| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D J Bast, D E Low, C L Duncan, L Kilburn, L A Mandell, R J Davidson, J C de Azaved. Fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae: contributions of type II topoisomerase mutations and efflux to levels of resistance. Antimicrobial agents and chemotherapy. vol 44. issue 11. 2001-01-04. PMID:11036021. |
isolates with intermediate-level (mics, 16 to 32 microgram/ml) and high-level (mics, 64 microgram/ml) resistance harbored substitutions of phe and tyr for ser-79 or asn and ala for asp-83 in parc and an additional substitution in gyra which included either glu-85-lys (gly) or ser-81-phe (tyr). |
2001-01-04 |
2023-08-12 |
Not clear |
| G C Sui, B Wima. The Bbeta-sheet in the PAI-1 molecule plays an important role for its stability. Thrombosis and haemostasis. vol 83. issue 6. 2000-12-11. PMID:10896245. |
the residues from his(219) to tyr(241) (except for gly(230) and pro(240)), covering the s2b and s3b strands, and in addition his(185) and his(190)) were substituted by amino acids with opposite properties. |
2000-12-11 |
2023-08-12 |
Not clear |
| A Mastrolorenzo, A Scozzafava, C T Supura. 4-toluenesulfonylureido derivatives of amines, amino acids and dipeptides: a novel class of potential antitumor agents. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 11. issue 4. 2000-11-28. PMID:11033076. |
the screening of a series of arylsulfonylureido derivatives of amines (such as histamine, or dopamine), aliphatic/aromatic amino acids (such as gly, beta-ala, val, lys, arg, phe, tyr, dopa, etc.) |
2000-11-28 |
2023-08-12 |
Not clear |
| D G White, L J Piddock, J J Maurer, S Zhao, V Ricci, S G Thaye. Characterization of fluoroquinolone resistance among veterinary isolates of avian Escherichia coli. Antimicrobial agents and chemotherapy. vol 44. issue 10. 2000-11-24. PMID:10991884. |
all isolates contained a mutation in gyra replacing ser83 with leu; seven isolates also contained mutations replacing asp87 with either gly or tyr. |
2000-11-24 |
2023-08-12 |
Not clear |
| B Tripet, K Wagschal, P Lavigne, C T Mant, R S Hodge. Effects of side-chain characteristics on stability and oligomerization state of a de novo-designed model coiled-coil: 20 amino acid substitutions in position "d". Journal of molecular biology. vol 300. issue 2. 2000-11-21. PMID:10873472. |
our results showed a thermodynamic stability order (in order of decreasing stability) of: leu, met, ile, tyr, phe, val, gln, ala, trp, asn, his, thr, lys, ser, asp, glu, arg, orn, and gly. |
2000-11-21 |
2023-08-12 |
Not clear |
| T R Mackle, D A Dwyer, K L Ingvartsen, P Y Chouinard, D A Ross, D E Bauma. Evaluation of whole blood and plasma in the interorgan supply of free amino acids for the mammary gland of lactating dairy cows. Journal of dairy science. vol 83. issue 6. 2000-11-14. PMID:10877395. |
concentrations of aa in red blood cells were either higher (asn+asp, gly, his, leu, met, orn, ser, tau, thr, and tyr), lower (ala, arg, cit, cys, ile, and val), or similar (gln+glu, phe, and pro) to that of plasma. |
2000-11-14 |
2023-08-12 |
Not clear |
| T L Sorensen, J P Anderse. Importance of stalk segment S5 for intramolecular communication in the sarcoplasmic reticulum Ca2+-ATPase. The Journal of biological chemistry. vol 275. issue 37. 2000-10-13. PMID:10871620. |
the rate of the ca(2+) binding transition, determined at 0 degrees c, was enhanced relative to wild type in mutants ile(743) --> ala, val(747) --> ala, glu(748) --> ala, glu(749) --> ala, met(757) --> gly, and gln(759) --> ala and reduced in mutants asp(737) --> ala, asp(738) --> ala, ala(752) --> leu, and tyr(754) --> ala. |
2000-10-13 |
2023-08-12 |
Not clear |
