| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Kirmaier, C He, D Holte. Manipulating the direction of electron transfer in the bacterial reaction center by swapping Phe for Tyr near BChl(M) (L181) and Tyr for Phe near BChl(L) (M208). Biochemistry. vol 40. issue 40. 2001-11-01. PMID:11580288. |
one conclusion that comes from this work is that the tyr (m208) --> phe and gly(m201) --> asp mutations near the l-side bacteriochlorophyll (bchl(l)) raise the free energy of p(+)bchl(l)(-) by comparable amounts. |
2001-11-01 |
2023-08-12 |
Not clear |
| P Kumar, N Ahuja, R Bhatnaga. Purification of anthrax edema factor from Escherichia coli and identification of residues required for binding to anthrax protective antigen. Infection and immunity. vol 69. issue 10. 2001-10-25. PMID:11553601. |
sequence analysis revealed a stretch of seven amino acids, val tyr tyr glu ile gly lys, present both in ef (residues 136 to 142) and lethal factor (residues 147 to 153). |
2001-10-25 |
2023-08-12 |
Not clear |
| D A Cochran, S Penel, A J Doi. Effect of the N1 residue on the stability of the alpha-helix for all 20 amino acids. Protein science : a publication of the Protein Society. vol 10. issue 3. 2001-09-27. PMID:11344315. |
the rank order for free energies is asp(-), ala > glu(-) > glu(0) > trp, leu, ser > asp(0), thr, gln, met, ile > val, pro > lys(+), arg, his(0) > cys, gly > phe > asn, tyr, his(+). |
2001-09-27 |
2023-08-12 |
Not clear |
| M M Gromiha, S Selvara. Role of medium--and long-range interactions in discriminating globular and membrane proteins. International journal of biological macromolecules. vol 29. issue 1. 2001-09-27. PMID:11429186. |
residue-wise analysis indicates that in tmh proteins, the residues cys, glu, gly, pro, gln, ser and tyr have higher long-range contacts than medium-range contacts in contrast with all-alpha class of globular proteins. |
2001-09-27 |
2023-08-12 |
Not clear |
| L Alexander, D Knutson, J D Kittilson, M A Sherida. Localization of somatostatin mRNAs in the brain and pancreas of rainbow trout (Oncorhynchus mykiss). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. vol 129. issue 2-3. 2001-09-13. PMID:11399453. |
rainbow trout possess three distinct mrnas, each encoding a separate precursor: ppss i, which contains a 14-amino acid sequence at its c-terminus (somatostatin-14) that is highly conserved among vertebrates, as well as two others, ppss ii' and ppss ii", both containing [tyr(7), gly(10)]-somatostatin-14 at their c-terminus. |
2001-09-13 |
2023-08-12 |
Not clear |
| H W Yang, Y Z Chen, J Takita, E Soeda, H Y Piao, Y Hayash. Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at chromosome 1p36.2. Oncogene. vol 20. issue 36. 2001-09-13. PMID:11526494. |
a missense mutation at codon 1554, gtg (gly) to atg (met), silent mutations at codon 409 (acg to aca) and codon 1721 (acc to act), and polymorphisms at codon 170, gat (asp) to gaa (glu), and at codon 1087, tat (tyr), to tgt (cys), were all identified, although their functional significances remain to be determined. |
2001-09-13 |
2023-08-12 |
mouse |
| W Jiratchariyakul, C Wiwat, M Vongsakul, A Somanabandhu, W Leelamanit, I Fujii, N Suwannaroj, Y Ebizuk. HIV inhibitor from Thai bitter gourd. Planta medica. vol 67. issue 4. 2001-08-09. PMID:11458453. |
the twenty amino acid sequence from the n-terminus was in the following order: 1asp val asn phe arg leu ser gly ala 10asp pro arg x tyr gly met phe ile glu 20asp. |
2001-08-09 |
2023-08-12 |
Not clear |
| S O Brennan, A P Fellowes, P M Georg. Molecular mechanisms of hypo- and afibrinogenemia. Annals of the New York Academy of Sciences. vol 936. 2001-08-02. PMID:11460528. |
reverse phase chromatography, isoelectric focussing, electrospray mass spectrometry, and tryptic peptide mass mapping have shown that chains with heterozygous mutations of gamma 284 gly-->arg, b beta 316 asp-->tyr and gamma 371 thr-->ile are absent from plasma fibrinogen. |
2001-08-02 |
2023-08-12 |
Not clear |
| S W Cho, H Y Yoon, J Y Ahn, E Y Lee, J Le. Cassette mutagenesis of lysine 130 of human glutamate dehydrogenase. An essential residue in catalysis. European journal of biochemistry. vol 268. issue 11. 2001-07-26. PMID:11389722. |
the mutant enzymes containing glu, gly, met, ser, or tyr at position 130, as well as the wild-type human gdh encoded by the synthetic gene, were efficiently expressed as a soluble protein and are indistinguishable from that isolated from human and bovine tissues. |
2001-07-26 |
2023-08-12 |
human |
| J B Kim, A Johansson, J M Conlo. Anomalous rates of evolution of pancreatic polypeptide and peptide tyrosine-tyrosine (PYY) in a tetraploid frog, Xenopus laevis (Anura:Pipidae). Peptides. vol 22. issue 3. 2001-07-19. PMID:11287085. |
despite the fact that the amino acid sequence of pp has, in general, been very poorly conserved during the evolution of tetrapods (only pro(5), pro(8), gly(9), ala(12), tyr(27), arg(33) and arg(35) are invariant among species studied so far), the two xenopus pps differ by only a single amino acid substition (asp(22)-->glu). |
2001-07-19 |
2023-08-12 |
xenopus_laevis |
