosine hydroxylase are detected early in fetal life (13, 15 and 14.5 days respectively) but monoamine oxidase activity was not found before 18 days. |
1984-11-09 |
2023-08-12 |
rat |
| T L Perry, V W Yong, M Ito, J G Foulks, R A Wall, D V Godin, R M Clavie. Nigrostriatal dopaminergic neurons remain undamaged in rats given high doses of L-DOPA and carbidopa chronically. Journal of neurochemistry. vol 43. issue 4. 1984-10-25. PMID:6147392. |
when sacrificed 60 days after l-dopa treatment ended, all rats had normal tyrosine hydroxylase activities and dopamine contents in their striata, and cell counts were normal in the substantia nigra. |
1984-10-25 |
2023-08-12 |
rat |