| T L Sorensen, J P Anderse. Importance of stalk segment S5 for intramolecular communication in the sarcoplasmic reticulum Ca2+-ATPase. The Journal of biological chemistry. vol 275. issue 37. 2000-10-13. PMID:10871620. |
in mutant arg(762) --> ile, the rate of the ca(2+) binding transition was wild type like at 0 degrees c, whereas it was 3.5-fold reduced relative to wild type at 25 degrees c. the rate of dephosphorylation of the adp-insensitive phosphoenzyme was increased conspicuously in mutants ile(743) --> ala and tyr(754) --> ala (close to 20-fold in the absence of k(+)) and increased to a lesser extent in asn(739) --> ala, glu(749) --> ala, gly(750) --> ala, ala(752) --> gly, met(757) --> gly, and arg(762) --> ile, whereas it was reduced in mutants asp(737) --> ala, val(744) --> gly, val(744) --> ala, val(747) --> ala, and ala(752) --> leu. |
2000-10-13 |
2023-08-12 |
Not clear |
| R A Ettinger, A W Liu, G T Nepom, W W Kwo. Beta 57-Asp plays an essential role in the unique SDS stability of HLA-DQA1*0102/DQB1*0602 alpha beta protein dimer, the class II MHC allele associated with protection from insulin-dependent diabetes mellitus. Journal of immunology (Baltimore, Md. : 1950). vol 165. issue 6. 2000-10-10. PMID:10975839. |
an asp at beta57 was found to be critical for sds stability, whereas tyr at beta30, gly at beta70, and ala at beta86 played secondary roles. |
2000-10-10 |
2023-08-12 |
Not clear |
| P Gouldson, P Legoux, C Carillon, B Delpech, G Le Fur, P Ferrara, D Shir. The agonist SR 146131 and the antagonist SR 27897 occupy different sites on the human CCK(1) receptor. European journal of pharmacology. vol 400. issue 2-3. 2000-10-10. PMID:10988332. |
in contrast, numerous mutations throughout the receptor either reduced sr 146131 agonist potency, phe(97), gly(122), phe(198), trp(209), ile(229), asn(333), arg(336) and leu(356) or increased it, tyr(48), cys(94), asn(98), leu(217) and ser(359). |
2000-10-10 |
2023-08-12 |
human |
| Y Osako, T Otsuka, M Taniguchi, T Oka, H Kab. Oxytocin depresses spontaneous gamma-aminobutyric acid-ergic inhibitory postsynaptic currents in cultured mitral cells of the rat olfactory bulb by a presynaptic mechanism. Neuroscience letters. vol 289. issue 1. 2000-10-06. PMID:10899400. |
the effect of ot on sipscs was mimicked by the ot receptor agonist [thr(4), gly(7)]-ot in a reversible manner and blocked by the ot receptor antagonist desgly-nh(2)(9), d(ch(2))(5)-[tyr(me)(2), thr(4)]-ornithine-vasotocin. |
2000-10-06 |
2023-08-12 |
rat |
| T Suzuki, H Fukuta, H Nagato, M Umekaw. Arginine kinase from Nautilus pompilius, a living fossil. Site-directed mutagenesis studies on the role of amino acid residues in the Guanidino specificity region. The Journal of biological chemistry. vol 275. issue 31. 2000-09-07. PMID:10811656. |
a crystal structure for limulus arginine kinase showed that four amino acid residues (ser(63), gly(64), val(65), and tyr(68)) are hydrogen-bonded with the substrate arginine. |
2000-09-07 |
2023-08-12 |
Not clear |
| T Suzuki, H Fukuta, H Nagato, M Umekaw. Arginine kinase from Nautilus pompilius, a living fossil. Site-directed mutagenesis studies on the role of amino acid residues in the Guanidino specificity region. The Journal of biological chemistry. vol 275. issue 31. 2000-09-07. PMID:10811656. |
we introduced three independent mutations, ser(63) --> gly, ser(63) --> thr, and tyr(68) --> ser, in nautilus arginine kinase. |
2000-09-07 |
2023-08-12 |
Not clear |
| I Takahashi, T Kojima, M Sano, T Watanabe, T Kamiya, H Sait. Detailed characterization of an anti-factor IX monoclonal antibody that neutralizes the prolonged ox brain prothrombin time of hemophilia B(M) by synthetic peptides. Peptides. vol 21. issue 5. 2000-09-01. PMID:10876041. |