| G P Hayhurst, J Harlow, J Chowdry, E Gross, E Hilton, M S Lennard, G T Tucker, S W Elli. Influence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6. The Biochemical journal. vol 355. issue Pt 2. 2001-05-24. PMID:11284724. |
we have tested this hypothesis by replacing phe(481) with tyrosine (phe(481)-->tyr), a conservative substitution, and with leucine (phe(481)-->leu) or glycine (phe(481)-->gly), two non-aromatic residues, and have compared the properties of the wild-type and mutant enzymes in microsomes prepared from yeast cells expressing the appropriate cdna-derived protein. |
2001-05-24 |
2023-08-12 |
Not clear |
| R M Masanés, I Rafecas, X Remesa. Splanchnic amino acid balance is affected by moderate variations of dietary protein in the developing Zucker rat. International journal of food sciences and nutrition. vol 52. issue 2. 2001-04-26. PMID:11303466. |
conversely, the hp group showed net uptake of gln, pro, ala, tyr and lys, and the lp group took up gly and ala and released asn, gln and cit. |
2001-04-26 |
2023-08-12 |
rat |
| T Toyo'oka, D Jin, N Tomoi, T Oe, H Hiranum. R(-)-4-(3-Isothiocyanatopyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole, a fluorescent chiral tagging reagent: sensitive resolution of chiral amines and amino acids by reversed-phase liquid chromatography. Biomedical chromatography : BMC. vol 15. issue 1. 2001-04-19. PMID:11180302. |
the three dl-amino acid residues (tyr, ala and gly) in [l-ala2]-leucine-enkephalin and [d-ala2]-leucine-enkephalin were perfectly identidied with the autoanalysis. |
2001-04-19 |
2023-08-12 |
human |
| H Pelemans, A Aertsen, K Van Laethem, A M Vandamme, E De Clercq, M J Pérez-Pérez, A San-Félix, S Velázquez, M J Camarasa, J Balzarin. Site-directed mutagenesis of human immunodeficiency virus type 1 reverse transcriptase at amino acid position 138. Virology. vol 280. issue 1. 2001-04-12. PMID:11162823. |
seven rt mutants (i.e., ala, asp, gln, gly, lys, phe, and tyr) were constructed by site-directed mutagenesis. |
2001-04-12 |
2023-08-12 |
human |
| S H Tsang, C K Yamashita, K Doi, D J Salchow, N Bouvier, M Mendelsohn, P Gouras, D B Farber, S P Gof. In vivo studies of the gamma subunit of retinal cGMP-phophodiesterase with a substitution of tyrosine-84. The Biochemical journal. vol 353. issue Pt 3. 2001-04-05. PMID:11171042. |
the y84g (tyr(84)-->gly) allele of pdegamma has previously been shown in experiments carried out in vitro to reduce the regulatory control of the pde catalytic core (pdealphabeta) exerted by the wild-type gamma subunit. |
2001-04-05 |
2023-08-12 |
mouse |
| H Yonezawa, H Kaizuka, T Uchikoba, K Arima, M Kaned. Substrate specificity of cucumisin on synthetic peptides. Bioscience, biotechnology, and biochemistry. vol 64. issue 10. 2001-02-22. PMID:11129582. |
in order to identify the substrate specificity at p1 position, leu-leu-pro-x-ala-leu (x; gly, ala, val, leu, ile, pro, asp, glu, lys, arg, asn, gln, phe, tyr, ser, thr, met, trp, his) were synthesized and digested by cucumisin. |
2001-02-22 |
2023-08-12 |
Not clear |
| A L Shen, C B Kaspe. Differential contributions of NADPH-cytochrome P450 oxidoreductase FAD binding site residues to flavin binding and catalysis. The Journal of biological chemistry. vol 275. issue 52. 2001-01-26. PMID:11022049. |
the precise orientation of key residues (arg(454), tyr(456), cys(472), gly(488), thr(491), and trp(677)) has been defined by x-ray crystallography (wang, m., roberts, d. l., paschke, r., shea, t. m., masters, b. s., kim, j.-j. |
2001-01-26 |
2023-08-12 |
Not clear |
| Y C Chen, I Bab, N Mansur, A Muhlrad, A Shteyer, M Namdar-Attar, H Gavish, M Vidson, M Chore. Structure-bioactivity of C-terminal pentapeptide of osteogenic growth peptide [OGP(10-14)]. The journal of peptide research : official journal of the American Peptide Society. vol 56. issue 3. 2001-01-25. PMID:11007271. |
collectively, these data suggest that the integrity of the pharmacophores presented by tyr and phe side chains, as well as the gly residues at the c-terminus, are important for optimal bioactivity of ogp(10-14). |
2001-01-25 |
2023-08-12 |
Not clear |
| T Suzuki, Y Yamamoto, M Umekaw. Stichopus japonicus arginine kinase: gene structure and unique substrate recognition system. The Biochemical journal. vol 351 Pt 3. 2001-01-18. PMID:11042111. |
in typical arginine kinases four residues, ser(63), gly(64), val(65) and tyr(68) (numbering from the limulus polyphemus sequence), in the gs region are highly conserved and are associated with substrate binding. |
2001-01-18 |
2023-08-12 |
human |
| D J Bast, D E Low, C L Duncan, L Kilburn, L A Mandell, R J Davidson, J C de Azaved. Fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae: contributions of type II topoisomerase mutations and efflux to levels of resistance. Antimicrobial agents and chemotherapy. vol 44. issue 11. 2001-01-04. PMID:11036021. |
the amino acid substitutions in parc conferring low-level resistance (mics, 4 to 8 microgram/ml) included phe, tyr, and ala for ser-79; asn, ala, gly, tyr, and val for asp-83; asn for asp-78; and pro for ala-115. |
2001-01-04 |
2023-08-12 |
Not clear |