in the replacement set of amino acids, peptides showing low or no reactivity to 65-10 were (175)phe --> asp, glu, gly, lys, arg, thr, val, (176)asn --> asp, glu, phe, ile, lys, leu, pro, val, tyr, (177)asp --> cys, glu, phe, ile, lys, leu, met, pro, gln, arg, ser, thr, val, trp, tyr, and (178) phe --> pro. |
2000-09-01 |
2023-08-12 |
cattle |
| S Z Kim, S Y Kang, S J Lee, K W Ch. Localization of receptors for natriuretic peptide and endothelin in the duct of the epididymis of the freshwater turtle. General and comparative endocrinology. vol 118. issue 1. 2000-08-02. PMID:10753564. |
bindings of (125)i-anp((1-28)) and (125)i-[tyr(0)]-cnp((1-22)) to these sites were also displaced by des[gln(18),ser(19),gly(20), leu(21),gly(22)]anf((4-23)), a specific ligand of the np clearance receptor. |
2000-08-02 |
2023-08-12 |
Not clear |
| M M Ehrman, G T Melroe, J D Kittilson, M A Sherida. The expression of preprosomatostatin II mRNAs in the Brockmann bodies of rainbow trout, Oncorhynchus mykiss, is regulated by glucose. General and comparative endocrinology. vol 118. issue 1. 2000-08-02. PMID:10753577. |
we previously characterized two cdnas that encode for distinct preprosomatostatin molecules containing [tyr(7), gly(10)]-somatostatin-14 at their c-termini (ppss ii' and ppss ii") and found that these cdnas were differentially expressed in the endocrine pancreas (brockmann body) of rainbow trout, oncorhynchus mykiss. |
2000-08-02 |
2023-08-12 |
Not clear |
| C Paolini, A Lahm, R De Francesco, P Gallinar. Mutational analysis of hepatitis C virus NS3-associated helicase. The Journal of general virology. vol 81. issue Pt 7. 2000-07-27. PMID:10859369. |
three full-length mutated ns3 proteins containing tyr(392)ala, val(432)gly and trp(501)ala single substitutions, respectively, together with a tyr(392)ala/trp(501)ala double-substituted protein were expressed in escherichia coli and purified to homogeneity. |
2000-07-27 |
2023-08-12 |
Not clear |
| J B Thoden, T M Wohlers, J L Fridovich-Keil, H M Holde. Crystallographic evidence for Tyr 157 functioning as the active site base in human UDP-galactose 4-epimerase. Biochemistry. vol 39. issue 19. 2000-06-27. PMID:10801319. |
comparison of the polypeptide chains for the resting enzyme and for the protein with bound nadh and udp-glucose demonstrates that the major conformational changes which occur upon substrate binding are limited primarily to the regions defined by glu 199 to asp 240 and gly 274 to tyr 308. |
2000-06-27 |
2023-08-12 |
human |
| S Vasudevan, J R Roberts, R A McClintock, J A Dent, R Celikel, J Ware, K I Varughese, Z M Rugger. Modeling and functional analysis of the interaction between von Willebrand factor A1 domain and glycoprotein Ibalpha. The Journal of biological chemistry. vol 275. issue 17. 2000-06-02. PMID:10777573. |
each of the vwf residues tyr(565), glu(596), and lys(599) proved to be strictly required for a1 domain function, which, in agreement with previous findings, was also dependent on gly(561). |
2000-06-02 |
2023-08-12 |
Not clear |
| L Piubelli, A Aliverti, A K Arakaki, N Carrillo, E A Ceccarelli, P A Karplus, G Zanett. Competition between C-terminal tyrosine and nicotinamide modulates pyridine nucleotide affinity and specificity in plant ferredoxin-NADP(+) reductase. The Journal of biological chemistry. vol 275. issue 14. 2000-05-08. PMID:10744737. |
although it is distant from the 2'-phosphoryl group of nadp(+), replacement of the c-terminal tyrosine (tyr(308) in the pea enzyme) by trp, phe, gly, and ser produced enzyme forms in which the preference for nadph over nadh was decreased about 2-, 10-, 300-, and 400-fold, respectively. |
2000-05-08 |
2023-08-12 |
cat |